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Congenital and Perinatal Cytomegalovirus Infection

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Magnetic Resonance of Myelination and Myelin Disorders

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References and Further Reading

  • Adler SP. Immunoprophylaxis against cytomegalovirus disease. Scand J Infect Dis Suppl 1995; 99: 105–109

    CAS  PubMed  Google Scholar 

  • Adler SP. Current prospects for immunization against cytomegalovirus disease. Infect Agents Dis 1996; 85: 29–35

    Google Scholar 

  • Ahlfors K, Ivarsson S-A, Harris S. Report on a long-term study of maternal and congenital cytomegalovirus infection in Sweden. Review of prospective studies available in the literature. Scand J Infect Dis 1999; 31: 443–457

    CAS  PubMed  Google Scholar 

  • Alford CA, Stagno S, Pass RF, Britt WJ. Congenital and perinatal cytomegalovirus infections. Rev Infect Dis 1990; 12: 45–53

    Google Scholar 

  • Allen RD, Pellett PE, Stewart JA, Koopmans M. Nonradioactive PCR-enzyme-linked immunosorbent assay method for detection of human cytomegalovirus DNA. J Clin Microbiol 1995; 33: 725–728

    CAS  PubMed  Google Scholar 

  • Anderson KS, Amos CS, Boppana S, Pass R. Ocular abnormalities in congenital cytomegalovirus infection. J Am Optom Assoc 1996; 67: 273–278

    CAS  PubMed  Google Scholar 

  • Atkins JT, Demmler GJ, Williamson WD, McDonald JM, Istas AS, Buffone GJ. Polymerase chain reaction to detect cytomegalovirus DNA in the cerebrospinal fluid of neonates with congenital infection. J Infect Dis 1994; 169:1334–1337

    CAS  Google Scholar 

  • Bale JR Jr, Bray PF, Bell WE. Neuroradiographic abnormalties in cogentical cytomegalovirus infection. Pediatr Neurol 1985; 1: 42–47

    Article  PubMed  Google Scholar 

  • Bale JR Jr, Sato Y, Eisert D. Progressive postnatal subependymal necrosis in an infant with congenital cytomegalovirus infection. Pediatr Neurol 1986; 2: 367–370

    Article  PubMed  Google Scholar 

  • Bale JR Jr, Blackman JA, Sato Y. Outcome in children with symptomatic congenital cytomegalovirus infection. J Child Neurol 1989; 4: 131–136

    Google Scholar 

  • Bale JR Jr, Zimmerman B, Dawson JD, Souza IE, Petheram SJ, Murph JR. Cytomegalovirus transmission in child care homes. Arch Pediatr Adolesc Med 1999; 153; 75–79

    PubMed  Google Scholar 

  • Barbi M, Binda S, Primache V, Caroppo S, Didò P, Guidotti P, Corbetta C, Melotti D. Cytomegalovirus DNA detection in Guthrie cards: a powerful tool for diagnosing congenital infection. J Clin Virol 2000; 17: 159–165

    Article  CAS  PubMed  Google Scholar 

  • Barkovich AJ, Lindan CE. Congenital cytomegalovirus infection of the brain: imaging analysis and embryologic considerations. AJNR Am J Neuroradiol 1994; 15: 703–715

    CAS  PubMed  Google Scholar 

  • Boesch C, Issakainen J, Kewitz G, Kikinis R, Martin E, Boltshauser E. Magnetic resonance imaging of the brain in congenital cytomegalovirus infection. Pediatr Radiol 1989; 19: 91–93

    CAS  PubMed  Google Scholar 

  • Boom R, Sol C, Weel J, Gerrits Y, de Boer M, Ertheim-van Dillen P. A highly sensitive assay for detection and quantitation of human cytomegalovirus DNA in serum and plasma by PCR and electrochemiluminescence. J Clin Microbiol 1999; 37: 1489–1497

    CAS  PubMed  Google Scholar 

  • Boppana S, Amos C, Britt W, Stagno S, Alford C, Pass R. Late onset and reactivation of chorioretinitis in children with congenital cytomegalovirus infection. Pediatr Infect Dis J 1994; 13: 1139–1142

