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Targeting Endothelin Axis in Cancer

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Molecular Targeting and Signal Transduction

Part of the book series: Cancer Treatment and Research ((CTAR,volume 119))

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References

  1. Levin E.R. Endothelins. N Engl J Med 1995; 333:356–63

    Article  CAS  PubMed  Google Scholar 

  2. Goldie R.G. Endothelins in health and disease: an overview. Clin Exp Pharmacol Physiol 1999; 26:145–48

    Article  CAS  PubMed  Google Scholar 

  3. Masaki T. The endothelin family: an overview. J Cardiovasc Pharmacol. 2000; 35:S3–5.

    Article  Google Scholar 

  4. Battistini B., Chailler P., D’Orleans-Juste P., Briere N., Sirois P. Growth regulatory properties of endothelins. Peptides 1993; 14:385–99

    Article  CAS  PubMed  Google Scholar 

  5. Nelson J.B., Chan-Tack K., Hedican S.P., Magnuson S.R., Opgenorth T.J., Bova G.S., Simons J.W. Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer. Cancer Res 1996; 56:663–68

    CAS  PubMed  Google Scholar 

  6. Nelson J.B., Hedican S.P., George D.J., Reddi A.H., Piantadosi S., Eisenberger M.A., Simons J.W. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med 1995; 1:944–49

    Article  CAS  PubMed  Google Scholar 

  7. Gohji K., Kitazawa S., Tamada H., Katsuoka Y., Nakajima M. Expression of endothelin receptor a associated with prostate cancer progression. J Urol 2001; 165:1033–36

    Article  CAS  PubMed  Google Scholar 

  8. Nelson J.B., Lee W.H., Nguyen S.H., Jarrard D.F., Brooks J.D., Magnuson S.R., Opgenorth T.J., Nelson W.G., Bova G.S. Methylation of the 5′ CpG island of the endothelin B receptor gene is common in human prostate cancer. Cancer Res. 1997; 57:35–7

    CAS  PubMed  Google Scholar 

  9. Bagnato A., Salani D., Di Castro V., Wu-Wong J.R., Tecce R., Nicotra M.R., Venuti A., Natali P.G. Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: evidence for an autocrine role in tumor growth. Cancer Res 1999; 59:720–27

    CAS  PubMed  Google Scholar 

  10. Moraitis S., Langdon S.P., Miller W.R. Endothelin expression and responsiveness in human ovarian carcinoma cell lines. Eur J Cancer 1997; 33:661–8

    Article  CAS  PubMed  Google Scholar 

  11. Salani D., Di Castro V., Nicotra M.R., Rosano L., Tecce R., Venuti A., Natali P.G., Bagnato A. Role of endothelin-1 in neovascularization of ovarian carcinoma. Am J Pathol 2000; 157:1537–47

    CAS  PubMed  Google Scholar 

  12. Moraitis S., Miller W.R., Smyth J.F., Langdon S.P. Paracrine regulation of ovarian cancer by endothelin. Eur J Cancer 1999; 35:1381–7

    Article  CAS  PubMed  Google Scholar 

  13. Bagnato A., Tecce R., Moretti C., Di Castro V., Spergel D., Catt K. Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells Clin Cancer Res 1995; 1:1059–66

    CAS  PubMed  Google Scholar 

  14. Yohn J.J., Smith C., Stevens T., Hoffman T.A., Morelli J.G., Hurt D.L., Yanagisawa M., Kane M.A., Zamora M.R. Human melanoma cells express functional endothelin-1 receptors. Biochem Biophys Res Commun 1994; 201:449–57

    Article  CAS  PubMed  Google Scholar 

  15. Kikuchi K., Nakagawa H., Kadono T., Etoh T., Byers H.R., Mihm M.C., Tamaki K. Decreased ET(B) receptor expression in human metastatic melanoma cells. Biochem Biophys Res Commun 1996; 219:734–9

    Article  CAS  PubMed  Google Scholar 

  16. Eberle J., Weitmann S., Thieck O., Pech H., Paul M., Orfanos C.E. Downregulation of endothelin B receptor in human melanoma cell lines parallel to differentiation genes. J Invest Dermatol 1999; 112:925–32

    Article  CAS  PubMed  Google Scholar 

  17. Demunter A., De Wolf-Peeters C., Degreef H., Stas M., van den Oord J.J. Expression of the endothelin-B receptor in pigment cell lesions of the skin. Evidence for its role as tumor progression marker in malignant melanoma. Virchows Arch 2001; 438:485–91

    Article  CAS  PubMed  Google Scholar 

  18. Lahav R., Heffner G., Patterson P.H. An endothelin receptor B antagonist inhibits growth and induces cell death in humanmelanoma cells in vitro and in vivo. Proc Natl Acad Sci U S A 1999; 96:11496–500

