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Internal Medicine Infectious Disease

Infectious Disease

Update on managing RSV in older adults

A review of prevention and treatment strategies for respiratory syncytial virus infection in older adults, with a special focus on the novel vaccines now available.

Perforated appendicitis: room for improvement?

Free for a limited time Appendicitis Review

Appendicitis has been described for over 300 years, but care practices vary widely. Explore the risk factors for perforated appendicitis in children and recommendations for surgical and antimicrobial management.

An unusual complication of hemorrhagic fever with renal syndrome

Open Access Hypopituitarism Case Study

Partial hypopituitarism with adrenocorticotropin deficiency as the main manifestation in a man who presented with fatigue, nausea, poor appetite, and a history of HFRS.

Cardiac events common in hospitalized older adults with RSV

Acute cardiac events occur in almost a quarter of adults aged 50 years or older who are hospitalized for respiratory syncytial virus infection.

Shortened rifampicin regimen promising as a tuberculosis preventive treatment

18-04-2024 Tuberculosis News

A 2-month regimen of daily rifampicin at 20 mg/kg has a comparable safety profile to the standard 4-month regimen of 10 mg/kg, but an inexplicably lower completion rate.

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An unusual complication of hemorrhagic fever with renal syndrome

Open Access Hypopituitarism Case Study

Partial hypopituitarism with adrenocorticotropin deficiency as the main manifestation in a man who presented with fatigue, nausea, poor appetite, and a history of HFRS.

Bacterial ventriculitis in a patient with severe periodontitis

Open Access Inflammatory Brain Disease Case Study

Poor dental health can lead to life-threatening CNS infections, even in a healthy individual. This is the first case of ventriculitis caused by an oral pathogen.

Bacterial endocarditis caused by contact lens use

Open Access Endocarditis Case Study

A 17-year-old female presented with high fever, general fatigue, and dim eyesight. She had used colored contact lenses 3 weeks previously. Traumatic injury of the eye vessels led to systemic hematogenous infection and subsequent endocarditis. 

Current Reviews

Digital Strategies Supporting Social Network Approaches to HIV Testing: A Scoping Review

HIV testing is vital for HIV prevention as it is the crucial point for the care continuum and declined transmission, critical to achieving the 95–95-95 targets of testing and treatment among people living with HIV by 2025 [ 1 , 2 ]. However, the …

Lessons Learned from Model-based Economic Evaluations of COVID-19 Drug Treatments Under Pandemic Circumstances: Results from a Systematic Review

Open Access COVID-19 Systematic Review

In a world where resources are limited and healthcare costs keep rising, health technology assessment (HTA) becomes crucial to making informed decisions about the allocation of resources for health-related interventions. Even (and perhaps …

The Assessment of Social Isolation and Loneliness in Cancer Patients and Survivors in the Pre-COVID-19 Period: A Systematic Review

COVID-19 Special Issue: Meta-Analyses and Reviews

Social isolation has been defined as an objective condition characterized by lack of contact with other people and being disengaged from groups and social activities [ 1 ]. By contrast, loneliness is a distinct but related construct defined as a …

Clinical Outcomes of Integrase Strand Transfer Inhibitors Containing Antiretroviral Therapy in HIV-2: A Narrative Review

The human immunodeficiency virus type 2 (HIV-2) is a particular subtype of HIV, which is endemic in West Africa and is characterized by a more indolent course than HIV-1. As people living with HIV-2 (PWH-2) are at risk for the development of …

Further Reading

Prevalence of Mental Health Disorders and Their Associated Risk Factors Among People Living with HIV in Rwanda: A Cross-Sectional Study

Open Access Human Immunodeficiency Virus Original Paper

While life expectancy of people living with HIV is increasing, their burden of non-communicable diseases, including mental health disorders, is growing as well. The aim of this study is to investigate the prevalence and identify the risk factors …

Clinical Characteristics and Fatality Risk Factors for Patients with Listeria monocytogenes Infection: A 12-Year Hospital-Based Study in Xi’an, China

Open Access Listeriosis Original Research

Listeria monocytogenes ( L. monocytogenes ) is a Gram-positive intracellular pathogen that is widespread in the environment [ 1 ]. The main routes of L. monocytogenes transmission are believed to be contracted through consumption of contaminated …

Cost-effectiveness Analysis of Maternal Immunization with RSVpreF Vaccine for the Prevention of Respiratory Syncytial Virus Among Infants in Spain

Open Access Respiratory Syncytial Virus Infection Original Research

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in children under 1 year of age, mainly those related to bronchiolitis and pneumonia. All infants are at risk of acquiring an RSV infection with …

Cost-effectiveness of PCV20 to Prevent Pneumococcal Disease in the Pediatric Population: A German Societal Perspective Analysis

Open Access Pneumonia Original Research

Streptococcus pneumoniae is the leading cause of bacterial pneumonia and global mortality in children [ 2 – 5 ]. In 2016, S. pneumoniae has been estimated to account for approximately 197 million cases of pneumonia and 1.1 million deaths [ 6 ].