    CAS  PubMed  Google Scholar 

  • Boppana SB, Pass RF, Britt WJ, Stagno S, Alford CA. Symptomatic congenital cytomegalovirus infection: neonatal morbidity and mortality. Pediatr Infect Dis J 1992; 11: 93–99

    CAS  PubMed  Google Scholar 

  • Boppana SB, Fowler KB, Viad Y, Hedlund G, Stagno S, Britt WJ, Pass RF. Neuroradiographic findings in the newborn period and long-term outcome in children with symptomatic congenital cytomegalovirus infection. Pediatrics 1997; 99: 409–414

    Article  CAS  PubMed  Google Scholar 

  • Boppana SB, Fowler KB, Britt WJ, Stagno S, Pass RF. Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirus. Pediatrics 1999; 104: 55–60

    Article  CAS  PubMed  Google Scholar 

  • Boppana SB, Rivera LB, Fowler KB, Mach M, Britt WJ. Intrauterine transmission of congenital cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med 2001; 344: 1366–1371

    Article  CAS  PubMed  Google Scholar 

  • Brown HL, Abernathy MP. cytomegalovirus infection. Semin Perinatol 1998; 22: 260–266

    CAS  PubMed  Google Scholar 

  • Bryant P, Morley C, Garland S, Curtis N. Cytomegalovirus transmission for breast milk in premature babies: does it matter? Arch Dis Child Fetal Neonatal Ed 2002; 87: F75–F77

    CAS  PubMed  Google Scholar 

  • Ceballos R, Ch’ien LT, Whitley RJ, Brans YW. Cerebellar hypoplasia in an infant with congenital cytomegalovirus infection. Pediatrics 1976; 57: 155–157

    CAS  PubMed  Google Scholar 

  • Cinque P, Marenzi R, Ceresa D. Cytomegalovirus infections of the nervous system. Intervirology 1997; 40: 85–97

    CAS  PubMed  Google Scholar 

  • Conboy TJ, Pass RF, Stagno S, Alford CA, Myers GJ, Britt WJ, McCollister FP, Summers MN, McFarland CE, Boll TJ. Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infection. J Pediatr 1987; 111: 343–348

    CAS  PubMed  Google Scholar 

  • Connolly PK, Jerger S, Williamson WD, Smith RJH, Demmler G. Evaluation of higher-level auditory function in children with asymptomatic congenital cytomegalovirus infection. Am J Otol 1992; 13: 185–193

    CAS  PubMed  Google Scholar 

  • Damato EG, Winnen CW. Cytomegalovirus infection: prenatal implications. J Obstet Gynecol Neonatal Nurs 2002; 31: 86–92

    PubMed  Google Scholar 

  • Daniel Y, Gull I, Reuben Peyser M, Lessing JB. Congenital cytomegalovirus infection. Eur J Obstet Gynecol Reprod Biol 1995; 63: 7–16

    Article  CAS  PubMed  Google Scholar 

  • Darin N, Bergström T, Fast A, Kyllerman M. Clinical, seriological and PCR evidence of cytomegalovirus infection in the central nervous system in infancy and childhood. Neuropediatrics 1994; 25: 316–322

    CAS  PubMed  Google Scholar 

  • Das VK. Aetiology of bilateral sensorineural hearing impairment in children: a 10 year study. Arch Dis Child 1996; 74: 8–12

    CAS  PubMed  Google Scholar 

  • Davis LE, Stewart JA, Rarey KE, McLaren LC. Recovery and probable persistence of cytomegalovirus in human inner ear fluid without cochlear damage. Ann Otol Laryngol 1987; 96: 380–383

    CAS  Google Scholar 

  • Demmler GJ. Infectious diseases society of America and Centers for disease control. Summary of a workshop on surveillance for congenital cytomegalovirus disease. Rev Infect Dis 1991; 13: 315–329

    CAS  PubMed  Google Scholar 

  • Demmler GJ. Congenital cytomegalovirus infection and disease. Adv Pediatr infect Dis 1996; 11: 135–162

