Abstract
K+ channels are transmembrane proteins dedicated to allowing K+ fluxes through physiological membranes. Topologically, they can be described as transmembrane segments surrounding a pore-forming region directly involved in K+ selectivity and transfer. As originally depicted by Hodgkin and Huxley (1952a)-Hodgkin and Huxley (1952d), K+ channels are involved in the propagation of the action potential. Their opening is regulated by the level of membrane depolarization, and their role is to return the membrane to its resting potential. However, far beyond this unique role, K+ channels form the most diverse ion channel family described so far. They are present in nearly all cell types, and their biophysical as well as their pharmacological profiles are among the most complex ever seen.
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Blanc, E., Darbon, H. (2001). Pharmacology of Small-Conductance, Calcium-Activated K+Channels. In: Archer, S.L., Rusch, N.J. (eds) Potassium Channels in Cardiovascular Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1303-2_14
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