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Cochrane Database of Systematic Reviews Protocol - Intervention

Behavioral interventions for decreasing HIV infection in racial and ethnic minorities in high‐income economies

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Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The objectives of this review are fourfold:

1. To locate and describe available outcome studies evaluating the effects of behavioral prevention interventions for persons of African or Afro‐Caribbean origin, Asian origin, Latin American, Amer‐Indian and Pacific Islander origin living in high‐income economies.

2. To undertake a critical review of these studies.

3. To synthesize the broad question of prevention effectiveness for reducing HIV‐risk behavior in four identified subgroups of these populations (MSM, injection drug users, heterosexuals and youth/adolescents) and to identify both patterns of success/failure in these interventions as well as the best evidence of effective interventions. These issues have not been directly addressed by previous Cochrane reviews, and reviews currently in progress (e.g. behavioral interventions) do not focus specifically on interventions aimed towards sub‐groups of racial and ethnic minorities.

4. To identify any adverse consequences or effects of interventions either targeted directly at these minority groups or reaching them by way of interventions targeted at the general population to decrease HIV infection.

Background

As we enter the third decade of the HIV pandemic, there is yet no cure or vaccine. At this time, our principal means for deterring the further spread of HIV remain behavioral risk prevention interventions. Behavioral interventions have directly contributed to decreases in HIV infections throughout the world. For example, in 1982 there were 8,000 new HIV infections in San Francisco, California. In 1992, the number had dropped to 1,000, and as of 1998 infections had dropped still further to less than 500 per year. There is strong evidence that the decrease in infection rates was due to an enormous decline in the levels of unprotected anal intercourse among men who have sex with men (Coates, 1998). Both Uganda and Thailand have demonstrated similar decreases in infection rates. In Uganda, surveys found that people made significant behavioral changes between 1989 and 1995. For example, young people delayed their initiation of sexual activity (e.g., the percentage of 15 year old boys reporting they had never had sex rose from 20% to 50%) and adults increased their condom use (for men from 15% to 55%; for women from 6% to 39%) (UNAIDS, 2001). Concurrently, HIV incidence declined, and behavioral change contributed to this decline (UNAIDS, 2001). In Thailand a rapid escalation of the HIV epidemic was met with prompt behavioral changes encouraged by national prevention programs. For example, visits to sex workers decreased, and condom use increased with both sex workers and casual partners. Similar to Uganda sharp decreases in risk behavior were found as well as a rapid decline in new HIV infections (UNAIDS, 2001). UNAIDS has stated that the experience of Thailand is one of the clearest examples of behavioral changes having a direct link to decreases in HIV infection (UNAIDS, 2001). As these behavioral changes were the result of interventions undertaken on both individual and community levels, developing and implementing effective interventions that focus on behavioral prevention are of utmost importance.

Recent statistics have demonstrated that there is a significant over‐representation of new HIV infections among population sub‐groups characterized by both non‐European racial/ethnic origin and by lower socioeconomic status in high‐income economies. For example, in the United States recent statistics show that over 50% of newly diagnosed HIV infections are occurring among African Americans (FN1) (CDC, 2000) although they only comprise approximately 12% of the U.S. population (U.S. Census, 2000). In Europe, over 50% of heterosexually acquired HIV infections (newly diagnosed between 1997‐2000) are in people from countries with a generalized HIV epidemic (e.g., Sub‐Saharan Africa) (WHO, 2000). Though the WHO estimates that approximately 64% of those newly diagnosed may have been infected prior to their migration (WHO, 2000), migrants new to their country who are not yet infected may be at heightened risk. Thus, although overall prevalence rates of HIV infection may be relatively low in countries such as the U.S., Great Britain and Canada, there are sub‐groups of the population (e.g., in the U.S., African‐American men who have sex with men) who have prevalence rates of HIV infection that rival parts of Sub‐Saharan Africa (Valleroy, 2000).

Specifically, in North America and Europe high prevalence rates of HIV infection among racial and ethnic minorities are present in the following sub‐groups: men who have sex with men (MSM), injection drug users (IDU), heterosexuals and youth/adolescents. For example, prevalence rates by race for HIV infection in participants in a national study of young MSM in the U.S. were 33% for African‐American, 14% for Latino, 2% for Caucasian, and 0% for Asian Americans (Valleroy, 2000). In Canada, Aboriginal persons are over‐represented among HIV‐infected IDU, and persons of African or Afro‐Caribbean origin are over‐represented among HIV infected heterosexuals. In Europe, certain risk groups, such as IDU and heterosexuals, have over‐representation from people of non‐European origin (WHO, 2000). Thus, though some high‐income economies (FN2) may have relatively low prevalence rates of HIV infection they also have certain sub‐groups at increased risk, and these sub‐groups demonstrate prevalence rates close to that of countries more universally impacted by the HIV epidemic.

