Abstract
Every year in the USA millions of people suffer from somatosensory deficits caused by acute injury to the peripheral nervous system (PNS). Because of the broad scope of the specialty with procedures ranging from trauma to dentoalveolar and orthognathic surgery, oral and maxillofacial surgeons will likely encounter patients who experience such an injury. These injuries result in symptoms that range from a loss of sensation (hypoesthesia), to nonpainful tingling sensations (paresthesia), to increased sensitivity to touch or pressure with or without numbness or discomfort (dysesthesia), to peripheral neuropathic pain. The symptoms of somatosensory injury are not constant over time and may include only an abnormal reaction to a stimulus and/or spontaneous pain in the affected area [60, 84]. Treatment options for individuals with persistent altered sensation following peripheral nerve injury remain limited. Microsurgical nerve decompression and repair can be beneficial in some patients but is costly and not indicated for all patients who have persistent, bothersome altered sensation. Recently, two noninvasive therapies have been identified that improve patients’ perception of residual altered sensation (sensory retraining) or accelerate functional recovery (vitamin B12 administration). Evidence supporting the use of these therapies in patients with trigeminal nerve injuries will be presented in this chapter.
The projects were supported in part by the Oral and Maxillofacial Surgery Foundation, an investigator-initiated application to Qol Medical, NIDCR R01 005215, and UNC Clinical Translational Research Center #2572.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abe N, Cavalli V (2008) Nerve injury signaling. Curr Opin Neurobiol 18:276–283
Al-Shubaili AF, Farah SA, Hussein JM, Trontelj JV, Khuraibet A (1998) Axonal and demyelinating neuropathy with reversible proximal conduction block, an unusual feature of vitamin B12 deficiency. Muscle Nerve 21:1341–1343
Atusmi Y, Imai T, Matsumoto K, Sakuda M, Maeda T, Kurisu K, Wakisaka S (2000) Effects of different types of injury to the inferior alveolar nerve on the behavior of Schwann cells during the regeneration of periodontal nerve fibers of rat incisor. Arch Histol Cytol 63:43–54
Becerra L, Morris S, Bazes S, Gostic R et al (2006) Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J Neurosci 26:10646–10657
Bell-Krotoski J, Weinstein S, Weinstein C (1993) Testing sensibility, including tough-pressure, two-point discrimination, point localization, and vibration. J Hand Ther 6:114–123
Bouhassira D, Attal N, Fermanian J, Alchaar H, Gautron M, Masquelier E, Rostaing S, Lanteri-Minet M, Collin E, Grisart J, Boureau F (2004) Development and validation of the neuropathic pain symptom inventory. Pain 108(3):248–257
Bouhassira D, Attal N, Alchaar H, Boureau F, Brochet B, Bruxelle J, Cunin G, Fermanian J, Ginies P, Grun-Overdyking A, Jafari-Schluep H, Lantéri-Minet M, Laurent B, Mick G, Serrie A, Valade D, Vicaut E (2005) Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire. Pain 114(1–2):29–36
Boyd JG, Gordon T (2003) Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol Neurobiol 27:277–324
Callahan AD (1995) Methods of compensation and re-education for sensory dysfunction. In: Hunter JM, Mackin EJ, Callahan AD (eds) Rehabilitation of the hand. Mosby, St. Louis
Campbell RL, Shamaskin RG, Harkins SW (1987) Assessment of recovery from injury to inferior alveolar and mental nerves. Oral Surg Oral Med Oral Pathol 64:519–526
Cunningham LL, Tiner BD, Clark GM, Bays RA, Keeling SD, Rugh JD (1996) A comparison of questionnaire versus monofilament assessment of neurosensory deficit. J Oral Maxillofac Surg 54:454–459
