Skip to main content
SpringerLink
Log in

Pattern Recognition Methods in 1H MRS Monitoring In Vivo of Normal Appearing Cerebellar Tissue After Treatment of Posterior Fossa Tumors

  • Conference paper
  • First Online:
Brain Edema XIV

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 106))

Abstract

The objective of this study was to investigate the metabolic responses of normal appearing cerebellar tissue after posterior fossa tumor treatment, and to identify characteristics of the particular treatment method. Moreover, this work examined the metabolic alterations of normal appearing tissue induced by a particular tumor state including resection, stagnation, progression, and recurrence. The studied group consisted of 29 patients treated for posterior fossa tumors. All of them were irradiated with a total dose of 54 Gy at 1.8 Gy/fraction (median values). In addition, 13 underwent chemotherapy, 25 underwent total tumor resection, 18 were tumor-free in control examinations, 5 had a stable disease, and tumor progression or recurrence was observed in 2 and 4 cases, respectively. The 69 spectra, acquired using a MRI/MRS 2T system, were analyzed using Partial Least Squares Discriminant Analysis (PLS-DA) with orthogonal signal correction (OSC) spectral filtering. A significantly elevated spectral region (0.97–1.55 ppm) was observed in patients after total resection in comparison to non-operated subjects. Patients treated with chemotherapy showed an elevated band between 1.15–1.75 and 2.7–3.0 ppm and had decreases in the remaining parts of the spectra. Increases in lactate and decreases in the remaining metabolites were characteristic for the tumor progression/recurrence group. Pattern recognition methods coupled with MRS revealed significant treatment-dependent alterations in normal appearing cerebellar tissue, as well as metabolic changes induced by tumor progression/recurrence.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Beebe DW, Ris MD, Armstrong FD, Fontanesi J, Mulhern R, Holmes E, Wisoff JH (2005) Cognitive and adaptive outcome in low-grade pediatric cerebellar astrocytomas: evidence of diminished cognitive and adaptive functioning in national collaborative research studies (CCG 9891/POG 9130). J Clin Oncol 23:5198–5204

    Article  PubMed  Google Scholar 

  2. Chong Chong VFH, Khoo JBK, Chan LL, Rumpel H (2002) Neurological changes following radiation therapy for head and neck tumours. Eur J Radiol 44:120–129

    Article  Google Scholar 

  3. Chu WC, Chik KW, Chan YL, Yeung DK, Roebuck DJ, Howard RG, Li CK, Metreweli C (2003) White matter and cerebral metabolite changes in children undergoing treatment for acute lymphoblastic leukemia: longitudinal study with MR imaging and 1H MR spectroscopy. Radiology 229:659–669

    Article  PubMed  Google Scholar 

  4. Devos A, Lukas L, Suykensa JAK, Vanhamme L, Tate AR, Howe FA, Majos C, Moreno-Torres A, van der Graaf M, Arus C, van Huffel S (2004) Classification of brain tumours using short echo time 1H MR spectra. J Magn Reson 170(1):164–175

    Article  PubMed  CAS  Google Scholar 

  5. George AP, Kuehn SM, Vassilyadi M, Richards PMP, Parlow SE, Keene DL, Ventureyra ECG (2003) Cognitive sequelae in children with posterior fossa tumors. Pediatr Neurol 28:42–47

    Article  PubMed  Google Scholar 

  6. Gujar SK, Maheshwari S, Bjorkman-Burtscher I, Sundgren PC (2005) Magnetic Resonance Spectroscopy. J Neuro-Ophthalmol 25:217–226

    Article  Google Scholar 

  7. Li X, Vigneron DB, Cha S, Graves EE, Crawford F, Changc SM, Nelson SJ (2005) Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo. Am J Neuroradiol 26:760–769

    PubMed  Google Scholar 

  8. Lindskog M, Spenger C, Jarvet J, Graslund A, Kogner P (2004) Predicting resistance or response to chemotherapy by proton magnetic resonance spectroscopy in neuroblastoma. J Natl Cancer Inst 96:1457–1466

    Article  PubMed  CAS  Google Scholar 

  9. Lindskog M, Spenger C, Klason T, Jarvet J, Gräslund A, Johnsen JI, Ponthan F, Douglas L, Nordell B, Kogner P (2005) Proton magnetic resonance spectroscopy in neuroblastoma: Current status, prospects and limitations. Cancer Lett 228:247–255

    Article  PubMed  CAS  Google Scholar 

  10. Matulewicz Ł, Sokół M, Wydmański J, Hawrylewicz L (2006) Could lipid CH2/CH3 analysis by in vivo 1H MRS help in differentiation of tumor recurrence and post-radiation effects? Folia Neuropathol 44(2):116–124

