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Neurosensory Rehabilitation

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Trigeminal Nerve Injuries

Abstract

Every year in the USA millions of people suffer from somatosensory deficits caused by acute injury to the peripheral nervous system (PNS). Because of the broad scope of the specialty with procedures ranging from trauma to dentoalveolar and orthognathic surgery, oral and maxillofacial surgeons will likely encounter patients who experience such an injury. These injuries result in symptoms that range from a loss of sensation (hypoesthesia), to nonpainful tingling sensations (paresthesia), to increased sensitivity to touch or pressure with or without numbness or discomfort (dysesthesia), to peripheral neuropathic pain. The symptoms of somatosensory injury are not constant over time and may include only an abnormal reaction to a stimulus and/or spontaneous pain in the affected area [60, 84]. Treatment options for individuals with persistent altered sensation following peripheral nerve injury remain limited. Microsurgical nerve decompression and repair can be beneficial in some patients but is costly and not indicated for all patients who have persistent, bothersome altered sensation. Recently, two noninvasive therapies have been identified that improve patients’ perception of residual altered sensation (sensory retraining) or accelerate functional recovery (vitamin B12 administration). Evidence supporting the use of these therapies in patients with trigeminal nerve injuries will be presented in this chapter.

The projects were supported in part by the Oral and Maxillofacial Surgery Foundation, an investigator-initiated application to Qol Medical, NIDCR R01 005215, and UNC Clinical Translational Research Center #2572.

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References

  1. Abe N, Cavalli V (2008) Nerve injury signaling. Curr Opin Neurobiol 18:276–283

    Article  PubMed  CAS  Google Scholar 

  2. Al-Shubaili AF, Farah SA, Hussein JM, Trontelj JV, Khuraibet A (1998) Axonal and demyelinating neuropathy with reversible proximal conduction block, an unusual feature of vitamin B12 deficiency. Muscle Nerve 21:1341–1343

    Article  PubMed  CAS  Google Scholar 

  3. Atusmi Y, Imai T, Matsumoto K, Sakuda M, Maeda T, Kurisu K, Wakisaka S (2000) Effects of different types of injury to the inferior alveolar nerve on the behavior of Schwann cells during the regeneration of periodontal nerve fibers of rat incisor. Arch Histol Cytol 63:43–54

    Article  Google Scholar 

  4. Becerra L, Morris S, Bazes S, Gostic R et al (2006) Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J Neurosci 26:10646–10657

    Article  PubMed  CAS  Google Scholar 

  5. Bell-Krotoski J, Weinstein S, Weinstein C (1993) Testing sensibility, including tough-pressure, two-point discrimination, point localization, and vibration. J Hand Ther 6:114–123

    Article  PubMed  CAS  Google Scholar 

  6. Bouhassira D, Attal N, Fermanian J, Alchaar H, Gautron M, Masquelier E, Rostaing S, Lanteri-Minet M, Collin E, Grisart J, Boureau F (2004) Development and validation of the neuropathic pain symptom inventory. Pain 108(3):248–257

    Article  PubMed  Google Scholar 

  7. Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B, Bruxelle J, Cunin G, Fermanian J, Ginies P, Grun-Overdyking A, Jafari-Schluep H, Lantéri-Minet M, Laurent B, Mick G, Serrie A, Valade D, Vicaut E (2005) Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire. Pain 114(1–2):29–36

    Article  PubMed  Google Scholar 

  8. Boyd JG, Gordon T (2003) Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol Neurobiol 27:277–324

    Article  PubMed  CAS  Google Scholar 

  9. Callahan AD (1995) Methods of compensation and re-education for sensory dysfunction. In: Hunter JM, Mackin EJ, Callahan AD (eds) Rehabilitation of the hand. Mosby, St. Louis

    Google Scholar 

  10. Campbell RL, Shamaskin RG, Harkins SW (1987) Assessment of recovery from injury to inferior alveolar and mental nerves. Oral Surg Oral Med Oral Pathol 64:519–526

