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Chlamydial Infections

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Sexually Transmitted Diseases

Part of the book series: Current Clinical Practice ((CCP))

Abstract

Chlamydia trachomatis is the most commonly reported infectious disease in the United States and is the most common sexually transmitted bacterial infection (1). The word chlamys is Greek for “cloaked” or “draped,” descriptive of the intracytoplasmic inclusion bodies that are “draped” around the host cell nucleus. A large reservoir of infection sustains the continued spread of C. trachomatis because chlamydial infections rarely cause symptoms in women, they have a long incubation period, and the infection persists for at least several months. The annual cost of shortand long-term impacts of chlamydial infections in the United States was estimated to be $2.4 billion in 1987 and has increased since that time (2).

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References

  1. Centers for Disease Control and Prevention. Trends in reportable sexually transmitted diseases in the United States, 2004: national surveillance data for chlamydia, gonorrhea and syphilis. Atlanta, GA: Centers for Disease Control and Prevention, 2005. Available from: http://www.cdc.gov/std/stats/. Accessed Nov. 24, 2006.

    Google Scholar 

  2. Washington AE, Johnson RE, Sanders LL Jr. Chlamydia trachomatis infections in the United States. What are they costing us? JAMA 1987; 257:2070–2072.

    Article  CAS  PubMed  Google Scholar 

  3. Turner CF, Rogers SM, Miller HG, et al. Untreated gonococcal and chlamydial infection in a probability sample of adults. JAMA 2002; 287:726–733.

    Article  PubMed  Google Scholar 

  4. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance, 2004. Atlanta, GA: US Department of Health and Human Services, 2005. Available from: http://www.cdc.gov/std/stats/. Accessed Nov. 24, 2006.

    Google Scholar 

  5. Groseclose SL, Zaidi AA, DeLisle SJ, Levine WC, St Louis ME. Estimated incidence and prevalence of genital Chlamydia trachomatis infections in the United States, 1996. Sex Transm Dis 1999; 26:339–344.

    Article  CAS  PubMed  Google Scholar 

  6. World Health Organization. Global prevalence and incidence of selected curable sexually transmitted infections: overview and estimates. Geneva: World Health Organization, 2001.

    Google Scholar 

  7. Stamm WE. Chlamydia trachomatis infections of the adult. In: Holmes KK, Mårdh PA, Sparlin PF, et al., eds., Sexually Transmitted Diseases, 3rd Ed. New York, NY: Mc-Graw Hill, 1999, pp. 407–422.

    Google Scholar 

  8. Sweet RL, Gibbs RS. Chlamydial infections. In: Sweet RL, Gibbs RS, eds., Infectious Diseases of the Female Genital Tract, 4th Ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2002, pp. 57–100.

    Google Scholar 

  9. Miller WC, Ford CA, Morris M, et al. Prevalence of chlamydial and gonococcal infections among young adults in the United States. JAMA 2004; 291:2229–2236.

    Article  CAS  PubMed  Google Scholar 

  10. Howell MR, Gaydos JC, McKee KT Jr, Quinn TC, Gaydos CA. Control of Chlamydia trachomatis infections in female army recruits: cost-effective screening and treatment in training cohorts to preventpelvic inflammatory disease. Sex Transm Dis 1999; 26:519–526.

    Article  CAS  PubMed  Google Scholar 

  11. Joesoef MR, Mosure DJ. Prevalence trends in chlamydial infections among young women entering the national job training program, 1998–2004. Sex Transm Dis 2006; 33:571–575.

    Article  PubMed  Google Scholar 

  12. Bernstein KT, Chow JM, Ruiz J, et al. Chlamydia trachomatis and Neisseria gonorrhea infections among men and women entering California prisons. Am J Public Health 2006; 96:1826–1866.

    Article  Google Scholar 

  13. Centers for Disease Control and Prevention. High prevalence of chlamydial and gonococcal infection in women entering jails and juvenile detention centers—Chicago, Birmingham, and San Francisco, 1998. MMWR Morb Mortal Wkly Rep 1999; 48:793–796.