    PubMed  CAS  Google Scholar 

  11. Menze BH, Lichy MP, Bachert P, Kelm BM, Schlemmer HP, Hamprecht FA (2006) Optimal classification of long echo time in vivo magnetic resonance spectra in the detection of recurrent brain tumors. NMR Biomed 19:599–609

    Article  PubMed  CAS  Google Scholar 

  12. Ruben JD, Dally M, Bailey M, Smith R, McLean CA, Fedele P (2006) Cerebral radiation necrosis: incidence, outcomes, and risk factors with emphasis on radiation parameters and chemotherapy. Int J Radiat Oncol Biol Phys 65:499–508

    Article  PubMed  Google Scholar 

  13. Rutkowski T, Tarnawski R, Sokół M, Maciejewski B (2003) 1H-MR spectroscopy of normal brain tissue before and after postoperative radiotherapy because of primary brain tumors. Int J Radiat Oncol Biol Phys 56(5):1381–1389

    Article  PubMed  Google Scholar 

  14. Tarnawski R, Sokół M, Pieniżek P, Maciejewski B, Walecki J, Miszczyk L, Krupska T (2002) 1H-MRS in vivo predicts the early treatment outcome of postoperative radiotherapy for malignant gliomas. Int J Radiat Oncol Biol Phys 52(5):1271–1276

    Article  PubMed  Google Scholar 

  15. Waldrop SM, Davis PC, Padgett CA, Shapiro MB, Morris R (1998) Treatment of brain tumors in children is associated with abnormal MR spectroscopic ratios in brain tissue remote from the tumor site. Am J Neuroradiol 19:963–970

    PubMed  CAS  Google Scholar 

  16. Walecki J, Sokół M, Pieniżek P, Maciejewski B, Tarnawski R, Krupska T, Wydmański J, Brzeziński J, Grieb P (1999) Role of short TE 1H-MR spectroscopy in monitoring of post-operation irradiated patients. Eur J Radiol 30:154–161

    Article  PubMed  CAS  Google Scholar 

  17. Wold S, Anttia H, Lindgrenb F, Öhman J (1998) Orthogonal signal correction of near-infrared spectra. Chemom Intell Lab Sys 44:175–185

    Article  CAS  Google Scholar 

  18. Wold S, Sjostrom M, Eriksson L (2001) PLS-regression: a basic tool for chemometrics. Chemom Intell Lab Sys 58:109–130

    Article  CAS  Google Scholar 

  19. Young G, Toretsky JA, Campbell AB, Eskenazi AE (2000) Recognition of common childhood malignancies. Am Fam Physician 61:2144–2154

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Physics, Maria SkВodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej 15, Gliwice, 44-101, Poland

    Łukasz Boguszewicz

  2. Department of Radiotherapy, Maria SkВodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej 15, Gliwice, 44-101, Poland

    Sławomir Blamek

  3. Department of Medical Physics, Center of Oncology, Maria SkВodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Wybrzeże Armii Krajowej 15, Gliwice, 44-101, Poland

    Maria Sokół

Authors
  1. Łukasz Boguszewicz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sławomir Blamek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Maria Sokół
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Łukasz Boguszewicz .

Editor information

Editors and Affiliations

  1. Medical Research Center, PAN Warszawa, Ceglowska St. 80, Warszawa, 01-809, Poland

    Zbigniew Czernicki

  2. Klinikum Großhadern, Universitätsklinikum München, Marchioninistr. 15, München, 81377, Germany

    Alexander Baethmann

  3. Dept. Neurosurgery, Musashino Red Cross Hospital, Kyonan-cho 1-26-1, Musashino City, Tokyo, 180, Japan

    Umeo Ito

  4. School of Medicine, Nihon University, Oyaguchikami-machi 30-1 , Tokyo, 173-8610, Japan

    Yoichi Katayama

  5. Dept. Neuropathology, Medical Research Institute, Yushima 1-5-45, Tokyo, 113-8510, Japan

    Toshihiko Kuroiwa

  6. Dept. Neurosurgery, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE46BE, United Kingdom

    David Mendelow

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag/Wien

About this paper

Cite this paper

Boguszewicz, Ł., Blamek, S., Sokół, M. (2010). Pattern Recognition Methods in 1H MRS Monitoring In Vivo of Normal Appearing Cerebellar Tissue After Treatment of Posterior Fossa Tumors. In: Czernicki, Z., Baethmann, A., Ito, U., Katayama, Y., Kuroiwa, T., Mendelow, D. (eds) Brain Edema XIV. Acta Neurochirurgica Supplementum, vol 106. Springer, Vienna. https://doi.org/10.1007/978-3-211-98811-4_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-211-98811-4_31

  • Published:

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-98758-2

  • Online ISBN: 978-3-211-98811-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation