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Al-Alawi, N., Rose, D. W., Buckmaster, C., Ahn, N., Rapp, U., Meinkoth, J. and Feramisco, J. R., 1995, Thyrotropin-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade, Mol Cell Biol. 15: 1162–8.
Asakawa, H. and Kobayashi, T., 2002, Multistep carcinogenesis in anaplastic thyroid carcinoma: a case report, Pathology. 34: 94–7.
Avvedimento, E. V., Monticelli, A., Tramontano, D., Polistina, C., Nitsch, L. and Di Lauro, R., 1985, Differential expression of thyroglobulin gene in normal and transformed thyroid cells, Eur J Biochem. 149: 467–472.
Barone, M. V., Sepe, L., Melillo, R. M., Mineo, A., Santelli, G., Monaco, C., Castellone, M. D., Tramontano, D., Fusco, A. and Santoro, M., 2001, RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho, Oncogene. 20: 6973–82.
Bond, J. A., Wyllie, F. S., Rowson, J., Radulescu, A. and Wynford-Thomas, D., 1994, In vitro reconstruction of tumour initiation in a human epithelium, Oncogene. 9: 281–290.
Bruni, P., Boccia, A., Baldassarre, G., Trapasso, F., Santoro, M., Chiappetta, G., Fusco, A. and Viglietto, G., 2000, PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells is mediated by p27kip1, Oncogene. 19: 3146–3155.
Burns, J., Barton, C., Wynford-Thomas, D. and Lemoine, N., 1993, In vitro transformation of epithelial cells by ras oncogenes, Epithelial Cell Biol. 2: 26–43.
Busca, R., Abbe, P., Mantoux, F., Aberdam, E., Peyssonnaux, C., Eychene, A., Ortonne, J. P. and Ballotti, R., 2000, Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes, EMBO J. 19: 2900–10.
Cass, L. A. and Meinkoth, J. L., 1998, Differential effects of cyclic adenosine 3’, 5’-monophosphate on p70 ribosomal S6 kinase, Endocrinol. 139: 1991–1998.
Cass, L. A. and Meinkoth, J. L., 2000, Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation, Oncogene. 19: 924–32.
Cass, L. A., Summers, S. A., Prendergast, G. V., Backer, J. M., Birnbaum, M. J. and Meinkoth, J. L., 1999, Protein kinase A-dependent and-independent signaling pathways contribute to cyclic AMP-stimulated proliferation, Mol Cell Biol. 19: 5882–91.
Castellone, M. D., Cirafici, A. M., De Vita, G., De Falco, V., Malorni, L., Tallini, G., Fagin, J. A., Fusco, A., Melillo, R. M. and Santoro, M., 2003, Ras-mediated apoptosis of PC CL 3 rat thyroid cells induced by RET/PTC oncogenes, Oncogene. 22: 246–55.
Chen, C.-Y., Liou, J., Forman, L. W. and Faller, D. V., 1998, Differential regulation of discrete apoptotic pathways by Ras, J Biol Chem. 273: 16700–16709.
Cheng, G., Lewis, A. E. and Meinkoth, J. L., 2003, Ras stimulates aberrant cell cycle progression and apoptosis in rat thyroid cells, Mol Endocrinol. 17: 450–9.
Cheng, G. and Meinkoth, J. L., 2001, Enhanced sensitivity to apoptosis in Ras-transformed thyroid cells, Oncogene. 20: 7334–41.
Chiu, V. K., Bivona, T., Hach, A., Sajous, J. B., Silletti, J., Wiener, H., Johnson, R. L., 2nd, Cox. A. D. and Philips, M. R., 2002, Ras signalling on the endoplasmic reticulum and the Golgi, Nat Cell Biol. 4: 343–50.
Ciullo, I., Diez-Roux, G., Di Domenico, M., Migliaccio, A. and Avvedimento, E. V., 2001, cAMP signaling selectively influences Ras effectors pathways, Oncogene. 20: 1186–92.
Cobellis, G., Missero, C. and Di Lauro, R., 1998, Concomitant activation of MEK-1 and Rac-1 increases the proliferative potential of thyroid epithelial cells, without affecting their differentiation, Oncogene. 17: 2047–57.
Cohen, Y., Xing, M., Mambo, E., Guo, Z., Wu, G., Trink, B., Beller, U, Westra, W. H., Ladenson, P. W and Sidransky, D., 2003, BRAF mutation in papillary thyroid carcinoma, J. Null. Cane. Inst. 95: 625–627.
Cook, S. J. and McCormick, F., 1993, Inhibition by cAMP of Ras-dependent activation of Raf, Science. 262: 1059–1062.
Coulonval, K., Vandeput, F., Stem, R. C., Kozma, S. C., Lamy, F. and Dumont, J. E., 2000, Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin, Biochem J. 348: 351–8.
Damante, G. and Di Lauro, R., 1994, Thyroid-specific gene expression, Biochim Biophys Acta. 1218: 255–266.
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B. A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G. J., Bigner, D. D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J. W., Leung, S. Y., Yuen, S. T., Weber, B. L., Seigler, H. F., Darrow, T. L., Paterson, H., Marais, R., Marshall, C.J., Wooster, R., Stratton, M. R. and Futreal, P. A., 2002, Mutations of the BRAF gene in human cancer, Nature. 417: 949–54.
DeRooij, J., Zwartkruis, F. J. T., Verheijen, M. H. G., Cool, R. H., Nijman, S. M. B., Wittinghofer, A. and Bos, J. L., 1998, Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP, Nature. 396: 474–477.
Di Jeso, B., Ulianich, L., Racioppi, L., D’Armiento, F., Feliciello, A., Pacifico, F., Consiglio, E. and Formisano, S., 1995, Serum withdrawal induces apoptotic cell death in Ki-ras transformed but not in normal differentiated thyroid cells, Biochem Biophys Res Commun. 214: 819–24.
Dremier, S., Pohl, V., Poteet-Smith, C., Roger, P., Corbin, J., Doskeland, S. O., Dumont, J. E. and Maenhaut, C., 1997, Activation of cyclic AMP-dependent protein kinase is required but may not be sufficient to mimic cyclic AMP-dependent DNA synthesis and thyroglobulin expression in dog thyroid cells, Mol. Cell. Biol. 17: 6717–6726.
Erhardt, P., Troppmair, J., Rapp, U. and Cooper, G. M., 1995, Differential regulation of Raf-1 and B-Raf and Ras-dependent activation of mitogen-activated protein kinase by cyclic AMP in PC1 2 cells, Mol Cell Biol. 15: 5524–5530.
Erickson, L. A., Jin, L., Wollan, P. C., Thompson, G. B., van Heerden, J. and Lloyd, R. V., 1998, Expression of p27kip1 and Ki-67 in benign and malignant thyroid tumors, Mod Pathol. 11: 169–74.
Esapa, C. T., Johnson, S. J., Kendall-Taylor, P., Lennard, T. W. and Harris, P. E., 1999, Prevalence of Ras mutations in thyroid neoplasia, Clin Endocrinol 50: 529–35.
Fagin, J. A., 2002, Minireview: branded from the start-distinct oncogenic initiating events may determine tumor fate in the thyroid, Mol Endocrinol. 16: 903–11.
Fagin, J. A., 2002, Perspective: lessons learned from molecular genetic studies of thyroid cancer-insights into pathogenesis and tumor-specific therapeutic targets, Endocrinology. 143: 2025–8.
Farid, N. R., Shi, Y., and Zou, M., 1994, Molecular basis of thyroid cancer, Endocrine Reviews. 15: 202–232.
