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The Control of Influenza

  • Chapter
Influenza

Abstract

Influenza is essentially an uncontrolled disease. The effect of current vaccination programs on morbidity is insignificant, and that on mortality marginal. Although effective artificial immunization against influenza was demonstrated soon after the first isolation of the virus from man (Chenoweth et al., 1936), the antigenic variability of the virus has hampered vaccine production and precluded effective control (Table 11–1). The transient protection afforded by presently available inactivated virus vaccines is related, in part, to a rapid decline in vaccine-induced homologous antibody but also to vaccine obsolescence as the result of continuous viral mutation to antigens unlike or less like those of viral predecessors contained in the vaccine (Kilbourne, 1978).

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References

  • Allan, W. H., Madeley, C. R., and Kendal, A. P., 1971, Studies with avian influenza A viruses: Cross protection experiments in chickens, J. Gen. Virol 12:79–84.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, R. M., and May, R. M., 1985, Vaccination and herd immunity to infectious diseases, Nature 318:323–329.

    Article  PubMed  CAS  Google Scholar 

  • Anonymous, 1978, Influenza immunization in lupus erythematosus: Safe, effective? Ann. Intern. Med. 88:833–834.

    Google Scholar 

  • Armerding, D., Rossiter, H., Ghazzouli, I., et al., 1982, Evaluation of live and inactivated influenza A virus vaccines in a mouse model, J. Infect. Dis. 145:320–330.

    Article  PubMed  CAS  Google Scholar 

  • Atassi, M. Z., and Webster, R. G., 1983, Localization, synthesis, and activity of an antigenic site on influenza virus hemagglutinin, Proc. Natl. Acad. Sci. U.S.A. 80:840–844.

    Article  PubMed  CAS  Google Scholar 

  • Baez, M., Palese, P., and Kilbourne, E. D., 1980, Gene composition of high-yielding influenza vaccine strains obtained by recombination,J. Infect. Dis. 141:362–365.

    Article  PubMed  CAS  Google Scholar 

  • Banks, J., Bevan, C., Fennerty, A., et al., 1985, Association between rise in antibodies and increase in airway sensitivity after intramuscular injection of killed influenza virus in asthmatic patients, Eur. J. Respir. Dis. 66:268–272.

    PubMed  CAS  Google Scholar 

  • Barker, W. H., and Mullooly, J. P., 1980, Influenza vaccination of elderly persons, J.A.M.A. 244:2547–2549.

    Article  PubMed  CAS  Google Scholar 

  • Barker, W. H., and Mullooly, J. P., 1982, Pneumonia and influenza deaths during epidemics: Implications for prevention, Arch. Intern. Med. 142:85–89.

    Article  PubMed  CAS  Google Scholar 

  • Barry, D. W., Mayner, R. E., Hochstein, H. D., et al., 1976a, Comparative trial of influenza vaccines. II. Adverse reactions in children and adults, Am. J. Epidemiol. 104:47–59.

    PubMed  CAS  Google Scholar 

  • Barry, D. W., Mayner, R. E., Staton, E., et al., 1976b, Comparative trial of influenza vaccines. I. Im-munogenicity of whole virus and split product vaccines in man, Am. J. Epidemiol. 104:34–46.

    PubMed  CAS  Google Scholar 

  • Baskerville, A., Thomas, G., and Peacock, S., 1975, Pathological aspects of immunization of mice against influenza virus infection, Br. J. Exp. Pathol. 56: 17–27.

    PubMed  CAS  Google Scholar 

  • Beare, A. S., 1975, Live viruses for immunization against influenza, Prog. Med. Virol. 20:49–83.

    PubMed  CAS  Google Scholar 

  • Beare, A. S., and Bynoe, M. L., 1969, Attenuation of human influenza A viruses, Br. Med. J. 4:198–201.

    Article  PubMed  CAS  Google Scholar 

  • Beare, A. S., Bynoe, M. L., and Tyrrell, D. A. J., 1968a, Investigation into the attenuation of influenza viruses by serial passage, Br. Med. J. 4:482–484.

    Article  PubMed  CAS  Google Scholar 

  • Beare, A. S., Hobson, D., Reed, S. E., et al., 1968b, A comparison of live and killed influenza-virus vaccines, Lancet 2:418–420.

    Article  PubMed  CAS  Google Scholar 

  • Beare, A. S., Schild, G. C., and Craig, J. W., 1975, Trials in man with live recombinants made from A/PR/8/34 (H0N1) and wild H3N2 influenza viruses, Lancet 2:729–738.

    Article  PubMed  CAS  Google Scholar 

  • Becht, H., Huang, R. T. C., Fleisher, B., et al., 1984, Immunogenic properties of the small chain HA2 of the haemagglutinin of influenza viruses, J. Gen. Virol. 65:173–183.

    Article  PubMed  CAS  Google Scholar 

  • Beebe, G. W., Simon, A. H., and Vivona, S., 1964, Follow-up study on army personnel who received adjuvant influenza virus vaccine, 1951–1953, Am. J. Med. Sci. 247:385–406.

    Article  PubMed  CAS  Google Scholar 

  • Bell, T. D., Chai, H., Berlow, B., et al., 1978, Immunization with killed influenza virus in children with chronic asthma, Chest 73:140–145.

    Article  PubMed  CAS  Google Scholar 

  • Bennink, J. R., Yewdell, J. W., Smith, G. L., et al., 1984, Recombinant vaccinia virus primes and stimulates influenza hemagglutinin-specific cytotoxic T cells, Nature 311:578–579.

    Article  PubMed  CAS  Google Scholar 

  • Bernstein, D. I., and Cherry, J. D., 1983, Clinical reactions and antibody responses to influenza vaccines, Am. J. Dis. Child. 137:622–626.

    PubMed  CAS  Google Scholar 

  • Bernstein, D. I., Zahradnik, J. M., DeAngelis, C. J., et al., 1982, Influenza immunization in children and young adults, Am. J. Dis. Child. 36:513–517.

    Google Scholar 

  • Betts, R. F., Douglas, R. G., Jr., Roth, F. K., et al., 1977, Efficacy of live attenuated influenza A/Scot-land/74 (H3N2) virus vaccine against challenge with influenza A/Victoria/3/75 (H3N2) virus, J. Infect. Dis. 136:746–753.

    Article  PubMed  CAS  Google Scholar 

  • Beutner, K. R., Chow, T., Rubi, E., et al., 1979, Evaluation of a neuraminidase-specific influenza A virus vaccine in children: Antibody responses and effects on two successive outbreaks of natural infection, J. Infect. Dis. 140:844–850.

    Article  PubMed  CAS  Google Scholar 

  • Bierman, C. W., Shapiro, G. G., Pierson, W. E., et al., 1977, Safety of influenza vaccination in allergic children, J. Infect. Dis. 136:S652–S655.

    Article  PubMed  Google Scholar 

  • Biro, J., and Beregi, E., 1980, The influence of influenza vaccinations on human peripheral lymphocytes relating to aging, Akt. Gerontol. 10:319–322.

    CAS  Google Scholar 

  • Blumberg, S., Bienfang, D., and Kantrowitz, F. G., 1980, A possible association between influenza vaccination and small-vessel vasculitis, Arch. Intern. Med. 140:847–848.

    Article  PubMed  CAS  Google Scholar 

  • Boffey, P. M., 1976, Swine flu campaign: Should we vaccinate the pigs? Science 192:870.

    Article  PubMed  CAS  Google Scholar 

  • Both, G. W., Shi, C. H., and Kilbourne, E. D., 1983, Hemagglutinin of swine influenza virus: A single amino acid change pleiotropically affects viral antigenicity and replication, Proc. Natl. Acad. Sci. U.S.A. 80:6996–7000.

    Article  PubMed  CAS  Google Scholar 

  • Brooks, R., and Reznik, A., 1980, Guillain-Barre syndrome following trivalent influenza vaccine in an elderly patient, Mt. Sinai J. Med. 47:190–191.

    PubMed  CAS  Google Scholar 

  • Brown, L. A., Dopheide, T. A. A., Ward, C. W., et al., 1980, Antigenic determinants of influenza virus hemagglutinin. V. Antigenicity of the HA2 chain, J. Immunol. 125:1583–1588.

    PubMed  CAS  Google Scholar 

  • Bruyn, H. B., Meiklejohn, G., and Brainerd, H. D., 1949, Influenza vaccination: A comparison of antibody response obtained by various methods of administration, J. Immunol. 62:1–11.

    PubMed  CAS  Google Scholar 

  • Buchner, D. M., Carter, W. B., and Inui, T. S., 1985, The relationship of attitude changes to compliance with influenza immunization, Med. Care 23:771–779.

    Article  PubMed  CAS  Google Scholar 

  • Budnick, L. D., Stricof, R. L., and Ellis, F., 1984, An outbreak of influenza A in a nursing home, 1982, N.Y. State J. Med. 84:235–238.

    PubMed  CAS  Google Scholar 

  • Bukowskyj, M., Munt, P. W., Wigle, R., et al., 1984, Theophylline clearance, Am. Rev. Respir. Dis. 129:672–675.

    PubMed  CAS  Google Scholar 

  • Burlington, D. B., Wright, P. F., van Wyke, K. L., et al., 1985, Development of subtype-specific and heterosubtypic antibodies to the influenza A virus hemagglutinin after primary infection in children, J. Clin. Microbiol. 21:847–849.

    PubMed  CAS  Google Scholar 

  • Burnet, F. M., 1943, Immunization against epidemic influenza with living attenuated virus, Med. J. Aust. 1:385–389.

    Google Scholar 

  • Buttar, K., Chernesky, M., and Dolovich, J., 1981, Cutaneous responses to tests with influenza vaccines, Ann. Allergy 46:183–188.

    PubMed  CAS  Google Scholar 

  • Cannata, J., Cuesta, V., Peral, V., et al., 1981, Reactivation of vasculitis after influenza vaccination, Br. Med. J. 83:526.

    Article  Google Scholar 

  • Caspary, E. A., Currie, S., Walton, J. N., et al., 1971, Lymphocyte sensitization to nervous tissues and muscle in patients with the Guillain-Barre syndrome, J. Neurol. Neurosurg. Psychiatry 34:179–181.

