Skip to main content
  • 1095 Accesses

Abstract

This is a perennial, herbaceous plant of the CARICACEAE family, with copious milky latex reaching to as high as 10 meters. The stem is about 25 cm thick, simple or branched above the middle and roughened with leaf scars. Leaves, clustered around the apex of the stem and branches, have nearly cylindrical stalks, 25 to 100 cm long; the leaf blade has 7 to 11 main lobes and some secondary irregular pointed lobes and prominent veins; leaf surface is yellow-green to dark-green above and paler beneath. Usually male and female flowers are borne on separate plants, but hermaphrodite flowers often occur, and a male plant may convert to a female after being beheaded. Flowers emerge singly or in clusters from the main stem among the lower leaves, the female short-stalked, the male with drooping peduncles 25 to 100 cm long.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Quisumbing, E. Medicinal plants of the Philippines. Tech Bull 16, Rep Philippines, Dept Agr Nat Resources, Manila 1951; 1.

    Google Scholar 

  2. Alvaro Viera, R. Subsidio para o Estudio da Flora Medicinal da Guinea Portuguesa. Agencia-General do Ultramar, Lisboa, 1959.

    Google Scholar 

  3. Vasileva, B. Plantes Medicinales de Guinee. Conarky, Republique, 1969.

    Google Scholar 

  4. Spencer, C. F., F. R. Koniuszy, E. F. Rogers et al. Survey of plants for antimalarial activity. Lloydia 1947; 10: 145–174.

    Google Scholar 

  5. Medora, R. S., J. M. Campbell and G. P. Mell. Proteolytic enzymes in papaya tissue cultures. Lloydia 1973; 36: 214.

    PubMed  CAS  Google Scholar 

  6. Kapoor, M., S. K. Garg and V. S. Mathur. Antiovulatory activity of five indigenous plants in rabbits. Indian J Med Res 1974; 62: 1225–1227.

    PubMed  CAS  Google Scholar 

  7. Gimlette, J. D. Malay Poisons and Charm Cures. J & A Churchill, London, 3rd Edition, 1929.

    Google Scholar 

  8. Hikino, H., K. Aota and T. Takemoto. Structure and absolute configuration of cyperotundone. Chem Pharm Bull 1966; 14: 890.

    Article  PubMed  CAS  Google Scholar 

  9. Milne, L. Shans at Home. John Murray, London, 1910; 181.

    Google Scholar 

  10. Maugham, R. C. F. Portuguese East Africa, the History, Scenery and Great Game of Manica and Sofala. John Murray, London, 1906; 271.

    Google Scholar 

  11. Berhault, J. Flore Illustree du Senegal II. Govt. Senegal, Min Rural Dev, Water and Forest Div. Dakar, 2.1974.

    Google Scholar 

  12. Sareen, K. N., N. Misra, D. R. Varma, M. K. P. Amma and M. L. Gujral. Oral contraceptives. V. Anthelmintics as antifertility agents. Indian J Physiol Pharmacol 1961; 5: 125–135.

    PubMed  CAS  Google Scholar 

  13. Burdick, E. M. Carpaine: An alkaloid of Caricapapaya, its chemistry and pharmacology. Econ Bot 1971; 25: 363.

    Article  CAS  Google Scholar 

  14. Garg, S. K. and G. P. Garg. Antifertility screening of plants. Part VII. Effect of five indigenous plants on early pregnancy in albino rats. Indian J Med Res 1970; 59: 302.

    Google Scholar 

  15. Gimlette, J. D. A Dictionary of Malayan Medicine, Oxford Univ. Press., New York, USA, 1939.

    Google Scholar 

  16. Murray, J. A. Plants and Drugs of Sind. Richardson and Co., London, 1881.

    Google Scholar 

  17. Khurana, S. M. P. Studies on Calotropis procera latex as an inhibitor of tobacco mosaic virus. Phytopathol 1972; Z 73: 341.

    Article  Google Scholar 

  18. Petelot, A. Les Plantes Medicinales du Cambodge, du Laos et du Vietnam, Vol. 1–4. Archives des Recherches Agronomiques et Pastorales au Vietnam No. 23, 1954.

    Google Scholar 

  19. Kerharo, J. and A. Bouquet. Plantes Medicinales et Toxiques de La CoteDIvoire — Haute-Volta. Vigot Freres, Paris, 1950; 297pp.

    Google Scholar 

  20. Nagaty, H. F., M. A. Rifatt and T. A. Morsy. Trials on the effect on dog ascaris In vivo produced by the latex of Ficus carica and Papaya carica growing in Cairo gardens. Ann Trop Med Parasitol 1959; 53: 215.

    PubMed  CAS  Google Scholar 

  21. Pillai, N. C., C. S. Vaidyanathan and K. V. Gir. A blood anticoagulant factor from the latex of Carica papaya. 1. Purification and general properties. Proc Indian Acad Sci Ser B 1955; 42: 316.

    Google Scholar 

  22. Bose, B. C., A. Q. Saifi, R. Vijayvargiya and A. W. Bhagwat. Pharmacological study of Carica papaya seeds, with special reference to its anthelmintic action: Preliminary report. Indian J Med Sci 1961; 15: 888.

    PubMed  CAS  Google Scholar 

  23. Badami, R. C. and C. D. Daulatabad. The component acids of Carica papaya (Caricaceae) seed oil. J Sci Food Agr 1967; 18: 360.