Fedele, M., Pierantoni, G. M., Berlingieri, M. T., Battista, S., Baldassarre, G., Munshi, N., Dentice, M., Thanos, D., Santoro, M., Viglietto, G. and Fusco, A., 2001, Overexpression of proteins HMGA1 induces cell cycle deregulation and apoptosis in normal rat thyroid cells, Cancer Res. 61: 4583–90.
Feunteun, J., Michiels, F., Rochefort, P., Caillou, B., Talbot, M., Fournes, B., Mercken, L., Schlumberger, M. and Monier, R., 1997, Targeted oncogenesis in the thyroid of transgenic mice, Horm Res. 47: 137–9.
Francis-Lang, H., Zannini, M., De Felice, M., Berlingieri, M. T., Fusco, A. and Di Lauro, R., 1992, Multiple mechanisms of interference between transformation and differentiation in thyroid cells, Mol Cell Biol. 12: 5793–800.
Fusco, A., Berlingieri, M. T., Di Fiore, P. P., Portella, G., Grieco, M. and Vecchio, G., 1987, One-and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes, Mol Cell Biol. 7: 3365–70.
Gallo, A., Feliciello, A., Varrone, A., Cerillo, R., Gottesman, M. E. and Avvedimento, E. V., 1995, Ki-ras oncogene interferes with the expression of cycliin AMP-dependent promoters, Cell Growth and Difftn. 6: 91–95.
Gimm, O., 2001, Thyroid cancer, Cancer Lett. 163: 143–56.
Gire, V., Marshall, C. and Wynford-Thomas, D., 2000, PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS, Oncogene. 19: 2269–76.
Gire, V., Marshall, C. J. and Wynford-Thomas, D., 1999, Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras, Oncogene. 18: 4819–32.
Gire, V. and Wynford-Thomas, D., 2000, RAS oncogene activation induces proliferation in normal human thyroid epithelial cells without loss of differentiation, Oncogene. 19: 737–44.
Hall-Jackson, C. A., Jones, T, Eccles, N. G., Dawson, T. P., Bond, J. A., Gescher, A. and Wynford-Thomas, D., 1998, Induction of cell death by stimulation of protein kinase C in human epithelial cells expressing a mutant ras oncogene: a potential therapeutic target, Br J Cancer. 78: 641–51.
Hamad, N. M., Elconin, J. H., Karnoub, A. E., Bai, W., Rich, J. N., Abraham, R. T., Der, C. J. and Counter, C. M., 2002, Distinct requirements for Ras oncogenesis in human versus mouse cells, Genes Dev. 16: 2045–57.
Hirai, A., Nakamura, S., Noguchi, Y., Yasuda, T., Kitagawa, M., Tatsuno, I., Oeda, T., Tahara, K., Terano, T., Narumiya, S., Kohn, L. D. and Saito, Y., 1997, Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells, J Biol Chem. 272: 13–6.
Ivan, M., Wynford-Thomas, D. and Jones, C. J., 1996, Abnormalities of the p16INK4a gene in thyroid cancer cell lines, Eur J. Canc. 32: 2369–2370.
Jhiang, S. M., 2000, The RET proto-oncogene in human cancers, Oncogene. 19: 5590–7.
Jones, C. J., Kipling, D., Morris, M., Hepburn, P., Skinner, J., Bounacer, A., Wyllie, F. S., Ivan, M., Bartek, J., Wynford-Thomas, D. and Bond, J. A., 2000, Evidence for a telomere-independent “clock” limiting RAS oncogenc-driven proliferation of human thyroid epithelial cells, Mol Cell Biol. 20: 5690–9.
Jones, C. J., Shaw, J. J., Wyllie, F. S., Gaillard, M., Schlumberger, M. and Wynford-Thomas, D., 1996, High frequency deletion of the tumour suppressor gene p16INK4a (MTS1) in human thyroid cancer cell lines, Mol Cell Endocrinol 116: 115–119.
Kawasaki, H., Springett, G. M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D. E. and Graybiel, A. M., 1998, A family of cAMP-binding proteins that directly activate Rap1, Science. 282: 2275–2279.
