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Neuropilin and Class 3 Semaphorins in Nervous System Regeneration

  • Chapter
Neuropilin: From Nervous System to Vascular and Tumor Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 515))

Abstract

Injury to the mature mammalian central nervous system (CNS) is often accompanied by permanent loss of function of the damaged neural circuits. The failure of injured CNS axons to regenerate is thought to be caused, in part, by neurite outgrowth inhibitory factors expressed in and around the lesion. These include several myelin associated inhibitors, proteoglycans, and tenascin-R. Recent studies have documented the presence of class 3 semaphorins in fibroblast-like meningeal cells present in the core of the neural scar formed following CNS injury. Class 3 semaphorins display neurite growth-inhibitory effects on growing axons during embryonic development. The induction of the expression of class 3 semaphorins in the neural scar and the persistent expression of their receptors, the neuropilins and plexins, by injured CNS neurons suggest that they contribute to the regenerative failure of CNS neurons. Neuropilins are also expressed in the neural scar in a subpopulation of meningeal fibroblast and in neurons in the vicinity of the scar. Semaphorin/neuropilin signaling might therefore also be important for cell migration, angiogenis and neuronal cell death in or around neural scars.

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  1. Netherlands Institute for Brain Research, Meibergdreef 33, Amsterdam, 1105 AZ, The Netherlands

    Fred De Winter

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  1. Fred De Winter
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  2. Anthony J. G. D. Holtmaat
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  3. Joost Verhaagen
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  1. Maître de Conférences, Université Louis Pasteur, 67084, Strasbourg, France

    Dominique Bagnard Ph.D.

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De Winter, F., Holtmaat, A.J.G.D., Verhaagen, J. (2002). Neuropilin and Class 3 Semaphorins in Nervous System Regeneration. In: Bagnard, D. (eds) Neuropilin: From Nervous System to Vascular and Tumor Biology. Advances in Experimental Medicine and Biology, vol 515. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0119-0_10

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