Abstract
Tissue destruction of the lacrimal and salivary glands is the cardinal feature of Sjögren’s syndrome. Although lymphocyte infiltration accompanies this destruction, the mechanism of tissue destruction has not been elucidated. Recently, it was suggested that granzyme A and perforin are associated with immune-mediated cytolysis in such autoimmune diseases as rheumatoid arthritis, where the up-regulation of these compounds in synovial fluid lymphocytes causes tissue destruction.1 We have investigated whether granzyme A and perforin are associated with Sjögren’s syndrome.
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References
G. Griffiths, S. Alpert, E. Lambert, J. McGuire, and I. Weissman, Perforin and granzyme A expression idendifying cytolytic lymphocytes in rheumatoid arthritis. Proc. Natl. Acad. Sci.USA 89:549 (1992).
C. Lie, S. Rafii, A. Granelli-Piperno, J. Trapani, and J. Young, Perforin and serine esterase gene expression in stimulated human T cells, J. Exp. Med. 170:2105 (1989).
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© 1994 Springer Science+Business Media New York
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Tsubota, K., Saito, I., Miyasaka, N. (1994). Expression of Granzyme A and Perforin in Lacrimal Gland of Sjögren’s Syndrome. In: Sullivan, D.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology, vol 350. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2417-5_106
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DOI: https://doi.org/10.1007/978-1-4615-2417-5_106
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6025-4
Online ISBN: 978-1-4615-2417-5
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