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Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems

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CNS Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Naturally occurring neoplasia of the nervous system has been documented in many species in addition to humans, which include dogs, cats, mice, and even zebrafish. Some of the tumors in these species share many features including histopathological appearance, neuroimaging characteristics, tumor genetics, molecular targets, and biological behavior. Based on such similarities, studying the CNS tumors of dogs and mice and the genetics of neuronal neoplasia in Drosophila and zebrafish has been suggested as a valuable pursuit in the field of cancer research which can aid in the following areas: identification of cancer-associated genes, environmental risk factors, tumor biology, and progression and the development of novel therapeutics. This chapter reviews the current knowledge on the types of neoplasia documented to spontaneously affect the nervous system in dogs, mice, Drosophila, and zebrafish and demonstrates the potential utility of these naturally occurring models in cancer research.

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Acknowledgments

The author would like to thank Dr. Erwin Van Meir and Dr. Gang Chen of Emory University School of Medicine, Atlanta for assistance in the preparation of this chapter.

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    Simon R. Platt

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    Erwin G. Meir

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Platt, S.R. (2009). Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems. In: Meir, E. (eds) CNS Cancer. Cancer Drug Discovery and Development. Humana Press. https://doi.org/10.1007/978-1-60327-553-8_13

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