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Open Access 12-03-2025 | Vulgar Psoriasis | Original Article

Efficacy of Aster chinensis aerial parts metabolites in BALB/c mice model of Imiquimod-induced psoriasis skin inflammation

Authors: Mai S. Hendawy, Mona M. Hashem, Ahmed A. Zaki, Mostafa A. Rabie, Nesrine S. El Sayed, Riham Salah El Dine, Ali M. El-Halawany

Published in: Inflammopharmacology

Abstract

Using a bioassay-guided fractionation approach, the most potent anti-psoriatic components of Aster squamatus herb, Aster chinensis stalks, and Aster chinensis flowers, cultivated in Egypt, were identified and evaluated against Imiquimod (IMQ)-induced psoriasis in female BALB/c mice and compared to standard drug, mometasone. The topical application of A. chinensis stalk methanolic extract exhibited the strongest anti-psoriatic effects against IMQ-induced psoriasis model, as evidenced by improvements in psoriasis area severity index (PASI) score, histopathological analysis, and spleen index. Further fractionation of A. chinensis stalk methanolic extract using petroleum ether, methylene chloride, ethyl acetate, and n-butanol revealed that the methylene chloride fraction (MCF) was the most potent. Indeed, MCF significantly reduced the PASI score, alleviated histopathological changes, and restored spleen index. Mechanistically, MCF exerted its anti-psoriatic effects by suppressing inflammation, evidenced by decreased TLR-4 gene expression and lower levels of HMGB1 and NFκBp65 protein contents. Additionally, MCF reduced serum levels of pro-inflammatory cytokines interleukin (IL)-1β, IL-6, IL-23, and IL-17 while mitigating oxidative stress through increased superoxide dismutase (SOD) activity and reduced malondialdehyde (MDA) content. Notably, the efficacy of MCF was comparable to that of mometasone, with no significant differences observed. In parallel, the chemical profile of the MCF was analyzed using UHPLC-MS/MS techniques in negative and positive ionization full scan modes. MCF of A. chinensis stalk could be used a potential therapeutic agent for psoriasis.

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Abdelkader DH, Abosalha AK, Khattab MA, Aldosari BN, Almurshedi AS (2021) A Novel sustained anti-inflammatory effect of atorvastatin—calcium plga nanoparticles: in vitro optimization and in vivo evaluation. Pharmaceutics 13:1658. https://doi.org/10.3390/pharmaceutics13101658CrossRefPubMedPubMedCentral

Abdou RM, El-maadawy WH, Hassan M, El-dine RS, Aboushousha T, El-tanbouly ND, El-sayed AM (2021) Nephroprotective activity of Aframomum melegueta seeds extract against diclofenac-induced acute kidney injury: a mechanistic study. J Ethnopharmacol 273:113939. https://doi.org/10.1016/j.jep.2021.113939CrossRefPubMed

Agrawal Y, Petkar KC, Sawant KK (2010) Development, evaluation and clinical studies of acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis. Int J Pharm 401:93–102. https://doi.org/10.1016/j.ijpharm.2010.09.007CrossRefPubMed

Batista R (2014) Uses and potential applications of ferulic acid. Ferulic acid: antioxidant properties, uses and potential health benefits. Nova Science, New York, pp 39–70

Bhargav V, Kumar R, Shivashankara KS, Rao TM, Dhananjaya MV, Sane A, Bharathi TU, Venugopalan R, Roy TK (2018) Diversity of flavonoids profile in China aster [Callistephus chinensis (L.) Nees.] genotypes. Ind Crops Prod 111:513–519. https://doi.org/10.1016/j.indcrop.2017.11.023CrossRef

Bi, LiuXiaChenMuLiuHouZhao XWXLTJYY (2014) Effects of Callistephus chinensis flower polyphones on improving metabolic disorders in high-fat diet-induced mice. Food Funct 5:3304–3310. https://doi.org/10.1039/C4FO00637BCrossRefPubMed