Cusick CG, Wall JT, Whiting JHJ, Wiley RG (1990) Temporal progression of cortical reorganization following nerve injury. Brain Res 537(1–2):355–358
Daniele HR, Aguado L (2003) Early compensatory sensory re-education. J Reconstr Microsurg 19:107–110
Dellon AL (1988) Re-education of sensation. John D Lucas, Baltimore
Dubner R, Ruda MA (1992) Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 15(3):96–103
Edin BB, Johansson N (1995) Skin strain patterns provide kinaesthetic information to the human central nervous system. J Physiol (Lond) 1:243
Essick GK (1992) Comprehensive clinical evaluation of perioral sensory function. Oral Maxillofac Surg Clin North Am 4(2):503–526
Essick G (2004) Psychophysical assessment of patients with posttraumatic neuropathic trigeminal pain. J Orofac Pain 18:345–354
Essick G, Patel J, Trulsson M (2002) Mechanosensory and thermosensory changes across the border of impaired sensitivity to pinprick after mandibular nerve injury. J Oral Maxillofac Surg 60(11):1250–1266
Essick G, Guest S, Martinez E, Chen C, McGlone F (2004) Site-dependent and subject-related variations in perioral thermal sensitivity. Somatosens Mot Res 21:159–175
Essick GK, Phillips C, Turvey TA, Tucker M (2007) Facial altered sensation and sensory impairment after orthognathic surgery. Int J Oral Maxillofac Surg 36:577–582
Essick GK, Phillips C, Zuniga J (2007) Effect of facial sensory retraining on sensory thresholds. J Dent Res 86:571–575
Essick GK, Phillips C, Kim SK, Zuniga J (2009) Sensory retraining following orthognathic surgery: effect on threshold measures of sensory function. J Oral Rehabil 36:415–426
Faggin BM, Nguyen KT, Nicolelis MAL (1997) Immediate and simultaneous sensory reorganization at cortical and subcortical levels of the somatosensory system. Proc Natl Acad Sci USA 94:9428–9433
Feldman S, Essick G, Zuniga JR, Phillips C (1997) Interexaminer reliability of three subjective clinical neurosensory tests. Int J Adult Orthod Orthognath Surg 12:273–275
Fine EJ, Soria ED (1991) Myths about vitamin B12 deficiency. South Med J 84(12):1475–1481
Fiorio M, Haggard P (2005) Viewing the body prepares the brain for touch: effects of TMS over somatosensory cortex. Eur J Neurosci 22:773–777
Florence SL, Boydston LA, Hackett TA, Taub Lachoff H, Strata F, Niblock MM (2001) Sensory enrichment after peripheral nerve injury restores cortical, not thalamic, receptive field organization. Eur J Neurosci 13:1755–1766
Fridrich KL, Holton TJ, Pansegrau KJ, Buckley MJ (1995) Neurosensory recovery following the mandibular bilateral sagittal split osteotomy. J Oral Maxillofac Surg 53:1300–1306
Gandevia SC, Phegan CML (1999) Perceptual distortions of the human body image produced by local anaesthesia, pain and cutaneous stimulation. J Physiol 2:609–616
Gregg JM (1990) Studies of traumatic neuralgias in the maxillofacial region: surgical pathology and neural mechanisms. J Oral Maxillofac Surg 48(s):228–237
Gregg JM (1992) Nonsurgical management of traumatic trigeminal neuralgias and sensory neuropathies. Oral Maxillofac Surg Clin North Am 4:375–392
Hanz S, Fainzilber M (2006) Retrograde signaling in injured nerve-the axon reaction revisited. J Neurochem 99:13–19
Hashiba Y, Ueki K, Marukawa K, Shimada M, Yoshida K, Shimizu C, Alam S, Nakagawa K (2007) A comparison of lower lip hypoesthesia measured by trigeminal somatosensory-evoked potential between different types of mandibular osteotomies and fixation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104(2):177–185
Havelius U, Hindfelt B, Rosén I (1982) Reversibility of neurological deficits in vitamin B12 deficiency. Arch Psychiatr Nervenkr 232:473–478
Herdegen T, Skene P, Bahr M (1997) The c-Jun transcription factor – bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 20:227–231