    Article  PubMed  CAS  Google Scholar 

  11. Cunningham LL, Tiner BD, Clark GM, Bays RA, Keeling SD, Rugh JD (1996) A comparison of questionnaire versus monofilament assessment of neurosensory deficit. J Oral Maxillofac Surg 54:454–459

    Article  PubMed  CAS  Google Scholar 

  12. Cusick CG, Wall JT, Whiting JHJ, Wiley RG (1990) Temporal progression of cortical reorganization following nerve injury. Brain Res 537(1–2):355–358

    Article  PubMed  CAS  Google Scholar 

  13. Daniele HR, Aguado L (2003) Early compensatory sensory re-education. J Reconstr Microsurg 19:107–110

    Article  PubMed  Google Scholar 

  14. Dellon AL (1988) Re-education of sensation. John D Lucas, Baltimore

    Google Scholar 

  15. Dubner R, Ruda MA (1992) Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 15(3):96–103

    Article  PubMed  CAS  Google Scholar 

  16. Edin BB, Johansson N (1995) Skin strain patterns provide kinaesthetic information to the human central nervous system. J Physiol (Lond) 1:243

    Google Scholar 

  17. Essick GK (1992) Comprehensive clinical evaluation of perioral sensory function. Oral Maxillofac Surg Clin North Am 4(2):503–526

    Google Scholar 

  18. Essick G (2004) Psychophysical assessment of patients with posttraumatic neuropathic trigeminal pain. J Orofac Pain 18:345–354

    PubMed  Google Scholar 

  19. Essick G, Patel J, Trulsson M (2002) Mechanosensory and thermosensory changes across the border of impaired sensitivity to pinprick after mandibular nerve injury. J Oral Maxillofac Surg 60(11):1250–1266

    Article  PubMed  Google Scholar 

  20. Essick G, Guest S, Martinez E, Chen C, McGlone F (2004) Site-dependent and subject-related variations in perioral thermal sensitivity. Somatosens Mot Res 21:159–175

    Article  PubMed  Google Scholar 

  21. Essick GK, Phillips C, Turvey TA, Tucker M (2007) Facial altered sensation and sensory impairment after orthognathic surgery. Int J Oral Maxillofac Surg 36:577–582

    Article  PubMed  CAS  Google Scholar 

  22. Essick GK, Phillips C, Zuniga J (2007) Effect of facial sensory retraining on sensory thresholds. J Dent Res 86:571–575

    Article  PubMed  CAS  Google Scholar 

  23. Essick GK, Phillips C, Kim SK, Zuniga J (2009) Sensory retraining following orthognathic surgery: effect on threshold measures of sensory function. J Oral Rehabil 36:415–426

    Article  PubMed  CAS  Google Scholar 

  24. Faggin BM, Nguyen KT, Nicolelis MAL (1997) Immediate and simultaneous sensory reorganization at cortical and subcortical levels of the somatosensory system. Proc Natl Acad Sci USA 94:9428–9433

    Article  PubMed  CAS  Google Scholar 

  25. Feldman S, Essick G, Zuniga JR, Phillips C (1997) Interexaminer reliability of three subjective clinical neurosensory tests. Int J Adult Orthod Orthognath Surg 12:273–275

    Google Scholar 

  26. Fine EJ, Soria ED (1991) Myths about vitamin B12 deficiency. South Med J 84(12):1475–1481

    Article  PubMed  CAS  Google Scholar 

  27. Fiorio M, Haggard P (2005) Viewing the body prepares the brain for touch: effects of TMS over somatosensory cortex. Eur J Neurosci 22:773–777

    Article  PubMed  Google Scholar 

  28. Florence SL, Boydston LA, Hackett TA, Taub Lachoff H, Strata F, Niblock MM (2001) Sensory enrichment after peripheral nerve injury restores cortical, not thalamic, receptive field organization. Eur J Neurosci 13:1755–1766

    Article  PubMed  CAS  Google Scholar 

  29. Fridrich KL, Holton TJ, Pansegrau KJ, Buckley MJ (1995) Neurosensory recovery following the mandibular bilateral sagittal split osteotomy. J Oral Maxillofac Surg 53:1300–1306