Although other sociological issues such as socioeconomic status, racism and education are important factors to consider when examining the context in which HIV infection occurs, this review is focused on individually‐focused behavioral interventions. The figures presented above underscore the necessity for examining the results of behaviorally‐focused primary prevention interventions aimed at sub‐groups of racial and ethnic minorities in high‐income economies, focusing on the primary risk groups.

In this systematic review we examine evidence of the effectiveness of prevention interventions for persons of African of Afro‐Caribbean origin, Asian origin and Latin American origin living in high‐income economies. Previous literature reviews have been conducted on racial and ethnic minorities living in the U.S. (e.g. Marin, 1995, for African Americans and Latinos) and a Cochrane review is in progress addressing behavioral prevention interventions for HIV (Cochrane 1998b), but no prior review has systematically reviewed behavioral prevention interventions for all racial and ethnic minorities living in high‐income economies.

Footnotes:
(1) African American is the term used to describe persons of African or Caribbean ancestry living in the United States. It does not usually imply recent migration status.
(2) High‐income economies are defined by the World Bank by gross national income and are: Andorra, Germany, New Caledonia, Aruba, Greece, New Zealand, Australia, Greenland, Northern Mariana Islands, Austria, Guam, Norway, Bahamas, Hong Kong, China, Portugal, Barbados, Iceland, Qatar, Belgium, Ireland, San Marino, Bermuda, Israel, Singapore, Brunei, Italy, Slovenia, Canada, Japan, Spain, Cayman Islands, Kuwait, Sweden, Channel Islands, Liechtenstein, Switzerland, Cyprus, Luxembourg, United Arab Emirates, Denmark, Macao, China, United Kingdom, Faeroe Islands, Malta, United States, Finland, Monaco, Virgin Islands (U.S.), France, Netherlands, French Polynesia, Netherlands, Antilles.

Objectives

The objectives of this review are fourfold:

1. To locate and describe available outcome studies evaluating the effects of behavioral prevention interventions for persons of African or Afro‐Caribbean origin, Asian origin, Latin American, Amer‐Indian and Pacific Islander origin living in high‐income economies.

2. To undertake a critical review of these studies.

3. To synthesize the broad question of prevention effectiveness for reducing HIV‐risk behavior in four identified subgroups of these populations (MSM, injection drug users, heterosexuals and youth/adolescents) and to identify both patterns of success/failure in these interventions as well as the best evidence of effective interventions. These issues have not been directly addressed by previous Cochrane reviews, and reviews currently in progress (e.g. behavioral interventions) do not focus specifically on interventions aimed towards sub‐groups of racial and ethnic minorities.

4. To identify any adverse consequences or effects of interventions either targeted directly at these minority groups or reaching them by way of interventions targeted at the general population to decrease HIV infection.

Methods

Criteria for considering studies for this review

Types of studies

We will include randomized controlled trials and other controlled interventions that evaluated the effects of interventions designed to influence behavior change on at least one outcome measure related to HIV transmission. We will include randomized and quasi‐randomized controlled trials and studies utilizing a comparison group.

Types of participants

We will include the following:

1. Studies comprised of 100% of participants of African or Afro‐Caribbean origin, Asian origin, Latin American origin, Amer‐Indian origin, or Pacific Islander origin living in high‐income economies. These categories cover international racial or ethnic sub‐groups such as Aboriginals in Australia, Africans in Europe, and Amer‐Indians in Canada. Participants must be permanent residents of the country in which the intervention takes place. They must self identify as a member of a racial or ethnic sub‐group. The racial and ethnic sub‐groups are comparable to those defined by the Bureau of the Census in the United States, and the National Census in Great Britain.

2. Studies comprised of less than 100% of participants from these populations in their samples with intervention effects analyzed by race/ethnicity.

3. Participants from all settings (e.g., sex workers, prisoners) will be included as long as the requirements for racial or ethnic sub‐groups are met.

4. Participants may be of either gender, adolescents or older.

5. We will exclude studies of persons from high‐income economies who are living in other high‐income economies.

6. As we are only including studies of primary prevention any studies including participants who are already HIV positive and move to another country are excluded (due to the focus on primary prevention).

7. Newborns and children are excluded (due to the focus on individual risk behavior, e.g. sexual or drug‐using behavior).

Types of interventions

We will include three types of interventions directed at changing individuals' behavior:

· Behavioral interventions: These are interventions that aim to change individual behaviors only without explicit or direct attempts to change the norms of the community or the target population as a whole. Components of such interventions would include counseling, HIV‐testing and counseling, peer education, referrals, skills training, and the provision of risk reduction materials.

