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36188 search results for:

Glioma 

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  1. 03-05-2024 | Glioma | Online First

    Revisiting prognostic factors of gliomatosis cerebri in adult-type diffuse gliomas

    Gliomatosis cerebri (GC) is defined as a diffuse glioma that exhibits an infiltrative growth pattern affecting at least three lobes of the brain while grossly maintaining the underlying normal brain architecture [ 1 , 2 ]. Initially recognized as a …

  2. 22-05-2024 | Radiotherapy | Online First

    Radiotherapy for pediatric low-grade glioma

    Pediatric low-grade glioma (pLGG) is the most common brain tumor in children and represents nearly one-third of all pediatric central nervous system (CNS) tumors [ 1 ]. PLGG has a predilection for the posterior fossa, diencephalon, and optic …

  3. 24-05-2024 | Glioma | Online First

    Constitutive type-1 interferons signaling activity in malignant gliomas

    Gliomas are a heterogeneous group of central nervous system tumors classified by the World Health Organization (WHO) into four grades based on histopathological features [ 1 ]. Grade I gliomas are benign and slow-growing, whereas grade II, III, and …

  4. Free for a limited time 18-05-2024 | Glioma | Online First

    Low-grade glioma in adolescents and young adults

    Pediatric-type low-grade glioma (PLGG) encompasses a heterogeneous group of WHO grade 1 or 2 tumors and is the most common central nervous system

  5. Open Access 01-12-2024 | Glioma | OriginalPaper

    7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading

    Gliomas are the most common primary CNS tumor entities and still challenging for both patients and healthcare providers. Treatment involves resection, post-surgical radiation and chemotherapy, or a combination thereof. Monitoring and management …

  6. Open Access 01-12-2024 | Glioma | OriginalPaper

    Ultrasound-assisted resection of insular gliomas

    The challenges in management of insular gliomas have in the past been attributed to the complex shape, proximity to critical vasculature, functional significance, and organization of the insular cortex [ 1 ]. However, over the past two decades, a …

  7. 16-01-2024 | Glioma | OriginalPaper

    Usefulness of magnetic resonance imaging characteristics in discriminating H3 K27M-mutant gliomas from wildtype gliomas in spinal cord

    In the 2021 fifth edition of World Health Organization classification of tumors of the central nervous system, H3 K27M-mutant glioma is a new group of tumors defined as an infiltrative midline high-grade glioma with a K27M mutation in the histone …

  8. 24-05-2024 | Epilepsy | Online First

    Low-grade glioma of the temporal lobe and tumor-related epilepsy in children

    Low-grade glioma (LGG) is the most common primary central nervous system tumor in children, representing about one-third of all brain tumors in the pediatric population [ 1 , 2 ]. These tumors are either grade 1 or 2 under the 2021 World Health …

  9. Open Access 01-12-2024 | Glioma | OriginalPaper

    Tumour growth rate predicts overall survival in patients with recurrent WHO grade 4 glioma

    World Health Organization (WHO) grade 4 glioma is the most common malignant primary brain tumour; it is often rapidly progressive and portends poor prognosis [ 1 ]. Current standard treatment comprises maximal surgical resection, radiation therapy …

  10. Open Access 01-12-2024 | Glioma | OriginalPaper

    Evaluation of the rapid Idylla IDH1-2 mutation assay in FFPE glioma samples

    IDH1 and IDH2 mutational status is a critical biomarker with diagnostic, prognostic, and treatment implications in glioma. Although IDH1 p.R132H-specific immunohistochemistry is available, it is unable to identify other mutations in IDH1/2.

  11. Open Access 15-05-2024 | Glioma | Online First

    Reirradiation for diffuse intrinsic pontine glioma: prognostic radiomic factors at progression

  12. Open Access 24-05-2024 | Glioma | Online First

    Predicting post-surgical functional status in high-grade glioma with resting state fMRI and machine learning

    High-grade gliomas (HGG) account for 60–70% of new cases of brain tumors [ 1 ]. The efficacy of therapeutic interventions has been limited by various factors, such as genetic heterogeneity, accelerated cellular proliferation, and …

  13. Open Access 01-12-2024 | Glioma | OriginalPaper

    HIF-1α facilitates glioma proliferation and invasion by activating pyroptosis signaling axis

    Brain glioma is the primary malignant tumor with the highest incidence rate of the central nervous system in adults, with an annual incidence rate of about 6.4 per 100,000, of which the incidence rate of World Health Organization (WHO) grade 4 …

  14. Open Access 01-12-2024 | Glioblastoma | ReviewPaper

    Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives

    Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a formidable challenge due to its immunosuppressive microenvironment, thereby confounding conventional therapeutic interventions. Despite the established treatment …

  15. Open Access 01-05-2024 | Glioma | OriginalPaper

    Fluorescein-guided surgery in high-grade gliomas: focusing on the eloquent and deep-seated areas

    Gliomas are the most common intracranial tumors, High-grade gliomas (HGGs) refer to WHO grade 3 and 4 tumors, representing the highest degree of malignancy. The survival rates at 1-, 3-, and 5-year for HGGs are 64.09%, 29.26%, and 15.26% …

  16. 01-04-2024 | Glioma | ReviewPaper

    Advances in pediatric gliomas: from molecular characterization to personalized treatments

    Pediatric gliomas, consisting of both pediatric low-grade (pLGG) and high-grade gliomas (pHGG), are the most frequently occurring brain tumors in children. Over the last decade, several milestone advancements in treatments have been achieved as a …

  17. 06-05-2024 | Glioma | Online First

    Surgical treatment of pediatric low-grade glioma in developing countries

    Pediatric low-grade gliomas constitute the most common brain tumors worldwide, though with some peculiarities in the presentation and surgical care in different parts of the world. The symptomatology in developing countries is likely to be over …

  18. 04-04-2024 | Glioma | ReviewPaper

    Perioperative Neurocognitive Function in Glioma Surgery

    Gliomas represent a relatively rare neoplasm, typically involving the supratentorial cerebral hemispheres, and are most often high-grade malignancies (85% WHO grades 3 and 4) [ 1 , 2 ]. Despite low yearly incidence (six per 100,000 individuals) …

  19. Open Access 25-05-2024 | Glioma | Online First

    MOST wanted: navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models

    Understanding the molecular and cellular mechanisms driving pediatric low-grade glioma (pLGG)—the most prevalent brain tumor in children—is essential for the identification and evaluation of novel effective treatments. This review explores the …

  20. 14-05-2024 | Glioma | Online First

    The role of surgery for optic pathway gliomas in the era of precision medicine

    Optic pathway gliomas (OPGs) represent a unique subset of brain tumours that primarily affect the paediatric population. Traditionally, these tumours are managed conservatively due to their location to and association with vital structures. This …

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