    Article  CAS  PubMed  Google Scholar 

  19. Nambi P., Wu H.L., Lipshutz D., Prabhakar U. Identification and characterization of endothelin receptors on rat osteoblastic osteosarcoma cells: down-regulation by 1,25-dihydroxy-vitamin D3. Mol Pharmacol. 1995; 47:266–71

    CAS  PubMed  Google Scholar 

  20. Yamashita J., Ogawa M., Inada K., Yamashita S., Matsuo S., Takano S. A large amount of endothelin-1 is present in human breast cancer tissues. Res Commun Chem Pathol Pharmacol 1991; 74:363–9.

    CAS  PubMed  Google Scholar 

  21. Alanen K., Deng D.X., Chakrabarti S. Augmented expression of endothelin-1, endothelin-3 and the endothelin-B receptor in breast carcinoma. Histopathology 2000; 36:161–7.

    Article  CAS  PubMed  Google Scholar 

  22. Giaid A., Hamid Q.A., Springall D.R., Yanagisawa M., Shinmi O., Sawamura T., Masaki T., Kimura S., Corrin B., Polak J.M. Detection of endothelin immunoreactivity and mRNA in pulmonary tumours. J Pathol 1990; 162:15–22

    Article  CAS  PubMed  Google Scholar 

  23. Thevarajah S., Udan M.S., Zheng H., Pfluyg B.R., Nelson J.B. Endothelin axis expression in renal cell carcinoma. J Urol 1999; 161:137–43

    Article  Google Scholar 

  24. Ahmed S.I., Thompson J., Coulson J.M., Woll P.J. Studies on the expression of endothelin, its receptor subtypes, and converting enzymes in lung cancer and in human bronchial epithelium. Am J Respir Cell Mol Biol 2000; 22:422–31

    CAS  PubMed  Google Scholar 

  25. Egidy G., Juillerat-Jeanneret L., Jeannin J.F., Korth P., Bosman F.T., Pinet F. Modulation of human colon tumor-stromal interactions by the endothelin system. Am J Pathol 2000; 157:1863–74

    CAS  PubMed  Google Scholar 

  26. Eberl L.P., Egidy G., Pinet F., Juillerat-Jeanneret L. Endothelin receptor blockade potentiates FasL-induced apoptosis in colon carcinoma cells via the protein kinase C-pathway. J Cardiovasc Pharmacol 2000; 36:S354–6

    Google Scholar 

  27. Eberl L.P., Valdenaire O., Saintgiorgio V., Jeannin J.F., Juillerat-Jeanneret L. Endothelin receptor blockade potentiates FasL-induced apoptosis in rat colon carcinoma cells. Int J Cancer 2000; 86:182–7

    Article  CAS  PubMed  Google Scholar 

  28. Venuti A., Salani D., Manni V., Poggiali F., Bagnato A. Expression of endothelin-1 and endothelin A receptor in HPV-associated cervical carcinoma: new potential targets for anticancer therapy. FASEB J 2000; 14:2277–83

    Article  CAS  PubMed  Google Scholar 

  29. Bagnato A., Cirilli A., Salani D., Simeone P., Muller A., Nicotra M.R., Natali P.G., Venuti A. Growth inhibition of cervix carcinoma cells in vivo by endothelin A receptor blockade. Cancer Res 2002; 62:6381–4

    CAS  PubMed  Google Scholar 

  30. Bagnato A., Rosano L., Di Castro V., Albini A., Salani D., Varmi M., Nicotra M.R., Natali P.G. Endothelin receptor blockade inhibits proliferation of Kaposi’s sarcoma cells. Am J Pathol 2001; 158:841–7

    CAS  PubMed  Google Scholar 

  31. Rosanò L., Spinella F., Di Castro V., Nicotra M.R., Albini A., Natali P.G., Bagnato A. Endothelin receptor blockade inhibits molecular effectors of tumor invasion in Kaposi’s sarcoma. Am J Pathol 2003;163:753–62

    PubMed  Google Scholar 

  32. Pagotto U., Arzberger T., Hopfner U., Sauer J., Renner U., Newton C.J., Lange M., Uhl E., Weindl A., Stalla G.K. Expression and localization of endothelin-1 and endothelin receptors in human meningiomas. Evidence for a role in tumoral growth. J Clin Invest 1995; 96:2017–25

    Article  CAS  PubMed  Google Scholar 

  33. Pagotto U., Arzberger T., Hopfner U., Weindl A., Stalla G.K. Cellular localization of endothelin receptor mRNAs (ETA and ETB) in brain tumors and normal human brain. J Cardiovasc Pharmacol 1995; 26(Suppl 3):S104–6