    Article  PubMed  CAS  Google Scholar 

  • Centers for Disease Control, 1985a, Immunization Practices Advisory Committee, recommendations, Morbid. Mortal. Weekly Rep. 34:262–267.

    Google Scholar 

  • Centers for Disease Control, 1985b, Implementation of recommendations for influenza control, Morbid. Mortal. Weekly Rep. 34:639–643.

    Google Scholar 

  • Chenoweth, A., Waltz, A. D., Stokes, J., Jr., et al., 1936, Active immunization with the viruses of human and swine influenza, Am. J. Dis. Child. 52:757–758.

    Google Scholar 

  • Clark, A., Potter, C. W., Jennings, R., et al., 1983, A comparison of live and inactivated influenza A (H1N1) virus vaccines, J. Hyg. (Camb.) 90:361–370.

    Article  CAS  Google Scholar 

  • Clements, M. L., and Murphy, B. R., 1986, Development and persistence of local systemic antibody responses in adults given live attenuated or inactivated influenza A virus vaccine, J. Clin. Microbiol. 23:66–72.

    PubMed  CAS  Google Scholar 

  • Clements, M. L., O’Donnell, S., Levine, M. M., et al., 1983, Dose response of A/Alaska/6/77 (H3N2) cold-adapted reassortant vaccine virus in adult volunteers: Role of local antibody in resistance to infection with vaccine virus, Infect. Immun. 40:1044–1051.

    PubMed  CAS  Google Scholar 

  • Clements, M. L., Betts, R. F., Maassab, H. F., et al., 1984a, Dose response of influenza A/Washing-tonJ897J80 (H3N2) cold-adapted reassortment virus in adult volunteers, J. Infect. Dis. 149:814.

    Article  PubMed  CAS  Google Scholar 

  • Clements, M. L., Betts, R. F., and Murphy, B. R., 1984b, Advantage of live attenuated cold-adapted influenza A virus over inactivated vaccine for A/Washington/80 (H3N2) wild-type virus infection, Lancet 1:705.

    Article  PubMed  CAS  Google Scholar 

  • Clements, M. L., Betts, R. F., Tierney, E. L., et al., 1986, Resistance of adults to challenge with influenza A wild-type virus after receiving live or inactivated virus vaccine, J Clin. Microbiol. 23:73–76.

    PubMed  CAS  Google Scholar 

  • Cole, P. J., and Molyneux, M. E., 1980, Immunological sensitization of human lymphocytes after influenza vaccination, J Infect. 2:67–77.

    Article  PubMed  CAS  Google Scholar 

  • Cook, S. D., Dowling, P. C., and Whitaker, J. N., 1970, The Guillain-Barre syndrome, Arch. Neurol. 22:470–474.

    Article  PubMed  CAS  Google Scholar 

  • Couch, R. B., Douglas, R. G., Fedson, D. S., et al., 1971, Correlated studies of a recombinant influenza-virus vaccine. III. Protection against experimental influenza in man, J. Infect. Dis. 124:473–480.

    Article  PubMed  CAS  Google Scholar 

  • Couch, R. B., Kasel, J. A., Gerin, J. L., et al., 1974, Induction of partial immunity to influenza by a rieuramirridase-specificvaccine, J Infect. Dis. 129:411–420.

    Article  PubMed  CAS  Google Scholar 

  • Couch, R. B., Webster, R. G., Kasel, J. A., et al., 1979, Efficacy of purified influenza subunit vaccines and relation to the major antigenic determinants on the hemagglutinin molecule, J. Infect. Dis. 140:553–559.

    Article  PubMed  CAS  Google Scholar 

  • Cox, N. J., and Kendal, A. P., 1984, Genetic stability of A/Ann Arbor/6/60 cold-mutant (temperature-sensitive) live influenza virus genes: Analysis by oligonucleotide mapping of recombinant vaccine strains before and after replication in volunteers, J. Infect. Dis. 149:194–200.

    Article  PubMed  CAS  Google Scholar 

  • Cox, N. J., Kendal, A. P., Shilov, A. A., et al., 1985, Comparative studies of A/Leningrad/134/57 wild-type and 47-times passaged cold-adapted mutant influenza viruses: Oligonucleotide mapping and RNA-RNA hybridization studies, J. Gen. Virol. 66:1697–1704.

    Article  PubMed  CAS  Google Scholar 

  • Crawford, C. R., Jennings, R., Bradford, N., et al., 1982, The effect of bacterial peptidoglycans on the immune response of hamsters to influenza virus vaccines, Clin. Exp. Immunol. 48:739–746.

    PubMed  CAS  Google Scholar 

  • Crawford, C. R., Faiza Mukhlis, F. A., Jennings, R., et al., 1984, Use of zwitterionic detergent for the preparation of an influenza virus vaccine. 1. Preparation and characterization of disrupted virions, Vaccine 2: 193–198.

    Article  PubMed  CAS  Google Scholar 

  • Davenport, F. M. 1961, Applied immunology of mineral oil adjuvants, J. Allergy 32:177–189.

    Article  Google Scholar 

  • Davis, A. R., Bos, T., Ueda, M., et al., 1983, Immune response to human influenza virus hemagglutinin expressed in Escherichia coli, Gene 21:273–284.

    Article  PubMed  CAS  Google Scholar 

  • Dierckx, J. P., Raindorf, M., and Gillard, C., 1976, Surveillance da la fonction respiratoire chez des sujects souffrant de bronchopathie chronique, vaccines par une souche vivante attenuee de virus grippal (RIT 4025), Acta Tuberc, Pneumon. Belg. 67:23–31.

    CAS  Google Scholar 

  • Dolin, R., Wise, T. G., Mazur, M. H., et al., 1977, Immunogenicity and reactogenicity of influenza A/New Jersey/76 virus vaccines in normal adults, J. Infect. Dis. (Suppl.) 136:435–442.

    Google Scholar 

  • Dolin, R., Reichman, R. C., Madore, H. P., et al., 1982, A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection, N. Engl J. Med. 307:580–584.

    Article  PubMed  CAS  Google Scholar 

  • Dowdle, W. R., 1977, The swine flu vaccine program, Am. Soc. Microbiol News 43:243–246.

    Google Scholar 

  • Dowdle, W. R., Millar, J. D., Schonberger, L. B., et al., 1980, Influenza immunization policies and practices in Japan, J. Infect. Dis. 141:258–264.

    Article  PubMed  CAS  Google Scholar 

  • Downie, J. C., 1984, A genetic and monoclonal analysis of high-yielding reassortants of influenza A virus used for human vaccines, J. Biol. Stand. 12:101–110.

    Article  PubMed  CAS  Google Scholar 

  • Dreesman, G. R., and Kennedy, R. C., 1985, Anti-idiotypic antibodies: Implications of internal image-based vaccines for infectious diseases, J. Infect. Dis. 151:761–765.

    Article  PubMed  CAS  Google Scholar 

  • Dull, W. L., Seria, J., Bloomfield, J., et al., 1980, Effects of influenza vaccination on pulmonary function, Bull Eur. Physiopathol. Respir. 16:655–661.

    PubMed  CAS  Google Scholar 

  • Dunn, G. F. N., and Wormald, P. J., 1973, Influenza-A Hong-Kong vaccine and the new variant A/ENG/42/72, Lancet 1:95.

    Article  PubMed  CAS  Google Scholar 

  • Ennis, R. A., Dowdle, W. R., Barry, D. W., et al., 1977a, Endotoxin content and clinical reactivity to influenza vaccines, J. Biol. Stand. 5:165–172.

    Article  PubMed  CAS  Google Scholar 

  • Ennis, F. A., Mayner, R. E., Barry, D. N., et al., 1977b, Correlation of laboratory studies with clinical responses to A/New Jersey influenza vaccines, J. Infect. Dis. 136:S397–406.

    Article  PubMed  Google Scholar 

  • Ennis, F. A., Yi-Hua, Q., and Schild, G. C., 1982, Antibody and cytotoxic T lymphocyte responses of humans to live and inactivated influenza vaccines, J. Gen. Virol 58:273–281.

    Article  PubMed  CAS  Google Scholar 

  • Erickson, A. H., 1977, Different trypsin-sensitivity of the hemagglutinin from antigenically similar recombinant influenza vaccines, Doctoral dissertation, The City University of New York.

    Google Scholar 

  • Evans, A. S., and Kraus, G., 1978, Immunization against swine influenza in the Yale University community, Yale J. Biol. Med. 51:165–176.

    PubMed  CAS  Google Scholar 

  • Fedson, D. S., and Kessler, H. A., 1983, A hospital-based influenza immunization program, 1977–78, Am. J. Public Health 73:442–445.

    Article  PubMed  CAS  Google Scholar 

  • Felix, J. K., Schwartz, R. H., and Myers, G. J., 1976, Isolated hypoglossal nerve paralysis following influenza vaccination, Am. J. Dis. Child. 130:82–83.

    PubMed  CAS  Google Scholar 

  • Fell, P. J., O’Donnell, H. F., Watson, N. P., et al., 1977, Longer term effects of live influenza vaccine in patients with chronic pulmonary disease, Lancet 1:1282–1284.

    Article  PubMed  CAS  Google Scholar 

  • Foy, H. M., Cooney, M., McMahan, R., et al., 1969, A field trial of Hong Kong-strain influenza vaccine in Seattle schoolchildren, Bull WHO 41:564–566.

    PubMed  CAS  Google Scholar 

  • Francis, T., Pearson, H. E., Salk, J. E., et al., 1944, Immunity in human subjects artificially infected with influenza virus, type B, Am. J. Public Health 34:317–334.

    Article  CAS  Google Scholar 

  • Frank, A. L., Webster, R. G., Glezen, W. P., et al., 1981, Immunogenicity of influenza A/USSR (H1N1) subunit vaccine in unprimed young adults, J. Med. Virol 7:135–142.

    Article  PubMed  CAS  Google Scholar 

  • Ganz, P. A., Shanley, J. D., and Cherry, J. D., 1978, Responses of patients with neoplastic diseases to influenza virus vaccine, Cancer 42:2244–2247.

