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References
Feldman C (2000) Nonspecific host defenses: Mucociliary clearance and cough. In: MS Niederman, GA Sarosi, J Glassroth (eds): Respiratory infections. Williams and Wilkins, Philadelphia, 13–25
Feldman C, Anderson R, Rutman A, Cole PJ, Wilson R (1998) Human ciliated epithelium in vitro — mechanisms of injury and protection. In: GL Baum, Z Priel, Y Roth, N Liron, EJ Ostfeld (eds): Cilia, mucus, and mucociliary interactions. Marcel Dekker, Inc., New York, 461–71
Wilson R, Dowling RB, Jackson AD (1996) The biology of bacterial colonization and invasion of the respiratory mucosa. Eur Respir J 9: 1523–30
Feldman C, Read R, Rutman A, Jeffery PK, Brain A, Lund V, Mitchell TJ, Andrew PW, Boulnois GJ, Todd HC et al (1992) The interaction of Streptococcus pneumoniae with intact human respiratory mucosa in vitro. Eur Respir J 5: 576–83
Feldman C, Anderson R, Theron AJ, Cole P, Wilson R (2001) The cytoprotective effects of macrolides, azalides, and ketolides on human ciliated epithelium in vitro. In: M Salathe (ed): Cilia and mucus. From development to respiratory defense. Marcel Dekker, Inc., New York, 145–53
Tamaoki J, Chiyotani A, Sakai N, Takeyama K, Takizawa T (1992) Effect of erythromycin on ciliary motility in rabbit airway epithelium in vitro. J Antimicrob Chemother 29: 173–8
Sugiura Y, Ohashi Y, Nakai Y (1997) Roxythromycin stimulates the mucociliary activity of the Eustachian tube and modulates neutrophil activity in the healthy guinea pig. Acta Otolaryngol (Stockh) (Suppl) 531: 34–8
Nakano T, Ohashi Y, Tanaka A, Kakinoki Y, Washio Y, Nakai Y (1998) Roxythromycin reinforces epithelial defence function in rabbit trachea. Acta Otolaryngol (Stockh) (Suppl) 538: 233–8
Rutman A, Dowling R, Wills P, Feldman C, Cole PJ, Wilson R (1998) Effect of dirithromycin on Haemophilus influenzae infection of the respiratory mucosa. Antimicrob Agents Chemother 42: 772–8
Tsang KW, Rutman A, Kanthakumar K, Belcher J, Lund V, Roberts DE, Read RC, Cole PJ, Wilson R (1993) Haemophilus influenzae infection of human respiratory mucosa in low concentrations of antibiotics. Am Rev Respir Dis 148: 201–7
Dowling RB, Rayner CFJ, Rutman A, Jackson AD, Kanthakumar K, Dewar A, Taylor GW, Cole PJ, Johnson M, Wilson R (1997) Effect of salmeterol on Pseudomonas aeruginosa infection of respiratory mucosa. Am J Respir Crit Care Med 155: 327–36
Takeyama K, Tamaoki J, Chiyotani A, Tagaya E, Konno K (1993) Effect of macrolide antibiotics on ciliary motility in rabbit airway epithelium in vitro. J Pharm Pharmacol 45: 756–8
Lagrou K, Peetermans WE, Jorissen M, Verhaegen J, Van Damme J, Van Eldere J (2000) Sub-inhibitory concentrations of erythromycin reduce pneumococcal adherence to respiratory epithelial cells in vitro. J Antimicrob Chemother 46: 717–23
Spreer A, Kerstan H, Bottcher T, Gerber J, Siemer A, Zysk G, Mitchell TJ, Eiffert H, Nau R (2003) Reduced release of pneumolysin by Streptococcus pneumoniae in vitro and in vivo after treatment with nonbacteriolytic antibiotics in comparison to ceftriaxone. Antimicrob Agents Chemother 47: 2649–54
Tanaka E, Kanthakumar K, Cundell DR, Tsang KWT, Taylor GW, Kuze F, Cole PJ, Wilson R (1994) The effect of erythromycin on Pseudomonas aeruginosa and neutrophil mediated epithelial damage. J Antimicrob Chemother 33: 765–75
Dowling RB, Johnson M, Cole PJ, Wilson R (1998) Effect of salmeterol on Haemophilus influenzae infection of respiratory mucosa in vitro. Eur Respir J 11: 86–90
Dowling RB, Johnson M, Cole PJ, Wilson R (1999) Effect of fluticasone propionate and salmeterol on Pseudomonas aeruginosa infection of the respiratory mucosa in vitro. Eur Respir J 14: 363–9
Dowling RB, Johnson M, Cole PJ, Wilson R (1999) The effect of rolipram, a type IV phosphodiesterase inhibitor, on Pseudomonas aeruginosa infection of respiratory mucosa. J Pharmacol Exp Ther 282: 1565–71
Feldman C, Anderson R, Theron AJ, Ramafi G, Cole PJ, Wilson R (1997) Roxithromycin, clarithromycin, and azithromycin attenuate the injurious effects bioactive phospholipids, on human respiratory epithelium in vitro. Inflammation 21: 655–65
