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Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Neurology
Free for a limited time Dementia Review

Biomarkers for dementia with Lewy bodies

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DLB remains underdiagnosed due to its clinical and pathological heterogeneity, but emerging diagnostic and prognostic biomarkers could herald a new age of precision medicine.

Editor's Choice

Reducing relapse risk in Sydenham chorea

14-05-2024 Post-Infection Chorea News

Treating patients with Sydenham chorea with antibiotics, corticosteroids, or sodium valproate reduces the risk of relapse.

Hypotensive twilight zone in Parkinson’s disease

Free for a limited time Parkinson's Disease Case Study

Almost daily episodes of reduced responsiveness lasting up to an hour, with the patient slumped back in a chair but staying upright, indicated an under-recognised presentation of orthostatic hypertension.

Antipsychotic use in dementia has broad adverse outcomes

10-05-2024 Dementia News

Antipsychotic treatment of behavioral and psychological symptoms in patients with dementia is known to increase risk of stroke and death, but new findings indicate a broader range of adverse outcomes.

CGRP-targeting therapy for migraine

Free for a limited time Migraine Review

Calcitonin gene-related peptide (CGRP)-targeting agents are potential candidates for disease-modifying migraine therapy, but most studies have focused on efficacy. What are the long-term outcomes after discontinuation?

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Latest News

Reducing relapse risk in Sydenham chorea

14-05-2024 Post-Infection Chorea News

Tirofiban beats aspirin in cutting risk for early neurological deterioration after stroke

13-05-2024 Ischemic Stroke News

Antipsychotic use in dementia has broad adverse outcomes

10-05-2024 Dementia News

Early menopause linked to cognitive decline

03-05-2024 Alzheimer's Disease News

Delirium associated with an increased risk for dementia

02-05-2024 Dementia News

APPRAIS(ing) the use of erenumab in migraine prevention

26-04-2024 Migraine News
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on sleep in brain health

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Live event concluded

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

On-demand video coming soon

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
Developed by: Springer Medicine

Case Studies

Hypotensive twilight zone in Parkinson’s disease

Free for a limited time Parkinson's Disease Case Study

Almost daily episodes of reduced responsiveness lasting up to an hour, with the patient slumped back in a chair but staying upright, indicated an under-recognised presentation of orthostatic hypertension.

Extensive neurogenic heterotopic ossification

Open Access Pain Due to Spasticity Case Study

After TBI, 10–20% of patients go on to develop progressive periarticular lamellar bone formation in extraskeletal tissues. This rare case involved significant pain and impaired motion in all four limbs.

CHANTER syndrome from fentanyl exposure in a young child

Open Access Cerebral Edema Case Study

Cerebellar, hippocampal, and basal nuclei transient edema with restricted diffusion (CHANTER) syndrome is a rare disorder associated with opioid neurotoxicity and almost exclusively seen in adults.

Current Reviews

Sublingual apomorphine in the treatment of Parkinson’s disease

Levodopa Neurology and Preclinical Neurological Studies - Review Article

Advanced Parkinson´s disease (PD) is often complicated by fluctuations of disability depending on plasma levels of levodopa. For most patients OFF phases with worsening of tremor and immobility, but also pain, depression, autonomic symptoms are …

Pharmacotherapies for the Treatment of Progressive Supranuclear Palsy: A Narrative Review

Open Access Progressive Supranuclear Palsy Review

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder resulting from the deposition of misfolded and neurotoxic forms of tau protein in specific areas of the midbrain, basal ganglia, and cortex. It is one of the most representative …

The Role of Astrocytes in Migraine with Cortical Spreading Depression: Protagonists or Bystanders? A Narrative Review

Open Access Migraine REVIEW

Cortical spreading depression (CSD) is a slow wave of cortical depolarization closely associated with migraines with an aura. Previously, it was thought that CSD depolarization was mainly driven by neurons, with characteristic changes in neuronal …

HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation

Open Access Stroke Review

Stroke in China is distinguished by its high rates of morbidity, recurrence, disability, and mortality. The ultra-early administration of rtPA is essential for restoring perfusion in acute ischemic stroke, though it concurrently elevates the risk …
Alzheimer's Disease Independent Medical Education

Advances in Alzheimer's

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Alzheimer's research and care is changing rapidly. Keep up with the latest developments from key international conferences, together with expert insights on how to integrate these advances into practice.