    CAS  PubMed  Google Scholar 

  • De Vries LS, Gunardi H, Barth PG, Bok LA, Verboon-Maciolek MA, Groenendaal F. The spectrum of cranial ultrasound and magnetic resonance imaging abnormalities in congenital cytomegalovirus infection. Neuropediatrics 2004; 35: 113–9

    PubMed  Google Scholar 

  • Eggers M, Metzger C, Enders G. Differentiation between acute primary and recurrent human cytomegalovirus infection in pregnancy, using a microneutralization assay. J Med Virol 1998; 56: 351–358

    Article  CAS  PubMed  Google Scholar 

  • Fischler B, Rodensjö P, Nemeth A, Forsgren M, Lewensohn-Fuchs I. Cytomegalovirus DNA detection on Guthrie cards in patients with prenatal cholestasis. Arch Dis Child Fetal Neonat Ed 1999; 80: F130–F134

    CAS  Google Scholar 

  • Fowler KB, McCollister FP, Dahle AJ, Boppana S, Britt WJ, Pass RF. Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection. J Pediatr 1997; 130: 624–630

    CAS  PubMed  Google Scholar 

  • Fowler SL. A light in the darkness: predicting outcomes for congenital cytomegalovirus infections. J Pediatr 2000; 137: 4–6

    Article  CAS  PubMed  Google Scholar 

  • Fritschy J-M, Brandner S, Aguzzi A, Koedood M, Lüscher B, Mitchell PJ. Brain cell type specification and gliosis-induced activation of the human cytomegalovirus immediate-early promotor in transgenic mice. J Neurosci 1996; 16: 2275–2282

    CAS  PubMed  Google Scholar 

  • Gaytant MA, Steegers EAP, Semmekrot BA, Merkus HMMW, Galama JMD. Congenital cytomegalovirus infection: review of the epidemiology and outcome. Obstet Gynecol Surv 2002; 67: 245–256

    Google Scholar 

  • Gomes AL, Vieira JP, Saldanha J. Non-progressive leuko-encephalopathy with bilateral temporal cysts. Eur J Pediatr Neurol 2001; 5: 121–125

    CAS  Google Scholar 

  • Grangeot-Keros L, Cointe D. Diagnosis and prognostic markers of HCMV infection. J Clin Virol 2001; 21: 213–221

    Article  CAS  PubMed  Google Scholar 

  • Grant EG, Williams AL, Schellinger D, Slovis TL. Intracranial calcification in the infant and neonate: evaluation by sonography and CT. Radiology 1985; 157: 63–68

    CAS  PubMed  Google Scholar 

  • Griffith BP, Booss J. Neurological infections of the fetus and newborn. Neurol Clin 1994; 12: 541–564

    CAS  PubMed  Google Scholar 

  • Hagay ZJ, Biran G, Ornoy A, Reece EA. Congenital cytomegalovirus infection: a long-standing problem still seeking a solution. Am J Obstet Gynecol 1996; 174: 241–245

    Article  CAS  PubMed  Google Scholar 

  • Haginoya K, Ohura T, Kon K, Yagi T, Sawaishi Y, Ishii KK, Funato T, Higano S, Takahashi S, Iinuma K. Abnormal white matter lesions with sensorineural hearing loss caused by congenital cytomegalovirus infection: retrospective diagnosis by PCR using Guthrie cards. Brain Dev 2002; 24: 710–714

    Article  PubMed  Google Scholar 

  • Hayward JC, Titelbaum DS, Clancy RR, Zimmerman RA. Lissencephaly-pachygyria associated with congenital cytomegalovirus infection. J Child Neurol 1991; 6: 109–114

    CAS  PubMed  Google Scholar 

  • Istas AS, Demmler GJ, Dobbins JG, Stewart JA. Surveillance for congenital cytomegalovirus disease: a report from the National Congenital Cytomegalovirus Disease Registry. Clin Infect Dis 1995; 20: 665–670