    Google Scholar 

  34. Harland S.P., Kuc R.E., Pickard J.D., Davenport A.P. Expression of endotheinA receptors in human gliomas and meningiomas, with high affinity for the selective antagonist PD156707. Neurosurgery 1998; 43:890–8

    Article  CAS  PubMed  Google Scholar 

  35. Bagnato A., Cart K.J. Endothelin as autocrine regulators of tumor cell growth. Trends Endocrinol Metab 1998; 9:378–83

    Article  CAS  PubMed  Google Scholar 

  36. Nelson J.B., Bagnato A., Battistini B., Nisen P. The endothelin axis: emerging role in cancer. Nature Rev Cancer 2003; 3:110–16

    Article  CAS  Google Scholar 

  37. Opgenorth T.J. Endothelin receptor antagonism. Adv Pharmacol 1995; 33:1–65

    Article  CAS  PubMed  Google Scholar 

  38. Wu C., Radford Decker E., Holland G.W., Brown P.M., Stavros F.D., Brock T.A., Dixon R.A.F. Nonpeptide endothelin antagonist in clinical development. Drugs of Today 2001; 37:441–53

    Article  CAS  PubMed  Google Scholar 

  39. Remuzzi G., Perico N., Benigni A. New therapeutics that antagonize endothelin: promises and frustations. Nature Rev Drug Disc 2002; 1: 986–1000

    Article  CAS  Google Scholar 

  40. Bagnato A., Tecce R., Di Castro V., Catt K.J. Activation of mitogenic signaling by endothelin-1 in ovarian carcinoma cells. Cancer Res 1997; 57: 1306–11

    CAS  PubMed  Google Scholar 

  41. Vacca F., Bagnato A., Catt K.J., Tecce R. Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells. Cancer Res 2000; 60:5310–17

    CAS  PubMed  Google Scholar 

  42. Salani D., Taraboletti G., Rosanò L., Di Castro V., Borsotti P., Giavazzi R., Bagnato A. Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Am J Pathol 2000; 157:1703–11

    CAS  PubMed  Google Scholar 

  43. Spinella F., Rosanò L., Di Castro V., Natali P.G., Bagnato A. Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor lα in ovarian carcinoma cells. J Biol Chem 2002; 277:27850–5

    Article  CAS  PubMed  Google Scholar 

  44. Del Bufalo D., Di Castro V., Biroccio A., Varmi M., Salani D., Rosanó L., Trisciuoglio D., Spinella S., Bagnato A. Endothelin-1 protects ovarian carcinoma cells against paclitaxel-induced apoptosis: requirement for Akt activation. Mol Pharmacol 2002; 61:524–32

    Article  PubMed  Google Scholar 

  45. Rosanò L., Varmi M, Salani D., Di Castro V., Spinella F., Natali P.G., Bagnato A. Endothelin-1 induces tumor proteinase activation and invasiveness of ovarian carcinoma cells. Cancer Res 2001; 61:8340–6

    PubMed  Google Scholar 

  46. Spinella F., Rosanò L., Di Castro V., Nicotra M.R., Natali P.G., Bagnato A. Endothelin-1 decreases gap-junctional intercellular communication by inducing phosphorylation of connexin 43 in human ovarian carcinoma cells. J Biol Chem 2003; 278:41294–301

    Article  CAS  PubMed  Google Scholar 

  47. Rosanò L., Spinella F., Salani D., Di Castro V., Venuti A., Nicotra M.R., Natali P.G., Bagnato A. Therapeutic targeting of endothelin A receptor in human ovarian carcinoma. Cancer Res 2003; 63:2447–53

    PubMed  Google Scholar 

  48. Carducci M.A., Nelson J.B., Bowling M.K., Rogers T., Eisenberger M.A., Sinibaldi V., Donehower R., Leahy T.L., Carr R.A., Isaacson J.D., Janus T.J., Andre A., Hosmane B.S., Padley R.J. Atrasentan, an endothelin-receptor antagonist for refractory adenocarcinomas: safety and pharmacokinetics. J Clin Oncol 2002; 20:2171–218

    Article  CAS  PubMed  Google Scholar 

  49. Carducci M.A., Padley R.J., Breul J., Vogelzang N.J., Zonnenberg B.A., Daliani D.D., Schulman C.C., Nabulsi A.A., Humerickhouse R.A., Weinberg M.A., Schmitt J.L., Nelson J.B. Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trial. J Clin Oncol 2003; 21:679–89

    Article  CAS  PubMed  Google Scholar 

  50. van der Boon J. New drug slows prostate-cancer progression. Lancet Oncol 2002; 3:201

