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RAMPs and CGRP Receptors

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RAMPs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 744))

Abstract

Receptor activity modifying protein 1 (RAMP1) forms a complex with calcitonin receptor-like receptor (CLR) to produce the receptor for calcitonin gene-related peptide (CGRP). RAMP1 has two main roles. It facilitates the cell-surface expression of CLR. It is also essential for the binding of CGRP to the receptor. It seems likely that Y66, F93, H97 and F101, amongst other residues, form a binding site for CLR. These cluster together on the same face of the extracellular portion of RAMP1, probably close to where it enters the plasma membrane. Residues at the other end of RAMP1 are most likely to be involved in CGRP recognition, although it is currently unclear how they do this. Within this area, W74 is important for the binding of the nonpeptide antagonist, BIBN4096BS, although it does not seem to be involved in the binding of CGRP itself. It has been shown that there is an epitope within residues 23–60 of CLR that are essential for RAMP recognition. Under some circumstances, changes in the expression of RAMP1 can alter the sensitivity of cells to CGRP, demonstrating that regulation of its levels may be of physiological or pathophysiological importance.

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Authors and Affiliations

  1. School of Life and Health Sciences, Aston University, Birmingham, UK

    James Barwell, Denise Wootten & David R. Poyner

  2. Department of Pharmacology, University of Monash, Clayton, Victoria, Australia

    John Simms

  3. School of Biological Sciences, University of Auckland, Auckland, New Zealand

    Debbie L. Hay

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  1. James Barwell
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  2. Denise Wootten
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  4. Debbie L. Hay
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  5. David R. Poyner
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Correspondence to David R. Poyner .

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Editors and Affiliations

  1. Department of Physiology, Michigan State University, East Lansing, Michigan, USA

    William S. Spielman PhD  & Narayanan Parameswaran PhD  & 

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© 2012 Landes Bioscience and Springer Science+Business Media

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Barwell, J., Wootten, D., Simms, J., Hay, D.L., Poyner, D.R. (2012). RAMPs and CGRP Receptors. In: Spielman, W.S., Parameswaran, N. (eds) RAMPs. Advances in Experimental Medicine and Biology, vol 744. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-2364-5_2

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