Kim, D. W., Hwang, J. H., Suh, J. M., Kim, H., Song, J. H., Hwang, E. S., Hwang, I. Y., Park, K. C., Chung, H. K., Kim, J. M., Park, J., Hemmings, B. A. and Shong, M., 2003, RET/PTC (Rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinate 1 (PDK1): An alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1, Mol Endo 17: 1382–1394.
Kimura, E. T., Nikiforova, M. N., Zhu, Z., Knauf, J. A., Nikiforov, Y. E. and Fagin, J. A., 2003, High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma, Cancer Res. 63: 1454–7.
Kimura, T., Van Keymeulen, A., Golstein, J., Fusco, A., Dumont, J. E. and Roger, P. P., 2001, Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models, Endocrine Reviews. 23: 631–656.
Kitayama, H., Sugimoto, Y., Matsuzaki, T., Ikawa, Y. and Noda, M., 1989, A ras-related gene with transformation suppressor activity, Cell. 56: 77–84.
Kupperman, E., Wen, W. and Meinkoth, J. L., 1993, Inhibition of thyrotropin-stimulated DNA synthesis by microinjection of inhibitors of cellular Ras and cyclic AMP-dependent protein kinase, Mol Cell Biol. 13: 4477–84.
Lamy, F., Wilkin, F., Baptist, M., Posada, J., Roger, P. P. and Dumont, J. E., 1993, Phosphorylation of mitogen-activated protein kinases is involved in the epidermal growth factor and phorbol ester, but not in the thyrotropin/cAMP, thyroid mitogenic pathway, J Biol Chem. 268: 8398–401.
Lazzereschi, D., Sambuco, L., Carnovale Scalzo, C., Ranieri, A., Mincione, G., Nardi, F. and Colletta, G., 1998, Cyclin D1 and Cyclin E expression in malignant thyroid cells and in human thyroid carcinomas, Int J Cancer. 76: 806–11.
Lemoine, N. R., Staddon, S., Bond, J., Wyllie, F. S., Shaw, J. J. and Wynford-Thomas, D., 1990, Partial transformation of human thyroid epithelial cells by mutant Ha-ras oncogene, Oncogene. 5: 1833–7.
Lung, J. C., Chu, J. S., Yu, J. C., Yue, C. T., Lo, Y. L., Shen, C. Y. and Wu, C. W., 2002, Aberrant expression of cell-cycle regulator cyclin D1 in breast cancer is related to chromosomal genomic instability, Genes Chromosomes Cancer. 34: 276–84.
Maher, J., Baker, D. A., Manning, M., Dibb, N. J. and Roberts, I. A. G., 1995, Evidence for cell-specific differences in transformation by N-, H-and K-ras, Oncogene. 11: 1639–1647.
Martelli, M. L., Juliano, R., LePera, I., Sama, I., Monaco, C., Cammarota, S., Kroll, T., Chiariotti, L., Santoro, M. and Fusco, A., 2002, Inhibitory effects of peroxisome proliferator-activated receptor gamma on thyroid carcinoma cell growth, J Clin Endocrinol Metab. 87: 4728–4735.
Matallanas, D., Arozarena, I., Berciano, M. T., Aaronson, D. S., Pellicer, A., Lafarga, M. and Crespo, P., 2003, Differences on the inhibitory specificities of H-Ras, K-Ras and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization, J Biol Chem. 278: 4572–4581.
Medina, D. L., Rivas, M., Cruz, P., Barroso, I., Regadera, J. and Santisteban, P., 2002, RhoA activation promotes transformation and loss of thyroid cell differentiation interfering with thyroid transcription factor-1 activity, Mol Endocrinol. 16: 33–44.
Medina, D. L. and Santisteban, P., 2000, Thyrotropin-dependent proliferation of in vitro rat thyroid cell systems, Eur J Endocrinol. 143: 161–78.
