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Although no standard definition exists, the term coronary event is used in clinical research to refer to adverse events caused by disease processes affecting the coronary arteries. These may include what are termed “hard” events such as deaths that are attributed to coronary artery disease and nonfatal myocardial infarctions, but also occasionally “soft” events such as angina or revascularizations for worsening coronary artery stenosis. Because coronary event is often such a composite of clinical events of varying significance, there remains considerable debate on what should constitute the most appropriate component endpoints and how to define them, with the recognition that these choices may significantly influence the results and impact of clinical trials and other studies (Kip, Hollabaugh, Marroquin, & Williams, 2008). To address this, guidelines such as the 2001 ACC Clinical Data Standards and the 2007 Joint ESC/ACCF/AHA/WHF Task Force for the...
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References and Readings
ACC Writing Committee for Acute Coronary Syndromes Clinical Data Standards & ACC Task Force on Clinical Data Standards. (2001). American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes. Journal of the American College of Cardiology, 38(7), 2114–2130.
Kip, K. E., Hollabaugh, K., Marroquin, O. C., & Williams, D. O. (2008). The problem with composite end points in cardiovascular studies. Journal of the American College of Cardiology, 51(7), 701–707.
Thygesen, K., Alpert J. S., White H. D., on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. (2007). Universal definition of myocardial infarction. European Heart Journal, 28(20), 2525–2538.
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© 2013 Springer Science+Business Media, New York
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Ye, S. (2013). Coronary Event. In: Gellman, M.D., Turner, J.R. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1005-9_395
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DOI: https://doi.org/10.1007/978-1-4419-1005-9_395
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