    Article  CAS  Google Scholar 

  24. Panse, T. B. and A. S. Paranjpe. Carpasemine isolated from Carica papaya seeds. Proc Indian Acad Sci Ser A 1943; 18: 140.

    Google Scholar 

  25. Ogan, A. U. West African medicinal plants. II. Basic constituents of the leaves of Carica papaya. Phytochemistry 1971; 10: 2544.

    Article  CAS  Google Scholar 

  26. Brailski, K., K. Mao and K. Kuk. The action of certain tropical fruits on the gastric function. VOPR Pitaniya 1960; 19(4): 39.

    CAS  Google Scholar 

  27. Panse, T. B. and A. S. Paranipe. An alkaloid substance isolated from Carica papaya seeds. Rasayanam 1941; 1: 215.

    CAS  Google Scholar 

  28. Ettlinger, M. G. and J. E. Hodgkins. The mustard of papaya seeds. J Org Chem 1956; 21: 204.

    Article  CAS  Google Scholar 

  29. Yamamoto, H. Y. Comparison of the carotenoids in yellow- and red-fleshed Carica papaya. Nature (London) 1964; 201: 1049.

    Article  CAS  Google Scholar 

  30. Bischoff, F., M. L. Long and M. Sahyun. Investigations of the hypoglycemic properties of reglykol pancreatine and papaw. J Pharmacol Exp Ther 1929; 36: 311.

    CAS  Google Scholar 

  31. Govindachari, T. R., B. R. Pai and N. S. Narasimhan. Pseudocarpaine, a new alkaloid from Carica papaya. J Chem Soc 1954; 1954: 1847.

    Article  Google Scholar 

  32. Biswas, A. B. and C. V. N. Rao. Structural investigation of the galactan component of the pectic substance from Carica papaya. Aust J Chem 1969; 22: 2001.

    Google Scholar 

  33. Noble, I. G. Fruta bomba (Carica papaya) in hypertension. An Acad Cienc Med Fis Nat Habana 1947; 85: 198.

    CAS  Google Scholar 

  34. Smalberger, T. M., G. J. H. Rall and H. L. Waal. Carica papaya alkaloids. Tydskr Natuurwetr 1968; 8: 156.

    CAS  Google Scholar 

  35. Cairns, T. M. Isolation and indentification of caricacin, a plant growth inhibitor in the methanolic extract of Carica papaya. Diss Abstr Int B 1969; 29: 2689.

    Google Scholar 

  36. Krishnakumari, M. K. and S. K. Majumder. Bioassay of piperazine & some plant products with earthworms. J Sci Ind Res 1960; C 19: 202.

    Google Scholar 

  37. Watt, J. M. and M. G. Breyer-Brandwijk. The Medicinal and Poisonous Plants of Southern and Eastern Africa. 2nd Ed, E. S. Livingstone, Ltd., London, 1962.

    Google Scholar 

  38. Griffiths, L. A. On the distribution of gentisic acid in green plants. J Exp Biol 1959; 10: 437.

    CAS  Google Scholar 

  39. Peckolt, G. Brazilian anthelmintic plants. Rev Flora Med 1942; 9(7): 333.

    Google Scholar 

  40. Katague, D. B. and E. R. Kirch. Chromatographic analysis of the volatile components of papaya fruit. J Pharm Sci 1965; 54: 891.

    Article  PubMed  CAS  Google Scholar 

  41. Ritthibut, A. and R. Charoenphol. Enzymes and vitamins in raw and ripe papaya fruit. Undergraduate Special Project Report 1971; 19pp.

    Google Scholar 

  42. Sornsuchaat, T. Isolation of papain from papaya latex. Undergraduate Special Project Report, Chulalongkorn University, Bangkok, Thailand 1951; 10pp.

    Google Scholar 

  43. Economic Botany. 1991; Volume 45.

    Google Scholar 

  44. Glasby, J. H. Dictionary of Plants Containing Secondary Metabolites. Taylor and Francis. New York. 1991; 488pp.

    Google Scholar 

  45. Journal of Food Science 1961; Vol. 14.

    Google Scholar 

  46. Pederson, M. Nutritional Herbology. Pederson Publishing. Bountiful, UT, 1987; 377pp.

    Google Scholar 

  47. The Wealth of India. Council of Scientific and Industrial Research. New Delhi, 1948–1976.

    Google Scholar 

  48. List, P. H. and L. Horhammer. Hager’s Handbuch der Pharmazeutischen Praxis. Springer-Verlag, Berlin. 1969–1079.

    Google Scholar 

  49. Journal of Agriculture and Food Chemistry 1992; Volume 40.

    Google Scholar 

  50. USDA Agricultural Handbook No. 8 and sequels; strictly nutritional data.

    Google Scholar 

  51. Ortiz De Montellano, B. Empirical Aztec medicine. Science 1975; 188: 215–220.

    Article  Google Scholar 

  52. Bodhankar, S. L., S. K. Garg and V. S. Mathur. Antifertility screening of plants. Part IX. Effect of five indigenous plants on early pregnancy in female albino rats. Indian J Med Res 1974; 62: 831–837.

    PubMed  CAS  Google Scholar 

  53. Yagashi, R. Papain for the control of termites. Patent-Japan Kokai-74 125,520: 1974.

    Google Scholar 

  54. Garg, S. K. Antifertility effect of oil from few indigenous plants on female albino rats. Planta Med 1974; 26: 391–393.

    Article  Google Scholar 

  55. Lal, J., S. Chandra, V. Raviprakash and M. Sabir. In vitro anthelmintic action of some indigenous medicinal plants on Ascardia galli worms. Indian J Physiol Pharmacol 1976; 20: 64.