    CAS  PubMed  Google Scholar 

  • Jauniaux E, Jurkovic D, Gulbis B, Liesnard C, Lees C, Campbell S. Materno-fetal immunoglobulin transfer and passive immunity during the first trimester of human pregnancy. Hum Reprod 1995; 10: 3297–330

    CAS  PubMed  Google Scholar 

  • Johansson PJH, Jönsson M, Ahlfors K, Ivarsson SA, Svanberg L, Guthenberg C. Retrospective diagnostics of congenital cytomegalovirus infection performed by polymerase chain reaction in blood stored on filter paper. Scand J Infect Dis 1997; 29: 465–468

    CAS  PubMed  Google Scholar 

  • Jones CA, Isaacs D. Predicting the outcome of symptomatic congenital cytomegalovirus infection. J Paediatr Child Health 1995; 31: 70–71

    CAS  PubMed  Google Scholar 

  • Kimberlin DW, Lin C-Y, Sanches PJ, Demmler GJ, Danker W, Shelton M, Jacobs RF, Vaudry W, Pass RF, Kiell JM, Soong S-J, Whitley RJ. Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: a randomized, controlled trial. J Pediatr 2003; 143: 16–25

    CAS  PubMed  Google Scholar 

  • Koedood M, Fichtel A, Meier P, Mitchell PJ. Human cytomegalovirus (HCMV) immediate-early enhancer/promoter specificity during embryogenesis defines target tissues of congenital HCMV infection. J Virol 1995; 69: 2194–2207

    CAS  PubMed  Google Scholar 

  • Kohyama J, Kajiwara M, Shimohira M, Iwakawa Y, Okawa H. Human cytomegalovirus DNA in cerebrospinal fluid. Arch Dis Child 1994; 71: 414–418

    CAS  PubMed  Google Scholar 

  • Koi H, Zhang J, Parry S. The mechanisms of placental viral infection. Ann NY Acad Sci 2001; 943: 148–156

    CAS  PubMed  Google Scholar 

  • Koopmans M, Sánchez-Martinéz D, Patton J, Stewart J. Evaluation of antigen and antibody detection in urine specimens from children with congenital human cytomegalovirus infection. J Med Virol 1995; 46: 321–328

    CAS  PubMed  Google Scholar 

  • Lagasse N, Dhooge I, Govaert P. Congenital CMV-infection and hearing loss. Acta Otolaryngol Belg 2000; 54: 431–436

    CAS  Google Scholar 

  • Lamy ME, Mulongo KN, Gadisseux J-F, Lyon G, Gaudy V, van Lierde M. Prenatal diagnosis of fetal cytomegalovirus infection. Am J Obstet Gynecol 1992; 166: 91–94

    CAS  PubMed  Google Scholar 

  • Lazzarotto T, Guerra B, Spezzacatena P, Varani S, Gabrielli L, Pradelli P, Rumpianesi F, Banzi C, Bovicelli L, Landini MP. Prenatal diagnosis of congenital cytomegalovirus infection. J Clin Microbiol 1998; 36: 3540–3544

    CAS  PubMed  Google Scholar 

  • Lazzarotto T, Spezzacatena P, Varani S, Gabrielli L, Pradelli P. Guerra B, Landini MP. Anticytomegalovirus (anti-CMV) immunoglobulin G avidity in identification of pregnant woman at risk of transmitting congenital CMV infection. Clin Diagn Lab Immunol 1999; 6: 127–129

    CAS  PubMed  Google Scholar 

  • Lazzarotto T Varani S, Gabrielli L, Spezzacatena P, Landini MP. New advances in the diagnosis of congenital cytomegalovirus infection. II. Diagnostics and antiviral therapy. Intervirology 1999; 42: 390–397

    Article  CAS  PubMed  Google Scholar 

  • Lazzarotto T, Varani S, Guerra B, Nicolosi A, Lanari M, Landini MP. Prenatal indicators of congenital cytomegalovirus infection. J Pediatr 2000; 137: 90–95

    Article  CAS  PubMed  Google Scholar 

  • Mahlm G, Gröndahl EH, Lewensohn-Fuchs I. Congenital cytomegalovirus infection: a retrospective diagnosis in a child with pachygyria. Pediatr Neurol 2000; 22: 407–408