    Article  PubMed  CAS  Google Scholar 

  30. Gandevia SC, Phegan CML (1999) Perceptual distortions of the human body image produced by local anaesthesia, pain and cutaneous stimulation. J Physiol 2:609–616

    Article  Google Scholar 

  31. Gregg JM (1990) Studies of traumatic neuralgias in the maxillofacial region: surgical pathology and neural mechanisms. J Oral Maxillofac Surg 48(s):228–237

    Article  PubMed  CAS  Google Scholar 

  32. Gregg JM (1992) Nonsurgical management of traumatic trigeminal neuralgias and sensory neuropathies. Oral Maxillofac Surg Clin North Am 4:375–392

    Google Scholar 

  33. Hanz S, Fainzilber M (2006) Retrograde signaling in injured nerve-the axon reaction revisited. J Neurochem 99:13–19

    Article  PubMed  CAS  Google Scholar 

  34. Hashiba Y, Ueki K, Marukawa K, Shimada M, Yoshida K, Shimizu C, Alam S, Nakagawa K (2007) A comparison of lower lip hypoesthesia measured by trigeminal somatosensory-evoked potential between different types of mandibular osteotomies and fixation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104(2):177–185

    Article  PubMed  Google Scholar 

  35. Havelius U, Hindfelt B, Rosén I (1982) Reversibility of neurological deficits in vitamin B12 deficiency. Arch Psychiatr Nervenkr 232:473–478

    Article  Google Scholar 

  36. Herdegen T, Skene P, Bahr M (1997) The c-Jun transcription factor – bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 20:227–231

    Article  PubMed  CAS  Google Scholar 

  37. Ide H, Fujiya S, Asanuma Y, Tsuji M, Sakai H, Agashi Y (1987) Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy. Clin Ther 9:183–192

    PubMed  CAS  Google Scholar 

  38. Imai H, Tajima T, Natsumi Y (1991) Successful reeducation of functional sensibility after median nerve repair at the wrist. J Hand Surg 16:60–65

    Article  CAS  Google Scholar 

  39. Jääskeläinen SK (2004) The utility of clinical neurophysiological and quantitative sensory testing for trigeminal neuropathy. J Orofac Pain 18:355–359

    PubMed  Google Scholar 

  40. Jääskelainen SK, Teerijoki-Oksa T, Virtanen A, Tenovuo O, Forssell H (2004) Sensory regeneration following intraoperatively verified trigeminal nerve injury. Neurology 62:1951–1957

    Article  PubMed  Google Scholar 

  41. Jalaludin MA (1995) Methylcobalamin treatment of Bell’s palsy. Methods Find Exp Clin Pharmacol 17:539–544

    PubMed  CAS  Google Scholar 

  42. Jenkins WM, Merzenich MM, Ochs MT, Allard T, Guic-Robles E (1990) Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation. J Neurophysiol 63:82–104

    PubMed  CAS  Google Scholar 

  43. Jian-bo L, Cheng-ya W, Jia-wei C, Ziao-lu L, Zhen-qing F, Hong-tai M (2010) The preventive efficacy of methylcobalamin on rat peripheral neuropathy influenced by diabetes via neural IGF-1 levels. Nutr Neurosci 13:79–86

    Article  PubMed  Google Scholar 

  44. Jones TA, Hawrylak N, Klintsova AY, Greenough WT (1998) Brain damage, behavior, rehabilitation, recovery, and brain plasticity. Ment Retard Dev Disabil Res Rev 4:231–237

    Article  Google Scholar 

  45. Jones TA, Ghu CJ, Grande LA, Gregory AD (1999) Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neurosci 19(22):10153–10163

    PubMed  CAS  Google Scholar 

  46. Kaas JH, Collins CE (2003) Anatomic and functional reorganization of somatosensory cortex in mature primates after peripheral nerve and spinal cord injury. Adv Neurol 93:87–95

    PubMed  Google Scholar 

  47. Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J (1998) Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 21:1775–1778

