Abstract
Peyronie’s disease (PD) is a psychologically and physically devastating disorder that is manifest by a fibrous inelastic scar of the tunica albuginea, resulting in palpable penile lesion in the flaccid condition and causing penile deformity including penile curvature, hinging, narrowing, shortening, and painful erections. In spite of multiple treatment options offered since Francois de la Peyronie described PD in 1743 [1]. PD remains a considerable therapeutic dilemma even to today’s practicing physicians.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
La Peyronie F. Sur quelques obstaclesqui sópposent à l’éjaculation nautrelle de la semence. Mem Acad Royale Chir. 1743;1:337–42.
Akkus E. Historical review of Peyronie’s disease. In: Levine LA, Levine LA, editors. Peyronie’s disease a guide to clinical management. Totowa, NJ: Humana; 2007.
Borgogni T. Cyrurgia Edita et Compilata. Venice, 1498 (written 1265–1275).
Murphy LJT. Miscellanea: Peyronie’s disease (fibrous cavernositis). In: The history of urology. 1st ed. Springfield, IL: Charles C. Thomas, 1972. p. 485–6.
Wesson MD. Peyronie’s disease (plastic induration) cause and treatment. J Urol. 1943;49:350–6.
Devine Jr CJ, Somers KD, Jordan SG, Schlossberg SM. Proposal: trauma as the cause of the Peyronie’s lesion. J Urol. 1997;157(1):285–90.
Zargooshi J. Trauma as the cause of Peyronie’s disease: penile fracture as a model of trauma. J Urol. 2004;172(1):186–8.
DiPietro LA. Wound healing: the role of the macrophage and other immune cells. Shock. 1995;4:233.
Ravanti L, Kahari VM. Matrix metalloproteinases in wound repair. Int J Mol Med. 2000;6:391–407.
El Sakka AI, Hassoba HM, Chui RM. An animal model of Peyronie’s like condition associated with an increase of transforming growth factor b mRNA and protein expression. J Urol. 1997;158:2284–90.
Kucharewicz I, Kowal K, Buczko W, et al. The plasmin system in airway remodeling. Thromb Res. 2003;112:1–7.
Van de Water L. Mechanisms by which fibrin and fibronectin appear in healing wounds: implications for Peyronie’s disease. J Urol. 1997;157:306–10.
Davila H, Magee TR, Rajfer J, et al. Peyronie’s disease is associated with an increase of plasminogen activator inhibitor-1 in fibrotic plaque. Urology. 2005;65:645–8.
Davila H, Ferrini M, Rajfer J, et al. Fibrin induction of a Peyronie’s-like plaque in the rat penile tunica albuginea. BJU Int. 2003;91:830–8.
Qian A, Meals RA, Rajfer J, et al. Comparison of gene expression profiles between Peyronie’s disease and Dupuytren’s contracture. Urology. 2004;64(2):399–404.
Levine LA, Greenfield JM. Establishing a standardized evaluation of the man with Peyronie’s disease. Int J Impot Res. 2003;15(5):103–12.
Savoie M, Kim SS, Soloway MS. A prospective study measuring penile length in men treated with radical prostatectomy for prostate cancer. J Urol. 2003;169(4):1462–4.
Moreland RB. Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res. 1998;10(2):113–20.
Moreland RB, Traish A, McMillin MA. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol. 1995;153(3 Pt 1):826–34.
Leungwattanakij S, Bivalacqua TJ, Usta MF, et al. Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum. J Androl. 2003;24(2):239–45.
Ciancio SJ, Kim ED. Penile fibrotic changes after radical retropubic prostatectomy. BJU Int. 2000;85:101.
Tal R, Heck M, Teloken P, et al. Peyronie’s disease following radical prostatectomy: incidence and predictors. J. Anrol. 2010;7(3):1254–61
Valente EG, Vernet D, Ferrini M, et al. L-Arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie’s fibrotic plaque and related fibroblast cultures. Nitric Oxide. 2003;9:229–44.
Dean BWO, Lue TF RC. Treatment of Peyronie’s disease with oral pentoxifylline. Nat Clin Pract Urol. 2006;3:111–5.