    Article  PubMed  CAS  Google Scholar 

  • Gaydos, J. C., Hodder, R. A., Top, F. H., et al., 1977a, Swine influenza at Fort Dix, New Jersey (January-February 1976). I. Case finding and clinical study of cases, J. Infect. Dis. 136:S356–S362.

    Article  PubMed  Google Scholar 

  • Gaydos, J. C., Hodder, R. A., Top, F. H., et al., 1977b, Swine influenza at Fort Dix, New Jersey (January-February 1976). II. Transmission and morbidity in units with cases, J Infect. Dis. 136:S363–S375.

    Article  PubMed  Google Scholar 

  • Ghendon, Y. Z., Polezhaev, F. I., Lisovskaya, K. V., et al., 1984, Recombinant cold-adapted attenuated influenza A vaccines for use in children: Molecular genetic analysis of the cold-adapted donor and recombinants, Infect. Immun. 44:730–733.

    PubMed  CAS  Google Scholar 

  • Goldfield, M., Bartley, J. D., Pizzuti, W., et al., 1977, Influenza in New Jersey in 1976: Isolations of influenza A/New Jersey/76 virus at Fort Dix, J. Infect. Dis. 136:S347–S355.

    Article  PubMed  Google Scholar 

  • Gomolin, I. H., Chapron, D. J., and Luhan, P. A., 1985, Lack of effect of influenza vaccine on theophylline levels and warfarin anticoagulation in the elderly, J. Am. Geriatr. Soc. 33:269–272.

    PubMed  CAS  Google Scholar 

  • Goodeve, A., Potter, C. W., Clark, A., et al., 1983, A graded-dose study of inactivated, surface antigen influenza B vaccine in volunteers: Reactogenicity, antibody response and protection to challenge virus infection, J. Hyg. (Camb.) 90:107–115.

    Article  CAS  Google Scholar 

  • Goodeve, A. C., Jennings, R., and Potter, C. W., 1985, Reassortants of influenza B viruses for use in vaccines: An evaluation, Arch. Virol. 83:169–179.

    Article  PubMed  CAS  Google Scholar 

  • Graves, P. N., Schulman, J. L., Young, J. F., et al., 1983, Preparation of influenza virus subviral particles lacking the HAl subunit of hemagglutinin: Unmasking of cross-reactive HA2 determinants, Virology 126:106–116.

    Article  PubMed  CAS  Google Scholar 

  • Green, N., Alexander, H., Olson, A., et al., 1982, Immunogenic structure of the influenza virus hemagglutinin, Cell 28:477–487.

    Article  PubMed  CAS  Google Scholar 

  • Greenstreet, R. L., 1984, Estimation of the probability that Guillain-Barre syndrome was caused by the swine flu vaccine: U.S. experience (1976–1977), Med. Sci. Law 24:61–67.

    PubMed  CAS  Google Scholar 

  • Gremillion, D. H., Meiklejohn, G., Graves, P., et al., 1983, Efficacy of single-dose influenza immunization in Air Force recruits,J. Infect. Dis. 147:1099.

    Article  PubMed  CAS  Google Scholar 

  • Gross, P. A., 1977, Reactogenicity and immunogenicity of bivalent influenza vaccine in one-and two-dose trials in children: A summary, J. Infect. Dis. 136:S616–S625.

    Article  PubMed  Google Scholar 

  • Gross, P. A., Ennis, F. A., Gaerlan, P. F., et al., 1981, Comparison of new triton X-100 and tween-ether-treated split-product vaccines in children, J. Clin. Microbiol. 14:534–538.

    PubMed  CAS  Google Scholar 

  • Gross, P. A., Gould, A. L., and Brown, A. E., 1985, Effect of cancer chemotherapy on the immune response to influenza virus vaccine: Review of published studies, Rev. Infect. Dis. 7:613–618.

    Article  PubMed  CAS  Google Scholar 

  • Grossebauer, K., Langmaack, H., Schmidt, B., et al., 1969, Enhancement and neutralization of pyroge-nicity of influenza viruses by biologically active substances, Arch. Ges. Virusforsch. 28:151–164.

    Article  Google Scholar 

  • Gwaltney, J. M., DeSanctis, A. N., Metzgar, D. P., et al., 1977, Systematic reactions to influenza B vaccine. Am. J. Epidemiol. 105:252–260.

    PubMed  CAS  Google Scholar 

  • Hackett, C. J., Taylor, P. M., and Askonas, B. A., 1983, Stimulation of cytotoxic T cells by liposomes containing influenza virus or its components, Immunology 49:255–263.

    PubMed  CAS  Google Scholar 

  • Hackett, C. J., Hurwitz, J. L., Dietzschold, B., et al., 1985, A synthetic decapeptide of influenza virus hemagglutinin elicits helper T cells with the same fine recognition specificities as occur in response to whole virus, J. Immunol. 135:1391–1394.

    PubMed  CAS  Google Scholar 

  • Hall, W. J., Douglas, R. G., Jr., Zaky, D. A., et al., 1976, Attenuated influenza virus in normal adults: Role of pulmonary function studies in vaccine trials, J. Infect. Dis. 133:145–152.

    Article  PubMed  CAS  Google Scholar 

  • Halperin, W., Weiss, W. I., Altman, R., et al., 1979, A comparison of intradermal and subcutaneous routes of influenza vaccination with A/New Jersey/76 (swine flu) and A/Victoria/75: Report of a study and review of the literature, Am. J. Public Health 69:1247–1251.

    Article  PubMed  CAS  Google Scholar 

  • Hamzawi, J., Jennings, R., and Potter, C. W., 1981, Antigenicity in hamsters of inactivated vaccines prepared from recombinant influenza viruses, J. Hyg. (Camb.) 87:453–464.

    Article  CAS  Google Scholar 

  • Hasselbacher, P., 1977, Neuropathy after influenza vaccination, Lancet 1:551–552.

    Article  PubMed  CAS  Google Scholar 

  • Helenius, A., and Simons, K., 1975, Solubilization of membranes by detergents, Biochim. Biophys. Acta 415:29.

    PubMed  CAS  Google Scholar 

  • Henle, W., and Henle, G., 1945, Effects of adjuvants on vaccination of human beings against influenza, Proc. Soc. Exp. Biol. Med. 59:179–181.

    Google Scholar 

  • Herbert, A. A., Larke, R. P. B., and Markstad, E. L., 1979, Comparison of responses to influenza A/New Jersey/76-A/Victoria/75 virus vaccine administered intradermally or subcutaneously to adults with chronic respiratory disease, J. Infect. Dis. 140:234–238.

    Article  PubMed  CAS  Google Scholar 

  • Higashihara, M. 1975, Studies on genetic recombinants of influenza virus, Kitasato Arch. Exp. Med. 48:183–188.

    PubMed  CAS  Google Scholar 

  • Hilleman, M. R., 1966, Critical appraisal of emulsified oil adjuvants applied to viral vaccines in: Progress in Medical Virology ,Volume 8 (J. L. Melnick, ed.), S. Karger, Basel, pp. 131–182.

    Google Scholar 

  • Hilleman, M. R., 1977, Serologic responses to split and whole swine influenza virus vaccines in light of the next influenza pandemic, J. Infect. Dis. 136:S683–S685.

    Article  PubMed  Google Scholar 

  • Hirst, G. K., Rickard, E. R., Whitman, L., et al., 1942, Antibody response of human beings following vaccination with influenza viruses, J. Exp. Med. 75:495–511.

    Article  PubMed  CAS  Google Scholar 

  • Hodder, R. A., Gaydos, J. C., Allen, R. G., et al., 1977, Swine influenza A at Fort Dix, New Jersey (January-February 1976). III. Extent of spread and duration of the outbreak, J. Infect. Dis. 136:S369–S375.

    Article  PubMed  Google Scholar 

  • Hodges, G. R., Davis, J. W., Lewis, D., et al., 1979, Response to influenza A vaccine among high-risk patients, South. Med. J. 72:29–32.

    Article  PubMed  CAS  Google Scholar 

  • Hoskins, T. W., 1977, Systemic reactions to influenza vaccine containing killed influenza A/.New Jersey/8/76, Practitioner 219:400–401.

    PubMed  CAS  Google Scholar 

  • Hoskins, T. W., Davies, J. R., Allchin, A., et al., 1973, Controlled trial of inactivated influenza vaccine containing the A/Hong Kong strain during an outbreak of influenza due to the A/England/42/72 strain, Lancet 2:116–120.

    Article  PubMed  CAS  Google Scholar 

  • Hoskins, T. W., Davies, J. R., Smith, A. J., et al., 1979, Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ’s Hospital, Lancet 1:33–35.

    Article  PubMed  CAS  Google Scholar 

  • Houston, T. P., 1983, Small-vessel vasculitis following simultaneous influenza and pneumococcal vaccination, N.Y. State J. Med. 83:1182–1183.

    PubMed  CAS  Google Scholar 

  • Hruskova, J., Syrucek, L., Zaradova, H., et al., 1978, Secretory antibody response to haemagglutinin of influenza virus A/Swine and A/Victoria in humans after administration of split and whole-virion vaccine, J. Biol. Stand. 6:181–185.

    Article  PubMed  CAS  Google Scholar 

  • Hurwitz, E. S., Schonberger, L. B., Nelson, D. B., et al., 1981, Guillain-Barre syndrome and the 1978–1979 influenza vaccine, N. Engl. J. Med. 304:1557–1561.

    Article  PubMed  CAS  Google Scholar 

  • Infectious Disease Branch, NIAID, 1976, Memo: Immunizations to protect individuals working with influenza virus, April 28, NIH, Bethesda.

    Google Scholar 

  • Iwasaki, T., and Nozima, T., 1977, Defense mechanisms against primary influenza virus infection in mice. I. The roles of interferon and neutralizing antibodies and thymus dependence of interferon and antibody production, J. Immunol. 118:256–263.

    PubMed  CAS  Google Scholar 

  • Jennings, R., and Potter, C. W., 1973, Enhanced response to influenza A vaccines in hamsters primed by prior heterotype influenza infection, Arch. Ges. Virusforsch. 42:197–206.