Feldman C, Anderson R, Theron A, Mokgobu I, Cole PJ, Wilson R (1999) The effect of ketolides on bioactive phospholipid-induced injury to human ciliated epithelium in vitro. Eur Respir J 13: 1022–8
Mokgobu I, Theron AJ, Anderson R, Feldman C (1999) The ketolide antimicrobial agent HMR-3004 inhibits neutrophil superoxide production by a membrane-stabilizing mechanism. International J Immunopharmacology 21: 365–77
Theron AJ, Feldman C, Anderson R (2000) Investigation of the anti-inflammatory and membrane-stabilizing potential of spiramycin in vitro. J Antimicrob Chemother 46: 269–71
Feldman C, Anderson R, Theron AJ, Steel HC, van Rensburg CEJ, Cole PJ, Wilson (2001) Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. Eur Respir J 18: 122–9
Gutierrez-Cabano CA, Raynald AC (1999) Gastroprotective effect of intragastric clarithromycin again damage induced by ethanol in rats. Dig Dis Sci 44: 1721–31
Dallegri F, Ottonello L (1997) Tissue injury in neutrophilic inflammation. Inflamm Res 46: 382–91
Witko-Sarsat V, Rieu P, Descamps-Latscha B, Lesavre P, Halbwachs-Mecarelli L (2000) Neutrophils: molecules and pathophysiological aspects. Lab Invest 80: 617–53
Feldman C, Anderson R, Kanthakumar K, Vargas A, Cole PJ, Wilson R (1994) Oxidantmediated ciliary dysfunction in human respiratory epithelium. Free Rad Biol Med 17: 1–10
Lewis S, Berg JR, Kleine TJ (1995) Modulation of epithelial permeability by extracellular molecules. Physiol Rev 75: 561–89
Ichikawa Y, Ninomiya H, Koga H, Tanaka M, Kinoshita M, Tokuna N, Yano T, Oizumi K (1992) Erythromycin reduces neutrophils and neutrophil-derived elastolytic-like activity in the lower respiratory tract of bronchiolitis patients. Am Rev Resp Dis 146: 196–203
Oda H, Kadota J, Kohno S, Hara K (1994) Erythromycin inhibits neutrophil chemotaxis in bronchoalveoli of diffuse panbronchiolitis. Chest 106: 1116–23
Ianaro A, Ialenti A, Maffia P, Sautebin L, Rombolo L, Carnuccio R, Iuvone T, D’Acquisto F, Di Rosa M (2000) Anti-inflammatory activity of macrolide antibiotics. J Pharmacol Exp Ther 292: 156–63
Lin HC, Wang CH, Liu CY, Yu CT, Kuo HP (2000) Erythromycin inhibits beta 2-integrins (CD11b/CD18) expression, interleukin-8 release and intracellular oxidative metabolism in neutrophils. Respir Med 94: 654–60
Kohyama T, Takizawa H, Kawasaki S, Akiyama N, Sato M, Ito K (1999) Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors. Antimicrob Agents Chemother 43: 907–11
Kikuchi T, Hagiwara K, Honda Y, Gomi K, Kobayashi T, Takahashi H, Tokue Y, Watanabe A, Nukiwa T (2002) Clarithromycin suppresses lipolysaccharide-induced interleukin-8 production by human monocytes through AP-1 and NF-kappa B transcription factors. J Antimicrob Chemother 49: 745–55
Kawasaki S, Takizawa H, Ohtoshi T, Takeuchi N, Kohyama T, Nakamura H, Kasama T, Kobayashi K, Nakahara K, Morita Y et al (1998) Roxithromycin inhibits cytokine production by and neutrophil attachment to bronchial epithelial cells in vitro. Antimicrob Agents Chemother 42: 1499–1502
Abe S, Nakamura H, Inoue S, Takeda H, Saito H, Kato S, Mukaida N, Matsushima K, Tomoike H (2000) Interleukin-8 gene repression by clarithromycin is mediated by the activator protein-1 binding site in human bronchial epithelial cells. Am J Resp Cell Mol Biol 22: 51–60
Takaki M, Ushikai M, Deguchi K, Nishimoto K, Matsune S, Kurono Y (2003) The role of nuclear factor-kappa B in interleukin-8 expression by human adenoidal fibroblasts. Laryngoscope 113: 1378–85
Strickland I, Kisich H, Hauk PJ, Vottero A, Chrousos GP, Klemm DJ, Leung DYM (2001) High constitutive glucocorticoid receptor β in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids. J Exp Med 193: 585–93
Li YJ, Azuma A, Takahashi S, Usuki J, Matsuda K, Aoyama A, Kudo S (2002) Fourteenmembered ring macrolides inhibit vascular cell adhesion molecule 1 messenger RNA induction and leukocyte migration: role in preventing lung injury and fibrosis in bleomycin-challenged mice. Chest 122: 2137–45
Anderson R (1989) Erythromycin and roxithromycin potentiate human neutrophil locomotion by inhibition of leukoattractant-activated superoxide generation and autooxidation. J Infect Dis 159: 966–73
Hand WL, Hand DL, King-Thomson NL (1990) Antibiotic inhibition of the respiratory burst in human polymorphonuclear leukocytes. Antimicrob Agents Chemother 34: 863–70