    PubMed  CAS  Google Scholar 

  56. Devereux, G. A Study of Abortion in Primitive Societies. The Julian Press, Inc, New York, 1976.

    Google Scholar 

  57. Giordani, R., M. Siepaio, J. Moulin-Traffort and P. Regli. Antifungal action of Carica papaya latex. Isolation of fungal cell wall hydrolysing enzymes. Mycoses 1991; 34(11/12): 469–477.

    PubMed  CAS  Google Scholar 

  58. Gupta, O. P., N. Sharma and D. Chad. A sensitive and relevant model for evaluating anti-inflammatory activity, papaya latex-induced rat paw inflammation. J Pharmacol Toxicol Meth 1992; 28(1): 15–19.

    Article  CAS  Google Scholar 

  59. Bhat, R. B., E. O. Eterjere and V. T. Oladipo. Ethnobotanical studies from Central Nigeria. Econ Bot 1990; 44(3): 382–390.

    Article  Google Scholar 

  60. Misas, C. A. J., N. M. R. Hernandez and A. M. L. Abraham. The biological assessment of Cuban plants. III. Rev Cub Med Trop 1979; 31(1): 21–27.

    Google Scholar 

  61. Topuriya, L. I. Pigments of the plastids and flavonoids of the leaves of Carica papaya. Chem Nat Comp 1990; 26(1): 98–99.

    Article  Google Scholar 

  62. Yasukawa, K., A. Yamaguchi, J. Arita, S. Sakurai, A. Ikeda and M. Takido. Inhibitory effect of edible plant extracts on 12–0-Tetradecanoylphorbol-13-Acetate-induced ear oedema in mice. Phytother Res 1993; 7(2): 185–189.

    Article  CAS  Google Scholar 

  63. Reddy, M. B., K. R. Reddy and M. N. Reddy. A survey of plant crude drugs of Anantapur District, Andhra Pradesh, India. Int J Crude Drug Res 1989; 27(3): 145–155.

    Google Scholar 

  64. Osato, J. A., L. A. Santiago, G. M. Reno, M. S. Cuadra and A. Mori. Antimicrobial and antioxidant activities of unripe papaya. Life Sci 1993; 53(17): 1383–1389.

    Article  PubMed  CAS  Google Scholar 

  65. Zamora-Martinez, M. C. and C. N. P. Pola. Medicinal plants used in some rural populations of Oaxaca, Puebla and Veracruz, Mexico. J Ethnopharmacol 1992; 35(3) 229–257.

    Article  PubMed  CAS  Google Scholar 

  66. Lim-Sylianco, C. Y., J. A. Concha, A. P. Jocano and C. M. Lim. Antimutagenic effects of expressions from twelve medicinal plants. Philippine J Sci 1986; 115(1): 23–30.

    Google Scholar 

  67. Bourdy, G. and A. Walter. Maternity and medicinal plants in Vanuatu I. The cycle of reproduction. J Ethnopharmacol 1992; 37(3): 179–196.

    Article  PubMed  CAS  Google Scholar 

  68. Holdsworth, D. Medicinal plants of the Gazelle peninsula, New Britain Island, Papau, New Guinea. Part 1. Int Pharmacog 1992; 30(3): 185–190.

    Article  Google Scholar 

  69. Holdsworth, D and L. Balun. Medicinal plants of the East and West Sepik Provinces, Papau, New Guinea. Int J Pharmacog 1992; 30(3): 218–222.

    Article  Google Scholar 

  70. Schmeda-Hirschmann, G. and A. Rojas de Arias. A screening method for natural products on Triatomine bugs. Phytother Res 1992; 6(2): 68–73.

    Article  Google Scholar 

  71. Hope, B. E., D. G. Massey and G. Fournier-Massey. Hawaiian materia medica for asthma. Hawaii Med J 1993; 52(6): 160–166.

    PubMed  CAS  Google Scholar 

  72. Holdsworth, D. K. Traditional medicinal plants of Rarotonga, Cook Islands Part 1. Int J Crude Drug Res 1990; 28(3): 209–218.

    Google Scholar 

  73. Morton, J. F. Medicinal and other plants used by people on North Caicos (Turks and Caicos Islands, West Indies), J Crude Drug Res 1977; 15: 1–24.

    Google Scholar 

  74. Anon. Pure proteolytic active enzymes from the latex of Carica papaya. Patent-Belg-838,750: 1976.

    Google Scholar 

  75. Strocchi, A., G. Lercker, G. Bonaga, and A. Maye. Composition of papaya seed oil. Riv Ital Sistanze Grasse 1977; 54: 429.

    CAS  Google Scholar 

  76. Chandrasekaran, E. V., J. N. Bemiller and S. C. D. Lee. Isolation, partial characterization, and biological prop- erties of polysaccharides from crude papain. Carbohydr Res 1978; 60: 105.

    Article  PubMed  CAS  Google Scholar 

  77. Marrero, M., J. Garcia, M. Bonera and F. Alonso. Industrial process for obtaining purified papain from the latex of the Carica papaya fruit. Rev Cubana Farm 1977; 11(1): 35.

    CAS  Google Scholar 

  78. Boum, R., J. L. Pousset, F. Lemonnier and M. Hadchouel. Action of extracts of Carica papaya on experimental jaundice induced in the rat by saponins extracted from Brenani brieyi. Toxicol Appl Pharmacol 1978; 46: 353.