Ide H, Fujiya S, Asanuma Y, Tsuji M, Sakai H, Agashi Y (1987) Clinical usefulness of intrathecal injection of methylcobalamin in patients with diabetic neuropathy. Clin Ther 9:183–192
Imai H, Tajima T, Natsumi Y (1991) Successful reeducation of functional sensibility after median nerve repair at the wrist. J Hand Surg 16:60–65
Jääskeläinen SK (2004) The utility of clinical neurophysiological and quantitative sensory testing for trigeminal neuropathy. J Orofac Pain 18:355–359
Jääskelainen SK, Teerijoki-Oksa T, Virtanen A, Tenovuo O, Forssell H (2004) Sensory regeneration following intraoperatively verified trigeminal nerve injury. Neurology 62:1951–1957
Jalaludin MA (1995) Methylcobalamin treatment of Bell’s palsy. Methods Find Exp Clin Pharmacol 17:539–544
Jenkins WM, Merzenich MM, Ochs MT, Allard T, Guic-Robles E (1990) Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation. J Neurophysiol 63:82–104
Jian-bo L, Cheng-ya W, Jia-wei C, Ziao-lu L, Zhen-qing F, Hong-tai M (2010) The preventive efficacy of methylcobalamin on rat peripheral neuropathy influenced by diabetes via neural IGF-1 levels. Nutr Neurosci 13:79–86
Jones TA, Hawrylak N, Klintsova AY, Greenough WT (1998) Brain damage, behavior, rehabilitation, recovery, and brain plasticity. Ment Retard Dev Disabil Res Rev 4:231–237
Jones TA, Ghu CJ, Grande LA, Gregory AD (1999) Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats. J Neurosci 19(22):10153–10163
Kaas JH, Collins CE (2003) Anatomic and functional reorganization of somatosensory cortex in mature primates after peripheral nerve and spinal cord injury. Adv Neurol 93:87–95
Kaji R, Kodama M, Imamura A, Hashida T, Kohara N, Ishizu M, Inui K, Kimura J (1998) Effect of ultrahigh-dose methylcobalamin on compound muscle action potentials in amyotrophic lateral sclerosis: a double-blind controlled study. Muscle Nerve 21:1775–1778
Karas ND, Boyd SB, Sinn DP (1990) Recovery of neurosensory function following orthognathic surgery. J Oral Maxillofac Surg 48:124–134
Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T (1999) Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med 38:472–475
Lundborg G (2003) Nerve injury and repair-A challenge to the plastic brain. J Peripher Nerv Syst 8:209–226
Lundborg G, Rosen B (2001) Sensory relearning after nerve repair. Lancet 358:809–810
Mandolesi G, Madeddu F, Bozzi Y, Maffei L, Ratto GM (2004) Acute physiological response of mammalian central neurons to axotomy: ionic regulation and electrical activity. FASEB J 18:1934–1936
Marchettini P (2005) The burning case of neuropathic pain wording. Pain 114(3):313–314
Merzenich MM, Recanzone G, Jenkins WM, Allard TT, Nudo RJ (1988) Cortical representational plasticity. In: Rakic P, Singer W (eds) Neurobiology of neocortex. John Wiley & Sons, New York
Meyer RA, Rath EM (2001) Sensory rehabilitation after trigeminal nerve injury or nerve repair. Atlas Oral Maxillofac Surg Clin North Am 13:365–376
Morani AS, Bodhankar SL (2010) Early co-administration of vitamin E acetate and methylcobalamin improves thermal hyperalgesia and motor nerve conduction velocity following sciatic nerve crush injury in rats. Pharmacol Rep 62:405–409
Nakagawa K, Ueki K, Takatsuka S, Yamamoto E (2003) Trigeminal nerve hypesthesia after sagittal split osteotomy in setback cases: correlation of postoperative computed tomography and long-term trigeminal somatosensory evoked potentials. J Oral Maxillofac Surg 61:898–903
Navarro X, Vivó M, Valero-Cabré A (2007) Neural plasticity after peripheral nerve injury and regeneration. Prog Neurobiol 82(4):163–201
Panula K, Finne K, Oikarinen K (2004) Neurosensory deficits after bilateral sagittal split ramus osteotomy of the mandible – influence of soft tissue handling medial to the ascending ramus. Int J Oral Maxillofac Surg 33:543–548
