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Naturally Occurring Autoantibodies Mediate Ischemia/Reperfusion-Induced Tissue Injury

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Naturally Occurring Antibodies (NAbs)

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 750))

Abstract

Ischemia and reperfusion events within the heart and brain and similar trauma-induced ischemia/reperfusion events lead to significant morbidity and mortality. In the past two decades, an excessive innate immune response has been identified as the mediator of reperfusion-induced tissue damage. Recent evidence indicates that naturally occurring autoantibody (NAb) activation of complement is a major mechanism of injury due to ischemia/reperfusion. This chapter focuses on the antigens exposed by ischemia and recognized by NAbs, the mechanism of complement activation by damaging NAbs and the protective role of IVIG in ischemia/reperfusion-induced pathology.

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  1. Division of Biology, Kansas State University, Manhattan, Kansas, USA

    Sherry D. Fleming

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  1. Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Hönggerberg, Zurich, Switzerland

    Hans U. Lutz

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Fleming, S.D. (2012). Naturally Occurring Autoantibodies Mediate Ischemia/Reperfusion-Induced Tissue Injury. In: Lutz, H.U. (eds) Naturally Occurring Antibodies (NAbs). Advances in Experimental Medicine and Biology, vol 750. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-3461-0_13

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