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Structure and Function in Dipeptidyl Peptidase IV and Related Proteins

  • Conference paper
Dipeptidyl Aminopeptidases

Part of the book series: Advances in Experimental Medicine and Biology ((volume 575))

9. Conclusions

Potential therapeutic applications of DPIV inhibitors have fuelled interest in understanding the biological roles of DPIV and its relatives. Such efforts are confounded by the ubiquitous expression of DPIV, inhibitor selectivity questions and the variety of identified substrates. DPIV is not essential, but is such a useful enzyme that all animal species express it. The enzyme activity’s ancient and primary function is probably nutritional, providing more complete proteolysis of food and recycled proteins. This function is unnecessary in well-fed humans. The development of selective inhibitors of proteolytic activity and identification of ligand binding activities in this gene family would lead to rapid advances in understanding the biology of the POP gene family.

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Authors and Affiliations

  1. A. W. Morrow Gastroenterology and Liver Centre at Royal Prince Alfred Hospital, Centenary Institute of Cancer Medicine and Cell Biology and The Discipline of Medicine, University of Sydney, Sydney, New South Wales, Australia

    Mark D. Gorrell, Xin M. Wang, Joohong Park, Katerina Ajami, Denise Ming Tse Yu, Heather Knott, Devanshi Seth & Geoffrey W. McCaughan

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  1. Mark D. Gorrell
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  2. Xin M. Wang
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  3. Joohong Park
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  4. Katerina Ajami
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  8. Geoffrey W. McCaughan
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  1. Otto-von-Guericke University, Magdeburg, Germany

    Uwe Lendeckel , Dirk Reinhold  & Ute Bank ,  & 

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Gorrell, M.D. et al. (2006). Structure and Function in Dipeptidyl Peptidase IV and Related Proteins. In: Lendeckel, U., Reinhold, D., Bank, U. (eds) Dipeptidyl Aminopeptidases. Advances in Experimental Medicine and Biology, vol 575. Springer, Boston, MA . https://doi.org/10.1007/0-387-32824-6_5

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