    Article  PubMed  CAS  Google Scholar 

  79. MacLeod, A. J., and N. M. Pieris. Volatile components of papaya (Cari ca papaya L.) with particular reference to glucosinolate products. J Agr Food Chem 1983; 31(5): 1005–1008.

    Article  CAS  Google Scholar 

  80. Spencer, K. C. and D. S. Seigler. Cyanogenic glycosides of Carica papaya and its phylogenetic position with respect to the volatiles and capparales. Amer J Bot 1984; 71(10): 1444–1447.

    Article  CAS  Google Scholar 

  81. Brocklehurst, K., E. Salih, R. Mc Kee and H. Smith. Fresh non-fruit latex of Carica papaya contains papain, multiforms of chymopapain A and papaya proteinase omega. Biochem J 1985; 228(2): 525–527.

    PubMed  CAS  Google Scholar 

  82. Idstein, H., C. Bauer and P. Schreier. Volatile acids from tropical fruits: Cherimoya (Annona cherimolia, Mill.) guava, (Psidium guajava, L.) mango (Mangifera indica, L., var. Alphonso) and papaya (Carica papaya, L). Z Lebensm-Unters Forsch 1985; 180(5): 394–397.

    Article  PubMed  CAS  Google Scholar 

  83. Kenrick, J. R. and D. G. Bishop. Phosphatidylglycerol and sulphoquinovosyldiacylglycerol in leaves and fruits of chilling-sensitive plants. Phytochemistry 1986; 25(6): 1293–1295.

    Article  CAS  Google Scholar 

  84. Bemiller, J. N. and S. B. Dikko. Structural analysis of papaya polysaccharide 11. Carbohydr Res 1986; 158: 173–181.

    Article  PubMed  CAS  Google Scholar 

  85. Schreier, P. and P. Winterhalter. Precursors of papaya (Carica papaya, L.) fruit volatiles. ACS Symp Ser 1986; 317: 85–98.

    Article  CAS  Google Scholar 

  86. Evans, D. A. and R. K. Raj. Extracts of Indian plants as mosquito larvicides. Indian J Med Res 1988; 88(1): 38–41.

    PubMed  CAS  Google Scholar 

  87. Saleh, N. A. M., A. E. A. El Sherbeiny and H. I. El Sissi. Local plants as potential sources of tannins in Egypt. Part IV. (Aceraceae to Flacourtiaceae). Qual Plant Mater Veg 1969; 17(4): 384–394.

    Article  CAS  Google Scholar 

  88. Asthana, A., H. V. Mall, K. Dixit and S. Gupta. Fungitoxic properties of latex of plants with special reference to that of croton Bonplandianus baill. Int J Crude Drugs Res 1989; 27(1): 25–58.

    Google Scholar 

  89. Le Grand, A. Anti-infectious phytotherapy of the tree-savannah, Senegal (Western Africa) III: A review of the phytochemical substances and antimicrobial activity of 43 species. J Ethnopharmacol 1989; 25(3): 315–338.

    Article  PubMed  Google Scholar 

  90. Shah, G. L. and G. V. Gopal. Ethnomedical notes from the tribal inhabitants of the North Gujarat (India). J Econ Taxon Botany 1985; 6(1): 193–201.

    Google Scholar 

  91. Webman, E. J., G. Edling and H. F. Mower. Free radical scavenging activity of papaya juice. Int J Rad Biol 1989; 55(3): 347–351.

    Article  PubMed  CAS  Google Scholar 

  92. Itokawa, H., F. Hirayama, S. Tsuruoka, K. Mizuno, K. Takeya and A. Nitta. Screening test for antitumor activity of crude drugs (III). Studies on antitumor activity of Indonesian medicinal plants. Shoyakugaku Zasshi 1990; 44(1): 58–62.

    Google Scholar 

  93. Msonthi, J. D. and D. Magombo. Medicinal herbs in Malawi and their uses. Hamdard 1983; 26(2): 94–100.

    Google Scholar 

  94. Le Grand, A. and P. A. Wondergem. Antiinfective phytotherapy of the savannah forests of Senegal (West Africa). I. An inventory. J Ethnopharmacol 1987; 21(2): 109–125.

    Article  PubMed  Google Scholar 

  95. Johns, T., J. O. Kokwaro and E. K. Kimanani. Herbal remedies of the Luo of Siaya District, Kenya. Establishing quantitative criteria for consensus. Econ Bot 1990; 44(3): 369–381.

    Article  Google Scholar 

  96. Nagaraju, N. and K. N. Rao. A survey of plant crude drugs of Rayalaseema, Andhra Pradesh, India. J Ethnopharmacol 1990; 29(2): 137–158.

    Article  PubMed  CAS  Google Scholar 

  97. Miwa, M., Z. L. Kong, K. Shinohara and M. Watanabee. Macrophage stimulating activity of foods. Agr Biol Chem 1990; 54(7): 1863–1866.

    Article  Google Scholar 

  98. Kambu, K., L. Tona, S. Kaba, K. Cimanga and N. Mukala. Antispas- modic activity of extracts proceeding of plant antidiarrheic traditional preparations used in Kinshasa, Zaire. Ann Pharm Fr 1990; 48(4): 200–208.

    PubMed  CAS  Google Scholar 

  99. Raja Reddy, K. Folk medicine from Chittoor District, Andhra Pradesh, India, used in the treatment of jaundice. Int J Crude Res 1988; 26(3): 127–140.

