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Indian Journal of Pediatrics

06-09-2024 | Zoledronic Acid | Correspondence

Effective Use of Zoledronic Acid for Refractory Hypercalcemia in Neonatal Subcutaneous Fat Necrosis

Authors: Emna Marmech, Ines Selmi, Jihed Kanzari, Haifa Ouarda, Ons Azzabi, Nadia Siala

Published in: Indian Journal of Pediatrics

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Excerpt

To the Editor: Subcutaneous fat necrosis of the newborn (SCFN) is an uncommon panniculitis often associated with fetal stress. While typically benign, SCFN can lead to severe hypercalcemia, requiring prompt intervention. Standard treatments include intravenous fluids, diuretics, corticosteroids, and bisphosphonates [1]. Zoledronic acid, a third-generation bisphosphonate, has been utilized in isolated cases, but data on its efficacy in neonates remain limited. …
Literature
1.
Stefanko NS, Drolet BA. Subcutaneous fat necrosis of the newborn and associated hypercalcemia: a systematic review of the literature. Pediatr Dermatol. 2019;36:24–30.CrossRefPubMed
2.
Chesover AD, Harrington J, Mahmud FH. Pamidronate as first-line treatment of hypercalcemia in neonatal subcutaneous fat necrosis: a case series. Paediatr Child Health. 2019;26:e52–6.CrossRefPubMedPubMedCentral
3.
Militello MA, Re MP, Vitaliti G, Finazzo F, Manzoni P, Vitaliti SM. Use of zoledronic acid in a neonate with subcutaneous fat necrosis complicated with severe, refractory hypercalcemia. Am J Perinatol. 2019;36:S134–8.CrossRefPubMed
4.
Metadata
Title
Effective Use of Zoledronic Acid for Refractory Hypercalcemia in Neonatal Subcutaneous Fat Necrosis
Authors
Emna Marmech
Ines Selmi
Jihed Kanzari
Haifa Ouarda
Ons Azzabi
Nadia Siala
Publication date
06-09-2024
Publisher
Springer India
Published in
Indian Journal of Pediatrics
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-024-05260-5