Akkus E, Carrier S, Rehman J, et al. Is colchicine effective in Peyronie’s disease? A pilot study. Urology. 1994;44:291–5.
Kadioglu A, Tefekli A, Koksal T, et al. Treatment of Peyronie’s disease with oral colchicine: long term results and predictive parameters of successful outcome. Int J Impot Res. 2000;12:169–75.
Safarinejad MR. Therapeutic effects of colchicine in the management of Peyronie’s disease: a randomized double-blind, placebo-controlled study. Int J Impot Res. 2004;16:238–43.
Zarafonetis CJ, Horrax TM. Treatment of Peyronie’s disease with potassium para-aminobenzoate (potaba). J Urol. 1959;81:770–2.
Hasche-Klunder R. Treatment of peyronie’s disease with para-aminobenzoacidic potassium (POTOBA) [author’s transl]. Urologe A. 1978;17:224–7.
Weidner W, Schroeder-Printzen I, Rudnick J. Randomized prospective placebo-controlled therapy of Peyronie’s disease (IPP) with Potaba (aminobenzoate potassium). J Urol. 1999;6:205.
Weidner W, Hauck EW, Schnitker J. Potassium paraaminobenzoate (Potaba) in the treatment of Peyronie’s disease: a prospective, placebo-controlled, randomized study. Eur Urol. 2005;47:530–5.
Martin DJ, Badwan K, Parker M, et al. Transdermal application of verapamil gel to the penile shaft fails to infiltrate the tunica albuginea. J Urol. 2002;168:2483–5.
Fitch WP, Easterling J, Talbert RL, et al. Topical Verapamil HCl, topical Trifluoperazine, and topical magnesium sulfate for the treatment of Peyronie’s disease – A Placebo-Controlled Pilot Study. J Sex Med. 2007;4:477–84.
Levine LA. Comment on Topical Verpamil HCl, topical Trfluoperazine, and topical magnesium sulfate for the treatment of Peyronie’s disease – A Placebo-Controlled Pilot Study. J Sex Med. 2007;4:1081–2.
Riedl CR, Plas E, Engelhard P, et al. Iontophoresis for treatment of Peyronie’s disease. J Urol. 2000;163:95–9.
Montorsi F, Salonia A, Guazzoni G, et al. Transdermal electromotive multi-drug administration for Peyronie’s disease: preliminary results. J Androl. 2000;21:85–90.
Di Stasi SM, Giannantoni A, Capelli G, et al. Transdermal electromotive administration of verapamil and dexamethasone for Peyronie’s disease. BJU Int. 2003;91:825–9.
Di Stasi SM, Giannantoni A, Stephen RL, et al. A prospective, randomized study using transdermal electromotive administration of verapamil and dexamethasone for Peyronie’s disease. J Urol. 2004;171:1605–8.
Levine LA, Estrada CR, Show W, et al. Tunica albuginea tissue analysis after electromotive drug administration. J Urol. 2003;169:1775–8.
Greenfield JM, Shah SJ, Levine LA. Verapamil vs. saline in electromotive drug administration (EDMA) for Peyronie’s disease: a double blind, placebo controlled trial. J Urol. 2007;177:972–5.
Ojingwa JC, Isseroff RR. Electrical stimulation of wound healing. J Invest Dermatol. 2003;121:1–12.
Bodner H, Howard AH, Kaplan JH. Peyronie’s disease: cortisone-hyaluronidase-hydrocortisone therapy. J Urol. 1954;72:400–3.
Winter CC, Khanna R. Peyronie’s disease: results with dermo-jet injection of dexamethasone. J Urol. 1975;114:898–900.
Williams G, Green NA. The non-surgical treatment of Peyronie’s disease. Br J Urol. 1980;52:392–5.
Gelbard MK, Walsh R, Kaufman JJ. Collagenase for Peyronie’s disease experimental studies. Urol Res. 1982;10:135–40.
Gelbard MK, Linkner A, Kaufman JJ. The use of collagenase in the treatment of Peyronie’s disease. J Urol. 1985;134:280–3.