    Google Scholar 

  • Malinger G, Lev D, Zahalka N, Aroia ZB, Watemberg N, Kidron D, Sira LB, Lerman-Sagie T. AJNR Am J Neuroradiol 2003; 24: 28–32

    PubMed  Google Scholar 

  • Marques Dias MJ, Harmant-van Rijckevorsel G, Landrieu P, Lyon G. Prenatal cytomegalovirus disease and cerebral microgyria: evidence for perfusion failure, not disturbance of histogenesis, as the major cause of fetal cytomegalovirus encephalopathy. Neuropediatrics 1984; 15: 18–24

    CAS  PubMed  Google Scholar 

  • Martinez A, Castro A, Gil C, Perez C. Recent strategies in the development of new human cytomegalovirus inhibitors. Med Res Rev 2001; 3: 227–244

    Google Scholar 

  • Michaels MG, Greenberg FP, Sabo DL, Wald ER. Treatment of children with congenital cytomegalovirus infection with ganciclovir. Pediatr Infect Dis J 2003; 22: 504–508

    Article  PubMed  Google Scholar 

  • Morris DJ, Sims S, Chiswick M, Das VK, Newton VE. Symptomatic congenital cytomegalovirus infection after maternal recurrent infection. Pediatr Infect Dis J 1994; 13: 61–64

    CAS  PubMed  Google Scholar 

  • Murph JR, Souza IE, Dawson JD, Benson P, Petheram SJ, Pfab D, Gregg A, O’Neill ME, Zimmerman B, Bale JF Jr. Epidemiology of congenital cytomegalovirus infection: maternal risk factors and molecular analysis of cytomegalovirus strains. Am J Epidemol 1998; 147: 940–947

    CAS  Google Scholar 

  • Mussi-Pinhata MM, Yamamoto AY, Figueiredo LTM, Cervi MC, Duarte G. Congenital and perinatal cytomegalovirus infection in infants born to mothers infected with human immunodeficiency virus. J Pediatr 1998; 132: 285–290

    CAS  PubMed  Google Scholar 

  • Negishi H, Yamada H, Hirayama E, Okuyama K, Sagawa T, Matsumoto Y, Fujimoto S. Intraperitoneal administration of cytomeglovirus hyperimmunoglobulin to the cytomegalovirus-infected fetus. J Perinatol 1998; 18: 466–469

    CAS  PubMed  Google Scholar 

  • Nelson CT, Istas AS, Wilkerson MK, Demmler GJ. PCR detection of cytomegalovirus DNA in serum as a diagnostic test for congenital cytomegalovirus infection. J Clin Microbiol 1995; 33: 3317–3318

    CAS  PubMed  Google Scholar 

  • Noyola DE, Demmler GJ, Williamson WD, Griesser C, Sellers S, Llorente A, Littman T, Williams S, Jarrett L, Yow MD. Cytomegalovirus urinary excretion and long term outcome in children with congenital cytomegalovirus infection. Pediatr Infect Dis J 2000; 19: 505–510

    Article  CAS  PubMed  Google Scholar 

  • Noyola DE, Demmler GJ, Nelson CT, Griesser C, Williamson WD, Atkins JT, Rozelle J, Turcich M, Llorente AM, Sellers-Vinson S, Reynolds A, Bale JF Jr, Gerson P, Yow MD. Early predictors of neurodevelopmental outcome in symptomatic congenital cytomegalovirus infection. J Pediatr 2001; 138: 325–331

    CAS  PubMed  Google Scholar 

  • Numazaki K. Human cytomegalovirus infection of breast milk. FEMS Immunol Med Microbiol 1997; 18: 91–98

    CAS  PubMed  Google Scholar 

  • Namazaki K, Chiba S. Current aspects of diagnosis and treatment of cytomegalovirus infections in infants. Clin Diagn Virol 1997; 8: 169–181

