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Anabolic Resistance

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The Stress Response of Critical Illness: Metabolic and Hormonal Aspects

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Abstract

Muscle atrophy is the hallmark of several catabolic conditions. Whatever the cause, the skeletal muscle loss is associated with comorbidities and poor survival. The mass of the skeletal muscle is maintained normally by equilibrium between protein synthesis and breakdown. Rate of synthesis in particular is positively regulated by nutrition and exercise. Anabolic resistance can be defined as a situation where the skeletal muscle is unable to respond appropriately to these anabolic stimuli by stimulating protein synthesis. Anabolic resistance contributes to muscle mass loss in elderly, during immobilization as well as in response to inflammation and cancer. The mechanisms responsible for this blunted response to anabolic stimuli are still under investigation. Several strategies may serve to compensate for anabolic resistance. Optimization of protein intake, resistance exercise, and anti-inflammatory agents appear promising to override this anabolic resistance and mitigate its consequence, the skeletal muscle mass loss.

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  1. Pôle Endocrinologie, Diabétologie et Nutrition, Institut de Recherches Expérimentales et Cliniques, Université Catholique de Louvain, Avenue Hippocrate 55 bte B1.55.06, Bruxelles, B-1200, Belgium

    Jean-Paul Thissen MD, PhD

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  1. Jean-Paul Thissen MD, PhD
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Correspondence to Jean-Paul Thissen MD, PhD .

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  1. Brussels, Belgium

    Jean-Charles Preiser

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Thissen, JP. (2016). Anabolic Resistance. In: Preiser, JC. (eds) The Stress Response of Critical Illness: Metabolic and Hormonal Aspects. Springer, Cham. https://doi.org/10.1007/978-3-319-27687-8_5

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  • DOI: https://doi.org/10.1007/978-3-319-27687-8_5

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