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Autonomic nervous system and large conduit arteries

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The Arterial System in Hypertension

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 144))

Abstract

The vessels have the ability to alter their caliber and to influence the regional vascular resistance and capacitance through the modification of the neuronal discharge or changes in circulating catecholamines. Several in vitro studies demonstrated the extreme diversity of responses in the control of vascular tone of large conduit arteries and smaller resistive vessels [1], resulting from differences in the response to adrenoreceptor stimulation and antagonism between large and small arteries. Firstly, aorta and large conduit arteries which contain highly sensitive vascular smooth muscle cells have an excess of alpha1-adrenoreceptors, and are quite sensitive to adrenergic stimulation [2, 3]. Second, abrupt decrease in responsiveness to catecholamines occurs close to the roots of many aortic branches, and continue to fall-off as the arteries get smaller and further divide [4]. Finally, the sympathetic control of vascular tone of large arteries is more sensitive to alpha-adrenergic blockade, than that of smaller vessels [5].

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Authors
  1. Gérard M. London
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  2. Michel E. Safar
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Editor information

Editors and Affiliations

  1. Broussais-Hôtel Dieu, Paris, France

    Michel E. Safar (Professor of Therapeutics) (Professor of Therapeutics)

  2. University of New South Wales, St. Vincent’s Hospital, Sydney, Australia

    Michael F. O’Rourke (Professor of Medicine) (Professor of Medicine)

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© 1993 Springer Science+Business Media Dordrecht

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London, G.M., Safar, M.E. (1993). Autonomic nervous system and large conduit arteries. In: Safar, M.E., O’Rourke, M.F. (eds) The Arterial System in Hypertension. Developments in Cardiovascular Medicine, vol 144. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0900-0_12

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  • DOI: https://doi.org/10.1007/978-94-011-0900-0_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4389-2

  • Online ISBN: 978-94-011-0900-0

  • eBook Packages: Springer Book Archive

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