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Metaplastic Breast Carcinoma: Detection Using Histology and Immunohistochemistry

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Methods of Cancer Diagnosis, Therapy and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 1))

Metaplastic breast carcinoma represents a group of rare diseases deviating from each other not only in their morphological appearance, but also in their prognosis. In addition to the routine histological analysis, immunohistochemistry plays a crucial role in delineating these tumors from usual breast carcinomas and sarcomas, in subtyping of these tumors into different prognostic categories and in the prediction of their response to individual therapy. Despite the wide variety of microscopic morphology of the lesions that are actually classified as metaplastic breast carcinoma, histological subtyping and grading separate properly patients with low-risk tumors adequately treated with wide surgical excision only and high-risk tumors requiring adjuvant therapy. Immunohistochemical receptor analysis shows presence or absence of therapeutic target molecules, and therefore is essential for adequate therapy planning.

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Authors and Affiliations

  1. Department of Pathology, Central Hospital, 791 82, Falun, Sweden

    Tibor Tot

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  1. Tibor Tot
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Editors and Affiliations

  1. Department of Biological Sciences, Kean University, Union, NJ, USA

    M. A. Hayat

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Tot, T. (2008). Metaplastic Breast Carcinoma: Detection Using Histology and Immunohistochemistry. In: Hayat, M.A. (eds) Methods of Cancer Diagnosis, Therapy and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8369-3_21

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  • DOI: https://doi.org/10.1007/978-1-4020-8369-3_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-1-4020-8368-6

  • Online ISBN: 978-1-4020-8369-3

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