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Measurement of Drug Action in Skin: Dermal Connective Tissue

  • Chapter
Pharmacology of the Skin II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 2))

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Abstract

Investigating the activity of a pharmacological agent on the dermis requires some knowledge of its potential effect. As described earlier (Chap. 27) the connective support of the skin is a complex tissue resulting from the biosynthetic activity of differentiated cells producing a variety of components interacting to achieve defined supportive properties. A modification induced in any one of these products of biosynthesis may lead to an alteration in the function of the dermis. There exists a large array of procedures that can measure the amount, the quality and often the physicochemical organisation of the macromolecules composing the dermis. The development of specific cDNA probes for the macromolecules forming the dermal connective tissue allows quantitative and qualitative analysis at the transcriptional level. However, one needs to define what component is involved before investigating the mechanism by which it occurs.

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Authors
  1. B. Nusgens
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  2. C. M. Lapière
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Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., Ph. D., F.R.C.P.

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Nusgens, B., Lapière, C.M. (1989). Measurement of Drug Action in Skin: Dermal Connective Tissue. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_9

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  • DOI: https://doi.org/10.1007/978-3-642-74054-1_9

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