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Introduction to Viral Vectors

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Viral Vectors for Gene Therapy

Part of the book series: Methods in Molecular Biology ((MIMB,volume 737))

Abstract

Viral vector is the most effective means of gene transfer to modify specific cell type or tissue and can be manipulated to express therapeutic genes. Several virus types are currently being investigated for use to deliver genes to cells to provide either transient or permanent transgene expression. These include adenoviruses (Ads), retroviruses (γ-retroviruses and lentiviruses), poxviruses, adeno-associated viruses, baculoviruses, and herpes simplex viruses. The choice of virus for routine clinical use will depend on the efficiency of transgene expression, ease of production, safety, toxicity, and stability. This chapter provides an introductory overview of the general characteristics of viral vectors commonly used in gene transfer and their advantages and disadvantages for gene therapy use.

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Authors and Affiliations

  1. School of Chemical & Bioprocess Engineering and Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland

    Mohamed Al-Rubeai

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  1. James N. Warnock
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  2. Claire Daigre
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  3. Mohamed Al-Rubeai
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Correspondence to Mohamed Al-Rubeai .

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  1. Généthon, rue de l'Internationale 1, Évry CX 2, 91002, France

    Otto-Wilhelm Merten

  2. Chemical & Bioprocess Engineering, University College Dublin, Belfield, Dublin, 4, Ireland

    Mohamed Al-Rubeai

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Warnock, J.N., Daigre, C., Al-Rubeai, M. (2011). Introduction to Viral Vectors. In: Merten, OW., Al-Rubeai, M. (eds) Viral Vectors for Gene Therapy. Methods in Molecular Biology, vol 737. Humana Press. https://doi.org/10.1007/978-1-61779-095-9_1

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