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Toxicology of Cosmetics

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Pharmacology of the Skin II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 2))

Abstract

In order to establish the safety of a new cosmetic or toiletry product it is necessary to gather a large quantity of information from a wide variety of sources. This chapter gives an account of the type of information that is required and the sources from which much of the information can be obtained. The use of the information in establishing the safety of a product is discussed.

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References

  • Ames BN, McCann J, Yamasaki E (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat Res 31:347–364

    PubMed  CAS  Google Scholar 

  • Buehler EV (1965) Delayed contact hypersensitivity in the guinea pig. Arch Dermatol 91:171–177

    Article  PubMed  CAS  Google Scholar 

  • Draize JH, Woodward G, Calvery HO (1944) Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther 82:377–390

    CAS  Google Scholar 

  • Finkelstein P, Laden K, Miechowski W (1963) New methods for evaluating cosmetic irritancy. J Invest Dermatol 40:11–14

    CAS  Google Scholar 

  • Fisher AA (1978) Contact dermatitis, 2nd edn. Lea and Febiger, Philadelphia

    Google Scholar 

  • Fregert S (1981) Manual of contact dermatitis, 2nd edn. Munksgaard, Copenhagen

    Google Scholar 

  • Frosch PJ, Kligman AM (1977) A method for appraising the stinging capacity of topically applied substances. J Soc Cosmet Chem 28:197–209

    Google Scholar 

  • Gloxhuber C (1970) Prüfung von Kosmetik-Grundstoffen auf fototoxische Wirkung. J Soc Cosmet Chem 21:825–833

    CAS  Google Scholar 

  • Ichikawa H, Armstrong RB, Harber LC (1981) Photoallergic contact dermatitis in guinea pigs: improved induction technique using Freund’s complete adjuvant. J Invest Dermatol 76:498–501

    Article  PubMed  CAS  Google Scholar 

  • Journal Officiel de la Republique Francaise (1971) 21 April, p 3862

    Google Scholar 

  • Kaidbey KH, Kligman AM (1978) Identification of topical photosensitising agents in humans. J Invest Dermatol 70:149–151

    Article  PubMed  CAS  Google Scholar 

  • Kaidbey KH, Kligman AM (1980) Photomaximisation test for identifying photoallergic contact sensitisers. Contact Dermatitis 6:161–169

    Article  PubMed  CAS  Google Scholar 

  • Klecak G (1977) Screening of fragrance materials for allergenicity in the guinea pig. I. Comparison of four testing methods. J Soc Cosmet Chem 28:53–64

    Google Scholar 

  • Kligman AM, Wooding WM (1967) A method for the measurement and evaluation of irritants on human skin. J Invest Dermatol 49:78–94

    PubMed  CAS  Google Scholar 

  • Magnusson B, Kligman AM (1969) The identification of contact allergens by animal assay. The guinea pig maximisation test. J Invest Dermatol 52:268–276

    PubMed  CAS  Google Scholar 

  • Marzulli FN, Maibach HI (1970) Perfume phototoxicity. J Soc Cosmet Chem 21:695–715

    CAS  Google Scholar 

  • Phillips L, Steinberg M, Maibach HI, Akers WA (1972) A comparison of rabbit and human skin response to certain irritants. Toxicol Appl Pharmacol 21:369–382

    Article  PubMed  CAS  Google Scholar 

  • Skog E (1980) Incidence of cosmetic dermatitis. Contact Dermatitis 6:449–451

    Article  PubMed  CAS  Google Scholar 

  • Smiles KA, Pollack ME (1977) A quantitative human patch testing procedure for low level skin irritants. J Soc Cosmet Chem 28:755–764

    Google Scholar 

  • Suskind RR (1979) Cutaneous reactions to cosmetics. J Dermatol (Tokyo) 6:203–209

    CAS  Google Scholar 

  • U.S. Federal Register (1973) Section 1500:41, vol 38 (187)

    Google Scholar 

  • Uttley M, van Abbe NJ (1973) Primary irritation of the skin, mouse ear test and human patch test procedures. J Soc Cosmet Chem 24:217–227

    Google Scholar 

  • Vinson LJ, Borselli VF (1966) A guinea pig assay of the photosensitising potential of topical germicides. J Soc Cosmet Chem 17:123–130

    CAS  Google Scholar 

  • Wilkinson DS (1968) Patch test reactions to certain halogenated salicylanilides and related compounds. Arch Dermatol 97:238–244

    Google Scholar 

  • Zaynoun ST, Johnson BE, Frain-Bell W (1977) A study of oil of bergamot and its importance as a phototoxic agent. Contact Dermatitis 3:225–239

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. J. D. Middleton
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Editor information

Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., Ph. D., F.R.C.P.

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© 1989 Springer-Verlag Berlin Heidelberg

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Middleton, J.D. (1989). Toxicology of Cosmetics. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin II. Handbook of Experimental Pharmacology, vol 87 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74054-1_16

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  • DOI: https://doi.org/10.1007/978-3-642-74054-1_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74056-5

  • Online ISBN: 978-3-642-74054-1

  • eBook Packages: Springer Book Archive

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