    Article  PubMed  CAS  Google Scholar 

  • Jennings, R., Smith, T. L., Spencer, R. C., et al., 1984, Inactivated influenza virus vaccines in man: A comparative study of subunit and split vaccines using two methods for assessment of antibody responses, Vaccine 2:75–80.

    Article  PubMed  CAS  Google Scholar 

  • Jennings, R., Smith, T. L., Mellersh, A. R., et al., 1985, Antibody response and persistence in volunteers following immunization with varying dosages of a trivalent surface antigen influenza virus vaccine, J. Hyg. (Camb.) 94:87–95.

    Article  CAS  Google Scholar 

  • Johannsen, R., Moser, H., Hinz, J., et al., 1983, The quantification of the haemagglutinin content of influenza whole virus and Tween-ether split vaccines,J. Biol. Stand. 11:341–352.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, P. R., Feldman, S., Thompson, J. M., et al., 1985, Comparison of long-term systemic and secretory antibody responses in children given live, attenuated, or inactivated influenza A vaccine, J. Med. Virol. 17:325–335.

    Article  PubMed  Google Scholar 

  • Journal of the American Medical Association ,1984, AMA offers recommendations for vaccine injury compensation, J.A.M.A. 252:2937–2946.

    Article  Google Scholar 

  • Kaplan, J. E., Katona, P., Hurwitz, E. S., et al., 1982, Guillain-Barre syndrome in the United States, 1979–1980 and 1980–1981, J.A.M.A. 248:698–700.

    Article  PubMed  CAS  Google Scholar 

  • Kasel, J. A., Six, H. R., Couch, R. B., et al., 1979, Variant-specific antihemagglutinin serum response to type A influenza natural infection and inactivated vaccines in adults, Proc. Soc. Exp. Biol. Med. 161:519–521.

    PubMed  CAS  Google Scholar 

  • Kava, T., and Laitinen, L. A., 1985, Effects of killed and live attenuated influenza vaccine on symptoms and specific airway conductance in asthmatics and healthy subjects, Allergy 40:42–47.

    Article  PubMed  CAS  Google Scholar 

  • Kavet, J., 1972, Influenza and Public Health ,Masters thesis, Harvard School of Public Health, Boston.

    Google Scholar 

  • Kavet, J., 1976, Vaccine utilization: Trends in the implementation of public policy in the U.S.A., in: Influenza: Virus Vaccines Strategy (P. Selby, ed.), Academic Press, New York, pp. 297–308.

    Google Scholar 

  • Kendal, A. P., Goldfield, M., Noble, G. R., 1977a, Identification and preliminary antigenic analysis of swine influenza-like viruses isolated during an influenza outbreak at Fort Dix, New Jersey, J. Infect. Dis. 136:S381–S385.

    Article  PubMed  Google Scholar 

  • Kendal, A. P., Noble, G. R., and Dowdle, W., 1977b, Neuraminidase content of influenza vaccines and neuraminidase antibody responses after vaccination of immunological primed and unprimed populations, J. Infect. Dis. 136:S415–424.

    Article  PubMed  Google Scholar 

  • Khan, M. W., Gallagher, M., Bucher, D., et al., 1982, Detection of influenza virus neuraminidase-specific antibodies by an enzyme-linked immunosorbent assay, J. Clin. Microsc. 16:115–122.

    CAS  Google Scholar 

  • Kilbourne, E. D., 1969, Future influenza vaccines and the use of genetic recombinants, Bull WHO 41:643–645.

    PubMed  CAS  Google Scholar 

  • Kilbourne, E. D., 1976a, Op-ed page, New York Times ,February 13, p. 33.

    Google Scholar 

  • Kilbourne, E. D., 1976b, Comparative efficacy of neuraminidase-specific and conventional influenza virus vaccines in the induction of anti-neuraminidase antibody in man, J. Infect. Dis. 134:384–394.

    Article  PubMed  CAS  Google Scholar 

  • Kilbourne, E. D., 1977, Influenza pandemics in perspective, J.A.M.A. 237:1225–1228.

    Article  PubMed  CAS  Google Scholar 

  • Kilbourne, E. D., 1978, Opinion: Influenza as a problem in immunology, J. Immunol. 120:1447–1452.

    PubMed  CAS  Google Scholar 

  • Kilbourne, E. D., 1979, Swine flu: The virus that vanished, Human Nature 2:68–73.

    Google Scholar 

  • Kilbourne, E. D., 1984, Immunization strategy: Infection-permissive vaccines for the modulation of infection, in: Modern Approaches to Vaccines (R. M. Chanock and R. A. Lerner, eds.), Cold Spring Harbor Laboratory, New York, pp. 269–274.

    Google Scholar 

  • Kilbourne, E. D., 1985, Problems inherent in artificial immunization, Microbiology-1985, 243–246.

    Google Scholar 

  • Kilbourne, E. D., and Murphy, J. S., 1960, Genetic studies of influenza viruses. I. Viral morphology and growth capacity as exchangeable genetic traits. Rapid in ovo adaptation of early passage Asian strain isolates by combination with PR8. J. Exp. Med. 111:387–406.

    Article  PubMed  CAS  Google Scholar 

  • Kilbourne, E. D., Laver, W. G., Schulman, J. L., et al., 1968, Antiviral activity of antiserum specific for an influenza virus neuraminidase. I. In vitro effects, J. Virol. 2:281–288.

    PubMed  CAS  Google Scholar 

  • Kilbourne, E. D., Schulman, J. L., Schild, G. C., et al., 1971, Correlated studies of a recombinant influenza-virus vaccine. I. Derivation and characterization of virus and vaccine. J. Infect. Dis. 124:449–462.

    Article  PubMed  CAS  Google Scholar 

  • Kilbourne, E. D., Chanock, R. M., Choppin, P. W., et al., 1974, Influenza vaccine: summary of influenza workshop V, J. Infect. Dis. 129:770–771.

    Article  Google Scholar 

  • Kilbourne, E. D., McGregor, S., and Easterday, B. C., 1981, Transmission of swine of hemagglutinin mutants of swine influenza virus, in: The Replication of Negative Strand Viruses (D. H. Bishop and R. W. Compans, eds.), Elsevier/North Holland, Amsterdam, pp. 449–453.

    Google Scholar 

  • Kilbourne, E. D., Gerhard, W., and Whitaker, C. W., 1983, Monoclonal antibodies to the hemagglutinin Sa antigenic site of A/PR/8/23 influenza virus distinguish biologic mutants of swine influenza virus, Proc. Natl. Acad. Sci. U.S.A. 80:6996–7000.

    Article  PubMed  Google Scholar 

  • Klimov, A., Ghendon, Y., Zavadova, H., et al., 1983, High reproduction capacity of recombinants between H3N2 human influenza and fowl plague viruses is due to the gene coding for M proteins, Acta Virol. 27:434–438.

    PubMed  CAS  Google Scholar 

  • Kramer, P., and McClain, C. J., 1981, Depression of aminopyrine metabolism by influenza vaccination, N Engl. J. Med. 305:1262–1264.

    Article  PubMed  CAS  Google Scholar 

  • Kramer, P., Tsuru, M., Cook, C. E., et al., 1984, Effect of influenza vaccine on warfarin anticoagulation, Clin. Pharmacol. Ther. 35:416–418.

    Article  PubMed  CAS  Google Scholar 

  • Kreuter, J., Mauler, R., Gruschkau, H., et al., 1976, The use of new polymethylmethacrylate adjuvants for split influenza vaccines, Exp. Cell Biol. 44:12–19.

    PubMed  CAS  Google Scholar 

  • Kuwert, E. K., Werner, J., Scheiermann, N., et al., 1979, Local and systemic antibody response after vaccination with 3 different types of vaccines against influenza. I. Hemagglutination inhibiting antibodies. Zentralbl. Bakteriol. Hyg. 244:155–174.

    CAS  Google Scholar 

  • Lamb, J. R., Eckels, D. D., Lake, P., et al., 1982, Human T-cell clones recognize chemically synthesized peptides of influenza hemagglutinin, Nature 300:66–69.

    Article  PubMed  CAS  Google Scholar 

  • La Montagne, J. R., Noble, G. R., Quinnan, G. V., et al., 1983, Summary of clinical trials of inactivated influenza vaccine-1978, Rev. Infect. Dis. 5:723–736.

    Article  PubMed  Google Scholar 

  • Lang, G., 1981, Turkey influenza vaccination. Vet. Rec. 108:425.

    Article  PubMed  CAS  Google Scholar 

  • Langmuir, A. D., 1979, Guillain-Barre syndrome: The swine influenza virus vaccine incident in the United States of America, 1976–77: Preliminary communication, J. R. Soc. Med. 72:660–669.

    PubMed  CAS  Google Scholar 

  • Langmuir, A. D., Bregman, D. J., Kurland, L. T., et al., 1984, An epidemiologic and clinical evaluation of Guillain-Barre syndrome reported in association with the administration of swine influenza vaccines,J. Epidemiol. 119:841–879.

    CAS  Google Scholar 

  • Lazzell, V., Waldman, R. H., Rose, C., 1984, Immunization against intluenza in humans using an oral enteric-coated killed virus vaccine, J. Biol. Stand. 12:315–321.

    Article  PubMed  CAS  Google Scholar 

  • Leibovitz, A., Coultrip, R. L., Kilbourne, E. D., et al., 1971, Correlated studies of a recombinant influenza-virus vaccine. IV. Protection against naturally occurring influenza in military trainees, J. Infect. Dis. 124:481–487.

    Article  PubMed  CAS  Google Scholar 

  • Lerman, S. J., Wright, P. F., and Patil, K. D., 1980, Antibody decline in children following A/New Jersey/76 influenza virus immunization, J. Pediatr. 96:271–274.

    Article  PubMed  CAS  Google Scholar 

  • Levine, M., Jones, M. W., and Gribble, M., 1984, Increased serum phenytoin concentration following influenza vaccination, Clin. Pharm. 3:505–509.