    Google Scholar 

  14. Cameron ST, Stewart S, Sutherland S. Can a busy abortion service cope with a screen-and-treat policy for Chlamydia trachomatis infection? Int J STD AIDS 2003; 14:50–54.

    Article  CAS  PubMed  Google Scholar 

  15. Kent CK, Chaw JK, Wong W, et al. Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003. Clin Infect Dis 2005; 41:67–74.

    Article  PubMed  Google Scholar 

  16. Jacobson DL, Peralta L, Graham NM, Zenilman J. Histologic development of cervical ectopy: relationship to reproductive hormones. Sex Transm Dis 2000; 27:252–258.

    Article  CAS  PubMed  Google Scholar 

  17. Quinn TC, Gaydos C, Shepherd M, et al. Epidemiologic and microbiologic correlates of Chlamydia trachomatis infection in sexual partnerships. JAMA 1996; 276:1737–1742.

    Article  CAS  PubMed  Google Scholar 

  18. Morre SA, Rozendaal L, van Valkengoed IG, et al. Urogenital Chlamydia trachomatis serovars in men and women with a symptomatic or asymptomatic infection: an association with clinical manifestations? J Clin Microbiol 2000; 38:2292–2296.

    CAS  PubMed Central  PubMed  Google Scholar 

  19. Davies JA, Rees E, Hobson D, Karayiannis P. Isolation of Chlamydia trachomatis from Bartholin’s ducts. Br J Vener Dis 1978; 54:409–413.

    CAS  PubMed Central  PubMed  Google Scholar 

  20. Saul HM, Grossman MB. The role of Chlamydia trachomatis in Bartholin’s gland abscess. Am J Obstet Gynecol 1988; 158:76–77.

    Article  CAS  PubMed  Google Scholar 

  21. Batteiger BE, Jones RB. Chlamydial infections. Infect Dis Clin North Am 1987; 1:55–81.

    CAS  PubMed  Google Scholar 

  22. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep 2006; 55(RR-11):38–42. Available from: http://www.cdc.gov/std/treatment/. Accessed Nov. 24, 2006.

    Google Scholar 

  23. Mutlu N, Mutlu B, Culha M, Hamsioglu Z, Demirtas M, Gokalp A. The role of Chlamydia trachomatis in patients with non-bacterial prostatitis. Int J Clin Pract 1998; 52:540–541.

    CAS  PubMed  Google Scholar 

  24. Ostaszewska I, Zdrodowska-Stefanow B, Badyda J, Pucilo K, Trybula J, Bulhak V. Chlamydia trachomatis: probable cause of prostatitis. Int J STD AIDS 1998; 9:350–353.

    Article  CAS  PubMed  Google Scholar 

  25. Ness RB, Markovic N, Carlson CL, Coughlin MT. Do men become infertile after having sexually transmitted urethritis? An epidemiologic examination. Fertil Steril 1997; 68:205–213.

    Article  CAS  PubMed  Google Scholar 

  26. Thompson CI, MacAulay AJ, Smith IW. Chlamydia trachomatis infections in the female rectums. Genitourin Med 1989; 65:269–273.

    CAS  PubMed Central  PubMed  Google Scholar 

  27. Wexner SD. Sexually transmitted diseases of the colon, rectum, and anus. The challenge of the nineties. Dis Colon Rectum 1990; 33:1048–1062.

    Article  CAS  PubMed  Google Scholar 

  28. Silveira LH, Gutierrez F, Scopelitis E, Cuellar ML, Citera G, Espinoza LR. Chlamydiainduced reactive arthritis. Rheum Dis Clin North Am 1993; 19:351–362.

    CAS  PubMed  Google Scholar 

  29. Hanada H, Ikeda-Dantsuji Y, Naito M, Nagayama A. Infection of human fibroblast-like synovial cells with Chlamydia trachomatis results in persistent infection and interleukin-6 production. Microb Pathog 2003; 34:57–63.