    Google Scholar 

  • Namazaki K, Asanuma H, Ikehata M, Chiba S. Detection of cytokines and cytomegalovirus DNA in serum as test for congenital infection. Early Hum Dev 1998; 52: 43–48

    Google Scholar 

  • Olivier M, Lenard HG, Aksu F, Gärtner J. A new leukoencephalopathy with bilateral anterior temporal lobe cysts. Neuropediatrics 1998; 29: 225–228

    CAS  PubMed  Google Scholar 

  • Pass RF. Immunization strategy for prevention of congenital cytomegalovirus infection. Infect Agents Dis 1996; 5: 240–244

    CAS  PubMed  Google Scholar 

  • Pass RF. Cytomegalovirus infection. Pediatr Rev 2002; 23: 163–169

    PubMed  Google Scholar 

  • Peckham C, Tookey P, Logan S, Giaquinto C. Screening options for prevention of congenital cytomegalovirus infection. J Med Screen 2001; 8: 119–124

    Article  CAS  PubMed  Google Scholar 

  • Peckham CS, Coleman JC, Hurley R, Chin KS, Henderson K, Preece PM. Cytomegalovirus infection in pregnancy: preliminary findings from a prospective study. Lancet 1983; I: 1352–1355

    Google Scholar 

  • Poland SD, Bambrick LL, Dakaban GA, Rice GPA. The extent of human cytomegalovirus replication in primary neurons is dependent on host cell differentiation. J Infect Dis 1994; 170: 1267–1271

    CAS  PubMed  Google Scholar 

  • Raine CS, Fields BN. Neurotropic viruses and the developing brain. N Y State Med 1973; 73: 1169–1179

    CAS  Google Scholar 

  • Ramenghi LA, Domizio S, Quartulli L, Sabatino G. Prenatal pseudocysts of the germinal matrix in preterm infants. J Clin Ultrasound 1997; 25: 169–173

    Article  CAS  PubMed  Google Scholar 

  • Revello MG, Baldanti F, Furione M, Sarasini A, Percivalle E, Zavattoni M, Gerna G. Polymerase chain reaction for prenatal diagnosis of congenital human cytomegalovirus infection. J Med Virol 1995; 47: 462–466

    CAS  PubMed  Google Scholar 

  • Revello MG, Sarasini A, Zavattoni M, Baldanti F, Gerna G. Improved prenatal diagnosis of congenital human cytomegalovirus infection by a modified nested polymerase chain reaction. J Med Virol 1998; 56: 99–103

    Article  CAS  PubMed  Google Scholar 

  • Schackelford GD, Fulling KH, Glasier CM Maj. Cysts of the subependymal germinal matrix: sonographic demonstration with pathologic correlation. Radiology 1983; 149: 117–121

    Google Scholar 

  • Schendel DE. Infection in pregnancy and cerebral palsy. J Am Med Womens Assoc 2001; 56:105–108

    CAS  PubMed  Google Scholar 

  • Schneeberger PM, Groenendaal F, de Vries LS, van Loon AM, Vroom TM. Variable outcome of a congenital cytomegalovirus infection in a quadruplet after primary infection of the mother during pregnancy. Acta Paediatr 1994; 83: 986–989

    CAS  PubMed  Google Scholar 

  • Schopper K, Lauber E, Krech U. Congenital cytomegalovirus infection in newborn infants of mothers infected before pregnancy. Arch Dis Child 1978; 53: 536–539

    Google Scholar 

  • Schwebke K, Henry K, Balfour HH Jr, Olson D, Crane RT, Jardan C. Clinical and laboratory observations. Congenital cytomegalovirus infection as a result of nonprimary cytomegalovirus disease in a mother with acquired immunodeficiency syndrome. J Pediatr 1995; 126: 293–295

    CAS  PubMed  Google Scholar 

  • Sener RN. Schizencephaly and congenital cytomegalovirus infection. J Neuroradiol 1998; 25: 151–152

    CAS  PubMed  Google Scholar 

  • Shaw C-M, Alvord EC Jr. Subependymal germinolysis. Arch Neurol 1974; 31: 374–381

