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Reversible Acetylation Of Non Histone Proteins

Role in cellular function and disease

  • Chapter
Chromatin and Disease

Part of the book series: Subcellular Biochemistry ((SCBI,volume 41))

Post-translational modifications of nonhistone proteins play a significant role in regulating the chromatin structure, dynamics and thereby gene regulation. Among the different posttranslational modifications, reversible acetylation of non-histone proteins has profound functional implications on wide range of cellular processes. The acetylation status of these proteins is regulated by several cellular and non-cellular factors like viruses, physiological stresses, DNA damaging agents and ROS. Mutations found in the acetylation sites of these proteins and aberrant acetylation are related to imbalances in different cellular pathways and various diseases. Several factor acetyltransferases and deacetylases are known to regulate the acetylation of the nonhistone proteins. Modulators of these enzymes derived from natural as well as synthetic sources can thus have important therapeutic implications. Designing strategies to specifically target the acetylation of these proteins can be used as a valuable tool for new generation drugs

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Authors and Affiliations

  1. Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore-64, India

    Kiran Batta, Chandrima Das, Shrikanth Gadad, Jayasha Shandilya & Tapas K. Kundu

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  1. Kiran Batta
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  2. Chandrima Das
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  3. Shrikanth Gadad
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  4. Jayasha Shandilya
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  5. Tapas K. Kundu
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Editors and Affiliations

  1. Jawaharlal Centre for Advanced Scientific Research, Jakkur, Bangalore, India

    Tapas K. Kundu

  2. Queens College,City University of New York, New York, USA

    R. Bittman

  3. Saha Institute of Nuclear Physics, Calcutta, India

    D. Dasgupta

  4. Max-Planck-Institute for Biochemistry, Munich, Germany

    H. Engelhardt

  5. MOLISA GmbH, Magdeburg, Germany

    L. Flohe

  6. German Cancer Research Center, Heidelberg, Germany

    H. Herrmann

  7. Texas A & M University, Texas, USA

    A. Holzenburg

  8. National University of Ireland, Galway, Ireland

    H-P. Nasheuer

  9. The Hebrew University, Jerusalem, Israel

    S. Rottem

  10. DSM Nutritional Products Ltd, Basel, Switzerland

    M. Wyss

  11. Max-Planck-Institute for Biochemistry, Munich, Germany

    P. Zwickl

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Batta, K., Das, C., Gadad, S., Shandilya, J., Kundu, T.K. (2007). Reversible Acetylation Of Non Histone Proteins. In: Kundu, T.K., et al. Chromatin and Disease. Subcellular Biochemistry, vol 41. Springer, Dordrecht. https://doi.org/10.1007/1-4020-5466-1_9

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