    Google Scholar 

  100. Gopalakrishnan, M. and M. R. Raj asekharasetty. Effect of papaya (Carica papaya) on pregnancy and estrous cycle in albino rats of wistar strain. Indian J Physiol Pharmacol 1978; 22: 66–70.

    PubMed  CAS  Google Scholar 

  101. Halberstein, R. A. and A. B. Saunders. Traditional medical practices and medicinal plant usage on a Bahamian Island, Cul Med Psychiat 1978; 2: 177–203.

    Article  Google Scholar 

  102. Mell, G. P., R. S. Medora and D. E. Bilderback. Substrate specificity of enzymes from papaya callus cultures. Z Pflanzenphysiol 1979; 91: 279–282.

    CAS  Google Scholar 

  103. Ayensu, E. S. Medicinal Plants of the West Indies. Unpublished Manuscript 1978; 110pp.

    Google Scholar 

  104. Devi, S. and S. Singh. Changes in placenta of rat fetuses induced by maternal administration of papain. Indian J Exp Biol 1978; 16: 1256–1260.

    PubMed  CAS  Google Scholar 

  105. Gupta, M. P., T. D. Arias, M. Correa and S. S. Lamba. Ethnopharmacognostic observations on Panamanian medicinal plants. Part 1. Q J Crude Drug Res 1979; 17(3/4): 115–130.

    Google Scholar 

  106. Tang, C. S. Macrocyclic piperidine and piperideine alkaloids in Carica papaya. Trop Foods Chem Nutr 1979; 1: 55–68.

    CAS  Google Scholar 

  107. Lynn, K. R. A purification and some properties of two proteases from papaya latex. Biochim Biophys Acta 1979; 569: 193–201.

    Article  PubMed  CAS  Google Scholar 

  108. Das, R. P. Effect of papaya seed on the genital organs and fertility of male rats. Indian J Exp Biol 1980; 18: 408–409.

    PubMed  CAS  Google Scholar 

  109. Chan Jr, H. T. and C. S. Tang. The chemistry and biochemistry of papaya. Trop Foods: Chem Nutr (Proc Int Conf) 1979; 1979: 33–53.

    Google Scholar 

  110. Pousset, J., B. Boum and A. Cave. Antihemolytic activity of xylitol isolated from the bark of Carica papaya. Planta Med 1981; 41: 40–47.

    Article  PubMed  CAS  Google Scholar 

  111. Rizvi, S. J. H., D. Mukerji and S. N. Mathur. A new report of some possible source of natural herbicide. Indian J Exp Biol 1980; 18: 777–781.

    Google Scholar 

  112. Khan, M. R., G. Ndaalio, M. H. Nkunya, H. Wevers and A. N. Sawhney. Studies on African medicinal plants. Part 1. Preliminary screening of medicinal plants for antibacterial activity. Planta Med (Supol) 1980; 40: 91–97.

    Article  Google Scholar 

  113. Tezuka, H. and K. Kitabatake. Growth-inhibitory activity in papaya latex against Candida species. Bull Brew Sci 1980; 26: 47–49.

    CAS  Google Scholar 

  114. Sofowora, E. A. and C. O. Adewunmi. Preliminary screening of some plant extracts for molluscicidal activity. Planta Med 1980; 39: 57–65.

    Article  Google Scholar 

  115. Holdsworth, D. K. Traditional medicinal plants of the North Solomons Province Papau, New Guinea. Q J Crude Drug Res 1980; 18: 33–44.

    CAS  Google Scholar 

  116. Dikko, S. B. and J. N. Be Miller. Structural elucidation of a polysaccharide isolated from crude papain. Diss Abstr Int 1982; B(43): 1483.

    Google Scholar 

  117. Sawhney, A. N., M. R. Khan, G. Ndaalio, M. H. H. Nkunya and H. Wevers. Studies on the rationale of African traditional medicine. Part III. Preliminary screening for antifungal activity. Pak J Sci Ind Res 1978; 21: 193–196.

    Google Scholar 

  118. Emeruwa, A. C. Antibacterial substance from Carica papaya fruit extract. J Nat Prod 1982; 45: 123–127.

    Article  PubMed  CAS  Google Scholar 

  119. Van Den Berghe, D. A., M. Ieven, F. Mertens, A. J. Vlietinck and E. Lammens. Screening of higher plants for biological activities. II. Antiviral activity. J Nat Prod 1978; 41: 463–467.

    Google Scholar 

  120. Adesina, S. K. Studies on some plants used as anticonvulsants in Amerindian and African traditional medicine. Fitoterapia 1982; 53: 147–162.

    CAS  Google Scholar 

  121. Baines, B. S. and K. Brocklehurst. Characterization of papaya peptidase A as a cysteine proteinase of Carica papaya L. with active-center properties that differ from those of papain by using 2,2&#x2032-dipyridyl disulfide and 4-chloro-7nitrobenzofuran as reactivity probes. Biochem J 1982; 205: 205–211.

    PubMed  CAS  Google Scholar 

  122. Tiwari, K. C., R. Majumder and S. Bhattacharjee. Folklore information from Assam for family planning and birth control. Int J Crude Drug Res 1982; 20: 133–137.

    PubMed  CAS  Google Scholar 

  123. Chen, C. F., S. M. Chen, S. Y. Chow and P. W. Han. Protective effects of Carica papaya Linn. on the exogenous gastric ulcers in rats. Amer J Chin Med 1981; 9: 205–212.

    Article  CAS  Google Scholar 

  124. Holdsworth, D. and B. Wamoi. Medicinal plants of the Admiralty Islands, Papau, New Guinea. Part I.Int J Crude Drug Res 1982; 20(4): 169–181.