    Article  PubMed  CAS  Google Scholar 

  48. Karas ND, Boyd SB, Sinn DP (1990) Recovery of neurosensory function following orthognathic surgery. J Oral Maxillofac Surg 48:124–134

    Article  PubMed  CAS  Google Scholar 

  49. Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T (1999) Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 38:472–475

    Article  PubMed  CAS  Google Scholar 

  50. Lundborg G (2003) Nerve injury and repair-A challenge to the plastic brain. J Peripher Nerv Syst 8:209–226

    Article  PubMed  Google Scholar 

  51. Lundborg G, Rosen B (2001) Sensory relearning after nerve repair. Lancet 358:809–810

    Article  PubMed  CAS  Google Scholar 

  52. Mandolesi G, Madeddu F, Bozzi Y, Maffei L, Ratto GM (2004) Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity. FASEB J 18:1934–1936

    PubMed  CAS  Google Scholar 

  53. Marchettini P (2005) The burning case of neuropathic pain wording. Pain 114(3):313–314

    Article  PubMed  CAS  Google Scholar 

  54. Merzenich MM, Recanzone G, Jenkins WM, Allard TT, Nudo RJ (1988) Cortical representational plasticity. In: Rakic P, Singer W (eds) Neurobiology of neocortex. John Wiley & Sons, New York

    Google Scholar 

  55. Meyer RA, Rath EM (2001) Sensory rehabilitation after trigeminal nerve injury or nerve repair. Atlas Oral Maxillofac Surg Clin North Am 13:365–376

    Google Scholar 

  56. Morani AS, Bodhankar SL (2010) Early co-administration of vitamin E acetate and methylcobalamin improves thermal hyperalgesia and motor nerve conduction velocity following sciatic nerve crush injury in rats. Pharmacol Rep 62:405–409

    Article  PubMed  CAS  Google Scholar 

  57. Nakagawa K, Ueki K, Takatsuka S, Yamamoto E (2003) Trigeminal nerve hypesthesia after sagittal split osteotomy in setback cases: correlation of postoperative computed tomography and long-term trigeminal somatosensory evoked potentials. J Oral Maxillofac Surg 61:898–903

    Article  PubMed  Google Scholar 

  58. Navarro X, Vivó M, Valero-Cabré A (2007) Neural plasticity after peripheral nerve injury and regeneration. Prog Neurobiol 82(4):163–201

    Article  PubMed  CAS  Google Scholar 

  59. Panula K, Finne K, Oikarinen K (2004) Neurosensory deficits after bilateral sagittal split ramus osteotomy of the mandible – influence of soft tissue handling medial to the ascending ramus. Int J Oral Maxillofac Surg 33:543–548

    Article  PubMed  CAS  Google Scholar 

  60. Phillips C, Essick G, Zuniga J, Tucker M, Blakey GH III (2006) Qualitative descriptors used by patients following orthognathic surgery to portray altered sensation. J Oral Maxillofac Surg 64:1751–1760

    Article  PubMed  Google Scholar 

  61. Phillips C, Essick G, Preisser JS, Turvey TA, Tucker M, Lin D (2007) Sensory retraining following orthognathic surgery: effect on patient perception of altered sensation. J Oral Maxillofac Surg 65(6):1162–1173

    Article  PubMed  Google Scholar 

  62. Phillips C, Kim S, Essick G, Tucker M, Turvey TA (2009) Sensory retraining following orthognathic surgery: effect on patient report of the presence of altered sensation. Am J Orthod Dentofacial Orthop 136(6):788–794

    Article  PubMed  Google Scholar 

  63. Phillips C, Kim S, Tucker M, Turvey TA (2010) Sensory retraining: burden in daily life related to altered sensation after orthognathic surgery, a randomized clinical trial. Orthod Craniofac Res 13(3):169–178

    Article  PubMed  CAS  Google Scholar 

  64. Phillips C, Blakey G III, Essick GK (2011) Sensory retraining: a cognitive behavioral therapy for altered sensation. Atlas Oral Maxillofac Surg Clin North Am 19:109–118

