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The Human Plasma and Serum Proteome

  • Chapter
Proteomics of Human Body Fluids

Abstract

Human plasma and serum are the preferred specimens for noninvasive studies of normal and disease-associated proteins in the circulation and arising from cells throughout the body. The attributes of extreme complexity, very wide dynamic range, genetic and physiological variation, endogenous and ex vivo modifications, and incompleteness of sampling by mass spectrometry all represent major challenges to reproducible, high-resolution, high-throughput analyses of the plasma proteome. This chapter summarizes the major reports to date identifying proteins in normal individuals and identifies paths to increased use of proteomics methods with human specimens for biomarker discovery and application in various diseases.

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Author information

Author notes

  1. Marcin Adamski

    Present address: Faculty of Biological and Chemical Sciences, Integrative Biology School, The University of Queensland, Brisbane, Australia

  2. Weimin Gao

    Present address: The Institute of Environmental and Human Health, Department of Environmental Toxicology, Texas Tech University, Lubbock, TX

Authors and Affiliations

  1. Michigan Proteomics Alliance for Cancer Research, Center for Computational Medicine and Biology, Departments of Internal Medicine and Human Genetics, University of Michigan Medical School, Ann Arbor, MI

    Gilbert S. Omenn

  2. Michigan Proteomics Alliance for Cancer Research, Center for Computational Medicine and Biology, University of Michigan Medical School, Ann Arbor, MI

    Rajasree Menon, Marcin Adamski & Thomas Blackwell

  3. Michigan Proteomics Alliance for Cancer Research, Van Andel Research Institute, Grand Rapids, MI

    Brian B. Haab

  4. Michigan Proteomics Alliance for Cancer Research, USA

    Weimin Gao

  5. Michigan Proteomics Alliance for Cancer Research, Center for Computational Medicine and Biology, Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI

    David J. States

Authors
  1. Gilbert S. Omenn
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  2. Rajasree Menon
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  3. Marcin Adamski
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  4. Thomas Blackwell
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Editor information

Editors and Affiliations

  1. Medical Molecular Biology Unit Office for Research and Development Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Visith Thongboonkerd MD, FRCPT

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© 2007 Humana Press Inc., Totowa, NJ

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Omenn, G.S. et al. (2007). The Human Plasma and Serum Proteome. In: Thongboonkerd, V. (eds) Proteomics of Human Body Fluids. Humana Press. https://doi.org/10.1007/978-1-59745-432-2_10

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