Skip to main content
SpringerLink
Log in

Wound Healing in Diabetes: Hemorheological and Microcirculatory Aspects

  • Conference paper
  • First Online:
Oxygen Transport to Tissue XXXII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 701))

Abstract

Diabetes is associated with many hemorheological alterations. The decrease of RBC deformability, increase of aggregability, vasoconstriction, increase of blood viscosity and decrease of oxygen supply have a significant effect on wound healing, such as in foot ulcers. Basically, there is endothelial dysfunction and alteration of permeability; these impair wound healing in diabetic patients. Microcirculation still functions and there is blood flow, even when there is a decrease in vessel diameter, without anatomical lesions in vessel walls. It is necessary to maintain a good oxygen supply. Analyzing microcirculation and hemorheology in diabetes and considering methodologies to treat diabetic foot ulcers (e.g., hyperbaric oxygen therapy, laser, and vacuum) may help in the treatment of patient pathologies.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Forconi S. (2006) Il microcircolo nella malattia diabetica – Microangiologia. Centro Scientif Edr. Torino;1:1-42.

    Google Scholar 

  2. Nathan DM, Cleary PA, Backlund JY. et al (2005) Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med ;353:2643-53.

    Article  PubMed  Google Scholar 

  3. Chien Shu et al (1971) Present state of blood rheology in hemodilution, theoretical basis and clinical application Int Symp Rottach-Egern, ; Karger Basel 1972:1-45.

    Google Scholar 

  4. Goldsmith HL. (1968) The microrheology of red blood cell suspension J Gen Physiol :52-8.

    Google Scholar 

  5. Schmid-Schönbein H,Wells RE. (1971) Rheological properties of human erythrocytes. Egern Physiol : 63-146.

    Google Scholar 

  6. Di Perri T. et al (1981) Aspetti Fisiopatologici e Clinici delle Sindromi da iperviscosità ematica. La Ric Clin Lab ;1,11:73-84.

    Google Scholar 

  7. Dintenfass L. Hyperviscosity and hyperviscosaemia MTP Press Lancaster, 1985.

    Google Scholar 

  8. Baskurt OK. Mechanisms of Blood Rheology Alterations. Handbook of Hemorheology. IOS Press 2007;170-90.

    Google Scholar 

  9. Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress and antioxidants: a review. J Biochem Mal Toxicol 2003;17,24-38.

    Article  CAS  Google Scholar 

  10. Nishikawa T, Edelstein D, Du XL. et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000;404,787-90.

    Article  PubMed  CAS  Google Scholar 

  11. Neu B, Meiselman HJ. Red Blood Cell Aggregation. Handbook of Hemorheology, IOS Press 2007;114-36.

    Google Scholar 

  12. Caimi G, Lo Presti RL. Techniques to evaluate erythrocyte deformability in diabetes mellitus. Acta Diabetologica 2004;41,99-103.

    CAS  Google Scholar 

  13. Bryszewska M, Watala C, Torzecka W. Changes in fluidity and composition of erythrocyte membranes and in composition of plasma lipids in type 1 diabetes Br J Haemat 1986;62:111- 6.

    Google Scholar 

  14. McMillanDE. Plasmaprotein changes, blood viscosity and diabetic microangiopathy. Diabetes 1976;25;858-64.

    Google Scholar 

  15. Volger E, Schmid-Schönbein H, Mehnert H. Microrheological changes of blood in diabetes mellitus. Bibl Anat 1975;13:97-8.

    PubMed  CAS  Google Scholar 

  16. Schmid-Schönbein H, Volger E. Red cell aggregation and red cell deformability in diabetes. Diabetes 1976;25:897-902.

    PubMed  Google Scholar 

  17. Baskurt OK,Temiz A, Meiselman HJ. Effect of superoxide anions on red blood cell rheologic properties. Free Radic Biol Med 1998;24:102-10.

    Article  PubMed  CAS  Google Scholar 

  18. Braun RD, Fisher TC, Meiselman HJ. et al. Decreased deformability of polymorphonuclear leukocytes in diabetic cats Microcirculation 1996;3:271-8.

    CAS  Google Scholar 

  19. Caimi G, Canino B, Montana M. et al., Polymorphonuclear leukocyte membrane fluidity and cytosolic calcium concentration in diabetes mellitus. Acta Diabetol 1998;35:158-60.

    Article  PubMed  CAS  Google Scholar 

  20. Sham SV, Wallin JD, Ellen SD. Chemiluminescence and superoxide anion production by leukocytes from diabetic patients. J Clin Endocrinol Metab 1983; 57:402-9.

    Article  Google Scholar 

  21. Sagel J, Colwell JA, Crock L. et. al., Increased platelet aggregation in early diabetes mellitus. Ann Int Med 1975;82:733-8.