Medina, D. L., Toro, M. J. and Santisteban, P., 2000, Somatostatin interferes with thyrotropin-induced G1-S transition mediated by cAMP-dependent protein kinase and phosphatidylinositol 3-kinase. Involvement of RhoA and cyclin E/cyclin-dependent kinase 2 complexes, J Biol Chem. 275: 15549–56.
Meikrantz, W. and Schlegel, R., 1995, Apoptosis and the cell cycle, J Cell Biochetm. 58: 160–74.
Miller, M. J., Prigent, S., Kupperman, E., Rioux, L., Park, S. H., Feramisco, J. R., White, M. A., Rutkowski, J. L. and Meinkoth, J. L., 1997, RalGDS functions in Ras-and cAMP-mediated growth stimulation, J Biol Chem. 272: 5600–5.
Miller, M. J., Rioux, L., Prendergast, G. V., Cannon, S., White, M. A. and Meinkoth, J. L., 1998, Differential effects of protein kinase A on Ras effector pathways, Mol Cell Biol. 18: 3718–26.
Missero, C., Cobellis, G., De Felice, M. and Di Lauro, R., 1998, Molecular events involved in differentiation of thyroid follicular cells, Mol Cell Endocrinol. 140: 37–43.
Missero, C., Pirro, M. T. and Di Lauro, R., 2000, Multiple ras downstream pathways mediate functional repression of the homeobox gene product TTF-1, Mol Cell Biol. 20: 2783–93.
Muro-Cacho, C. A., Holt, T., Klotch, D., Mora, L., Livingston, S. and Futran, N., 1999, Cyclin D1 expression as a prognostic parameter in papillary carcinoma of the thyroid, Otolaryngol Head Neck Surg. 120: 200–7.
Nahle, Z., Polakoff, J., Davuluri, R. V, McCurrach, M. E., Jacobson, M. D., Narita, M., Zhang, M. Q., Lazebnik, Y., Bar-Sagi, D. and Lowe, S. W., 2002, Direct coupling of the cell cycle and cell death machinery by E2F, Nat Cell Biol. 4: 859–64.
Namba, H., Rubin, S. A. and Fagin, J. A., 1990, Point mutations of Ras oncogenes are an early event in thyroid tumorigenesis, Mol. Endocrinol. 4: 1474–1479.
Nikiforova, M. N., Lynch, R. A., Biddinger, P. W., Alexander, E. K., Dorn, G. W. 2nd, Tallini, G., Kroll, T. G. and Nikiforov, Y. E., 2003, RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma, J Clin Endocrinol Metab. 88: 2318–26.
Olson, M. F., Paterson, H. F. and Marshall, C. J., 1998, Signals from Ras and Rho GTPases interact to regulate expression of p21 Waf1/Cip1, Nature. 394: 220–221.
Ouyang, B., Knauf, J. A., Ain, K., Nacev, B. and Fagin, J. A., 2002, Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1, Clin Endocrinol 56: 341–50.
Pak, Y., Pham, N. and Rotin, D., 2002, Direct binding of the Bl adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation, Mol Cell Biol. 22: 7942–7952.
Portella, G., Ferulano, G., Santoro, M., Grieco, M., Fusco, A. and Vecchio, G., 1989, The Kirsten murine sarcoma virus induces rat thyroid carcinomas in vivo, Oncogene. 4: 181–8.
Prior, I. A. and Hancock, J. F., 2001, Compartmentalization of Ras proteins, J. Cell. Sci. 114: 1603–1608.
Puxeddu, E. and Fagin, J. A., 2001, Genetic markers in thyroid neoplasia, Endocrinol Metab Clin North Am. 30: 493–513.
Rajagopalan, H., Bardelli, A., Lengauer, C., Kinzler, K. W., Vogelstein, B. and Velculescu, V. E., 2002, RAF/RAS oncogenes and mismatch-repair status, Nature. 418: 934.