Biswas S, Bordolui SK, Sadhukhan R (2021) Response of china aster (callistephus chinensis L.) genotypes towards foliar application of GA3. Am Int J Agric Stud 5:1–15. https://doi.org/10.46545/aijas.v5i1.197%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20%20

Bondia-Pons I, Barri T, Hanhineva K, Juntunen K, Dragsted LO, Mykkänen H, Poutanen K (2013) UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention. Mol Nutr Food Res 57:412–422. https://doi.org/10.1002/mnfr.201200571CrossRefPubMed

Boulechfar S, Zellagui A, Gherraf N (2014) Total phenolic and flavonoid content and in vitro antioxidant and antibacterial activity of Aster squamatus Hier. leaves extracts. Pharm Lett 6:112–115

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254. https://doi.org/10.1016/0003-2697(76)90527-3CrossRefPubMed

Cáceres-Velez PR, Ali A, Fournier-Level A, Dunshea FR, Jusuf PR (2022) Phytochemical and safety evaluations of finger lime, mountain pepper, and tamarind in zebrafish embryos. Antioxidants 11:1280. https://doi.org/10.3390/antiox11071280CrossRefPubMedPubMedCentral

Calixto-Campos C, Carvalho TT, Hohmann MSN, Pinho-Ribeiro FA, Fattori V, Manchope MF, Zarpelon AC, Baracat MM, Georgetti SR, Casagrande R, Jusuf Verri WA (2015) Vanillic acid inhibits inflammatory pain by inhibiting neutrophil recruitment, oxidative stress, cytokine production, and NFκB activation in mice. J Nat Prod 78:1799–1808. https://doi.org/10.1021/acs.jnatprod.5b00246CrossRefPubMed

Cannavacciuolo C, Pagliari S, Giustra CM, Carabetta S, Guidi Nissim W, Russo M, Branduardi P, Labra M, Campone L (2023) LC-MS and GC-MS data fusion metabolomics profiling coupled with multivariate analysis for the discrimination of different parts of faustrime fruit and evaluation of their antioxidant activity. Antioxidants 12:565. https://doi.org/10.3390/antiox12030565CrossRefPubMedPubMedCentral

Carregaro F, Stefanini ACB, Henrique T, Tajara EH (2013) Study of small proline-rich proteins (SPRRs) in health and disease: a review of the literature. Arch Dermatol Res 305:857–866. https://doi.org/10.1007/s00403-013-1415-9CrossRefPubMed

Chamcheu JC, Chaves-rodriquez M-I, Adhami VM, Siddiqui IA, Wood GS, Longley BJ, Mukhtar H (2016) Upregulation of PI3K/AKT/mTOR, FABP5 and PPARβ/δ in human psoriasis and imiquimod-induced murine psoriasiform dermatitis model. Acta Derm Venereol 96:854. https://doi.org/10.2340/00015555-2359

Chen H, Lu C, Liu H, Wang M, Zhao H, Yan Y, Han L (2017) Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-κB pathway. Int Immunopharmacol 48:110–117. https://doi.org/10.1016/j.intimp.2017.04.022CrossRefPubMed

Chen M, Kumar S, Anselmo AC, Gupta V, Slee DH, Muraski JA, Mitragotri S (2015a) Topical delivery of cyclosporine A into the skin using SPACE-peptide. J Controlled Release 199:190–197. https://doi.org/10.1016/j.intimp.2017.04.022CrossRef

Chen S-D, Lu C-J, Zhao R-Z (2015b) Identification and quantitative characterization of PSORI-CM01, a chinese medicine formula for psoriasis therapy, by liquid chromatography coupled with an LTQ orbitrap mass spectrometer. Molecules 20:1594–1609. https://doi.org/10.3390/molecules20011594

Chen Y, Zhang Q, Liu H, Lu C, Liang C-L, Qiu F, Han L, Dai Z (2018) Esculetin ameliorates psoriasis-like skin disease in mice by inducing CD4⁺Foxp3⁺ regulatory t cells. Front Immunol 9. https://doi.org/10.3389/fimmu.2018.02092