    Google Scholar 

  125. Rao, R. R. and N. S. Jamir. Ethnobotanical studies in Nagaland. I. Medicinal plants. Econ Bot 1982; 36: 176–181.

    Article  Google Scholar 

  126. Rao, V. S. Pharmacological screening and comparative efficacy of some indigenous anthelmintics. Abstr 4th Asian Symp Med Plants Spices Bangkok, Thailand 1980; 1980: 145.

    Google Scholar 

  127. Vitalyos, D. Phytotherapy in domestic traditional medicine in MatoubaPapaye (Guadeloupe). Dissertation — Ph.D.- Univ Paris 1979; 110pp.

    Google Scholar 

  128. Rojas Hernandez, N. M., C. A. Jimienez Misas, A. M. Lopez Abraham and C. Hernandez Suarez. Study of the inhibitory activity of plant extracts on microbial growth. Part V. Rev Cubana Farm 1981; 15: 139–145.

    Google Scholar 

  129. John, D. One hundred useful raw drugs of the Kani Tribes of Trivandrum Forest Division, Kerala, India. Int J Crude Drug Res 1984; 22(1): 17–39.

    Google Scholar 

  130. Miralles, J. Research on new sources of vegetable oils. Oleagineux 1983; 38(12): 665–667.

    CAS  Google Scholar 

  131. Lopez Abraham, A. N., N. M. Rojas Hernandez and C. A. Jimenez Misas. Potential antineoplastic activity of Cuban plants. IV. Rev Cubana Farm 1981; 15(1): 71–77.

    Google Scholar 

  132. Singh, Y. N., T. Ikahihifo, M. Panuve and C. Slatter. Folk medicine in Tonga. A study of the use of herbal medicines for obstetric and gynaecological conditions and disorders. J Ethnopharmacol 1984; 12(3): 305–329.

    Article  PubMed  CAS  Google Scholar 

  133. Arnold, H. J. and M. Gulumian. Pharmacopoeia of traditional medicine in Venda. J Ethnopharmacol 1984; 12(1): 35–74.

    Article  PubMed  CAS  Google Scholar 

  134. Kargbo, T. K. Traditional practices affecting the health of women and children in Africa. Unpublished Manuscript 1984.

    Google Scholar 

  135. Sircar, N. N. Pharmaco-therapeutics of Dasemani drugs. Ancient Sci Life 1984; 3(3): 132–135.

    CAS  Google Scholar 

  136. Hashem, F. M., M. Y. Haggag and A. M. S. Galal. A phytochemical study of Carica papaya L. growing in Egypt. Egypt J Pharm Sci 1980; 21(3/4): 199–214.

    CAS  Google Scholar 

  137. Whistler, W. A. Traditional and herbal medicine in Cook Islands. J Ethnopharmacol 1985; 13(3): 239–280.

    Article  PubMed  CAS  Google Scholar 

  138. Macfoy, C. A. and A. M. Sama. Medicinal plants in Pujehun District of Sierra Leone. J Ethnopharmacol 1983; 8(2): 215–223.

    Article  PubMed  CAS  Google Scholar 

  139. Chinoy, N. J., R. J. Verma, M. G. Sam- and O. M. D’Souza. Reversible antifertility effects of papaya seed extract in male rodents. J Androl 1985; 6(2): Abstr-M10

    Google Scholar 

  140. Khan, M. R., G. Ndaalio, M. H. H. Nkunya, H. Wevers. Studies on the rationale of African traditional medicine. Part II. Preliminary screening of medicinal plants for anti-gonoccoci activity. Pak J Sci Ind Res 1978; 27(5/ 6): 189–192.

    Google Scholar 

  141. Singh, Y. N. Traditional medicine in Fiji. Some herbal folk cures used by Fiji Indians. J Ethnopharmacol 1986; 15(1): 57–88.

    Article  PubMed  CAS  Google Scholar 

  142. Gundidza, M. Screening of extracts from Zimbabwean higher plants II: Antifungal properties. Fitoterapia 1986; 57(2): 111–113.

    Google Scholar 

  143. Weniger, B., M. Rouzier, R. Daguilh, D. Henrys, J. H. Henrys and R. Anthon. Popular medicine of the Central Plateau of Haiti. 2. Ethnopharmacological inventory. J Ethnopharmacol 1986; 17(1): 13–30.

    Article  PubMed  CAS  Google Scholar 

  144. Thomas, K. D. and B. Ajani. Antisickling agent in an extract of unripe pawpaw fruit (Carica papaya). Trans Roy Soc Trop Med Hyg 1987; 81(3): 510–511.

    Article  PubMed  CAS  Google Scholar 

  145. Kloss, H., F. W. Thiongo, J. H. Ouma and A. E. Butterworth. Preliminary evaluation of some wild and cultivated plants from snail control in Machakos District, Kenya. J Trop Med Hyg 1987; 90(4): 197–204.

    Google Scholar 

  146. Kulakkattolickal, A. Piscicidal plants of Nepal. Preliminary toxicity screening using grass carp (Ctenopharyngodon idella) fingerlings. J Ethnopharmacol 1987; 21(1): 1–9.

    Article  PubMed  CAS  Google Scholar 

  147. Kamboj, V. P. A review of Indian medicinal plants with interceptive activity. Indian J Med Res 1988; 4: 336–355.

    Google Scholar 

  148. Koshimizu, K., H. Ohigashi, H. Tokuda, A. Kondo and K. Yamaguchi. Screening of edible plants against possible anti-tumor promoting activity. Cancer Lett 1988; 39(3): 247–257.