    PubMed  CAS  Google Scholar 

  • Lyons, J. E., 1976, The manufacturers’ role in the preparation of swine flu vaccine, in: Meeting of the New Jersey Public Health Association, June 23, Fort Dix, N.J.

    Google Scholar 

  • Maassab, H. F., 1967, Adaptation and growth characteristics of influenza virus at 25°C, Nature 213:612–614.

    Article  PubMed  CAS  Google Scholar 

  • Maassab, H. F., Monto, A. S., and DeBorde, D. C., et al., 1981, Development of cold recombinants of influenza virus as live virus vaccines, in: Genetic Variation among Influenza Viruses (D. P. Nayak, ed.), ICN-UCLA Symposia on Molecular and Cellular Biology ,Vol. XXI, Academic Press, New York, pp. 617–637.

    Google Scholar 

  • Maassab, H. R., Kendal, A. P., Abrams, G. D., et al., 1982, Evaluation of a cold-recombinant influenza virus vaccine in ferrets, J. Infect. Dis. 146:780–790.

    Article  PubMed  CAS  Google Scholar 

  • MacKenzie, J. S., 1977, Influenza subunit vaccine: Antibody responses to one and two doses of vaccine and length of response, with particular reference to the elderly, Br. Med. J. 1:200–202.

    Article  PubMed  CAS  Google Scholar 

  • Macoul, K. L., 1982, Bilateral optic nerve atrophy and blindness following swine influenza vaccination, Ann. Ophthalmol. 14:398–399.

    PubMed  CAS  Google Scholar 

  • MacPherson, B. V., Ashikaga, T., Dennis, S. M., et al., 1980, A cohort study of preventive health behavior: Swine flu vaccination acceptance in Vermont, Del. Med. J. 52:427–432.

    PubMed  CAS  Google Scholar 

  • Marine, W. M., and Stuart-Harris, C., 1976, Reactions and serologic responses in young children and infants after administration of inactivated monovalent influenza A vaccine, J. Pediatr. 88:26–30.

    Article  PubMed  CAS  Google Scholar 

  • Marine, W. M., and Thomas, J. E., 1979, Antigenic memory to influenza A viruses in man determined by monovalent vaccines, Postgrad. Med. J. 55:98–108.

    Article  PubMed  CAS  Google Scholar 

  • Massicot, J. G., Murphy, B. R., Thierry, F., et al., 1980a, Temperature-sensitive mutants of influenza virus, Virology 101:242–249.

    Article  PubMed  CAS  Google Scholar 

  • Massicot, J. G., Murphy, B. R., Van Wyke, K., et al., 1980b, P1 and P3 genes are responsible for satisfactory level of attenuation of ts-142 recombinants bearing H1N1 or H3N2 surface antigens of influenza A virus, Virology 106:187–190.

    Article  PubMed  CAS  Google Scholar 

  • Masurel, N., Ophof, P., and dejong, P., 1981, Antibody response to immunization with influenza A/USSR/77 (H1N1) virus in young individuals primed or unprimed for A/New Jersey/76 (H1N1) virus, J. Hyg. (Camb.) 87:201–209.

    Article  CAS  Google Scholar 

  • Matzkin, H., and Nili, E., 1984, Accidental tenfold overdose of influenza A vaccine: A clinical and serological study, Isr. J. Med. Sci. 20:411–415.

    PubMed  CAS  Google Scholar 

  • McCahon, D., and Schild, G. C., 1972, Segregation of antigenic and biological characteristics during influenza virus recombination, J. Gen. Virol. 15:73–77.

    Article  PubMed  CAS  Google Scholar 

  • McCarroll, J. R., and Kilbourne, E. D., 1958, The equivalence of the subcutaneous and intradermal routes in immunization with Asiatic strain influenza vaccine, N. Engl. J. Med. 259:618–621.

    Article  PubMed  CAS  Google Scholar 

  • McDonald, J. C., Zuckerman, A. J., Beare, A. S., et al., 1962, Trials of live influenza vaccine in the Royal Air Force, Br. Med. J. 1:1036–1042.

    Article  PubMed  CAS  Google Scholar 

  • McLaren, C., Potter, C. W., and Jennings, R., 1974, Immunity to influenza in ferrets, Med. Microbiol. Immunol. 160:33–45.

    Article  PubMed  CAS  Google Scholar 

  • McLean, I. W., Jr., Beard, D., Taylor, A. R., et al., 1945, The relation of antibody response in swine to dose of the swine influenza virus inactivated with formalin and with ultraviolet light, J. Immunol. 51:65–99.

    Google Scholar 

  • McMichael, A. J., Gotch, F., Cullen, P., et al., 1981, The human cytotoxic T cell response to influenza A vaccination, Clin. Exp. Immunol. 43:276–284.

    PubMed  CAS  Google Scholar 

  • McMichael, A. J., Askonas, B. A., Webster, R. G., et al., 1982, B-cell or T-cell immunity? Immunol. Today 3:255–260.

    Article  Google Scholar 

  • Meiklejohn, G., 1958, Effectiveness of monovalent influenza A-prime vaccine during 1957 influenza A-prime epidemic, Am. J. Hyg. 67:237–249.

    PubMed  CAS  Google Scholar 

  • Meiklejohn, G., 1961, Asian influenza vaccination: Dosage, routes, schedules of inoculation and reactions, Am. Rev. Respir. Dis. 83:175–177.

    PubMed  Google Scholar 

  • Meiklejohn, G., Eickhoff, T. C., Graves, P., et al., 1978, Antigenic drift and efficacy of influenza virus vaccines, 1976–1977, J. Infect. Dis. 138:618–624.

    Article  PubMed  CAS  Google Scholar 

  • Melchizedek, A. N., Wabuke-Bunoti, Taku, A., et al., 1984, Cytolytic T lymphocyte and antibody responses to synthetic peptides of influenza virus hemagglutinin, J. Immunol. 133:2194–2201.

    Google Scholar 

  • Meredith, C. G., Christian, C., Johnson, R. F., et al., 1985, Effects of influenza virus vaccine on hepatic drug metabolism, Clin. Pharmacol. Ther. 37:396–401.

    Article  PubMed  CAS  Google Scholar 

  • Mihail, A., Popa, L. M., Petrescu, A., et al., 1981, Study of recombinants derived from autochthonous influenza virus type A strains, Rev. Roum, Med. Virol. 32:225–229.

    CAS  Google Scholar 

  • Miles, R., Potter, C. W., Clarke, A., et al., 1982, A comparative study of the reactogenicity and im-munogenicity of two inactivated influenza vaccines in children, J. Biol. Stand. 10:59–68.

    Article  PubMed  CAS  Google Scholar 

  • Mills, J., and Chanock, R. M., 1971, Temperature-sensitive mutants of influenza virus. I. Behavior in tissue culture and in experimental animals, J. Infect. Dis. 123:145–157.

    Article  PubMed  CAS  Google Scholar 

  • Mitchell, D. M., Fitzharris, P., Knight, R. A., et al., 1982, Kinetics of specific in vitro antibody production following influenza immunization, Clin. Exp. Immunol. 48:491–498.

    PubMed  CAS  Google Scholar 

  • Monto, A. S., and Ross, H. W., 1979, Swine influenza vaccine program in the community: Acceptability, reactions and responses, Am. J. Public Health 69:233–237.

    Article  PubMed  CAS  Google Scholar 

  • Monto, A. S., Miller, F. D., and Maassab, H. F., 1982, Evaluation of an attenuated, cold-recombinant influenza B virus vaccine, J. Infect. Dis. 145:57–64.

    Article  PubMed  CAS  Google Scholar 

  • Morein, B., and Simons, K., 1985, Subunit vaccines against enveloped viruses: Virosomes, micelles and other protein complexes, Vaccine 3:83–93.

    Article  PubMed  CAS  Google Scholar 

  • Mostow, S. R., Schoenbaum, S. C., Dowdle, W. R., et al., 1970, Studies on inactivated influenza vaccines. II. Effect of increasing dosage on antibody response and adverse reactions in man, Am. J. Epidemiol. 92:248–256.

    PubMed  CAS  Google Scholar 

  • Mostow, S. R., Dowdle, W. R., Schoenbaum, S. C., et al., 1973, Inactivated vaccines. 1. Volunteer studies with very high doses of influenza vaccine purified by zonal ultracentrifugation, Postgrad. Med. J. 49:152–158.

    Article  PubMed  CAS  Google Scholar 

  • MRC Advisory Group on Pulmonary Function Tests in Relation to Live Influenza Vaccines, 1984, Trials of live attenuated influenza virus vaccine in patients with chronic obstructive airways disease, Br. J. Dis. Chest 78:236–247.

    Article  Google Scholar 

  • Muldoon, R. L., Stanley, E. D., and Jackson, G. G., 1976, Use and withdrawal of amantadine chemoprophylaxis during epidemic influenza A, Am. Rev. Respir. Dis. 113:487–491.

    PubMed  CAS  Google Scholar 

  • Mumford, J., Wood, J. M., Scott, A. M., et al., 1983, Studies with inactivated equine influenza vaccine, J. Hyg. (Camb.) 90:385–395.

    Article  CAS  Google Scholar 

  • Murphy, B. R., and Chanock, R. M., 1985, Immunization against viruses, in: Virology (B. N. Fields, ed.), Raven Press, New York, pp. 349–370.

    Google Scholar 

  • Murphy, B. R., Chalhub, E. G., Nusinoff, S. R., et al., 1972, Temperature-sensitive mutants of influenza virus. II. Attenuation of ts recombinants for man, J. Infect. Dis. 126:170–178.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, B. R., Chalhub, E. G., Nusinoff, S. R., et al., 1973, Temperature sensitive mutants of influenza virus. III. Further characterization of the ts-l[E] influenza A recombinant, J. Infect. Dis. 128:479–487.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, B. R., Richman, D. D., Spring, S. B., et al., 1976, Use of temperature-sensitive mutants of influenza A virus as live virus vaccine strains: Evaluation in laboratory animals, adults and children, Postgrad. Med. 52:381–388.