    Article  CAS  PubMed  Google Scholar 

  30. Schachter J, Grossman M, Sweet RL, Holt J, Jordan C, Bishop E. Prospective study of perinatal transmission of Chlamydia trachomatis. JAMA 1986; 255:3374–3377.

    Article  CAS  PubMed  Google Scholar 

  31. Bell TA, Stamm WE, Kuo CC, Wang SP, Holmes KK, Grayston JT. Risk of perinatal transmission of Chlamydia trachomatis by mode of delivery. J Infect 1994; 29:165–169.

    Article  CAS  PubMed  Google Scholar 

  32. Jain S. Perinatally acquired Chlamydia trachomatis associated morbidity in young infants. J Matern Fetal Med 1999; 8:130–133.

    Article  CAS  PubMed  Google Scholar 

  33. Weiss SG, Newcomb RW, Beem MO. Pulmonary assessment of children after chlamydial pneumonia of infancy. J Pediatr 1986; 108:659–664.

    Article  CAS  PubMed  Google Scholar 

  34. Johnson RE, Newhall WJ, Papp JR, et al. Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections—2002. MMWR Recomm Rep 2002; 51:1–38.

    PubMed  Google Scholar 

  35. Rabenau HF, Kohler E, Peters M, Doerr HW, Weber B. Low correlation of serology with detection of Chlamydia trachomatis by ligase chain reaction and antigen EIA. Infection 2000; 28:97–102.

    Article  CAS  PubMed  Google Scholar 

  36. Akande VA, Hunt LP, Cahill DJ, Caul EO, Ford WC, Jenkins JM. Tubal damage in infertile women: prediction using chlamydia serology. Hum Reprod 2003; 18:1841–1847.

    Article  PubMed  Google Scholar 

  37. Martin DH, Mroczkowski TF, Dalu ZA, et al. A controlled trial of a single dose of azithromycin for the treatment of chlamydial urethritis and cervicitis. The Azithromycin for Chlamydial Infections Study Group. N Engl J Med 1992; 327:921–925.

    Article  CAS  PubMed  Google Scholar 

  38. Thorpe EM Jr, Stamm WE, Hook EW III, et al. Chlamydial cervicitis and urethritis: single dose treatment compared with doxycycline for seven days in community based practises. Genitourin Med 1996; 72:93–97.

    PubMed Central  PubMed  Google Scholar 

  39. Somani J, Bhullar VB, Workowski KA, Farshy CE, Black CM. Multiple drug-resistant Chlamydia trachomatis associated with clinical treatment failure. J Infect Dis 2000; 181: 1421–1427.

    Article  CAS  PubMed  Google Scholar 

  40. Augenbraun M, Bachmann L, Wallace T, Dubouchet L, McCormack W, Hook EW III. Compliance with doxycycline therapy in sexually transmitted diseases clinics. Sex Transm Dis 1998; 25:1–4.

    Article  CAS  PubMed  Google Scholar 

  41. Dessus-Babus S, Bebear CM, Charron A, Bebear C, de Barbeyrac B. Sequencing of gyrase and topoisomerase IV quinolone-resistance-determining regions of Chlamydia trachomatis and characterization of quinolone-resistant mutants obtained In vitro. Antimicrob Agents Chemother 1998; 42:2474–2481.

    CAS  PubMed Central  PubMed  Google Scholar 

  42. Ridgway GL. Treatment of chlamydial genital infection. J Antimicrob Chemother 1997; 40: 311–314.

    Article  CAS  PubMed  Google Scholar 

  43. Westrom L, Joesoef R, Reynolds G, Hagdu A, Thompson SE. Pelvic inflammatory disease and fertility. A cohort study of 1,844 women with laparoscopically verified disease and 657 control women with normal laparoscopic results. Sex Transm Dis 1992; 19:185–192.

