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Enterohormones and the Response to Critical Illness

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The Stress Response of Critical Illness: Metabolic and Hormonal Aspects

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Abstract

The secretion of a number of enterohormones is disordered in the critically ill which may mediate abnormalities in motility and glycaemia. However, these mediators can also potentially serve a protective role, dampening inflammation and modulating the enteral immune response. There are over 30 recognised enterohormones, and therapeutic manipulation of specific enterohormones or their receptors is a burgeoning area of critical care research with promising preclinical data and an increasing number of small clinical trials. Further characterisation of the effect of critical illness on the endocrine gut and how it can be manipulated to improve outcomes in critical illness warrants evaluation.

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Authors and Affiliations

  1. Discipline of Acute Care Medicine, University of Adelaide, Adelaide, Australia

    Mark P. Plummer MMBS & Adam M. Deane PhD

  2. Department of Anaesthesiology and Intensive Care, University of Tartu, Tartu, Estonia

    Annika Reintam Blaser PhD

  3. Department of Critical Care Services, Royal Adelaide Hospital, Adelaide, Australia

    Adam M. Deane PhD

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  1. Mark P. Plummer MMBS
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  3. Adam M. Deane PhD
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Correspondence to Mark P. Plummer MMBS .

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    Jean-Charles Preiser

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Plummer, M.P., Blaser, A.R., Deane, A.M. (2016). Enterohormones and the Response to Critical Illness. In: Preiser, JC. (eds) The Stress Response of Critical Illness: Metabolic and Hormonal Aspects. Springer, Cham. https://doi.org/10.1007/978-3-319-27687-8_13

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  • DOI: https://doi.org/10.1007/978-3-319-27687-8_13

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