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Garcinol and Its Role in Chronic Diseases

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Anti-inflammatory Nutraceuticals and Chronic Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 928))

Abstract

The various bioactive compounds isolated from leaves and fruits of Garcinia sps plants, have been characterized and experimentally demonstrated to be anti-oxidant, anti-inflammatory and anti-cancer in nature. Garcinol, a polyisoprenylated benzophenone, obtained from plant Garcinia indica has been found to be an effective inhibitor of several key regulatory pathways (e.g., NF-kB, STAT3 etc.) in cancer cells, thereby being able to control malignant growth of solid tumours in vivo. Despite its high potential as an anti-neoplastic modulator of several cancer types such as head and neck cancer, breast cancer, hepatocellular carcinoma, prostate cancer, colon cancer etc., it is still in preclinical stage due to lack of systematic and conclusive evaluation of pharmacological parameters. While it is promising anti-cancer effects are being positively ascertained for therapeutic development, studies on its effectiveness in ameliorating other chronic diseases such as cardiovascular diseases, diabetes, allergy, neurodegenerative diseases etc., though seem favourable, are very recent and require in depth scientific investigation.

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Acknowledgments

TKK was supported by grants from Department of Biotechnology, Govt. of India (Chromatin and Disease: Programme support (grant number: Grant BT/01/CEIB/10/III/01). TKK is a recipient of the Sir J.C. Bose National Fellowship, Department of Science and Technology, Government of India. AKB is a Senior Research Fellow of the Council of Scientific and Industrial Research, Government of India. We acknowledge contribution of Prof. Gautam Sethi, from NUS, Singapore for in vivo experiments on hepatocellular carcinoma with garcinol as part of collaborative research with us. GS was supported by grants from National Medical Research Council of Singapore [Grant R-184-000-211-213].

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Authors and Affiliations

  1. Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur P.O., Bangalore, 560064, India

    Amit K. Behera, Mahadeva M. Swamy & Tapas K. Kundu

  2. Central Government Health Scheme Dispensary, No. 3, Basavanagudi, Bangalore, India

    Nagashayana Natesh

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  1. Amit K. Behera
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  2. Mahadeva M. Swamy
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  3. Nagashayana Natesh
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  4. Tapas K. Kundu
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Correspondence to Tapas K. Kundu .

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Editors and Affiliations

  1. Banaras Hindu University , Varanasi, Uttar Pradesh, India

    Subash Chandra Gupta

  2. MD Anderson Cancer Center, University of Texas, Houston, Texas, USA

    Sahdeo Prasad

  3. Anti-Inflammation Research Institute, San Diego, California, USA

    Bharat B. Aggarwal

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Behera, A.K., Swamy, M.M., Natesh, N., Kundu, T.K. (2016). Garcinol and Its Role in Chronic Diseases. In: Gupta, S., Prasad, S., Aggarwal, B. (eds) Anti-inflammatory Nutraceuticals and Chronic Diseases. Advances in Experimental Medicine and Biology, vol 928. Springer, Cham. https://doi.org/10.1007/978-3-319-41334-1_18

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