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Takayasu Arteritis and Ulcerative Colitis: A Frequent Association?

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Systemic Vasculitides: Current Status and Perspectives

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Abstract

Previous studies have revealed that Takayasu arteritis (TAK) and ulcerative colitis (UC) sometimes develop in the same patients. However, the low prevalence of TAK has made it difficult to accumulate the number of cases to establish the ratio of co-occurrence. Recently, our Japanese group analyzed the data of 470 consecutive patients with TAK and revealed that 6.4 % of patients with TAK suffered from UC. This ratio is much higher than the prevalence of UC in Japan. HLA-B*52:01, the strongest susceptibility allele to both disease, showed strong enrichment in patients with these two diseases. IL12B, a common non-HLA susceptibility locus to both diseases, also showed a trend of enrichment. We also showed that other genetic determinants were shared between the two diseases. The high ratio of co-occurrence and genetic overlap suggest common molecular pathways centering on HLA-B*52:01 and IL12p40 underlying the two diseases.

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Acknowledgement

I’d like to thank to Dr. Yohei Kirino at the Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama for his kind provision of table of previous case series or reports of co-occurrence.

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Authors and Affiliations

  1. Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Chikashi Terao

  2. Center for the Promotion of Interdisciplinary Education and Research, Kyoto, Japan

    Chikashi Terao

  3. Division of Rheumatology, Immunology, and Allergy, Harvard Medical School, Boston, MA, USA

    Chikashi Terao

  4. Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Chikashi Terao

  5. Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA

    Chikashi Terao

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  1. Chikashi Terao
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Correspondence to Chikashi Terao .

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Editors and Affiliations

  1. University of Bari Medical School, Bari, Italy

    Franco Dammacco

  2. University of Bari Medical School, Bari, Italy

    Domenico Ribatti

  3. University of Bari Medical School, Bari, Italy

    Angelo Vacca

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Terao, C. (2016). Takayasu Arteritis and Ulcerative Colitis: A Frequent Association?. In: Dammacco, F., Ribatti, D., Vacca, A. (eds) Systemic Vasculitides: Current Status and Perspectives. Springer, Cham. https://doi.org/10.1007/978-3-319-40136-2_7

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