This content is intended for healthcare professionals outside of the UK.

Supported by: Lilly

Developed by: Springer Healthcare IME

CME & eLearning

News | Vodcasts | Podcasts (Link opens in a new window)

Alzheimer's Disease

1.5 AMA PRA Category 1 Credit(s)™

Emerging biomarkers and disease-modifying therapies for Alzheimer’s disease promise significant changes in how the condition is diagnosed and managed.

Guide yourself through this transition with our education program, led by world renowned experts and covering the biggest international conferences.

This content is intended for healthcare professionals outside of the UK.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME

Webinar (Link opens in a new window)

Amyloidosis

Interact with experts from established amyloidosis centers who can offer you specialized guidance to support your mission to set up a local center. Network with other HCPs in your locality to discuss region-specific challenges in establishing amyloidosis centers. 

Supported by:
  • AstraZeneca and Alexion
Developed by: Springer Healthcare IME

Webcast | eLearning | Infographic (Link opens in a new window)

Alzheimer's Disease

PET biomarkers are fast becoming critical in the new era of disease modification for Alzheimer’s disease. Techniques around amyloid and tau require the expertise of nuclear medicine and radiology physicians to investigate and interpret PET scans in clinical settings. This program examines current and emerging biomarkers and assists in identifying patterns from different PET tracers in an interactive perceptual learning environment.

Supported by:
  • Lilly
Developed by: Springer Healthcare IME
Alzheimer's Disease Independent Medical Education

Neuroimaging for Alzheimer’s disease: eLearning (Link opens in a new window)

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Neuroimaging plays an increasingly critical role in clinical practice. PET Pearls is an interactive activity designed to improve your confidence and accuracy when interpreting imaging for early signs of cognitive impairment.

Supported by: Lilly

Developed by: Springer Healthcare IME

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Further Reading

Clinical and kinematic characterization of parkinsonian soft signs in essential tremor

Open Access Tremor Neurology and Preclinical Neurological Studies - Original Article

Essential tremor (ET) is a common movement disorder characterized by bilateral action tremor of the upper limbs. The ET diagnosis requires no other signs of neurological disorders to be present (Bhatia et al. 2018 ). Recently, the term ET-plus has …

Regional hippocampal atrophy reflects memory impairment in patients with early relapsing remitting multiple sclerosis

Open Access Multiple Sclerosis Original Research

Multiple sclerosis (MS) is a chronic immune-mediated inflammatory disease of the central nervous system, characterized by the involvement of white matter (WM) and gray matter (GM) since the early stages [ 1 ]. The hippocampus, a complex structure …

The Role of Astrocytes in Migraine with Cortical Spreading Depression: Protagonists or Bystanders? A Narrative Review

Open Access Migraine REVIEW

Cortical spreading depression (CSD) is a slow wave of cortical depolarization closely associated with migraines with an aura. Previously, it was thought that CSD depolarization was mainly driven by neurons, with characteristic changes in neuronal …

HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation

Open Access Stroke Review

Stroke in China is distinguished by its high rates of morbidity, recurrence, disability, and mortality. The ultra-early administration of rtPA is essential for restoring perfusion in acute ischemic stroke, though it concurrently elevates the risk …

Related topics

10-05-2024 Dementia News

Antipsychotic use in dementia has broad adverse outcomes

Antipsychotic treatment of behavioral and psychological symptoms in patients with dementia is known to increase risk of stroke and death, but new findings indicate a broader range of adverse outcomes.

Read more

How neuroimmunology affects the heart

Open Access Circulatory Disease Review

Anti-PF4 antibody-related disorder initially presenting as ICH

Open Access Cerebral Hemorrhage Case Study

Preventing and treating stroke in type 2 diabetes

Open Access Type 2 Diabetes Review

A new way to prevent stroke after TAVR?