Reuther, G. W. and Der, C. J., 2000, The Ras branch of small GTPases: Ras family members don’t fall far from the tree, Curr Opin Cell Biol. 12: 157–165.
Ribeiro-Neto, F., Urbani, J., Lemee, N., Lou, L. and Altschuler, D. L., 2002, On the mitogenic properties of Rap1b: cAMP-induced G1/S entry requires activated and phosphorylated Rap1b, Proc. Natl. Acad. Sci. USA. 99: 5418–5423.
Ringel, M. D., Hayre, N., Saito, J., Saunier, B., Schuppert, F., Burch, H., Bernet, V., Burman, K. D., Kohn, L. D. and Saji, M., 2001, Overexpression and overactivation of Akt in thyroid carcinoma, Cancer Res. 61: 6105–11.
Rochefort, P., Caillou, B., Michiels, F. M., Ledent, C., Talbot, M., Schlumberger, M., Lavelle, F., Monier, R. and Feunteun, J., 1996, Thyroid pathologies in transgenic mice expressing a human activated Ras gene driven by a thyroglobulin promoter, Oncogene. 12: 111–8.
Saavedra, H. I., Fukasawa, K., Conn, C. W and Stambrook, P.J., 1999, MAPK mediates RAS-induced chromosome instability, J Biol Chem. 274: 38083–90.
Saavedra, H. I., Knauf, J. A., Shirokawa, J. M., Wang, J., Ouyang, B., Elisei, R., Stambrook, P.J. and Fagin, J. A., 2000, The RAS oncogene induces genomic instability in thyroid PCCL3 cells via the MAPK pathway, Oncogene. 19: 3948–54.
Saito, J., Kohn, A. D., Roth, R. A., Noguchi, Y., Tatsumo, I., Hirai, A., Suzuki, K., Kohn, L. D., Saji, M. and Ringel, M. D., 2001, Regulation of FRTL-5 thyroid cell growth by phosphatidylinositol (OH) 3 kinase-dependent Akt-mediated signaling, Thyroid. 11: 339–351.
Santelli, G., de Franciscis, V, Portella, G., Chiappetta, G., D’Alessio, A., Califano, D., Rosati, R., Mineo, A., Monaco, C., Manzo, G. and et al., 1993, Production of transgenic mice expressing the Ki-ras oncogene under the control of a thyroglobulin promoter, Cancer Res. 53: 5523–7.
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. and Lowe, S. W., 1997, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell. 88: 593–602.
Sevetson, B. R., Kong, X. and Lawrence, J. C., 1993, Increasing cAMP attenuates activation of mitogen-activated protein kinase, Proc. Natl. Acad. Sci. USA. 90: 10305–10309.
Sherr, C. J. and Roberts, J. M., 1999, CDK inhibitors: positive and negative regulators of Gl-phase progression, Genes Dev. 13: 1501–12.
Shi, Y.F., Zou, M.J., Schmidt, H., Juhasz, F., Stenzky, V., Robb, D., and Farid, N.R., 1991, Canc Res 51: 2690–2693.
Shields, J. M., Pruitt, K., McFall, A., Shaub, A. and Der, C. J., 2000, Understanding Ras: “it ain’t over’ till it’s over”, Trends in Cell Biol. 10: 147–153.
Shirokawa, J. M., Elisei, R., Knauf, J. A., Hara, T., Wang, J., Saavedra, H. I. and Fagin, J. A., 2000, Conditional apoptosis induced by oncogenic ras in thyroid cells, Mol Endocrinol. 14: 1725–38.
Smith, K. A., Agarwal, K. L., Chernov, M. V., Chernova, O. B., Deguchi, Y., Ishizaka, Y., Patterson, Y. E., Poupon, M. F. and Stark, G. R., 1995, Regulation and mechanisms of gene amplification, Philos Trans R Soc Lond B Biol Sci. 347: 49–56.