Phillips C, Essick G, Zuniga J, Tucker M, Blakey GH III (2006) Qualitative descriptors used by patients following orthognathic surgery to portray altered sensation. J Oral Maxillofac Surg 64:1751–1760
Phillips C, Essick G, Preisser JS, Turvey TA, Tucker M, Lin D (2007) Sensory retraining following orthognathic surgery: effect on patient perception of altered sensation. J Oral Maxillofac Surg 65(6):1162–1173
Phillips C, Kim S, Essick G, Tucker M, Turvey TA (2009) Sensory retraining following orthognathic surgery: effect on patient report of the presence of altered sensation. Am J Orthod Dentofacial Orthop 136(6):788–794
Phillips C, Kim S, Tucker M, Turvey TA (2010) Sensory retraining: burden in daily life related to altered sensation after orthognathic surgery, a randomized clinical trial. Orthod Craniofac Res 13(3):169–178
Phillips C, Blakey G III, Essick GK (2011) Sensory retraining: a cognitive behavioral therapy for altered sensation. Atlas Oral Maxillofac Surg Clin North Am 19:109–118
Phillips C, Blakey G III, Essick GK (2012) A tolerability study in orthognathic surgery patients of intranasal cyanocobalamin spray: a potential treatment for acute peripheral nerve injury. J Maxillofac Trauma 1:13–19
Phillips C, Essick GK, Chung Y, Blakey G III (2012) Non-invasive therapy for altered facial sensation following orthognathic surgery: an exploratory randomized clinical trial of intranasal vitamin B12 spray. J Maxillofac Trauma 1:20–29
Puri V, Chaudhry N, Goel S, Gulati P, Nehru R, Chowdhury D (2005) Vitamin B12 deficiency: a clinical and electrophysiological profile. Electromyogr Clin Neurophysiol 45(5):273–284
Recanzone GH, Jenkins WM, Hradek GT, Merzenich MM (1992) Progressive improvement in discriminative abilities in adult owl monkeys performing a tactile frequency discrimination task. J Neurophysiol 67:1015–1030
Recanzone GH, Merzenich MM, Jenkins WM, Grajski KA, Dinse HR (1992) Topographic reorganization of the hand representation in cortical area 3b of owl monkeys trained in a frequency-discrimination task. J Neurophysiol 67:1031–1056
Recanzone GH, Merzenich MM, Schreiner CE (1992) Changes in the distributed temporal response properties of SI cortical neurons reflect improvements in performance on a temporally based tactile discrimination task. J Neurophysiol 67:1071–1091
Ro T, Wallace R, Hagedorn J, Farne A, Pienkos E (2004) Visual enhancing of tactile perception in the posterior parietal cortex. J Cogn Neurosci 16:24–30
Rosen B, Lundborg G (2004) Sensory re-education after nerve repair: aspects of timing. Handchir Mikrochir Plast Chir 36:8–12
Rostand SG (1976) Vitamin B12 levels and nerve conduction velocities in patients undergoing maintenance hemodialysis. Am J Clin Nutr 29:691–697
Sathian K, Greenspan AI, Wolf SL (2000) Doing it with mirrors: a case study of a novel approach to neurorehabilitation. Neurorehabil Neural Repair 14:73–76
Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K (2005) Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients. J Neurol Sci 231:13–18
Scalabrino G, Buccellato FR, Veber D, Mutti E (2003) New basis of the neurotrophic action of vitamin B12. Clin Chem Lab Med 41:1435–1437
Shieh S-J, Chiu HOY, Lee J-W, Hsu H-Y (1995) Evaluation of the effectiveness of sensory reeducation following digital replantation and revascularization. Microsurgery 16:578–582
Sun Y, Lai M-S, Lu C-J (2005) Effectiveness of vitamin B12 on diabetic neuropathy: systematic review of clinical controlled trials. Acta Neurol Taiwan 14:48–54
Taylor-Clarke M, Kennett S, Haggard P (2002) Vision modulates somatosensory cortical processing. Curr Biol 12:233–236