    Google Scholar 

  22. Knobler H, Savion N, Shenkman B. et al., Adhesion and aggregation on sub-endothelium are increased in diabetic patients Thromb Res 1998;90:181-90.

    CAS  Google Scholar 

  23. Hunt TK. et al., The role of perfusion and oxygenation in wound healing.Wound Care Textbook 1998.

    Google Scholar 

  24. Laurie M. Rappl. Physiological changes in tissues denervated by SCI and possible effects on wound healing. Int Wound J 2008;5:435-44.

    Article  PubMed  Google Scholar 

  25. Kindig CA, SextonWl, FeddeMR. et al. Skeletal muscle microcirculatory structure and hemodynamics in diabetes. Respir Physiol 1998;111:163-75.

    Google Scholar 

  26. MacRury SM, Lowe GD. Blood rheology in diabetes mellitus. Diab Med 1990;7:285-91.

    Article  CAS  Google Scholar 

  27. International Consensus on Diabetic Foot 2000 - Mediserve Edr. Naples, Italy

    Google Scholar 

  28. Cicco G. et al. Peripheral perfusion and tissue oxygenation AEMB Plenum Press New York USA 1997;31:261-6.

    Google Scholar 

  29. Wagner FW. Foot Ankle Classification 1981 In: “Int. Cons. on Diab. Foot” Mediserve Naples, Italy 2000;13.

    Google Scholar 

  30. Lavery LA. Texas Wound Classification In: “Int. Cons. Diab. Foot” Mediserve Naples, Italy 2000,14.

    Google Scholar 

  31. Modena MG. et al. Diabetic arteriopathy Min Med 2004;12:81-9.

    Google Scholar 

  32. Nasole E. Ossigeno terapia Iperbarica in: “Arteriopatia Diabetica degli arti inferiori” edr Stella A. Min. Medica Torino 004;36:245-54.

    Google Scholar 

  33. Niinikoski J. Oxygen and wound healing Clin Plast Surg 1997;4:361-4.

    Google Scholar 

  34. Niinikoski J, Hunt TK. Oxygen and wound healing. In: Handbook of HOT. Springer edr. 1996;485-507.

    Google Scholar 

  35. Marangoni O, Longo L. Laser in phlebology. Trieste 2006; 5-24.

    Google Scholar 

  36. Masahiro Shibata et al. Wound repair and regeneration. Wound Rep Reg 2008;16:460-5.

    Article  Google Scholar 

  37. Mendoca DA, Papini R, Price PE. Negative pressure wound therapy: a snapshot of evidence. Int Wound J 2006;3:261-71.

    Article  Google Scholar 

  38. Pham CT. et al., The safety and efficacy of topical negative pressure in non healing wounds: a systematic review. J Wound Care 2006;15:240-50.

    PubMed  CAS  Google Scholar 

  39. Wasiak I, Cleveland H. Topical negative pressure (TNP) for partial thickness burns. Cochrane Database System Review 2007:3.

    Google Scholar 

  40. Nelson EA. Vacuum assisted closure for chronic wounds: a review of the evidence. EWMA J 2007;7:5-11.

    Google Scholar 

  41. Ubbink DT, Vermeulen H. A systemic review of topical negative pressure therapy for acute and chronic wounds. Br J Surg 2008;95:685-92.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hemorheology and Microcirculation Research Unit, University of Bari, Bari, Italy

    Giuseppe Cicco & Sebastiano Cicco

  2. Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy

    Francesco Giorgino

Authors
  1. Giuseppe Cicco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Francesco Giorgino
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sebastiano Cicco
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Giuseppe Cicco .

Editor information

Editors and Affiliations

  1. , Department of Physiology & Biophysics, Case Western Reserve University School o, 10900 Euclid Avenue, Cleveland, 44106, Ohio, USA

    Joseph C. LaManna

  2. , Department of Nutrition, Case Western Reserve University, Cleveland, 44106, Ohio, USA

    Michelle A. Puchowicz

  3. , Department of Neurology, Case Western Reserve University, Cleveland, 44106, Ohio, USA

    Kui Xu

  4. , Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom

    David K Harrison

  5. Synthesizer, Inc., Westminster Rd 2773, Ellicott City, 21043, Maryland, USA

    Duane F. Bruley

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media, LLC

About this paper

Cite this paper

Cicco, G., Giorgino, F., Cicco, S. (2011). Wound Healing in Diabetes: Hemorheological and Microcirculatory Aspects. In: LaManna, J., Puchowicz, M., Xu, K., Harrison, D., Bruley, D. (eds) Oxygen Transport to Tissue XXXII. Advances in Experimental Medicine and Biology, vol 701. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7756-4_35

Download citation

Publish with us

Policies and ethics

Search

Navigation