Abstract
There are both pharmacologic and practical reasons for recommending intraoperative intraperitoneal chemotherapy. From a pharmacologic point of view, direct installation of selected drugs into the peritoneal cavity results in a large increase in the amount of chemotherapy that reaches abdominal and pelvic surfaces. This pharmacologic advantage is the result of the peritoneal-plasma barrier. Molecules of large hydrophyllic drugs leave the peritoneal cavity more slowly than they are metabolized systemically. Three-fore, a great concentration difference exists at all times between drug concentration within the peritoneal cavity and drug concentration in the plasma [1,2].
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Jacquet P. The peritoneal-plasma barrier. In: Sugarbaker PH. ed. Peritoneal carcinomatosis: Principles of Management. Norwell, MA: Kluwer Academic Publishers, 1996, pp 53–63.
Myers CE, Collins JM. Pharmacology of intraperitoneal chemotherapy. Cancer Invest 1983;1:395–407.
Speyer JL, Sugarbaker PH, Collins JM, Dedrick RL, Klecker RW, Meyers CE. Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans. Cancer Res 1981;41:1916–1922.
Rosenhein H, Blake D, McIntryre P, Parmly T. The effect of volume on the distribution of substances instilled into the peritoneal cavity. Gynecol Oncol 1978;6:106–110.
Markman M, Cleary S, Howell SB, Lucas WE. Complications of extensive adhesion formation after intraperitoneal chemotherapy. Surg Gynecol Obstet 1986;162:445–448.
Fujimura T, Yonemura Y, Fushida S, Urade M, et al. Continuous hyperthermic peritoneal perfusion for the treatment of peritoneal dissemination in gastric cancers and subsequent second-look operation. Cancer 1990;65:65–71.
Gilly FN, Carry PY, Brachet A, et al. Treatment of malignant peritoneal effusion in digestive and ovarian cancer. Med Oncol Tumor Pharmacother 1992;9:177–181.
Los G, Sminia P, Wondergem J, Mutsaers PHA, et al. Optimization of intraperitoneal cisplatin therapy with regional hyperthermia in rats. Eur J Cancer 1991;27:472–477.
Fujimoto S, Takahashi M, Endoh F, Shresta RD, et al. A clinical study combining surgery with intraoperative pelvic hyperthermochemotherapy to prevent local recurrence of rectal cancer. Ann Surg 1991;213:43–47.
Yonemura Y, Ninomiya I, Kaji M, Sugiyama K, et al. Prophylaxis with intraoperative chemohyperthermia against peritoneal recurrence of serosal invasion-positive gastric cancer. World J Surg 1995;19:450–455.
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© 1996 Kluwer Academic Publishers, Boston
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Sugarbaker, P.H., Averbach, A.M., Jacquet, P., Stephens, A.D., Stuart, O.A. (1996). A simplified approach to hyperthermic intraoperative intraperitoneal chemotherapy (HIIC) using a self retaining retractor. In: Sugarbaker, P.H. (eds) Peritoneal Carcinomatosis: Principles of Management. Cancer Treatment and Research, vol 82. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1247-5_26
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DOI: https://doi.org/10.1007/978-1-4613-1247-5_26
Publisher Name: Springer, Boston, MA
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