On December 11, 2020, the U.S. Food and Drug Administration (FDA) approved Emergency Use Authorization (EUA) for the Pfizer-BioNTech mRNA-based COVID-19 vaccine (BNT162b2). A second EUA was issued for Moderna’s version of the vaccine (mRNA-1273) …

Felix Beuschlein (University of Zürich, Switzerland) and co-authors explain that glucocorticoid therapy is widespread and is applied by most medical disciplines, often for a prolonged duration.

A man with type 2 diabetes and IgG4-related kidney disease developed bullous pemphigoid. DPP4 inhibitor treatment, which also correlated with changes in renal function, was discontinued.

Ageing populations are a common problem for countries around the world [ 1 ]. It is an inevitable population trend at a certain stage of social and economic development [ 2 ]. In 1999, the population over 60 years old accounted for 10% of the total …

Commenting on the research in a related editorial, Pascale Khairallah (Baylor College of Medicine, Houston, Texas, USA) and Thomas Nickolas (Columbia University Irving Medical Center, New York, USA) suggest that the high rates of hypocalcemia seen with denosumab treatment “may be due to a confluence of nephrology practice patterns, inadequate communication between physicians, and lack of guidance on osteoporosis management in patients undergoing dialysis.”

However, they stress that their analysis highlights “the risks of gastrointestinal adverse events induced by GLP-1 [receptor agonists], and safety concern is especially warranted for high dose administration. medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2024 Springer Healthcare Ltd, part of the Springer Nature Group BMJ 2024; 384 : e076410

Febrile neutropenia (FN) is a well-established, serious side effect of myelosuppressive chemotherapies, typically considered to be a medical emergency when occurring following chemotherapy administration [ 1 , 2 ]. As FN episodes have a highly …

Moreover, “men at high risk for fragility fracture should receive osteoporotic drug therapy with proven antifracture benefit independent of any consideration of testosterone therapy,” the editorialists conclude. medwireNews is an independent medical news service provided by Springer Healthcare Ltd. © 2024 Springer Healthcare Ltd, part of the Springer Nature Group New Engl J Med 2024; 390 : 203–211 New Engl J Med 2024; 390 : 267–268

Additionally, the 2-year cumulative incidence of the side effect was 1.38 percentage points higher in 11,943 new users of hydrochlorothiazide (HCZ) in combination with a renin-angiotensin system (RAS) inhibitor compared with 85,784 new users of a RAS inhibitor alone, at 3.51% versus 2.12% The results also suggest a significantly increased risk for hyponatremia with thiazide-based treatment among individuals aged 70 years and older, compared with younger patients, and for those with a higher comorbidity burden, the investigators note.

Changing to a ciclosporin-based regimen resolved the signs and symptoms of hepatitis in a patient who presented with icterus, weakness, and lethargy two weeks after kidney transplantation and initiation of tacrolimus.

In a related commentary, John Ostrominski and Vanita Aroda (both from Harvard Medical School, Boston, Massachusetts, USA) observe that the benefit of aspirin in diabetes prevention is offset by the increase in major bleeding.