    Article  CAS  PubMed  Google Scholar 

  44. Buchan H, Vessey M, Goldacre M, Fairweather J. Morbidity following pelvic inflammatory disease. Br J Obstet Gynaecol 1993; 100:558–562.

    Article  CAS  PubMed  Google Scholar 

  45. Haggerty CL, Schulz R, Ness RB; PID Evaluation and Clinical Health Study Investigators. Lower quality of life among women with chronic pelvic pain after pelvic inflammatory disease. Obstet Gynecol 2003; 102:934–939.

    Article  PubMed  Google Scholar 

  46. Golden MR, Whittington WL, Handsfield HH, et al. Effect of expedited treatment of sex partners on recurrent or persistent gonorrhea or chlamydial infection. N Engl J Med 2005; 352:676–685.

    Article  CAS  PubMed  Google Scholar 

  47. Ryan GM Jr, Abdella TN, McNeeley SG, Baselski VS, Drummond DE. Chlamydia trachomatis infection in pregnancy and effect of treatment on outcome. Am J Obstet Gynecol 1990; 162:34–39.

    Article  PubMed  Google Scholar 

  48. Cohen I, Veille JC, Calkins BM. Improved pregnancy outcome following successful treatment of chlamydial infection. JAMA 1990; 263:3160–3163.

    Article  CAS  PubMed  Google Scholar 

  49. Todd CS, Jones RB, Golichowski A, Arno JN. Chlamydia trachomatis and febrile complications of postpartum tubal ligation. Am J Obstet Gynecol 1997; 176:100–102.

    Article  CAS  PubMed  Google Scholar 

  50. National Institute of Allergy and Infectious Diseases. Workshop Summary. Scientific evidence on condom effectiveness for sexually transmitted disease (STD) prevention. National Institutes of Health, Department of Health and Human Services, 2001. Available from: http://www.niaid.nih.gov/dmid/stds/condomreport.pdf. Accessed Nov. 24, 2006.

  51. Centers for Disease Control and Prevention. Fact sheet for public health personnel: male latex condoms and sexually transmitted diseases. Centers for Disease Control and Prevention, National Center for HIV, STD and TB Prevention, 2004. Available from: http://www.cdc.gov/nchstp/od/latex.htm. Accessed Nov. 24, 2006.

  52. Holmes KK, Levine R, Weaver M. Effectiveness of condoms in preventing sexually transmitted infections. Bull World Health Organ 2004; 82:454–461.

    PubMed Central  PubMed  Google Scholar 

  53. Warner L, Stone KM, Macaluso M, Buehler JW, Austin HD. Condom use and risk of gonorrhea and Chlamydia: a systematic review of design and measurement factors assessed in epidemiologic studies. Sex Transm Dis 2006; 33:36–51.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. School of Medicine, University of Southern California, Santa Monica, CA

    Albert John Phillips MD, FACOG (Clinical Professor of Obstetrics and Gynecology)

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  1. Albert John Phillips MD, FACOG
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Editors and Affiliations

  1. Harbor/UCLA Medical Center, Torrance, CA

    Anita L. Nelson MD

  2. Health Care Partners, Redondo Beach, CA

    JoAnn Woodward RNC, BSN, NP

  3. Harbor/UCLA Nurse Practitioner Program, Torrance, CA

    JoAnn Woodward RNC, BSN, NP

  4. National Association of Nurse Practitioners in Women’s Health, Washington, DC

    Susan Wysocki RNC, NP, FAANP (President and CEO) (President and CEO)

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© 2006 Humana Press Inc.,Totowa NJ

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Phillips, A.J. (2006). Chlamydial Infections. In: Nelson, A.L., Woodward, J., Wysocki, S. (eds) Sexually Transmitted Diseases. Current Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-040-9_6

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  • DOI: https://doi.org/10.1007/978-1-59745-040-9_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-58829-570-5

  • Online ISBN: 978-1-59745-040-9

  • eBook Packages: MedicineMedicine (R0)

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