    PubMed  Google Scholar 

  51. Guise T.A. Molecular mechanisms of osteolytic bone metastases. Cancer 2000; 88:2892–8

    Article  CAS  PubMed  Google Scholar 

  52. Chiao J.W., Moonga B.S., Yang Y.M., Kancherla R., Mittelman A., Wu-Wong J.R., Ahmed T. Endothelin-1 from prostate cancer cells is enhanced by bone contact which blocks osteoclastic bone resorption. Br J Cancer 2000; 83:360–5

    Article  CAS  PubMed  Google Scholar 

  53. Yin, J.J, Mohammed, K.S., Kakonen, S.M., Harris S., Wu-Wong J.R., Wessale J.L., Padley R.J., Garrett I.R., Chirgwin J.M., Guise T.A. A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastasis. Proc Natl Acad Sci USA 2003; 100:10954–9

    Article  CAS  PubMed  Google Scholar 

  54. Yohn, J.J., Smith, C., Stevens, T., Hoffman, T.A., Morelli, J.G., Hurt, D.L., Yanagisawa, M., Kane, M.A., Zamora, M.R. Human melanoma cells express functional endothelin-1 receptors. Biochem. Biophys. Res Commun 1994; 201:449–57

    Article  CAS  PubMed  Google Scholar 

  55. Bittner, M., Meltzer, P., Chen, Y., Jiang, Y., Seftor, E., Hendrix, M., Radmacher, M., Simon, R., Yakhini, Z., Ben-Dor, A., Sampas N., Dougherty E., Wang E., Marincola F., Gooden C., Lueders J., Glatfelter A., Pollock P., Carpten J., Gillanders E., Leja D., Dietrich K., Beaudry C., Berens M., Alberts D., Sondak V. Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 2000; 406:536–40

    Article  CAS  PubMed  Google Scholar 

  56. Demunter, A., De Wolf-Peeters, C., Degreef, H., Stas, M., van den Oord, J.J. Expression of the endothelin-B receptor in pigment cell lesions of the skin. Evidence for its role as tumor progression marker in malignant melanoma. Virchows Arch 2001; 438:485–91

    Article  CAS  PubMed  Google Scholar 

  57. Eberle, J., Fecker, L.F., Orfanos, C.E., Geilen, C.C. Endothelin-1 decreases basic apoptotic rates in human melanoma cell lines. J Invest Dermatol 2002; 119:549–55

    Article  CAS  PubMed  Google Scholar 

  58. Lahav, R., Heffner, G., Patterson, P.H. An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo. Proc Natl Acad Sci USA 1999; 96:11496–500

    Article  CAS  PubMed  Google Scholar 

  59. Li, G., Satyamoorthy, K., Meier, F., Berking, C., Bogenrieder T., Herlyn, M. Function and regulation of melanoma-stromal fibroblast interactions: when seeds meet soil. Oncogene 2003; 22:3162–71

    Article  CAS  PubMed  Google Scholar 

  60. Hsu, M., Andl, T., Li, G., Meinkoth, J.L., Herlyn, M. Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J Cell Science 2000; 113:1535–42

    CAS  PubMed  Google Scholar 

  61. Ruiter, D., Bogenrieder, T., Elder, D., Herlyn, M. Melanoma-stroma interactions: structural and functional aspects. Lancet Oncol 2002; 3:35–43

    Article  CAS  PubMed  Google Scholar 

  62. Bagnato A., Rosanò L. Spinella F., Di Castro V. Tecce R., Natali P.G. Endothelin B receptor blockade inhibits dynamic of cell interactions and communications in melanoma cell progression. Cancer Res 2004; 64

    Google Scholar 

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Authors and Affiliations

  1. Molecular Pathology and Ultrastructure Laboratory, Regina Elena Cancer Institute, Rome, Italy

    Anna Bagnato

  2. Immunology Laboratory, Regina Elena Cancer Institute, Rome, Italy

    Pier Giorgio Natali

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  1. Anna Bagnato
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  2. Pier Giorgio Natali
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Editors and Affiliations

  1. M. D. Anderson Cancer Center, The University of Texas, Houston, TX, USA

    Rakesh Kumar Ph.D.

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© 2004 Kluwer Academic Publishers

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Bagnato, A., Giorgio Natali, P. (2004). Targeting Endothelin Axis in Cancer. In: Kumar, R. (eds) Molecular Targeting and Signal Transduction. Cancer Treatment and Research, vol 119. Springer, Boston, MA. https://doi.org/10.1007/1-4020-7847-1_14

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  • DOI: https://doi.org/10.1007/1-4020-7847-1_14

  • Publisher Name: Springer, Boston, MA

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