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Thyroid Hormones, Glucocorticoids, Insulin, and Bone

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Bone Regulators and Osteoporosis Therapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 262))

Abstract

Several endocrine systems have important effects on bone tissue. Thyroid hormones are essential for normal growth and development. Excess of these hormones will result in clinically significant changes that may require intervention. Glucocorticoids also have a marked effect on bone metabolism by several pathways. Their endogenous or exogenous excess will induce pathological processes that might elevate the risk of fractures. Insulin and the carbohydrate metabolism elicit a physiological effect on bone; however, the lack of insulin (type 1 diabetes) or insulin resistance (type 2 diabetes) have deleterious influence on bone tissue.

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  1. 1st Department of Medicine, Semmelweis University, Budapest, Hungary

    Peter Lakatos, Balazs Szili, Bence Bakos, Istvan Takacs, Zsuzsanna Putz & Ildiko Istenes

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    Paula H. Stern

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Lakatos, P., Szili, B., Bakos, B., Takacs, I., Putz, Z., Istenes, I. (2019). Thyroid Hormones, Glucocorticoids, Insulin, and Bone. In: Stern, P.H. (eds) Bone Regulators and Osteoporosis Therapy. Handbook of Experimental Pharmacology, vol 262. Springer, Cham. https://doi.org/10.1007/164_2019_314

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