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Developmental Origins of Osteoporotic Fracture

  • Chapter
Breast-Feeding: Early Influences on Later Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 639))

Osteoporosis is a skeletal disorder characterised by low bone mass and micro-architectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fracture.1 It is a widespread condition, often unrecognised in clinical practice, which may have devastating health consequences through its association with fragility fractures. The term ‘osteoporosis’ was first used in the nineteenth century as a histologic description for aged bone tissue, but its clinical consequences were not appreciated until Sir Astley Cooper recognised that hip fractures might result from an age-related reduction in bone mass or quality over 150 years ago. Since one disadvantage of a fracture-based definition is that diagnosis and treatment will be delayed when prevention is considered optimal treatment, an expert panel convened by the World Health Organisation (WHO) has suggested that both low bone mineral density (BMD) and fracture be combined in a stratified definition of osteoporosis.2

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Authors and Affiliations

  1. MRC Epidemiology Resource Centre, (University of Southampton), Southampton General Hospital, Southampton, SO16 6YD

    C. Cooper, S. Westlake, N. Harvey & E. Dennison

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  1. C. Cooper
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  2. S. Westlake
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  3. N. Harvey
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  4. E. Dennison
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Editors and Affiliations

  1. MRC Human Nutrition Research, Cambridge, UK

    Gail Goldberg  & Ann Prentice  & 

  2. London School of Hygiene and Tropical Medicine, UK

    Andrew Prentice  & Suzanne Filteau  & 

  3. Institut de Recherche pour le Developpement, Montpellier, France

    Kirsten Simondon

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Cooper, C., Westlake, S., Harvey, N., Dennison, E. (2009). Developmental Origins of Osteoporotic Fracture. In: Goldberg, G., Prentice, A., Prentice, A., Filteau, S., Simondon, K. (eds) Breast-Feeding: Early Influences on Later Health. Advances in Experimental Medicine and Biology, vol 639. Springer, Dordrecht. https://doi.org/10.1007/978-1-4020-8749-3_16

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