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Open Access Mucosal Melanoma Case Study

Promising response to oncolytic virus therapy in mucosal melanoma

Intralesional treatment with the oncolytic virus talimogene laherparepvec led to a complete local response in a patient with oral mucosal melanoma who was ineligible for other anticancer therapies.

Axillary management: less can be more

Open Access Breast Cancer Review

Management of the axilla in patients with breast cancer has evolved considerably over the past three decades, from routine clearance to complete omission in select patients. Explore the evidence that has shaped these practice changes.

Low-grade glioma in adolescents and young adults

Free for a limited time Glioma Review

25% of gliomas in adolescents and young adults are pediatric-type LGG. Should treatment in this older age group be the same as in children?

New PARP inhibitor shows promise in advanced ovarian cancer

22-05-2024 Ovarian Cancer News

Women with advanced ovarian cancer who respond to first-line chemotherapy could benefit from maintenance treatment with the PARP inhibitor senaparib, irrespective of their BRCA mutation status.

A challenging diagnosis: melanoma or clear cell sarcoma?

Open Access Clear-Cell Sarcoma Case Study

A case of clear cell sarcoma of soft tissue misdiagnosed as malignant melanoma underscores the need for an integrated diagnostic approach involving clinical, histopathological, and radiological evaluations.

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Lung Cancer Clinical Trial Summary

At a glance: The KEYNOTE lung cancer trials

A quick guide to the KEYNOTE trials investigating the anti-PD-1 agent pembrolizumab in non-small-cell and small-cell lung cancer.

Developed by: Springer Medicine

Case Studies

Promising response to oncolytic virus therapy in mucosal melanoma

Open Access Mucosal Melanoma Case Study

Intralesional treatment with the oncolytic virus talimogene laherparepvec led to a complete local response in a patient with oral mucosal melanoma who was ineligible for other anticancer therapies.

A challenging diagnosis: melanoma or clear cell sarcoma?

Open Access Clear-Cell Sarcoma Case Study

A case of clear cell sarcoma of soft tissue misdiagnosed as malignant melanoma underscores the need for an integrated diagnostic approach involving clinical, histopathological, and radiological evaluations.

Hyalinizing trabecular tumor of the thyroid

Open Access Thyroid Cancer Case Study

Imaging, cytologic, histologic, and molecular investigations all contributed to the diagnosis of a rare case of HTT in a woman with an incidentally discovered mass in the left lobe of her thyroid gland.

Next-generation sequencing

Next-generation sequencing is a powerful tool that can identify mutations or fusions in a wide range of cancers, enabling physicians to provide targeted therapy to patients and improve outcomes. 

In this vodcast, Professor Andrew Beggs discusses practical aspects of this technique from the clinical viewpoint. 

Supported by: Illumina, Inc., and Eli Lilly and Company

Prof. Andrew Beggs
Developed by: Springer Healthcare

Current Reviews

An Annual Symposium on Disparities in Milwaukee, WI, with a 2023 Focus on Older Adults with Cancer

Milwaukee, the most populous city in Wisconsin, has high rates of health inequities among segregated communities and neighborhoods with living conditions below the poverty level [ 1 – 3 ]. Many communities with individuals from historically and …

Beyond Immune Checkpoint Inhibitors: Emerging Targets in Melanoma Therapy

Melanoma REVIEW

The advent of modern therapeutics targeting BRAF and immune-checkpoint blockade has driven clinical improvement for patients with melanoma. Prior to the introduction of immune checkpoint inhibitors (ICIs) and targeted therapy, metastatic melanoma …

Review of the cost-effectiveness of surveillance for hereditary pancreatic cancer

Open Access Pancreatic Cancer Review

Individuals with hereditary pancreatic cancer risk include high risk individuals (HRIs) with germline genetic susceptibility to pancreatic cancer (PC) and/or a strong family history of PC. Previously, studies have shown that PC surveillance in …

Low-grade glioma of the temporal lobe and tumor-related epilepsy in children

Epilepsy Review

Low-grade glioma (LGG) is the most common primary central nervous system tumor in children, representing about one-third of all brain tumors in the pediatric population [ 1 , 2 ]. These tumors are either grade 1 or 2 under the 2021 World Health …

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine

Webinar (Link opens in a new window)

1.25 AMA PRA Category 1 Credit(s)

A collaborative program highlighting the importance of molecular assessments and targeted treatment selection in people with biomarker-positive disease. Submit your questions for the experts now.

Supported by:
  • Roche and Illumina
Developed by: Springer Healthcare IME

Webcast | Videos | Cases (Link opens in a new window)

Identifying molecular biomarkers is crucial in determining the best targeted treatment options for your patients with advanced thyroid cancer.

Join our expert-led multi-format educational program that explores the continuing discovery of new genomic targets and delivers the latest research in molecular testing and the application of targeted therapies for thyroid cancer.

Start by watching our webcast and short vodcasts.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME

eLearning | Interviews | Digital Treatment Map (Link opens in a new window)

1.0 AMA PRA Category 1 Credit(s)

Expert-led, multiformat program which will address the individualized management of NSCLC, through education on the detection of NTRK gene fusions, current evidence-based guidelines, and new and emerging therapies. Will also include guidance on integrating shared decision making into your clinical practice, drawing on insights from a patient on how best to communicate.

Supported by:
  • Bayer HealthCare Pharmaceuticals Inc.
Developed by: Springer Healthcare IME
NSCLC Podcast

Episode 7: A deep dive into ADAURA

The ADAURA trial has, as of this year, demonstrated an overall survival benefit with the adjuvant use of osimertinib in people with resectable NSCLC. 

We take an in-depth look at the study with Dr. Luis Paz-Ares, who outlines the study findings, discusses the clinical implications, and addresses the pertinent questions raised by the trial.

Dr. Luis Paz-Ares

Further Reading

A Comparison of Near-Infrared Autofluorescence Findings in Benign Versus Malignant Adrenal Tumors

Open Access Adrenal Cancer Endocrine Tumors

This was an institutional review board-approved prospective study of patients at a single tertiary center undergoing minimally invasive adrenalectomy by the senior author between October 2021 and May 2023. Decision for adrenalectomy was based on …

Predictors and surgical outcome of hemorrhagic metastatic brain malignancies

Open Access Metastasis Research

Intracerebral metastases represent the predominant form of brain malignancy in adults, with lung cancer, breast cancer, colorectal cancer, melanoma, and renal cell carcinoma posing the highest risk of metastasizing to the brain [ 1 ]. With …

A novel nomogram and survival analysis for different lymph node status in breast cancer based on the SEER database

Open Access Breast Cancer Original Article

Breast cancer is the most frequently diagnosed malignancy and is currently considered the second most common death-related malignancy in females [ 1 ]. Previous statistical studies have shown that 266,120 women in the United States suffer from …

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Surgery, radiotherapy, and chemotherapy are the primary treatments for advanced head and neck cancer, but checkpoint inhibition has recently shown promise. Delve into the efficacy and safety data for the key agents.

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