    Article  PubMed  Google Scholar 

  65. Phillips C, Blakey G III, Essick GK (2012) A tolerability study in orthognathic surgery patients of intranasal cyanocobalamin spray: a potential treatment for acute peripheral nerve injury. J Maxillofac Trauma 1:13–19

    Google Scholar 

  66. Phillips C, Essick GK, Chung Y, Blakey G III (2012) Non-invasive therapy for altered facial sensation following orthognathic surgery: an exploratory randomized clinical trial of intranasal vitamin B12 spray. J Maxillofac Trauma 1:20–29

    Google Scholar 

  67. Puri V, Chaudhry N, Goel S, Gulati P, Nehru R, Chowdhury D (2005) Vitamin B12 deficiency: a clinical and electrophysiological profile. Electromyogr Clin Neurophysiol 45(5):273–284

    PubMed  CAS  Google Scholar 

  68. Recanzone GH, Jenkins WM, Hradek GT, Merzenich MM (1992) Progressive improvement in discriminative abilities in adult owl monkeys performing a tactile frequency discrimination task. J Neurophysiol 67:1015–1030

    PubMed  CAS  Google Scholar 

  69. Recanzone GH, Merzenich MM, Jenkins WM, Grajski KA, Dinse HR (1992) Topographic reorganization of the hand representation in cortical area 3b of owl monkeys trained in a frequency-discrimination task. J Neurophysiol 67:1031–1056

    PubMed  CAS  Google Scholar 

  70. Recanzone GH, Merzenich MM, Schreiner CE (1992) Changes in the distributed temporal response properties of SI cortical neurons reflect improvements in performance on a temporally based tactile discrimination task. J Neurophysiol 67:1071–1091

    PubMed  CAS  Google Scholar 

  71. Ro T, Wallace R, Hagedorn J, Farne A, Pienkos E (2004) Visual enhancing of tactile perception in the posterior parietal cortex. J Cogn Neurosci 16:24–30

    Article  PubMed  Google Scholar 

  72. Rosen B, Lundborg G (2004) Sensory re-education after nerve repair: aspects of timing. Handchir Mikrochir Plast Chir 36:8–12

    Article  PubMed  CAS  Google Scholar 

  73. Rostand SG (1976) Vitamin B12 levels and nerve conduction velocities in patients undergoing maintenance hemodialysis. Am J Clin Nutr 29:691–697

    PubMed  CAS  Google Scholar 

  74. Sathian K, Greenspan AI, Wolf SL (2000) Doing it with mirrors: a case study of a novel approach to neurorehabilitation. Neurorehabil Neural Repair 14:73–76

    Article  PubMed  CAS  Google Scholar 

  75. Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K (2005) Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients. J Neurol Sci 231:13–18

    Article  PubMed  CAS  Google Scholar 

  76. Scalabrino G, Buccellato FR, Veber D, Mutti E (2003) New basis of the neurotrophic action of vitamin B12. Clin Chem Lab Med 41:1435–1437

    Article  PubMed  CAS  Google Scholar 

  77. Shieh S-J, Chiu HOY, Lee J-W, Hsu H-Y (1995) Evaluation of the effectiveness of sensory reeducation following digital replantation and revascularization. Microsurgery 16:578–582

    Article  PubMed  CAS  Google Scholar 

  78. Sun Y, Lai M-S, Lu C-J (2005) Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 14:48–54

    PubMed  CAS  Google Scholar 

  79. Taylor-Clarke M, Kennett S, Haggard P (2002) Vision modulates somatosensory cortical processing. Curr Biol 12:233–236

    Article  PubMed  CAS  Google Scholar 

  80. Teerijoki-Oksa T, Jääskeläinen SK, Forssell K, Forssell H, Vahatalo K, Tammisalo T et al (2002) Risk factors of nerve injury during mandibular sagittal split osteotomy. Int J Oral Maxillofac Surg 31:33–39

    Article  PubMed  CAS  Google Scholar 

  81. Teerijoki-Oksa T, Jääskelainen S, Forssell K, Virtanen A, Forssell H (2003) An evaluation of clinical and electrophysiologic tests in nerve injury diagnosis after mandibular sagittal split osteotomy. Int J Oral Maxillofac Surg 32(1):15–23