    Article  CAS  Google Scholar 

  • Murphy, B. R., Markoff, L. J., Chanock, R. M., et al., 1980, Genetic approaches to attenuation of influenza A viruses for man, Phil. Trans. R. Soc. Lond. [Biol] 288:401–415.

    Article  CAS  Google Scholar 

  • Murphy, B. R., Buckler-White, A. J., London, W. T., et al., 1984, Avian-human reassortant influenza A viruses derived from mating avian and human influenza A viruses, J. Infect. Dis. 150:841–850.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, K. R., and Strunk, R. C., 1985, Safe administration of influenza vaccine in asthmatic children sensitive to egg proteins, J. Pediatr. 106:931–933.

    Article  PubMed  CAS  Google Scholar 

  • Murray, D. L., Imagawa, D. T., Kada, D. M., et al., 1979, Antibody response to nonvalent A/New Jersey/8/76 influenza vaccine in pregnant women, J. Clin. Microbiol. 10:184–187.

    PubMed  CAS  Google Scholar 

  • Murray, R., 1961, Some problems in the standardization and control of influenza vaccine in 1957, Am. Rev. Respir. Dis. 83:160–167.

    PubMed  Google Scholar 

  • Nature ,1985, Editorial: Statutory compensation urged, 316:476–477.

    Google Scholar 

  • Nestorowicz, A., Tregear, G. W., Southwell, C. N., et al., 1985, Antibodies elicited by influenza virus hemagglutinin fail to bind to synthetic peptides representing putative antigenic sites, Mol Immunol. 22:145–154.

    Article  PubMed  CAS  Google Scholar 

  • Neustadt, R. E., and Fineberg, H. V., 1978, The Swine Flu Affair, Decision Making on a Slippery Disease. U. S. Department of HEW, Washington.

    Google Scholar 

  • Newton Dunn, G. F., and Wormald, P. J., 1973, Influenza A Hong Kong vaccine and the new variant A/Eng/42/72, Lancet 1:95.

    Article  PubMed  CAS  Google Scholar 

  • Noble, G. R., Kaye, H. S., Kendal, A. P., et al., 1977, Age-related heterologous antibody responses to influenza virus vaccination, J. Infect. Dis. 136:S686–692.

    Article  PubMed  Google Scholar 

  • Odagiri, T., DeBorde, D. C., and Maassab, H. F., 1982, Cold-adapted recombinants of influenza A virus in MDCK cells. I. Development and characterization of A/Ann Arbor/6/60x A/Alaska/6/77 recombinant viruses, Virology 119:82–95.

    Article  PubMed  CAS  Google Scholar 

  • Odagiri, T., Smitka, C. W., and Maassab, H. G., 1983, Cold-adapted reassortants of influenza A virus in MDCK cells. II. Role of the temperature-sensitive property of cold-adapted reassortants in mice, Microbiol. Immunol. 27:203–206.

    PubMed  CAS  Google Scholar 

  • O’Donoghue, J. M., Ray, C. G., Terry, D. W., Jr., et al., 1973, Prevention of nosocomial influenza infection with amantadine, Am. J. Epidemiol. 97:276–282.

    PubMed  Google Scholar 

  • Ogra, P. L., Chow, T., Beutner, K. R., et al., 1977, Clinical and immunologic evaluation of neur-aminidase-specific influenza A virus vaccine in humans, J. Infect. Dis. 135:499–506.

    Article  PubMed  CAS  Google Scholar 

  • Okuno, Y., and Nakamura, K., 1966, Prophylactic effectiveness of live influenza vaccine in 1965, Biken J. 9:89–95.

    PubMed  CAS  Google Scholar 

  • Osborn, J. (ed.), 1977, Influenza in America, 1918–1976 9,Prodist, New York.

    Google Scholar 

  • Palese, P., and Schulman, J. L., 1976, RNA pattern of “swine” influenza virus isolated from man is similar to those of other swine influenza viruses, Nature 263:528–530.

    Article  PubMed  CAS  Google Scholar 

  • Panicali, D., Davis, S. W., Weinberg, R. L., et al., 1983, Construction of live vaccines by using genetically engineered poxviruses: Biological activity of recombinant vaccinia virus expressing influenza virus haemagglutinin, Proc. Natl. Acad. Sci. U.S.A. 80:5364.

    Article  PubMed  CAS  Google Scholar 

  • Paoletti, E., Weinberg, R. L., Davis, S. W., et al., 1984, Genetically engineered poxviruses: A novel approach to the construction of live vaccines, Vaccine 2:204–205.

    Article  PubMed  CAS  Google Scholar 

  • Parkman, P. D., Hopps, H. E., Rastogi, S. C., et al., 1977, Summary of clinical trials of influenza virus vaccines in adults, J. Infect. Dis. 136:S722–730.

    Article  PubMed  Google Scholar 

  • Patriarca, P. A., Kendal, A. P., Stricof, R. L., et al., 1983, Influenza vaccination and warfarin or theophylline toxicity in nursing-home residents, N. Engl. J. Med. 308:1601–1602.

    Article  PubMed  CAS  Google Scholar 

  • Patriarca, P. A., Kater, N. A., Kendal, A. P., et al., 1984, Safety of prolonged administration of rimantadine hydrochloride in the prophylaxis of influenza A virus infections in nursing homes, An-timicrob. Agents Chemother. 26:101–103.

    CAS  Google Scholar 

  • Patriarca, P. A., Weber, J. A., Parker, R. A., et al., 1985, Efficacy of influenza vaccine in nursing homes, J.A.M.A. 253:1136–1139.

    Article  PubMed  CAS  Google Scholar 

  • Payler, D. K., and Purdham, P. A., 1984, Influenza A prophylaxis with amantadine in a boarding school, Lancet 1:502–504.

    Article  PubMed  CAS  Google Scholar 

  • Pearman, W. A., 1978, Participation in flu immunization projects: What can we expect in the future? Am. J. Public Health 68:674–675.

    Article  PubMed  CAS  Google Scholar 

  • Pemberton, R. M., Jenning, R., and Smith, T. L., 1985, Morphology and antigenicity studies on reas-sortant influenza (H3N2) viruses for use in inactivated vaccines, J. Hyg. (Camb.) 94:229–239.

    Article  CAS  Google Scholar 

  • Perkins, F. T., 1972, Experience in the United Kingdom with oil adjuvant influenza vaccines, Ann. Allergy 30:288–291.

    PubMed  CAS  Google Scholar 

  • Perry, H. D., Mallen, F. J., Grodin, R. W., et al., 1979, Reversible blindness in optic neuritis associated with influenza vaccination, Ann. Ophthalmol. 11:545–550.

    PubMed  CAS  Google Scholar 

  • Petrescu, A., Cajal, N., Bronitki, A., et al., 1977, The experience of the Stefan S. Nicolau Institute of Virology in the preparation and administration of inactivated influenza vaccines applicable by nasal or oral route, Rev. Roum. Med. Virol. 28:213–217.

    CAS  Google Scholar 

  • Petrov, R. V., Zhdanov, V. M., Kabanov, V. A., et al., 1985, [Enhancement of the immune response to surface antigens of influenza virus as a result of their covalent binding with a synthetic carrier polymer], Biull. Eksp. Biol. Med. 99:184–186.

    PubMed  CAS  Google Scholar 

  • Phillips, C. A., Forsyth, B. R., Christmas, W. A., et al., 1970, Purified influenza vaccine: Clinical and serologic responses to varying doses and different routes of immunization, J. Infect. Dis. 122:26–32.

    Article  PubMed  CAS  Google Scholar 

  • Poser, C. M., Roman, G., and Emery, E. S. III, 1978, Recurrent disseminated vasculomyelinopathy, Arch. Neurol 35:166–170.

    Article  PubMed  CAS  Google Scholar 

  • Potter, C. W., Oxford, J. S., Shore, S. L., et al., 1972, Immunity to influenza in ferrets. I. Response to live and killed virus, Br. J. Exp. Pathol. 53:153–167.

    PubMed  CAS  Google Scholar 

  • Powers, R. D., Hayden, F. G., Samuelson, J., et al., 1984, Immune response of adults to sequential influenza vaccination, J. Med. Virol. 14:169–175.

    Article  PubMed  CAS  Google Scholar 

  • Quarles, J. M., Couch, R. B., Cate, T. R., et al., 1981, Comparison of amantadine and rimantadine for prevention of type A (Russian) influenza, Antivir. Res. 1:149–155.

    Article  PubMed  CAS  Google Scholar 

  • Quinnan, G. V., Schooley, R., Dolin, R., et al., 1983, Serologic responses and systemic reactions in adults after vaccination with monovalent A/USSR/77 and trivalent A/USSR/77, A/Texas/77, B/Hong Kong/72 influenza vaccines, Rev. Infect. Dis. 5:748–757.

    Article  PubMed  CAS  Google Scholar 

  • Ratner, E. R., and Fedson, D. S., 1983, Influenza and pneumococcal immunization in medical clinics, 1978–1980, Arch. Intern. Med. 143:2066–2069.

    Article  PubMed  CAS  Google Scholar 

  • Reeve, P., Pibermann, M., Bachmayer, H., et al., 1982, Studies in man with a cold-recombinant live influenza B virus vaccine, J. Med. Virol. 9:1–9.

    Article  PubMed  CAS  Google Scholar 

  • Reiss, C. S., and Schulman, J. L., 1980, Cellular immune responses of mice to influenza virus vaccines,J.. Immunol. 125:2182–2188.

    PubMed  CAS  Google Scholar 

  • Renton, K. W., Gray, J. D., and Hall, R. I., 1980, Decreased elimination of theophylline after influenza vaccination, Can. Med. J. 123:288–290.

    CAS  Google Scholar 

  • Riddiough, M. A., Sisk, J. E., and Bell, J. C., 1983, Influenza vaccination. Cost-effectiveness and public policy, J.A.M.A. 249:3189–3195.

    Article  PubMed  CAS  Google Scholar 

  • Rodda, S. J., Gallichio, H. A., and Hampson, A. W., 1981, The single radial immunodiffusion assay highlights small antigenic differences among influenza virus hemagglutinins, J. Clin. Microbiol. 14:479–482.