Gelbard MK, James K, Riach P, Dorey F. Collagenase vs. placebo in the treatment of Peyronie’s disease: a double blind study. J Urol. 1993;149:56–8.
Roth M, Eickelberg O, Kohler E, et al. Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix. Proc Natl Acad Sci USA. 1996;93:5478–82.
Mulhall JP, Anderson MS, Lubrano T, et al. Peyronie’s disease cell culture models: phenotypic, genotypic and functional analyses. Int J Impot Res. 2002;14:397–405.
Levine LA, Merrick PF, Lee RC. Intralesional verapamil injection for the treatment of Peyronie’s disease. J Urol. 1994;151:1522–4.
Rehman J, Benet A, Melman A. Use of intralesional verapamil to dissolve Peyronie’s disease plaque: a long term single-blind study. Urology. 1998;51:620–6.
Levine LA, Estrada CR. Intralesional verapamil for the treatment of Peyronie’s disease: a review. Int J Impot Res. 2002;14:324–8.
Bennett NE, Guhring P, Mulhall JP. Intralesional verapamil prevents the progression of Peyronie’s disease. Urology. 2007;69:1181–4.
Duncan MR, Berman B, Nseyo UO. Regulation of the proliferation and biosynthetic activities of cultured human Peyronie’s disease fibroblasts by interferons-αβ and γ. Scand J Urol Nephrol. 1991;25:89–94.
Wegner HE, Andreson R, Knipsel HH, et al. Treatment of Peyronie’s disease with local interferon-α-2b. Eur Urol. 1995;28:236–40.
Wegner HE, Andresen R, Knipsel HH, et al. Local interferon-α-2b is not an effective treatment in early-stage Peyronie’s disease. Eur Urol. 1997;32:190–3.
Ahuja S, Bivalacqua TJ, Case J, Vincent M, Sikka SC, Hellstrom WJ. A pilot study demonstrating clinical benefit from intralesional interferon alpha 2B in the treatment of Peyronie’s disease. J Androl. 1999;20:444–8.
Dang G, Matern R, Bivalacqua TJ, et al. Intralesional interferon-α-2b injections for the treatment of Peyronie’s disease. South Med J. 2004;97:42–6.
Hellstrom WJ, Kendirici M, Matern R, et al. Single-blind, multicenter placebo-controlled parallel study to assess the safety and efficacy of intralesional interferon-α-2b for minimally invasive treatment for Peyronie’s disease. J Urol. 2006;176:394–8.
Levine LA, Lenting EL. Experience with a surgical algorithm for Peyronie’s disease. J Urol. 1997;158:2149–52.
Moncada I, Jara J, Marinez J. et al. Managing penile shortening after peyronie’s disease surgery [Abst 750]. Annual Meeting of the American Urological Association. Anaheim, CA; 2007.
Taylor FL, Levine LA. Surgical correction of Peyronie’s disease via tunica albuginea plication or plaque partial excision with pericardial graft: long term follow-up [Abst 748]. Annual Meeting of the American Urological Association. Anaheim, CA; 2007.
Kadioglu A, Sanli O, Akman T, et al. Graft materials in Peyronie’s disease surgery: a comprehensive review. J Sex Med. 2007;4:581–95.
Greenfield JM, Estrada CR, Levine LA. Erectile dysfunction following surgical correction of Peyronie’s disease and a pilot study of the use of sildenafil citrate rehabilitation for postoperative erectile dysfunction. J Sex Med. 2005;2:241–7.
Carson CC, Hodge GB, Anderson EE. Penile prosthesis in Peyronie’s disease. Br J Urol. 1983;55:417–21.
Ghanem HM, Fahmy I, El Meliegy A. Malleable penile implants without plaque surgery in the treatment of Peyronie’s disease. Int J Impot Res. 1998;10:171–3.
Levine LA, Dimitriou RJ. A surgical algorithm for penile prosthesis placement in men with erectile failure and Peyronie’s disease. Int J Impot Res. 2000;12:147–51.
Levine LA, Estrada CR, Morgentaler A. Mechanical reliability and safety of and patient satisfaction with the Ambicor inflatable penile prosthesis: results of a two center study. J Urol. 2001;166:932–7.