Aortic Valve Replacement Review

Dual antiplatelet therapy reduces neurological deterioration in stroke

28-03-2024 Stroke News
Free for a limited time Dementia Review

Biomarkers for dementia with Lewy bodies

DLB remains underdiagnosed due to its clinical and pathological heterogeneity, but emerging diagnostic and prognostic biomarkers could herald a new age of precision medicine.

Read more

Antipsychotic use in dementia has broad adverse outcomes

10-05-2024 Dementia News

Delirium associated with an increased risk for dementia

02-05-2024 Dementia News

Healthy blood, healthy brain

Free for a limited time Dementia Review

Post-traumatic epilepsy increases risk for dementia later in life

20-03-2024 Epilepsy News

CSF biomarker abnormalities precede Alzheimer’s disease by up to 18 years

15-03-2024 Alzheimer's Disease News
08-04-2024 Epilepsy News

A link between antiseizure medication use in pregnancy and autism?

Children born to women with epilepsy who take topiramate when pregnant are not at increased risk for autism spectrum disorders, whereas there is an increased risk with valproate.

Read more

Post-traumatic epilepsy increases risk for dementia later in life

20-03-2024 Epilepsy News

Antiepileptic strategies for patients with brain tumors

Open Access Central Nervous System Cancer Review

Rescue therapies for seizure clusters

Open Access Epilepsy Review

Is it migraine or epilepsy?

Open Access Migraine Review

Cardiovascular risk increased in epilepsy

30-01-2024 Epilepsy News
Open Access Neurological Involvement in Infectious Disease Case Study

Multiorgan involvement of fungal infection after near drowning

Multiple lesions in the lungs, brain, and eyes developed shortly after near drowning in a car accident, caused by Scedosporium apiospermum. Fungal infection should be considered in rapidly progressing brain abscesses.

Read more

How neuroimmunology affects the heart

Open Access Circulatory Disease Review

Bacterial ventriculitis in a patient with severe periodontitis

Open Access Inflammatory Brain Disease Case Study

Pediatric relapsing autoimmune encephalitis

Open Access Autoimmune Encephalitis Review

Using combined PET-MRI to diagnose autoimmune limbic encephalitis

Open Access Autoimmune Encephalitis Case Study

Managing trigeminal postherpetic neuralgia

Open Access Trigeminal Neuralgia Review
Open Access Cerebral Edema Case Study

CHANTER syndrome from fentanyl exposure in a young child

Cerebellar, hippocampal, and basal nuclei transient edema with restricted diffusion (CHANTER) syndrome is a rare disorder associated with opioid neurotoxicity and almost exclusively seen in adults.

Read more

Multiorgan involvement of fungal infection after near drowning

Open Access Neurological Involvement in Infectious Disease Case Study

Improving drug delivery in glioblastoma

Open Access Glioblastoma Review

Bacterial ventriculitis in a patient with severe periodontitis

Open Access Inflammatory Brain Disease Case Study

Novel therapies for glioblastoma

Glioblastoma Review

A rare case of adult primary brain rhabdomyosarcoma

Open Access Rhabdomyosarcoma Case Study
Type 2 Diabetes Review

The gut microbiota, gut–brain axis, and type 2 diabetes

The gut microbiota and host communicate bidirectionally along the gut–brain axis to regulate glucose homeostasis, and evidence supports a role for dysbiosis of the gut microbiota in the development of type 2 diabetes.

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Orthopnea secondary to brachial plexitis with bilateral diaphragmatic paralysis

Open Access Neuralgic Shoulder Amyotrophy Case Study

Vasculitic neuropathies

Peripheral Nervous System Disease Review

Chronic cough as a genetic neurological disorder? Insights from CANVAS

Open Access Cough Review

Diabetic microvascular disease beyond the retina, kidney, and peripheral nerves

Open Access Diabetes-associated Diseases Review

Neurotoxicity of cancer immunotherapies

Cancer Immunotherapy Review
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