Abstract
Gastric cancer, despite a recent decline in the incidence, is still a leading cause of death in Japan. For this reason, much effort has been directed to the early detection of the cancer through mass screening programs throughout the country. In most workplaces in Japan, an indirect X-ray examination, using 10 cm square film, is the conventional first screening step, after which those suspected of having some abnormalities in the gastric mucosa are further investigated either with a higher quality X-ray examination or by endoscopy. However, the sensitivity of the conventional X-ray screening step is by no means high. To improve the effectiveness of gastric cancer screening, we have devised a new screening method that utilizes measurement of serum pepsinogen (pepsinogen I and II) levels. This new screening system is based on the facts that a considerable part of gastric cancers develop in gastric mucosa affected by severe and extensive atrophic gastritis (1) and that serum pepsinogen levels serve as a sensitive marker of chronic atrophic gastritis (2). We report the first application of serum pepsinogen measurement for mass screening of gastric cancer at a certain workplace and compare the results with those of the conventional X-ray screening method.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
P. Correa, The Gastric Precancerous Process, Cancer Surv. 2:437 (1983)
K. Miki, M. Ichinose, A. Shimizu, S. C. Huang, H. Oka, C. Furihata, T. Matsushima and K. Takahashi, Serum Pepsinogens as a Screening Test of Extensive Chronic Gastritis, Gastroenterol. Jpn. 22:133 (1987)
K. Miki, M. Ichinose, N. Kawamura, M. Matsushima, H. B. Ahmad, M. Kimura, J. Sano, T. Tashiro, N. Kakei, H. Oka, C. Furihata and K. Takahashi, The Significance of Low Serum Pepsinogen Levels to Detect Stomach Cancer Associated with Extensive Chronic Gastritis in Japanese Subjects, Jpn. J. Cancer Res. 80, 114 (1989)
M. Ichinose, K. Miki, C. Furihata, T. Kageyama, R. Hayashi, H. Niwa, H. Oka, T. Matsushima and K. Takahashi, Radioimmunoassay of Serum Group I and Group II Pepsinogens in Normal Controls and Patients with Various Disorders, Clin. Chim. Acta 126:183 (1982)
K. Miki, M. Ichinose, K. B. Ishikawa, N. Yahagi, M. Matsushima, N. Kakei, S. Tsukada, M. Kido, S. Ishihama, Y. Shimizu, T. Suzuki and K. Kurokawa, Clinical Application of Serum Pepsinogen I and II Levels for Mass Screening to Detect Gastric Cancer, Jpn. J. Cancer Res. 84:1086 (1993)
A. Fukao, S. Hisamichi, N. Ohsato, N. Fujino, N. Endo and M. Iha, Correlation between the Prevalence of Gastritis and Gastric Cancer in Japan, Cancer Causes and Control 4:17 (1992)
M. Kabuto, H. Imai, S. Tsugane and S. Watanabe, Correlation between Atrophic Gastritis Prevalance and Gastric Cancer Mortality among Middle-aged Men in 5 Areas in Japan, J. Epidemiol. 3:35 (1993)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Matsushima, M. et al. (1995). The Clinical Application of the Serum Pepsinogen I And II Levels as a Mass Screening Method for Gastric Cancer. In: Takahashi, K. (eds) Aspartic Proteinases. Advances in Experimental Medicine and Biology, vol 362. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1871-6_17
Download citation
DOI: https://doi.org/10.1007/978-1-4615-1871-6_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-5761-2
Online ISBN: 978-1-4615-1871-6
eBook Packages: Springer Book Archive