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337283 search results for:

Cancer Therapy 

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  1. 28-05-2024 | Online First

    Research advances on TIL therapy for colorectal cancer

    Colorectal cancer (CRC) is a prevalent gastrointestinal malignancy. Tumor-infiltrating lymphocyte (TIL) therapy, a form of adoptive cellular therapy (ACT), involves isolating T lymphocytes from tumor tissues, in vitro expansion, and reintroduction …

  2. Open Access 02-05-2024 | Heart Failure | ReviewPaper

    Relevance of Cardiovascular Exercise in Cancer and Cancer Therapy-Related Cardiac Dysfunction

    Cancer poses a major health and economic burden worldwide and warrants further improvement of diagnostic and treatment measures [ 1 , 2 ]. Prognosis of cancer patients depends not only on adequate and timely diagnostics and treatment of cancer but …

  3. 01-06-2024 | NSCLC | ReviewPaper

    PAQR4 oncogene: a novel target for cancer therapy

    Despite decades of basic and clinical research and trials of promising new therapies, cancer remains a major cause of morbidity and mortality due to the emergence of drug resistance to anticancer drugs. These resistance events have a very …

  4. Open Access 01-12-2024 | Cancer Therapy | ReviewPaper

    New-generation advanced PROTACs as potential therapeutic agents in cancer therapy

    Proteolysis-targeting chimeras (PROTACs) technology has garnered significant attention over the last 10 years, representing a burgeoning therapeutic approach with the potential to address pathogenic proteins that have historically posed challenges …

  5. Open Access 01-12-2024 | Cytostatic Therapy | ReviewPaper

    Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy

    A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during the process of tumorigenesis, even in the presence of abundant oxygen, shifting the main pathway of energy metabolism from …

  6. Open Access 28-05-2024 | Online First

    The impact of expanded access programs for systemic anticancer therapy in an Irish cancer centre

    Expanded access describes the therapeutic use of investigational drugs outside of clinical trials [ 1 ]. Other terms such as ‘compassionate use’ and ‘early access’ have been used, often synonymously, to describe this use of unlicensed drugs prior …

  7. 18-05-2024 | Photodynamic Therapy | Online First

    Neoadjuvant Photodynamic Therapy: An Updated Therapeutic Approach for Non-Melanoma Skin Cancers

    Non-melanoma skin cancers (NMSCs) are the most common malignancy and surgical excision is considered treatment of choice for the majority of cases. However, surgery can be very extensive in cases of large, multiple, or cosmetic-sensitive tumors …

  8. Open Access 08-05-2024 | Breast Cancer | Online First

    New Vaccine Therapy for Triple-Negative Breast Cancer

    Triple-negative breast cancer (TNBC) constitutes approximately 15%–20% of all breast cancer cases, is aggressive and has a high fatality rate approaching 40%. Aberrantly low expression of estrogen receptors (ER), progesterone receptors (PR), and …

  9. Open Access 01-12-2024 | Targeted Therapy | ReviewPaper

    Ferroptotic therapy in cancer: benefits, side effects, and risks

    Ferroptosis is a type of regulated cell death characterized by iron accumulation and uncontrolled lipid peroxidation, leading to plasma membrane rupture and intracellular content release. Originally investigated as a targeted therapy for cancer

  10. 21-05-2024 | Breast Cancer | Online First

    Development and psychometric evaluation of the adjuvant endocrine therapy beliefs scale for breast cancer survivors

    Cancer is a typical chronic disease, and breast cancer is the most common neoplasm in the world among women (American Cancer Society, 2023 ). Early detection and survival rate for breast cancer have significantly increased. Approximately 60–75% of …

  11. 01-06-2024 | Exercise Therapy | OriginalPaper

    Experiences and perceived benefits of remotely delivered dance/movement therapy for adult cancer patients: a multi-method program evaluation

    Receiving a cancer diagnosis profoundly impacts mental health and overall well-being. While survival rates of 69% are historically high [ 1 ], approximately 25% of cancer survivors continue to face enduring psychosocial issues and overall mental …

  12. 27-05-2024 | Esophageal Cancer | Online First

    ASO Author Reflections: Neoadjuvant Chemotherapy versus Definitive Chemoradiation Therapy for Locally Advanced Cervical Esophageal Cancer: A Retrospective Study

    Treatment strategies for cervical esophageal cancer must be individually selected according to the patient’s background, tumor location, and degree of progression, with the aim of achieving both curability and function. 1 Definitive chemoradiation …

  13. 04-04-2024 | Prostate Cancer | ReviewPaper

    Role of Metastasis-Directed Therapy in Genitourinary Cancers

    The treatment of oligometastatic genitourinary cancers is a rapidly advancing field with ablative radiotherapy as one of the critical treatment components. The oligometastatic disease state, which can be defined as 1–5 metastatic sites with a …

  14. Open Access 01-12-2024 | Gynecologic Cancer | OriginalPaper

    IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy in advanced gynecologic cancer

    Cervical, endometrial, and ovarian cancers represent the fourth, sixth, and eighth most commonly diagnosed malignancies among women globally [ 1 ]. While initial treatment with surgery and chemotherapy often leads to a high response rate, many …

  15. 24-05-2024 | Online First

    Development and evaluation of albumin binder-conjugated heterodimeric radiopharmaceuticals targeting integrin αvβ3 and CD13 for cancer therapy

    Angiogenesis plays a crucial role in tumor growth, progression, and metastasis by fulfilling the increasing demand for oxygen and nutrients [ 1 ]. Targeting neovascularization has emerged as a promising strategy in cancer diagnosis and treatment [ …

  16. 01-06-2024 | Cytostatic Therapy | OriginalPaper

    Effect of gradient pressure therapy on the prevention of chemotherapy-induced peripheral neuropathy in patients with breast cancer

    Research shows that breast cancer has become the most common malignant tumor worldwide, with its incidence rate ranking first and its mortality rate second only to lung cancer [ 1 ]. Chemotherapy is one of the main treatment options for breast …

  17. Open Access 01-12-2024 | NSCLC | OriginalPaper

    Combination of percutaneous thermal ablation and adoptive Th9 cell transfer therapy against non-small cell lung cancer

    With an estimated 2.2 million newly diagnosed cases and over 1.7 million deaths yearly, lung cancer (LC) remains the most prevalent malignancy and the leading cause of cancer-related mortalities globally, and non-small-cell lung cancer (NSCLC) …

  18. 01-05-2024 | Cancer Therapy | ReviewPaper

    Ferroptosis is an effective strategy for cancer therapy

    Ferroptosis is a form of intracellular iron-dependent cell death that differs from necrosis, autophagy and apoptosis. Intracellular iron mediates Fenton reaction resulting in lipid peroxidation production, which in turn promotes cell death.

  19. Open Access 01-12-2024 | Breast Cancer | OriginalPaper

    Autologous patient-derived exhausted nano T-cells exploit tumor immune evasion to engage an effective cancer therapy

    Nanoparticle-based nanomedicine has significantly improved drug delivery by targeting, passively accumulating within tumor tissues, and effectively penetrating cancer cells. Nanoparticles (NPs) present augmented attributes such as enhanced …

  20. Open Access 01-06-2024 | Telemedicine | OriginalPaper

    Telehealth cognitive behaviour therapy for the management of sleep disturbance in women with early breast cancer receiving chemotherapy: a feasibility study

    Breast cancer (BC) is the most common cancer in women [ 1 ] and up to 70% of patients with BC report sleep disturbance [ 2 ]. Sleep disturbance includes difficulty initiating or maintaining sleep, or circadian rhythm sleep–wake disorders, which can …

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