Abstract
Experimental rodent tumors commonly used in radiobiology exhibit a large inter-individual variability in the oxygenation status [1,2] and in the hypoxic cell fraction [3,4]. Paramount factors contributing to this variability may be tumor growth stage or tumor size [5], the cell line used, the growth site, the use of anaesthesia and certain tumor-host interactions (e.g. tumor-induced anemia). Concerning the basic pathogenetic mechanisms through which the above mentioned parameters can modulate tumor tissue oxygenation, variations of nutritive blood flow, inherent characteristics of the cell line (e.g. respiration rate or tumor growth rate), and finally changes in the O2 transport capacity of the arterial blood have to be considered.
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Dedicated to Prof. Dr. Dr. G. Thews to his 60th birthday
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© 1986 Plenum Press, New York
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Vaupel, P., Mueller-Klieser, W. (1986). Cell Line and Growth Site as Relevant Parameters Governing Tumor Tissue Oxygenation. In: Longmuir, I.S. (eds) Oxygen Transport to Tissue VIII. Advances in Experimental Medicine and Biology, vol 200. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5188-7_76
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DOI: https://doi.org/10.1007/978-1-4684-5188-7_76
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