Abstract
Hyperthermia exhibits various direct cytocidal effects (Dickson, 1977; Overgaard, 1977; Suit, 1977). During heat treatment in vivo, several indirect mechanisms enhance the direct cell-killing capacity of hyperthermia. Therefore, the effective use of hyperthermia can overcome some of the well-known problems involved in modern radiation therapy at least in some malignant tumors.
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Ardenne von, M., Lippmann, H.G., Reitnauer, P.G., and Justus, J., 1979, Histological proof for selective stop of microcirculation in tumor tissue at pH 6.1 and 41°C, Naturwissenschaften, 66: 59.
Dickson, J.A., 1977, The effects of hyperthermia in animal tumor systems, Recent Results Cancer Res., 59: 43.
Eddy, H.A., 1980, Alterations in tumor microvasculature during hyperthermia, Radiology, 137: 515.
Emami, B., Nussbaum, G.H., Hahn, N., Piro, A.J., Dritschilo, A., and Quimby, F., 1981, Histopathological study on the effects of hyperthermia on microvasculature, Int. J. Radiat. Oncol. Biol. Phys., 7: 343.
Grunewald, W.A., and Lübbers, D.W., 1976, Cryophotometry as a method for analyzing the intracapillary HbO2 saturation of organs under different O2 supply conditions, Adv. Exp. Med. Biol., 75: 55.
Lierke, E.G., Grossbach, R., Sudhof, H., Müller-Klieser, W., and Vaupel, P., 1982, A feedback control system for localized ultrasonic hyperthermia in tumors. I. Technical and functional description of equipment, Strahlentherapie, 158: 386.
Müller-Klieser, W., Lierke, E.G., and Vaupel, P., 1982b, A feedback control system for localized ultrasonic hyperthermia in tumors. II. Application and first experiments in DS-carcinosarcoma, Strahlentherapie, 158: 387.
Müller-Klieser, W., Manz, R., Otte, J., and Vaupel, P., 1982a, Effect of localized hyperthermia on tumor blood flow and oxygenation, Proc. 3rd Int. Congr. Thermol., in press.
Müller-Klieser, W., Vaupel, P., Manz, R., and Schmidseder, R., 1981, Intracapillary oxyhemoglobin saturation of malignant tumors in humans, Int. J. Radiol. Oncol. Biol. Phys., 7: 1397.
Müller-Klieser, W., Zander, R., and Vaupel, P., 1978, Oxygen consumption of tumor cells suspended in native ascitic fluid at 1–42°C, Pflügers Arch., 377:.R17.
Otte, J., Vaupel, P., and Gabbert, H., 1982, Changes in tumor microvasculature after localized hyperthermia, Proc. Ann. Meeting Microcirculat. Soc, Munich.
Overgaard, J., 1977, Effect of hyperthermia on malignant cells in vivo, Cancer, 39: 2637.
Overgaard, J., and Nielson, O.S., 1980, The role of tissue environmental factors on the kinetics and morphology of tumor cells exposed to hyperthermia, Ann. N.Y. Acad. Sci., 335: 254.
Suit, H.D., 1977, Hyperthermic effects on animal tissues, Radiology, 123: 483.
Vaupel, P., Frinak, S., Müller-Klieser, W., and Bicher, H.I., 1982a, Impact of localized hyperthermia on the cellular micro-environment in solid tumors, Natl. Cancer Inst. Monogr., 60, in press.
Vaupel, P., Manz, R., Müller-Klieser, W., and Grunewald, W.A., 1979, Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia, Microvasc. Res., 17: 181.
Vaupel, P., Müller-Klieser, W., Otte, J., Manz, R., and Kallinowski, F., 1982c, Blood flow, tissue oxygenation, and pH distribution in malignant tumors upon localized hyperthermia. Basic pathophysiological aspects and the role of various thermal doses, Strahlentherapie, in press.
Vaupel, P., Ostheimer, K., and Müller-Klieser, W., 1980, Circulatory and metabolic responses of malignant tumors during localized hyperthermia, J. Cancer Res. Clin. Oncol., 98: 15.
Vaupel, P., Otte, J., and Manz, R., 1982b, Oxygenation of malignant tumors after localized microwave hyperthermia, Radiat. Environ. Biophys., in press.
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© 1984 Plenum Press, New York
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Vaupel, P., Müller-Klieser, W., Otte, J., Manz, R. (1984). Impact of Various Thermal Doses on the Oxygenation and Blood Flow in Malignant Tumors Upon Localized Hyperthermia. In: Lübbers, D.W., Acker, H., Leniger-Follert, E., Goldstrick, T.K. (eds) Oxygen Transport to Tissue-V. Advances in Experimental Medicine and Biology, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1188-1_56
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DOI: https://doi.org/10.1007/978-1-4684-1188-1_56
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