Peripheral Nervous System Disease

Transthyretin cardiac amyloidosis (ATTR-CA) is an adult-onset, debilitating, progressive and often fatal cardiac disease caused by the extracellular deposition of transthyretin (TTR) fibrils in the heart [ 1 ••, 2 ••]. TTR is a tetrameric transport …

Cubital tunnel syndrome (CuTS) is the second most common peripheral neuropathy in the upper limb. It occurs due to ulnar nerve compression within the fibro-osseous cubital tunnel at the elbow joint. Although CuTS is typically diagnosed clinically …

Guillain–Barre syndrome (GBS) is an acute-onset immune-mediated polyneuropathy characterized by ascending symmetrical muscle weakness, diminished reflexes, and sensory symptoms. While GBS typically follows a monophasic course, some patients …

Orthognathic surgery is a surgical procedure aimed at rectifying facial skeletal components and restoring the normal anatomical and functional connections in individuals with dentofacial skeletal abnormalities. These abnormalities derive from …

Hereditary transthyretin amyloidosis (hATTR) is caused by mutations in the transthyretin (TTR) gene, encoding an unstable protein that triggers the multisystemic deposition of amyloid aggregates. The extracellular deposition of amyloid in the …

Hereditary transthyretin amyloidosis (ATTRv, v for ‘variant’) is an adult-onset, autosomal-dominant disease, caused by pathogenic variants in the TTR gene, encoding the transthyretin protein. Diffuse extracellular deposition of misfolded …

Several new treatment options with improved side effect profiles compared to conventional chemotherapeutics for neurological autoimmune disorders, such as multiple sclerosis, but also for rare neuromuscular disorders, such as myasthenia gravis …

Surgical procedures conducted in the vicinity of peripheral nerves pose risks of injury to those nerves through iatrogenic factors such as compression or manipulation. While typically transient in nature, postoperative nerve dysfunction of cranial …