    PubMed  CAS  Google Scholar 

  • Rogers, G. N., Daniels, R. S., Skehel, J. J., et al., 1985, Host-mediated selection of influenza virus receptor variants, J. Biol. Chem. 260:7362–7367.

    PubMed  CAS  Google Scholar 

  • Rose, H. J., 1980, The use of amantadine and influenza vaccine in a type A influenza epidemic in a boarding school, J. R. Coll. Gen. Pract. 30:619–621.

    PubMed  CAS  Google Scholar 

  • Rosen, C. M., Roman, G., and Emery, E. S. III, 1978, Recurrent disseminated vasculomyelinopathy, Arch. Neurol. 35:166–170.

    Article  Google Scholar 

  • Rosenzweig, D. Y., Dwyer, D. J., Ferstenfeld, J. E., et al., 1975, Changes in small airway function after live attenuated influenza vaccination, Am. Rev. Respir. Dis. 111:399–403.

    PubMed  CAS  Google Scholar 

  • Rott, R., Becht, H., and Oflich, M., 1974, The significance of influenza virus neuraminidase in immunity, J. Gen. Virol 22:35–41.

    Article  PubMed  CAS  Google Scholar 

  • Ruben, F. L., Potter, C. W., and Stuart-Harris, C. H,, 1975, Humoral and secretory antibody responses to immunization with low and high dosage split influenza virus vaccine, Arch. Virol 47:157–166.

    Article  PubMed  CAS  Google Scholar 

  • Rytel, M. W., Jackson, L. J., Ferstenfeld, J. E., et al., 1975, New live attenuated influenza A/En-gland/42/72JH3N2) vaccine (“Alice”) reactogenicity, immunogenicity, and protection efficacy, J. Infect. Dis. 132:652–659.

    Article  PubMed  CAS  Google Scholar 

  • Sabin, A. B., 1977, Swine flu: What happened. Sciences 17:14–30.

    Google Scholar 

  • Salk, J. E., 1948, Reactions to concentrated influenza vaccines, J. Immunol. 58:369–395.

    PubMed  CAS  Google Scholar 

  • Salk, J. E., Bailey, M. L., and Laurent, A. M., 1952, The use of adjuvants in studies on influenza immunization. II. Increased antibody formation in human subjects inoculated with influenza virus vaccine in a water-in-oil emulsion, Am. J. Hyg. 55:439.

    PubMed  CAS  Google Scholar 

  • Schiff, G. M., Linnemann, C. C., Shea, L., et al., 1975, Evaluation of a live, attenuated recombinant influenza vaccine in high school children, Infect. Immun. 11:754–757.

    PubMed  CAS  Google Scholar 

  • Schoenbaum, S. C., 1979, Influenza vaccine-unacceptable or unaccepted, Am. J. Public Health 69:219–221.

    Article  PubMed  CAS  Google Scholar 

  • Schoenbaum, S. C., McNeil, B. J., and Kavet, J., 1976, The swine-influenza decision, N. Engl. J. Med. 295:759–765.

    Article  PubMed  CAS  Google Scholar 

  • Scholtissek, C., Vallbracht, A., Flehmig, B., et al., 1979, Correlation of pathogenicity and gene constellation of influenza A viruses. II. Highly neurovirulent recombinants derived from non-neurovirulent or weakly neurvirulent parent virus strains, Virology 95:492–500.

    Article  PubMed  CAS  Google Scholar 

  • Schonberger, L. B., Bregman, D. J., Sullivan-Bolyai, J. Z., et al., 1979, Guillain-Barre syndrome following vaccination in the National Influenza Immunization Program, United States, 1976–1977, Am. J. Epidemiol 110:105–123.

    PubMed  CAS  Google Scholar 

  • Schulman, J. L., 1967, Experimental transmission of influenza virus infection in mice. III. Differing effects of immunity induced by infection and by inactivated influenza virus vaccine on transmission of infection, J. Exp. Med. 125:467–478.

    Article  PubMed  CAS  Google Scholar 

  • Schulman, J. L., 1975, Immunology of influenza, in: The Influenza Viruses and Influenza (E. D. Kilbourne, ed.), Academic Press, New York, pp. 373–390.

    Google Scholar 

  • Schulman, J. L., and Kilbourne, E. D., 1971, Correlated studies of a recombinant influenza-virus vaccine. II. Definition of antigenicity in experimental animals, J. Infect. Dis. 124:463–472.

    Article  PubMed  CAS  Google Scholar 

  • Schulman, J. L., and Palese, P., 1978, Biological properties of recombinants of A/Hong Kong and A/PR8 viruses: Effects of genes for matrix protein and nucleoprotein in virus yield in embryonated eggs, in: Negative Strand Viruses and the Host Cell (B. W. J. Mahy and R. D. Barry, eds.), Academic Press, New York, pp. 663–674.

    Google Scholar 

  • Schulman, J. L., Khakpour, M., and Kilbourne, E. D., 1968, Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice, J. Virol. 2:778–786.

    PubMed  CAS  Google Scholar 

  • Schutze, M.-P., Lerclerc, C., Jolivet, M., et al., 1985, Carrier-induced epitopic suppression, a major issue for future synthetic vaccines, J. Immunol. 135:2319–2322.

    PubMed  CAS  Google Scholar 

  • Serie, C., Barme, M., Hannoun, C., et al., 1977, Effects of vaccination on an influenza epidemic in a geriatic hospital, Dev. Biol. Stand. 39:317–321.

    PubMed  CAS  Google Scholar 

  • Seyal, M., Ziegler, D. K., and Couch, J. R., 1978, Recurrent Guillain-Barre syndrome following influenza vaccine, Neurology (Minneap.) 28:725–726.

    Article  CAS  Google Scholar 

  • Shapira, M., Jibson, M., Muller, G., et al., 1984, Immunity and protection against influenza virus by synthetic peptide corresponding to antigenic sites of hemagglutinin, Proc. Natl. Acad. Sci. U.S.A. 81:2461–2465.

    Article  PubMed  CAS  Google Scholar 

  • Sheps, S. B., Mathias, R. G., Wilson, R., et al., 1985, Influenza vaccine utilization in a metropolitan health department: supply side constraints, Can. J. Public Health 76:378–383.

    PubMed  CAS  Google Scholar 

  • Shore, S. L., Potter, C. W., and Stuart-Harris, C. H., 1973, Antibody response to inactivated influenza vaccine given by different routes in patients with chronic bronchopulmonary disease, Thorax 28:721–728.

    Article  PubMed  CAS  Google Scholar 

  • Siegert, R., and Braune, P., 1964, The pyrogens of myxoviruses. II. Resistance of influenza A pyrogens to heat, ultraviolet and chemical treatment, Virology 24:218–224.

    Article  PubMed  CAS  Google Scholar 

  • Silverstein, A. M., 1981, Pure Politics and Impure Science ,The Johns Hopkins University Press, Baltimore, London.

    Google Scholar 

  • Slepushkin, A. N., Ellengorn, N. S., Russina, A. E., et al., 1968, Assessment of the efficacy of mass influenza vaccinations. [Assessment of the efficacy of mass influenza vaccinations. Report II], (English summary), J. Microbiol. Epidemiol. Immunobiol. 10:26–32.

    Google Scholar 

  • Smith, G. L., Murphy, B. R., and Moss, B., 1983, Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters, Proc. Natl. Acad. Sci. U.S.A. 80:7155–7159.

    Article  PubMed  CAS  Google Scholar 

  • Smith, J. W. G., and Pollard, R., 1979, Vaccination against influenza: A five-year study in the Post Office, J. Hyg. (Camb.) 83:157–170.

    Article  CAS  Google Scholar 

  • Smorodintsev, A. A., Tushinsky, M. D., Drobyshevskaya, A. I., et al., 1937, Investigation on volunteers infected with influenza virus, Am. J. Med. Sci. 194:159–170.

    Article  Google Scholar 

  • Smorodintsev, A. A., Mikutskaya, B. A., Alexandrova, G. I., 1967, Data on safety and epidemiological efficiency of anti-influenza vaccine studied on pre-school children, J. Hyg. Epidemiol. Microbiol. Immunol. 11:265–277.

    PubMed  CAS  Google Scholar 

  • Smorodintsev, A. A., Karpuhin, G. I., Zlydnikov, D. M., et al., 1970, The prophylactic effectiveness of amantadine hydrochloride in an epidemic of Hong Kong influenza in Leningrad in 1969, Bull. 42:865–872.

    CAS  Google Scholar 

  • Soloviev, V. D., Orlova, T. G., Porubel, L. A., et al., 1961, Study of the genetic characters of vaccine strains of type A-2 influenza virus, Prob. Virol. 6:743–750.

    Google Scholar 

  • Spencer, M. J., Cherry, J. D., and Terasaki, P. I., 1976, HL-A antigens and antibody response after influenza A vaccination, N. Engl. J. Med. 294:13–16.

    Article  PubMed  CAS  Google Scholar 

  • Spring, S. B., Maassab, H. F., Kendal, A. P., et al., 1977, Arch. Virol. 55:233–246.

    Article  PubMed  CAS  Google Scholar 

  • Steinberg, E., Overturf, G. D., Portnoy, B., et al., 1978, Serologic and clinical response of children with sickle cell disease to bivalent influenza A split virus vaccine, J. Pediatr. 92:823–825.

    Article  PubMed  CAS  Google Scholar 

  • Steinherz, P. G., Brown, A. E., Gross, P. A., et al., 1980, Influenza immunization of children with neoplastic diseases, Cancer 45:750–756.

    Article  PubMed  CAS  Google Scholar 

  • Stewart-Tull, D. E. S., 1985, Immunopotentiating conjugates, Vaccine 3:40–44.

    Article  PubMed  CAS  Google Scholar 

  • Stiver, H. G., and Weinerman, B. H., 1978, Impaired serum antibody response to inactivated influenza A and B vaccine in cancer patients, Can. Med. Assoc. J. 119:733–735.

    PubMed  CAS  Google Scholar 

  • Stiver, H. G., Graves, P., Eickhoff, T. C., et al., 1973, Efficacy of “Hong Kong” vaccine in preventing “England” variant influenza A in 1972, N. Engl. J. Med. 289:1267–1271.