    Article  PubMed  CAS  Google Scholar 

  149. Ramirez, V. R., L. J. Mostacero, A. E. Garcia, C. F. Mejia, P. F. Pelaez, C. D. Medina and C. H. Miranda. Vegetales Empleados en Medicina Tradicional Norperuana. Banco Agrario Del Peru NACL Univ Trujillo, Trujillo, Peru, June 1988; 54pp.

    Google Scholar 

  150. Kone-Bamba, D., Y. Pelissier, Z. F. Ozoukou and D. Kouao. Hemostatic activity of 216 plants used in traditional medicine in the Ivory Coast. Plant Med Phytother 1987; 21(2): 122–130.

    Google Scholar 

  151. Gonzalez, F and M. Silva. A survey of plants with antifertility properties described in the South American folk medicine. Abstr Princess Congress I Thailand, Dec. 1987; 2Opp.

    Google Scholar 

  152. Singh, V. P., S. K. Sharma, and V. S. Khare. Medicinal plants from Ujjain District Madhya Pradesh. Part II. Indian Drugs Pharm Ind 1980; 5: 7–12.

    CAS  Google Scholar 

  153. Gupta, A., C. O. Wambebe and D. L. Parsons. Central and cardiovascular effects of the alcoholic extract of the leaves of Carica papaya. Int J Crude Drug Res 1990; 28(4): 257–266.

    Google Scholar 

  154. Chopra, R. N., R. L. Badhwar and S. Ghosh. Poisonous Plants of India. Manager of Publications, Government of India Press, Calcutta. Volume 1, 1949.

    Google Scholar 

  155. Garg, S. K. and G. P. Garg. A preliminary report on the smooth muscle stimulating property of some indigenous plants on isolated rat uterus. Bull P. G. I. 1970; 4: 162.

    Google Scholar 

  156. Khurana, S. M. P. and K. S. Bhargava. Effect of plant extracts on the activity of three papaya viruses. J Gen Appl Microbiol 1970; 16: 225–230.

    Article  Google Scholar 

  157. Dhawan, B. N., G. K. Patnaik, R. P. Rastogi, K. K. Singh and J. S. Tandon. Screening of Indian plants for biological activity. VI. Indian J Exp Biol 1977; 15: 208–219.

    PubMed  CAS  Google Scholar 

  158. Malik, M. Y., A. A. Sheikh and W. H. Shah. Chemical composition of indigenous fodder tree leaves. Pak J Sci 1967; 19: 171.

    Google Scholar 

  159. Kobayashi, J. Early Hawaiian uses of medicinal plants in pregnancy and childbirth. J Trop Pediatr Environ Child Health 1976; 22: 260.

    PubMed  CAS  Google Scholar 

  160. Frisbey, A., J. M. Roberts, J. C. Jennings, R. Y. Gottshall and E. H. Lucas. The occurrence of antifungal substances in seed plants with special reference to Mycobacterium tuberculosis (Third report). Mich State Univ Agr Appl Sci Quart Bull 1953; 35: 392–404.

    Google Scholar 

  161. Kafuku, K. and C. Hata. Mokka seed oil. J Chem Soc Japan 1932; 53: 439–441.

    CAS  Google Scholar 

  162. Asprey, G. F. and P. Thornton. Medicinal plants of Jamaica. III. West Indian Med 1955; J4: 69–82.

    Google Scholar 

  163. Shukla, O. P. and C. R. Krishna Murti. Bacteriolytic activity of plants latices. J Sci Ind Res 1961; C 20: 225–226.

    Google Scholar 

  164. Shivpuri, D. N. and K. L. Dua. Allergy to papaya tree (Carica papaya). Ann Allergy 1963; 21: 139–144.

    PubMed  CAS  Google Scholar 

  165. Tang, C. S. Localization of benzyl glucosinolate and thioglucosidase in Carica papaya fruit. Phytochemistry 1973; 12: 769–773.

    Article  CAS  Google Scholar 

  166. George, M. and K. M. Pandalai. Investigations on plant antibiotics. Part IV. Further search for antibiotic substances in Indian medicinal plants. Indian J Med Res 1949; 37: 169–181.

    CAS  Google Scholar 

  167. Osman, H. G. and E. W. Jwanny. Serological and chemical investigation on the agglutinins of Phaseolus montcalm. J Chem U A R 1963; 6(2): 191–204.

    CAS  Google Scholar 

  168. Wasuwat, S. A list of Thai medicinal plants, ASRCT, Bangkok, Report No. 1 on Res. Project. 17. A.S.R.C.T. Bangkok Thailand 1967; 17: 22pp.

    Google Scholar 

  169. Jamwal, K. S. and K. K. Anand. Preliminary screening of some reputed abortifacient indigenous plants. Indian J Pharm 1962; 24: 218–220.

    Google Scholar 

  170. Chan Jr., H. T., R. A. Heu, C. S. Tang, E. N. Okazaki and S. M. Ishizaki. Composition of papaya seeds. J Food Sci 1978; 43: 255.

    Article  CAS  Google Scholar 

  171. Der Marderosian, A. H. Pharmacognosy: Medicinal teas — Boon or bane? Drug Therapy 1977; 7: 178–186.

    Google Scholar 

  172. Gir, J., V. Bhuvaneswari and R. Tamilarasu. Evaluation of the nutritive content of five varieties of papaya in different stages of ripening. Indian J Nutr Diet 1980; 17: 319–325.