Teerijoki-Oksa T, Jääskeläinen SK, Forssell K, Forssell H, Vahatalo K, Tammisalo T et al (2002) Risk factors of nerve injury during mandibular sagittal split osteotomy. Int J Oral Maxillofac Surg 31:33–39
Teerijoki-Oksa T, Jääskelainen S, Forssell K, Virtanen A, Forssell H (2003) An evaluation of clinical and electrophysiologic tests in nerve injury diagnosis after mandibular sagittal split osteotomy. Int J Oral Maxillofac Surg 32(1):15–23
Teerijoki-Oksa T, Jääskelainen SK, Forssell K, Forssell H (2004) Recovery of nerve injury after mandibular sagittal split osteotomy. Diagnostic value of clinical and electrophysiologic tests in the follow-up. Int J Oral Maxillofac Surg 33(2):134–140
Teerijoki-Oksa T, Jääskelainen SK, Soukka T, Virtanen A, Forssell H (2011) Subjective sensory symptoms associated with axonal and demyelinating nerve injuries after mandibular sagittal split osteotomy. J Oral Maxillofac Surg 69:e208–e213
Trulsson M, Essick GK (1997) Low-threshold mechanoreceptive afferents in the human lingual nerve. J Neurophysiol 77:737–748
Van Boven R, Johnson K (1994) A psychophysical study of the mechanisms of sensory recovery following nerve injury in humans. Brain 117(Pt 1):149–167
Van Boven R, Johnson K (1994) The limits of tactile spatial resolution in humans: grating orientation discrimination at the lip, tongue, and finger. J Neurol 44:2361–2366
Wall JT, Kaas JH, Sur M, Nelson RJ, Felleman DF, Merzenich MM (1986) Functional reorganization in somatosensory cortical areas 3b and 1 of adult monkeys after median nerve repair: possible relationships to sensory recovery in humans. J Neurosci 6:218–223
Wall JT, Xu J, Wang X (2002) Human brain plasticity: an emerging view of the multiple substrates and mechanisms that cause cortical changes and related sensory dysfunctions after injuries of sensory inputs from the body. Brain Res Rev 39(2–3):181–215
Wang Z, Gan Q, Rupert RL, Zeng Y, Song X (2005) Thiamine, pyridoxine, cyanocobalamin and their combination inhibit thermal, but not mechanical hyperalgesia in rats with primary sensory neuron injury. Pain 114:266–277
Watanabe T, Kaji R, Oka N, Bara W, Kimura J (1994) Ultra-high dose methylcobalamin promotes nerve regeneration in experimental acrylamide neuropathy. J Neurol Sci 122:140–143
Waylett-Rendall J (1988) Sensibility evaluation and rehabilitation. Orthop Clin North Am 19:43–56
Wei F-C, Ma H-S (1995) Delayed sensory reeducation after toe-to-hand transfer. Microsurgery 16:583–585
Woolf CJ, Walters ET (1991) Common patterns of plasticity contributing to nociceptive sensitization in mammals and Aplysia. Trends Neurosci 14(2):74–78
Wynn Parry CB, Slater M (1976) Sensory re-education after median nerve lesions. Hand 8:250–257
Yaqub BA, Siddique A, Sulimani R (1992) Effects of methylcobalamin on diabetic neuropathy. Clin Neurol Neurosurg 94:105–111
Yoshida T, Nagamine T, Kobayashi T, Michimi N, Nakajima T, Sasakura H, Hanada K (1989) Impairment of the inferior alveolar nerve after sagittal split osteotomy. J Craniomaxillofac Surg 17:271–277
Acknowledgements
The authors wish to thank Debora Price for her participation in the data collection and analysis for all the research projects and Andrew Blank for technical assistance in manuscript preparation.
Conflict of InterestThe authors have no conflict of interest to report.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Essick, G.K., Blakey, G., Phillips, C. (2013). Neurosensory Rehabilitation. In: Miloro, M. (eds) Trigeminal Nerve Injuries. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-35539-4_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-35539-4_18
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-35538-7
Online ISBN: 978-3-642-35539-4
eBook Packages: MedicineMedicine (R0)