Montague DK, Angermeier KW, Lakin MM, Ingleright BJ. AMS 3-piece inflatable penile prosthesis implantation in men with Peyronie’s disease: comparison of CX and Ultrex cylinders. J Urol. 1996;156:1633–35.
Dowalczyk JJ, Mulcahy JJ. Penile curvatures and aneurismal defects with the Ultrex penile prosthesis corrected with insertion of the AMS 700CX. J Urol. 1996;156:398–401.
Montorsi F, Rigatti P, Carmignani G, et al. AMS three-piece inflatable implants for erectile dysfunction: a long-term multi-institutional study in 200 consecutive patients. Eur Urol. 2000;37:50–5.
Daitch JA, Angermeier KW, Montague DK. Modified corporoplasty for penile curvature: long-term results and patient satisfaction. J Urol. 1999;162:2006–9.
Gholami SS, Lue TF. Correction of penile curvature using the 16-dot plication technique: a review of 132 patients. J Urol. 2002;167:2066–9.
Syed AH, Abbasi Z, Hargreave TB. Nesbit procedure for disabling Peyronie’s curvature: a median follow-up of 84 months. Urology. 2003;61:999–1003.
Savoca G, Scieri F, Pietropaolo F, et al. Straightening corporoplasty for Peyronie’s disease: a review of 218 patients with median follow-up of 89 months. Eur Urol. 2004;6:610–4.
Rolle L, Tamagnone A, Timpano M, et al. The Nesbit operation for penile curvature: an easy and effective technical modification. J Urol. 2005;173:171–3.
Bella AJ, Beasley KA, Obied A, Brock GB. Minimally invasive intracorporeal incision of Peyronie’s plaque: initial experiences with a new technique. Urology. 2006;68:852–7.
Greenfield JM, Lucas S, Levine LA. Factors affecting the loss of length associated with tunica albuginea plication for correction of penile curvature. J Urol. 2006;175:238–41.
Taylor FL, Levine LA. Surgical correction of Peyronie’s disease via tunica albuginea plication or partial plaque excision with pericardial graft: long-term follow up. J Sex Med. 2008;5:2221–8.
Gelbard MK. Relaxing incisions in the correction of penile deformity due to Peyronie’s disease. J Urol. 1995;154:1457–60.
El-Sakka AI, Rashwan HM, Lue TF. Venous patch graft for Peyronie’s disease. Part II: outcome analysis. J Urol. 1998;160:2050–3.
Hatzichristou DG, Hatzimouratidis K, Apostolidis A, et al. Corporoplasty using tunica albuginea free grafts for penile curvature: surgical technique and long-term results. J Urol. 2002;167:1367–70.
Egydio PH, Lucon AM, Arap S. Treatment of Peyronie’s disease by incomplete circumferential incision of the tunica albuginea and plaque with bovine pericardium graft. Urology. 2002;59:570–4.
Levine LA, Estrada CR. Human cadaveric pericardial graft for the surgical correction of Peyronie’s disease. J Urol. 2003;170:2359–62.
Kalsi J, Minhas S, Christopher N, Ralph D. The results of plaque incision and venous grafting (Lue procedure) to correct the penile deformity of Peyronie’s disease. BJU Int. 2005;95:1029–33.
Breyer BN, Brant WO, Garcia MM, et al. Complications of porcine small intestine submucosa graft for Peyronie’s disease. J Urol. 2007;177:589–91.
Hsu GL, Chen HS, Hsieh CH, et al. Long-term results of autologous venous grafts for penile morphological reconstruction. J Androl. 2007;28:186–93.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Taylor, F.L., Levine, L.A. (2011). Peyronie’s Disease. In: Mulhall, J., Incrocci, L., Goldstein, I., Rosen, R. (eds) Cancer and Sexual Health. Current Clinical Urology. Humana Press. https://doi.org/10.1007/978-1-60761-916-1_15
Download citation
DOI: https://doi.org/10.1007/978-1-60761-916-1_15
Published:
Publisher Name: Humana Press
Print ISBN: 978-1-60761-915-4
Online ISBN: 978-1-60761-916-1
eBook Packages: MedicineMedicine (R0)