    Article  PubMed  CAS  Google Scholar 

  • Storms, W. W., Dick, E. C., and Busse, W. W., 1976, Intranasal immunization with attenuated live influenza vaccine in asthma, J. Allergy Clin. Immunol. 58:284–290.

    Article  PubMed  CAS  Google Scholar 

  • Takafuji, E. T., Johnson, D. E., and Segal, H. E., 1976, The swine antigen in previous influenza vaccines, N. Engl. J. Med. 295:1018.

    PubMed  CAS  Google Scholar 

  • Tian, S., Zhang, L., and Murphy, B. R., 1984, Characterization of the genotype and level of attenuation of an influenza A reassortant virus produced by mating the Xia-ts donor virus with AJ.Beij-ing/79 (H1N1) wild type virus, Vaccine 2:189–192.

    Article  PubMed  CAS  Google Scholar 

  • Tian, S.-F., Buckler-White, A. J., London, W. T., et al., 1985, Nucleoprotein and membrane protein genes are associated with restriction of replication of influenza A/Mallard/NY/78 virus and its reas-sortants in squirrel monkey respiratory tract, J.. Virol. 53:771–775.

    PubMed  CAS  Google Scholar 

  • Tolpin, M. D., Massicot, J. G., Mullinix, M. G., et al., 1981, Genetic factors associated with loss of the temperature-sensitive phenotype of the influenza A/Alaska/77-ts-lA2 recombinant during growth in vivo, Virology 112:505–517.

    Article  PubMed  CAS  Google Scholar 

  • Tolpin, M. D., Clements, M. L., Levine, M. M., et al., 1982, Evaluation of a phenotypic revertant of the A/Alaska/77-ts-lA2 reassortant virus in hamsters and in seronegative adult volunteers: Further evidence that the temperature-sensitive phenotype is responsible for attenuation of ts-lA2 reassortant viruses, Infect. Immun. 36:645–650.

    PubMed  CAS  Google Scholar 

  • Top. F. H., Jr., and Russell, P. K., 1977, Swine influenza A at Fort Dix, New Jersey (January-February 1976), IV. Summary and speculation, J. Infect. Dis. 136:S376–S379.

    Article  PubMed  Google Scholar 

  • van de Donk, H. J. M., de Jong, J. C., van Olderen, M. F., et al., 1984, Monoclonal antibodies for the control of influenza virus vaccines, Dev. Biol. Stand. 57:251–255.

    PubMed  Google Scholar 

  • Versluis, D. J., Beyer, W. E. P., Masurel, N., et al., 1985, Influenza vaccination in dialysis and transplant patients, Antiviral Res. (Suppl.) 1:289–292.

    Google Scholar 

  • Wabuke-Bunoti, M. A. N., Taku, A., Fan, D. P., et al., 1984, Cytolytic T lymphocyte and antibody responses to synthetic peptides of influenza virus hemagglutinin, J. Immunol. 133:2194–2201.

    PubMed  CAS  Google Scholar 

  • Wagner, R. R., Bennett, I. L., Jr., and LeQuire, V. S., 1949, The production of fever by influenzal viruses. I. Factors influencing the febrile response to single injections of virus, J. Exp. Med. 90:321–334.

    Article  PubMed  CAS  Google Scholar 

  • Waldman, R. H., Mann, J. J., and Small, P. A., Jr., 1969a, Immunization against influenza, J.A.M.A. 207:520–524.

    Article  PubMed  CAS  Google Scholar 

  • Waldman, R. H., Bond, J. O., Levitt, L. P., et al., 1969b, An evaluation of influenza immunization, Bull. WHO 41:543–548.

    PubMed  CAS  Google Scholar 

  • Waldman, R. H., Wood, S. H., Torres, E. J., et al., 1970, Influenza antibody response following aerosol administration of inactivated virus, Am. J. Epidemiol. 94:575–584.

    Google Scholar 

  • Waksman, B. H., and Adams, R. D., 1955, Allergic neuritis: An experimental disease of rabbits induced by the injection of peripheral nervous tissue and adjuvants, J. Exp. Med. 102:213–235.

    Article  PubMed  CAS  Google Scholar 

  • Warburton, M. F., Jacobs, D. S., Langsford, W. A., et al., 1972, Herd immunity following subunit influenza vaccine administration, Med. J. Aust. 2:67–70.

    PubMed  CAS  Google Scholar 

  • Watson, W. H., Parks, M., Porter, D. A., et al., 1972, Influenza vaccination in schoolboys, Lancet 1:1336.

    Article  PubMed  CAS  Google Scholar 

  • Webster, R. G., 1966, Original antigenic sin in ferrets: The response to sequential infections with influenza viruses, J. Immunol. 97:177–183.

    PubMed  CAS  Google Scholar 

  • Webster, R. G., and Askonas, B. A., 1980, Cross-protection and cross-reactive cytotoxic T cells induced by influenza virus vaccines in mice, Eur. J. Immunol. 10:396–401.

    Article  PubMed  CAS  Google Scholar 

  • Webster, R. G., Kasel, J. A., Couch, R. B., et al., 1976, Influenza virus subunit vaccines. II. Immunoge-nicity and original sin in humans, J. Infect. Dis. 134:48–58.

    Article  PubMed  CAS  Google Scholar 

  • Webster, R. G., Kawaoka, Y., Bean, W. J., et al., 1985, Chemotherapy and vaccination: A possible strategy for the control of highly virulent influenza virus, J. Virol. 55:173–176.

    PubMed  CAS  Google Scholar 

  • Weibel, R. E., McLean, A., Woodhour, A. F., et al., 1973, Ten-year follow-up study for safety of adjuvant 65 influenza vaccine in man, Proc. Soc. Exp. Biol. Med. 143:1053–1056.

    PubMed  CAS  Google Scholar 

  • Weintraub, M. I., and Chia, D. T. S., 1977, Paralytic brachial neuritis after swine flu vaccination, Arch. Neurol. 34:518.

    Article  PubMed  CAS  Google Scholar 

  • Wenzel, R. P., Hendley, O., Sande, M. A. et al., 1973, Revised (1972–1973) bivalent influenza vaccine, J.A.M.A. 226:435–438.

    Article  PubMed  CAS  Google Scholar 

  • Wesselius-de Casparis, A., Hogerzeil, H. H. W., and van Beek, A., 1973, Eleven years of experiences in industry with vaccination against influenza: Reduction in absenteeism, in: International Symposium on Influenza Vaccines for Men and Horses, London, 1972 (Symposium Series Immunobiology Standard ,Vol. 20), S. Karger, Basel, pp. 268–274.

    Google Scholar 

  • Wiederholt, W. C., Mulder, D. W., and Lambert, E. H., 1964, The Landry Guillain-Barre-Strohl syndrome or polyradiculoneuropathy: Historical review, report on 97 patients, and present concepts, Mayo Clin. Proc. 39:427–451.

    PubMed  CAS  Google Scholar 

  • Wiley, D. C., Wilson, I. A., and Skehel, J. J., 1981, Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation, Nature 289:373–378.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, I. A., Niman, H. L., Houghten, R. A., et al., 1984, The structure of an antigenic determinant in a protein, Cell 37:767–778.

    Article  PubMed  CAS  Google Scholar 

  • Wood, J. M., Schild, G. C., Newman, R. W., et al., 1977, An improved single-radial-immunodiffusion technique for the assay of influenza haemagglutinin antigen: Application for potency determinations of inactivated whole virus and subunit vaccines, J. Biol. Stand. 5:237–247.

    Article  PubMed  CAS  Google Scholar 

  • Wood, J. M., Seagroatt, V., Schild, G. C., et al., 1981, International collaborative study of single-radial-diffusion and Immunoelectrophoresis techniques for the assay of haemagglutinin antigen of influenza virus, J. Biol. Stand. 9:317–330.

    Article  PubMed  CAS  Google Scholar 

  • Woodhour, A. F., Friedman, A., Tytell, A. A., et al., 1969, Hyperpotentiation by synthetic double-stranded RNA of antibody responses to influenza virus vaccine in adjuvant 65, Proc. Soc. Exp. Biol. Med. 131:809–817.

    PubMed  CAS  Google Scholar 

  • World Health Organization, 1985, Recombinant vaccinia viruses as live virus vectors for vaccine antigens: Memorandum from a WHO/USPHS/NIBSC Meeting, Bull. WHO 63:471–477.

    Google Scholar 

  • Wright, P. F., Sell, S. H. W., Thompson, J., et al., 1976, Clinical reactions and serologic response following inactivated monovalent influenza type B vaccine in young children and infants, J. Pediatr. 88:31–35.

    Article  PubMed  CAS  Google Scholar 

  • Wright, P. F., Bhargava, M., Johnson, P. R., et al., 1985, Simultaneous administration of live, attenuated influenza A vaccines representing different serotypes, Vaccine 3:305–308.

    Article  PubMed  CAS  Google Scholar 

  • Yamane, N., Nakamura, Y., Yuki, M., et al., 1984, Serological evaluation of an influenza A virus cold-adapted reassortant live vaccine, CR-37 (H1N1) in Japanese adult volunteers, J. Hyg. (Camb.) 92:231–242.

    Article  CAS  Google Scholar 

  • Zahradnik, J. M., Kasel, J. A., Martin, R. R., et al., 1983, Immune responses in serum and respiratory secretions following vaccination with a live cold-recombinant (CR35) and inactivated A/USSR/77 (H1N1) influenza virus vaccine, J. Med. Virol. 11:277–285.

    Article  PubMed  CAS  Google Scholar 

  • Zeck, R., Solliday, N., Kehoe, T., et al., 1976, Respiratory effects of live influenza virus vaccine: Healthy older subjects and patients with chronic respiratory disease, Am. Rev. Respir. Dis. 114:1061–1067.

    PubMed  CAS  Google Scholar 

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    Edwin D. Kilbourne M.D. (Distinguished Service Professor)

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Kilbourne, E.D. (1987). The Control of Influenza. In: Influenza. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5239-6_11

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