Perry DK, Hand WL, Edmondson DE, Lambeth JD (1992) Role of phospholipase Dderived diarydyl-glycerol in the activation of the human neutrophil respiratory burst oxidase. J Immunol 149: 2749–58
Umeki S (1993) Anti-inflammatory action of erythromycin: its inhibitory effect on neutrophil NADPH-oxidase activity. Chest 104: 1191–3
Anderson R, Theron AJ, Feldman C (1996) Membrane-stabilizing, anti-inflammatory interactions of macrolides with neutrophils. Inflammation 20: 693–705
Abdelghaffar H, Vazifeh D, Labro MT (1997) Erythromycin A-derived macrolides modify the functional activities of human neutrophils by altering the phospholipase D-phosphatidate phosphohydrolase transduction pathway. J Immunol 159: 3995–4005
Kohri K, Tamaoki J, Kondo M, Aoshiba K, Tagaya E, Nagai A (2000) Macrolide antibiotics inhibit nitric oxide generation by rat pulmonary alveolar macrophages. Eur Respir J 15: 62–7
Shao DM, Segal AW, Dekker LV (2003) Lipid rafts determine efficiency of NADPH oxidase activation in neutrophils. Febs Lett 550: 101–6
Chilton FH, Averill FJ, Hubbard WC, Fonteh AN, Triggiana M, Liu MC (1996) Antigen-induced generation of lysophospholipids in human airways. J Exp Med 183: 2235–45
Ras GJ, Anderson R, Taylor GW, Savage JE, van Niekerk E, Joone G, Koornhof HJ, Saunders J, Wilson R, Cole PJ (1992) Clindamycin, erythromycin, and roxithromycin inhibit the proinflammatory interactions of Pseudomonas aeruginosa pigments with human neutrophils in vitro. Antimicrob Agents Chemother 36: 1236–40
Gorrini M, Lupi A, Viglio S, Pamparana F, Cetta G, Iadarola P, Powers JC, Luisetti M (2001) Inhibition of human neutrophil elastase by erythromycin and flurythromycin, two macrolide antibiotics. Am J Resp Cell Mol Biol 25: 492–9
Woolhouse IS, Bayley DL, Stockley RA (2002) Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha (1)-antitrypsin deficiency and the role of leukotriene B4 and interleukin 8. Thorax 57: 709–14
Lieberman J (2000) Augmentation therapy reduces frequency of lung infections in antitrypsin deficiency — A new hypothesis with supporting data. Chest 118: 1480–5
Hiemstra PS (2002) Novel roles of protease inhibitors in infection and inflammation. Biochem Soc Transact 30: 116–20
Greene C, Taggart C, Lowe G, Gallagher P, McElvaney N, O’Neill S (2003) Local impairment of anti-neutrophil elastase activity in community-acquired pneumonia. J Infect Dis 188: 769–76
Lim YP, Bendelja K, Opal SM, Siryaporn E, Hixson DC, Palardy JE (2003) Correlation between mortality and the levels of inter-alpha inhibitors in the plasma of patients with severe sepsis. J Infect Dis 188: 919–26
Aoshiba K, Nayai A, Konno K (1995) Erythromycin shortens neutrophil survival by accelerating apoptosis. Antimicrob Agents Chemother 39: 872–7
Yamaryo T, Oishi K, Yoshimine H, Tsuchihashi Y, Matsushima K, Nagatake T (2003) Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages. Antimicrob Agents Chemother 47: 48–53
Sofer D, Gilboa-Garber N, Belz A, Garber NC (1999) “Subinhibitory” erythromycin represses production of Pseudomonas aeruginosa lectins, autoinducer and virulence factors. Chemother 45: 335–41
Jain A, Sangal L, Basal E, Kaushal GP, Agarwal SK (2002) Anti-inflammatory effects of erythromycin and tetracycline on Propionobacterium acnes induced production of chemotactic factors and reactive oxygen species by human neutrophils. Dermatol Online J 8: 2
Musher DM, Phan HB, Baughn R (2001) Protection against bacteremic pneumococcal infection by antibody to pneumolysin. J Infect Dis 183: 827–30
Jounblat R, Kadioglu A, Mitchell TJ, Andrew PW (2003) Pneumococcal behavior and host responses during bronchopneumonia are affected differently by the cytolytic and complement-activating activities of pneumolysin. Infect Immun 71: 1813–9
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Feldman, C., Anderson, R. (2005). The cytoprotective interactions of antibiotics with human ciliated airway epithelium. In: Rubin, B.K., Tamaoki, J. (eds) Antibiotics as Anti-Inflammatory and Immunomodulatory Agents. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7310-5_3
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DOI: https://doi.org/10.1007/3-7643-7310-5_3
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