Spruck, C. H., Won, K. A. and Reed, S. I., 1999, Deregulated cyclin E induces chromosome instability, Nature. 401: 297–300.
Suarez, H. G., du Villard, J. A., Severino, M., Cailou, B., Schlumberger, M., M., T., Parmentier, C. and Monier, R., 1990, Presence of mutations in all three ras genes in human thyroid tumors, Oncogene. 5: 565–570.
Tsygankova, O. M., Kupperman, E., Wen, W. and Meinkoth, J. L., 2000, Cyclic AMP activates Ras, Oncogene. 19: 3609–15.
Tsygankova, O. M., Saavedra, A., Rebhun, J. F., Quilliam, L. A. and Meinkoth, J. L., 2001, Coordinated regulation of Rap1 and thyroid differentiation by cyclic AMP and protein kinase A, Mol Cell Biol. 21: 1921–1929.
Van Keymeulen, A., Roger, P. P., Dumont, J. E. and Dremier, S., 2000, TSH and cAMP do not signal mitogenesis through Ras activation, Biochem Biophys Res Commun. 273: 154158.
Vanvooren, V., Allgeier, A., Nguyen, M., Massart, C., Parma, J., Dumont, J. E. and Van Sande, J., 2001, Mutation analysis of the Epac-Rap1 signaling pathway in cold thyroid follicular adenomas, Eur J Endocrinol. 144: 605–10.
Vasko, V., Ferrand, M., Di Cristofaro, J., Carayon, P., Henry, J. F. and de Micco, C., 2003, Specific-pattern of RAS oncogene mutations in follicular thyroid tumors, J Clin Endocrinol Metab. 88: 2745–52.
Velasco, J. A., Acebron, A., Zannini, M., Martin-Perez, J., Di Lauro, R. and Santisteban, P., 1998, Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation, Endocrinology. 139: 2796–802.
Villalonga, P., Lopez-Alcala, C., Bosch, M., Chiloeches, A., Rocamora, N., Marais, R., Marshall, C. J., Bachs, O. and Agell, N., 2001, Calmodulin binds to K-Ras, but not to H-or N-Ras, and modulates downstream signaling, Mol. Cell. Biol. 21: 7345–7354.
Vossler, M. R., Yao, H., York, R. D., Pan, M.-G., Rim, C. S. and Stork, P. J., 1997, cAMP activates MAP kinase and elk-1 through a B-Raf-and Rap1-dependent pathway, Cell. 89: 73–82.
Walsh, A. B. and Bar-Sagi, D., 2001, Differential activation of the Rac pathway by Ha-Ras and K-Ras, J Biol Chem. 276: 15609–15615.
Wang, S., Wu, J., Savas, L., Patwardhan, N. and Khan, A., 1998, The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis, Hum Pathol. 29: 1304–9.
White, M. A., Nicolette, C., Minden, A., Polverino, A., Aelst, L. V., Karin, M. and Wigler, M. H., 1995, Multiple Ras functions can contribute to mammalian cell transformation, Cell 80: 533–541.
Wolfman, J. C., Palmby, T., Der, C. J. and Wolfman, A., 2002, Cellular N-Ras promotes cell survival by downregulation of Jun N-terminal protein kinase and p38, Mol Cell Biol. 22: 1589–1606.
Wu, J., Dent, P., Jelinek, T., Wolfman, A., Weber, M. J. and Sturgill, T. A., 1993, Inhibition of EGF-activated MAP kinase signaling pathway by adenosine 3’5’-monophosphate, Science. 262: 1065–1068.
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Meinkoth, J.L. (2005). Biology of Ras in Thyroid Cells. In: Farid, N.R. (eds) Molecular Basis of Thyroid Cancer. Cancer Treatment and Research, vol 122. Springer, Boston, MA. https://doi.org/10.1007/1-4020-8107-3_7
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Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4020-8106-4
Online ISBN: 978-1-4020-8107-1
eBook Packages: MedicineMedicine (R0)