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Neurology

Case Studies

Extensive neurogenic heterotopic ossification

Open Access Pain Due to Spasticity Case Study

After TBI, 10–20% of patients go on to develop progressive periarticular lamellar bone formation in extraskeletal tissues. This rare case involved significant pain and impaired motion in all four limbs.

CHANTER syndrome from fentanyl exposure in a young child

Open Access Cerebral Edema Case Study

Cerebellar, hippocampal, and basal nuclei transient edema with restricted diffusion (CHANTER) syndrome is a rare disorder associated with opioid neurotoxicity and almost exclusively seen in adults.

Unusual cause of respiratory failure

Open Access Myopathy Case Study

A patient with type II respiratory failure and pulmonary hypertension was diagnosed with RYR1-related myopathy, highlighting the importance of considering congenital myopathies in the differential diagnosis.

Multiorgan involvement of fungal infection after near drowning

Multiple lesions in the lungs, brain, and eyes developed shortly after near drowning in a car accident, caused by Scedosporium apiospermum. Fungal infection should be considered in rapidly progressing brain abscesses.

Anti-PF4 antibody-related disorder initially presenting as ICH

Open Access Cerebral Hemorrhage Case Study

Anti-platelet factor (PF4) disorders are severe and diagnosis may be challenging. Intracranial hemorrhage could present first but usually develops secondary to cerebral venous sinus thrombosis.

Bacterial ventriculitis in a patient with severe periodontitis

Open Access Inflammatory Brain Disease Case Study

Poor dental health can lead to life-threatening CNS infections, even in a healthy individual. This is the first case of ventriculitis caused by an oral pathogen.

A rare case of adult primary brain rhabdomyosarcoma

Open Access Rhabdomyosarcoma Case Study

Primary brain rhabdomyosarcoma primarily occurs in children, but this case in a 26-year-old sheds light on managing the condition in adults.

Tracking chronic traumatic encephalopathy as it develops

Encephalopathy Case Study

CTE is a degenerative tauopathy associated with repetitive head trauma. This case follows a former professional football player with short-term memory deficits at 69 years through to diagnosis with CTE at 82 years.

Coronary thrombectomy for a post-op MI after brain tumor resection

Open Access Myocardial Infarction Case Study

How should you react to an acute MI immediately after a craniotomy for tumor resection? Management of such patients requires carefully balancing the competing risks of myocardial ischemia and postoperative bleeding. 

Management of long-lasting active Graves’ orbitopathy

Open Access Hyperthyroidism Case Study

Late orbital radiotherapy combined with intravenous methylprednisolone successfully treated a patient with recurrent and long-lasting unilateral reactivating Graves’ orbitopathy.

Implantable monitor for heart failure in DMD

Open Access Telemonitoring in Cardiology Case Study

Assessing heart failure progression in patients with Duchenne muscular dystrophy is challenging due to the multisystem nature of the disease. This is the first use of an implantable pulmonary artery pressure monitor.

Using combined PET-MRI to diagnose autoimmune limbic encephalitis

Open Access Autoimmune Encephalitis Case Study

In the most common subtypes of autoimmune limbic encephalitis, existing biomarkers often display unspecific and subtle changes. But [18F]DPA-714-PET-MRI shows potential as a direct imaging marker of neuroinflammation.

Nonketotic hyperglycemia hemichorea-hemiballismus

Open Access Type 2 Diabetes Case Study

HC-HB is a rare movement disorder that can occur in patients with poorly controlled diabetes and hyperglycemia without ketoacidosis. The mainstay of treatment is prompt correction of hyperglycemia.

The blue catheter

In a patient with ventriculoperitoneal shunt dysfunction, exteriorization surgery revealed blue coloring of the catheter, indicating bacterial colonization. This phenomenon has been seen in urinary infections but not CNS pathologies.

Ravulizumab treats myasthenic crisis

Open Access Myasthenia Gravis Case Study

In generalized myasthenia gravis, debilitating muscle weakness can escalate to a crisis, requiring invasive ventilation for respiratory failure. Ravulizumab successfully treated a patient in severe crisis who was resistant to multiple standard therapies.

New-onset nummular headache after cerebral stenting

Open Access Headache Case Study

Headache is relatively common in patients after stent placement for intracranial atherosclerotic stenosis, but this is the first report of nummular headache.

Corticosteroids for hydrocephalus in neurosarcoidosis

Open Access Hydrocephalus Case Study

Hydrocephalus is a rare complication of neurosarcoidosis, usually requiring prompt high-dose IV corticosteroids and neurosurgical treatment. Neurosurgery can have severe complications, but select cases may be eligible for drug treatment only.

Cerebral air embolism following necrotizing pneumonia

Open Access Cerebral Air Embolism Case Study

In abrupt onset of cognitive impairment, seizures, or focal neurological deficits, particularly cases with underlying lesions or following procedures carrying a risk of air induction, cerebral air embolism could be the culprit.

Huge osteoma in the frontoparietal bone

Open Access osteoma Case Study

Osteomas are benign tumors containing cortical and cancellous bone tissues. 18 years after a head trauma, a huge osteoma was discovered following a month of headaches, syncope episodes, and blurred vision.

New ophthalmic signs of procedural stroke

Open Access Stroke Case Study

Procedural stroke is a major complication of cardiac catheterization and endovascular procedures, and recognizing the signs is crucial. In this case, internuclear ophthalmoplegia caused blurred vision, diplopia, and dizziness on lateral gaze.