    CAS  PubMed  Google Scholar 

  • Soussotte C, Maugey-Laulom B, Charles D, Diard F. Contribution of transvaginal ultrasonography and fetal cerebral MRI in a case of congenital cytomegalovirus infection. Fetal Diagn Ther 2000; 15: 219–223

    Article  CAS  PubMed  Google Scholar 

  • Souza IE, Gregg A, Pfab D, Dawson JD, Benson P. O’Neill ME, Murph JR, Petheram SJ, Bale FJ Jr. Cytomegalovirus infection in newborns and their family members: polymerase chain reaction analysis of isolates. Infection 1997; 25: 144–149

    Article  CAS  PubMed  Google Scholar 

  • Stamos JK, Rowley AH. Timely diagnosis of congenital infections. Pediatr Clin North Am 1994; 41: 1017–1033

    CAS  PubMed  Google Scholar 

  • Steinlin M. Non-progressive congenital ataxias. Brain Dev 1998; 20: 199–208

    CAS  PubMed  Google Scholar 

  • Steinlin M, Zürrer M, Marin E, Boesch CH, Largo RH, Boltshauser E. Contribution of magnetic resonance imaging in the evaluation of microcephaly. Neuropediatrics 1991; 22: 184–189

    CAS  PubMed  Google Scholar 

  • Steinlin MI, Nadal D, Eich GE, Martin E, Boltshauser EJ. Late intrauterine cytomegalovirus infection: Clinical and neuroimaging findings. Pediatr Neurol 1996; 15: 249–253

    Article  CAS  PubMed  Google Scholar 

  • Stronati M, Revello MG, Cerbo RM, Furione M, Rondini G, Gerna G. Ganciclovir therapy of congenital human cytomegalovirus hepatitis. Acta Paediatr 1995; 84: 340–341

    CAS  PubMed  Google Scholar 

  • Sugita K, Ando M, Makino M, Takanashi J, Fujimoto N, Niimi H. Magnetic resonance imaging of the brain in congenital rubella virus and cytomegalovirus infections. Neuroradiology 1991; 33: 239–242

    Article  CAS  PubMed  Google Scholar 

  • Titelbaum DS Hayward JC, Zimmerman RA. Pachygyriclike changes: topographic appearance at MR imaging ant CT and correlation with neurologic status. Radiology 1989; 173: 663–667

    CAS  PubMed  Google Scholar 

  • van der Knaap MS, Vermeulen G, Barkhof F, Hart AAM, Loeber JG, Weel JFL. A pattern of white matter abnormalities on MRI: polymerase chain reaction on Guthrie cards to link the pattern with congenital CMV. Radiology 2004; 230: 529–536

    PubMed  Google Scholar 

  • Weinberg A. The role of immune reconstruction in cytomegalovirus infection. Biodrugs 2002; 16: 89–95

    Article  CAS  PubMed  Google Scholar 

  • Williamson WD, Percy AK, Yow MD, Gerson P, Catlin FI, Koppelman ML, Thurber S. Asymptomatic congenital cytomegalovirus infection. Audiologica, Neuroradiologic, and neurodevelopmental abnormalities during the first year. Am J Dis Child 1990; 144: 1365–1368

    CAS  PubMed  Google Scholar 

  • Williamson WD, Demmler GJ, Percy AK, Catlin FI. Progressive hearing loss in infants with asymptomatic congenital cytomegalovirus infection. Pediatrics 1992; 90: 862–866

    CAS  PubMed  Google Scholar 

  • Yamashita Y, Outani Y, Kawano Y, Horikwawa M, Matsuishi T, Hashimoto T. Clinical analysis and short-term progress of neonates with subependymal cysts. Pediatr Neurol 1990; 6: 375–378

    Article  CAS  PubMed  Google Scholar 

  • Zaia JA, Lang DJ. Cytomegalovirus infection of the fetus and neonate. Neurol Clin 1984; 2: 387–410

    CAS  PubMed  Google Scholar 

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(2005). Congenital and Perinatal Cytomegalovirus Infection. In: Magnetic Resonance of Myelination and Myelin Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27660-2_85

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