    Google Scholar 

  173. Ratwijit, P. and Y. Tanphaibuun. Reducing sugars in fresh raw papaya. Undergraduate Special Project Report 1971: 18pp.

    Google Scholar 

  174. Pathak, N., P. K. Mishra, B. Manivannan and N. K. Lohiya. Sterility due to inhiobition of sperm motility by oral administration of benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats. Phytomedicine 2000; 7(4): 325–333.

    Article  PubMed  CAS  Google Scholar 

  175. Bhat, G. P. and N. Surolia. In vitro antimalarial activity of extracts of three plants used in the traditional medicine of India. Am J Trop Med Hyg 2001; 65(4): 304–308.

    PubMed  CAS  Google Scholar 

  176. Vieira, R. H., D. Rodrigues, F. A. Goncalves, F. G. Menezes, J. S. Aragao and O. V. Sousa. Microbicidal effect of medicinal plant extracts (Psidium guajava Linn. and Carica papaya Linn.) upon bacteria isolated from fish muscle and known to induce diarrhea in children. Rev Inst Med Trop Sao Paulo 2001; 43(3): 145–148.

    PubMed  CAS  Google Scholar 

  177. Verma, R. J. and N. J. Chinoy. Effect of papaya seed extract on microenvironment of cauda epididymis. Asian J Androl 2001; 3(2): 143–146.

    PubMed  CAS  Google Scholar 

  178. Kermanshai, R., B. E. McCarry, J. Rosenfeld, P. S. Summers, E. A. Weretilnyk and G. J. Sorger. Benzyl isothiocyanate is the chief or sole anthelmintic in papaya seed extracts. Phytochemistry 2001; 57(3): 427–435.

    Article  PubMed  CAS  Google Scholar 

  179. Sripanidkulchai, B., V. Wongpanich, P. Laupattarakasem, J. Suwansaksri and D. Jirakulsomchok. Diuretic effects of selected Thai indigenous medicinal plants in rats. J Ethnopharmacol 2001; 75(2–3): 185–190.

    Article  PubMed  CAS  Google Scholar 

  180. Lohiya, N. K., L. K. Kothari, B. Manivannan, P. K. Mishra and N. Pathak. Human sperm immobilization effect of Carica papaya seed extracts: an in vitro study. Asian J Androl 2000; 2(2): 103–109.

    PubMed  CAS  Google Scholar 

  181. Gandhi, N. N. and K. D. Mukherjee. Papaya (Carica papaya) lipase with some distinct acyl and alkyl specificities as compared with microbial lipases. Biochem Soc Trans 2000; 28(6): 977–978.

    Article  PubMed  CAS  Google Scholar 

  182. Udoh, P. and A. Kehinde. Studies on antifertility effect of pawpaw seeds (Carica papaya) on the gonads of male albino rats. Phytother Res 1999; 13(3): 226–228.

    Article  PubMed  CAS  Google Scholar 

  183. Sarma, H. N. and H. C. Mahanta. Modulation of morphological changes of endometrial surface epithelium by administration of composite root extract in albino rat. Contraception 2000; 62(1): 51–54.

    Article  PubMed  CAS  Google Scholar 

  184. Lohiya, N. K., P. K. Mishra, N. Pathak, B. Manivannan and S. C. Jain. Reversible azoospermia by oral administration of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rabbits. Adv Contracept 1999; 15(2): 141–161.

    Article  PubMed  CAS  Google Scholar 

  185. Eno, A. E., O. I. Owo, E. H. Ham and R. S. Konya. Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA-induced hypertension in the rat. Phytother Res 2000; 1494): 235–239.

    Article  Google Scholar 

  186. Cherian, T. Effect of papaya latex extract on gravid and non-gravid rat uterine preparations in vitro. J Ethnopharmacol 2000; 70(3): 205–212.

    Article  PubMed  CAS  Google Scholar 

  187. Hewitt, H., S. Whittle, S. Lopez, E. Bailey and S. Weaver. Topical use of papaya in chronic skin ulcer therapy in Jamaica. West Indian Med J 2000; 49(1): 32–33.

    PubMed  CAS  Google Scholar 

  188. Lans, C., T. Harper, K. George and E. Bridgewater. Medicinal plants used for dogs in Trinidad and Tobago. Prey Vet Med 2000: 45(3–4): 201–220.

    Article  CAS  Google Scholar 

  189. Lohiya, N. K., N. Pathak, P. K. Mishra and B. Manivannan. Contraceptive evaluation and toxicological study of aqueous extract of the seeds of Carica papaya in male rabbits. J Ethnopharmacol 2000; 70 (1): 17–27.

    Article  PubMed  CAS  Google Scholar 

  190. Starley, I. F., P. Mohammed, G. Schneider and S. W. Bickler. The treatment of pediatric burns using topical papaya. Burns 1999; 25(7): 636–639.

    Article  PubMed  CAS  Google Scholar 

  191. Lohiya, N. K., N. Pathak, P. K. Mishra and B. Manivannan. Reversible contraception with chloroform extract of Carica papaya Linn. Seeds in male rabbits. Reprod Toxicol 1999; 13(1): 59–66.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer Science+Business Media New York

About this chapter

Cite this chapter

Ross, I.A. (2003). Carica papaya. In: Medicinal Plants of the World. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-365-1_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-365-1_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-469-2

  • Online ISBN: 978-1-59259-365-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics