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Circadian variation of cell proliferation and cell cycle protein expression in man: Clinical implications

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Progress in Cell Cycle Research

Part of the book series: Progress in Cell Cycle Research ((PCCR))

Abstract

Most physiological, biochemical and behavioural processes have been shown to vary in a regular and predictable periodic manner with respect to time. This review focuses on the circadian rhythm in cell proliferation in bone marrow and gut and how this is associated with a circadian expression of cell cycle proteins in human oral mucosa. The control of circadian rhythms by the suprachiasmatic nuclei and the evolving understanding of the genetic and molecular biology of the circadian clock is outlined. Finally, the potential clinical impact of chronobiology in cancer medicine is discussed.

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Authors and Affiliations

  1. Division of Medical Oncology, Toronto-Sunnybrook Regional Cancer Centre, 2075 Bayview Ave., Toronto, Ontario, M4N 3M5, Canada

    Georg A. Bjarnason

  2. Department of Medicine, University of Toronto, Canada

    Georg A. Bjarnason

  3. Faculty of Dentistry, University of Toronto, Canada

    Richard Jordan

  4. Departments of Laboratory Medicine and Dentistry, Sunnybrook and Women’s College Health Sciences Centre, Toronto, Canada

    Richard Jordan

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  1. Georg A. Bjarnason
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  1. Centre National de la Recherche Scientifique, Roscoff, France

    Laurent Meijer  & Armelle Jézéquel  & 

  2. Centre National de la Recherche Scientifique, Université Paul Sabatier, Toulouse, France

    Bernard Ducommun

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Bjarnason, G.A., Jordan, R. (2000). Circadian variation of cell proliferation and cell cycle protein expression in man: Clinical implications. In: Meijer, L., Jézéquel, A., Ducommun, B. (eds) Progress in Cell Cycle Research. Progress in Cell Cycle Research. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4253-7_17

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