    Article  PubMed  CAS  Google Scholar 

  82. Teerijoki-Oksa T, Jääskelainen SK, Forssell K, Forssell H (2004) Recovery of nerve injury after mandibular sagittal split osteotomy. Diagnostic value of clinical and electrophysiologic tests in the follow-up. Int J Oral Maxillofac Surg 33(2):134–140

    Article  PubMed  CAS  Google Scholar 

  83. Teerijoki-Oksa T, Jääskelainen SK, Soukka T, Virtanen A, Forssell H (2011) Subjective sensory symptoms associated with axonal and demyelinating nerve injuries after mandibular sagittal split osteotomy. J Oral Maxillofac Surg 69:e208–e213

    Article  PubMed  Google Scholar 

  84. Trulsson M, Essick GK (1997) Low-threshold mechanoreceptive afferents in the human lingual nerve. J Neurophysiol 77:737–748

    PubMed  CAS  Google Scholar 

  85. Van Boven R, Johnson K (1994) A psychophysical study of the mechanisms of sensory recovery following nerve injury in humans. Brain 117(Pt 1):149–167

    Article  PubMed  Google Scholar 

  86. Van Boven R, Johnson K (1994) The limits of tactile spatial resolution in humans: grating orientation discrimination at the lip, tongue, and finger. J Neurol 44:2361–2366

    Article  Google Scholar 

  87. Wall JT, Kaas JH, Sur M, Nelson RJ, Felleman DF, Merzenich MM (1986) Functional reorganization in somatosensory cortical areas 3b and 1 of adult monkeys after median nerve repair: possible relationships to sensory recovery in humans. J Neurosci 6:218–223

    PubMed  CAS  Google Scholar 

  88. Wall JT, Xu J, Wang X (2002) Human brain plasticity: an emerging view of the multiple substrates and mechanisms that cause cortical changes and related sensory dysfunctions after injuries of sensory inputs from the body. Brain Res Rev 39(2–3):181–215

    Article  PubMed  CAS  Google Scholar 

  89. Wang Z, Gan Q, Rupert RL, Zeng Y, Song X (2005) Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain 114:266–277

    Article  PubMed  CAS  Google Scholar 

  90. Watanabe T, Kaji R, Oka N, Bara W, Kimura J (1994) Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 122:140–143

    Article  PubMed  CAS  Google Scholar 

  91. Waylett-Rendall J (1988) Sensibility evaluation and rehabilitation. Orthop Clin North Am 19:43–56

    PubMed  CAS  Google Scholar 

  92. Wei F-C, Ma H-S (1995) Delayed sensory reeducation after toe-to-hand transfer. Microsurgery 16:583–585

    Article  PubMed  CAS  Google Scholar 

  93. Woolf CJ, Walters ET (1991) Common patterns of plasticity contributing to nociceptive sensitization in mammals and Aplysia. Trends Neurosci 14(2):74–78

    Article  PubMed  CAS  Google Scholar 

  94. Wynn Parry CB, Slater M (1976) Sensory re-education after median nerve lesions. Hand 8:250–257

    Article  Google Scholar 

  95. Yaqub BA, Siddique A, Sulimani R (1992) Effects of methylcobalamin on diabetic neuropathy. Clin Neurol Neurosurg 94:105–111

    Article  PubMed  CAS  Google Scholar 

  96. Yoshida T, Nagamine T, Kobayashi T, Michimi N, Nakajima T, Sasakura H, Hanada K (1989) Impairment of the inferior alveolar nerve after sagittal split osteotomy. J Craniomaxillofac Surg 17:271–277

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

The authors wish to thank Debora Price for her participation in the data collection and analysis for all the research projects and Andrew Blank for technical assistance in manuscript preparation.

Conflict of InterestThe authors have no conflict of interest to report.

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Correspondence to Greg K. Essick DDS, PhD .

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Essick, G.K., Blakey, G., Phillips, C. (2013). Neurosensory Rehabilitation. In: Miloro, M. (eds) Trigeminal Nerve Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35539-4_18

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