· Social interventions: These are interventions that aim to change not only individual behaviors but also social norms or peer norms. Strategies such as community mobilization, diffusion, building networks, and structural and resource support are often used to bring about changes in social norms and/or peer norms.

· Policy interventions: These are interventions that aim to change individual behavior or peer/social norms or structures through administrative or legal decisions. Examples include needle exchange programs, condom availability in public settings, and mandated HIV education in all schools of a district.

Interventions that are to be included in this review are exclusively focused on directly changing individual's risk behavior in order to prevent HIV infection. Although there are other types of social and policy that may indirectly affect risk of HIV infection (e.g., universal access to health care, STD care, interventions to improve socioeconomic status or education of women, such as job skills training) these are beyond the scope of this review. We also specifically excluded biomedical interventions included efficacy of vaccination, medical devices (such as condoms), antiretroviral therapy, blood screening, Caesarean sections, avoidance of breast feeding and other perinatal strategies.

Types of outcome measures

Studies that report outcome measures directly related to HIV transmission (including self‐reported risk behavior, and biological outcomes) will be included. Examples of risk behavior outcomes include condom use (both female and male), number of sexual partners, and frequency of unprotected vaginal or anal intercourse. (3) Biological outcomes include incidence of STD and HIV infection. As the area of interest is primary prevention, all participants will be HIV negative at the outset of the intervention, therefore all HIV infections will be newly acquired.

(3) The full list of outcome measures follows: use of male condoms, use of female condoms, application of condom negotiation skills, not having sex if condoms not used, having unprotected sex, number of sex partners, multi‐person use of drug paraphernalia, use of new sterile needles/syringes, injecting drugs, initiation of drug injection, non‐injecting drug use, sex with substance use, STD incidence, HIV incidence.

Search methods for identification of studies

We will conduct systematic, comprehensive searches for relevant studies on electronic databases, through handsearching key journals and conference proceedings, by scanning reference lists of reports of relevant outcome evaluation studies and reviews, and by directly contacting researchers/research organizations. The main aim is to identify published and unpublished reports of outcome evaluation studies of HIV/AIDS behavioral prevention interventions targeting or including ethnic minority populations in high‐income economies. For studies up to 1996, the Behavioral Prevention Register of the Cochrane Collaborative Review Group on HIV infection and AIDS will be searched. More recent studies (1996 ‐ 2000) will be identified from searches on AIDSLINE, the Cochrane Controlled Trials Register, EMBASE, MEDLINE, PsycINFO, and Sociofile. For each of these databases, sensitive search strategies will be developed consisting of both controlled vocabulary terms (where available) and free text terms (Peersman, 1999).

All search results will be subsequently entered/downloaded into an electronic register (using BiblioScape, CG Information, Duluth, Georgia). The titles and abstracts where available will be scanned and classified according to their relevance to the review.

In addition, researchers and agencies whom are known to conduct or sponsor relevant research will be contacted to identify further studies not found and unpublished reports. Special efforts will be made to identify studies from developing countries.

Searches will be conducted such that studies that both target sub‐groups of ethnic and/or racial minorities (100% of participants are ethnic and/or racial minorities) as well as general population studies that include participants from these sub‐groups are identified. For more general population studies, the inclusion criteria will be that separate analyses are conducted for the participants by racial/ethnic minority sub‐groups in order to determine the effectiveness of the intervention specifically for those sub‐groups.

Searches will be conducted to identify articles in any language (by reviewing abstracts), and research programs and researchers from several countries will be contacted.

Full reports will be obtained for all relevant outcome evaluation studies and a standardized coding strategy will be developed to describe the key characteristics of each of these studies in terms of the country where the study was conducted, the type of intervention, the study population, age of the study population, sex of the study population, percent race/ethnicity, intervention setting, intervention components, theoretical orientation of the intervention, research design, the training of facilitators, and types of outcomes.

Data collection and analysis

Studies will be reviewed for relevance based on types of participants, interventions, outcome measures, and study design to determine inclusion or exclusion of the study in the review.

Two reviewers (LAD, GEK) will independently extract appropriate information using a standardized data abstraction form. Information retrieved from the studies will include details of the intervention content, setting and provider and other study characteristics, including the methodological quality of the evaluation (see below). Any disagreements will be resolved between the two reviewers, and when necessary with a third party (G.V.P. or G.W.R.).

Studies will be categorized according to percentage of ethnic minority population, location, study design, targeted risk group of intervention, and methodological quality in order to evaluate and summarize outcome information.

If necessary, authors will be contacted to obtain any missing outcome data. Narrative synthesis will be provided and If appropriate, a meta‐analysis will be conducted.