Choi J-H, Chung K-S, Jin B-R, Cheon S-Y, Nugroho A, Roh S-S, An H-J (2017) Anti-inflammatory effects of an ethanol extract of Aster glehni via inhibition of NF-κB activation in mice with DSS-induced colitis. Food Funct 8:2611–2620. https://doi.org/10.1039/C7FO00369BCrossRefPubMed

Contardi M, Lenzuni M, Fiorentini F, Summa M, Bertorelli R, Suarato G, Athanassiou A (2021) Hydroxycinnamic acids and derivatives formulations for skin damages and disorders: a review. Pharmaceutics 13:999. https://doi.org/10.3390/pharmaceutics13070999CrossRefPubMedPubMedCentral

Devkota HP, Aftab T (2022) Medicinal plants of the asteraceae family: traditional uses, phytochemistry and pharmacological activities. Springer Nature. https://doi.org/10.1007/978-981-19-6080-2CrossRef

Eklund PC, Backman MJ, Kronberg LÅ, Smeds AI, Sjöholm RE (2008) Identification of lignans by liquid chromatography-electrospray ionization ion-trap mass spectrometry. J Mass Spectrom 43:97–107. https://doi.org/10.1002/jms.1276CrossRefPubMed

Elgewelly MA, Elmasry SM, El sayed NS, Abbas H (2022) Resveratrol-loaded vesicular elastic nanocarriers gel in imiquimod-induced psoriasis treatment: in vitro and in vivo evaluation. J Pharm Sci 111:417–431. https://doi.org/10.1016/j.xphs.2021.08.023CrossRefPubMed

El-Hawary SS, El-Kammar HA, Farag MA, Saleh DO, El dine RS (2020) Metabolomic profiling of five Agave leaf taxa via UHPLC/PDA/ESI-MS inrelation to their anti-inflammatory, immunomodulatory and ulceroprotective activities. Steroids 160:108648. https://doi.org/10.1016/j.steroids.2020.108648CrossRefPubMed

Elkhawaga OY, Ellety MM, Mofty SO, Ghanem MS, Mohamed AO (2023) Review of natural compounds for potential psoriasis treatment. Inflammopharmacology 31:1183–1198. https://doi.org/10.1007/s10787-023-01178-0CrossRefPubMedPubMedCentral

El sayed Basam El-Naggar Marzouk El-Hawary AMSMEMBAHSS (2020) LC–MS/MS and GC–MS profiling as well as the antimicrobial effect of leaves of selected Yucca species introduced to Egypt. Sci Rep 10:17778. https://doi.org/10.1038/s41598-020-74440-yCrossRefPubMed

El-Shemy HA (2017) Aromatic and medicinal plants – back to nature. IntechOpen. https://doi.org/10.5772/63696CrossRef

Emad AM, Rasheed DM, El-Kased RF, El-Kersh DM (2022) Antioxidant, antimicrobial activities and characterization of polyphenol-enriched extract of egyptian celery (Apium graveolens L., Apiaceae) aerial parts via UPLC/ESI/TOF-MS. Molecules 27, 698. https://doi.org/10.3390/molecules27030698

Fu Q, Tong C, Guo Y, Xu J, Shi F, Shi S, Xiao Y (2020) Flavonoid aglycone–oriented data-mining in high-performance liquid chromatography–quadrupole time-of-flight tandem mass spectrometry: efficient and targeted profiling of flavonoids in Scutellaria barbata. Anal Bioanal Chem 412:321–333. https://doi.org/10.1007/s00216-019-02238-7CrossRefPubMed

Gao Y (2010) Chemical constituents from Aster sampsonii. China J Chin Mater Med 35:2289–2292

García-Perez ME, Kasangana PB, Stevanovic T (2017) Chapter 6 – Bioactive polyphenols for diabetes and inflammation in psoriasis disease. In: Attaur R (ed) Studies in Natural Products Chemistry. https://doi.org/10.1016/B978-0-444-63931-8.00006-0

Ghedini PC, Almeida CE, Burger M, De Freitas Bauermann L, Magni DV, Borgmann SHM (2002) Preliminary studies of anti-ulcerogenic effect of Aster squamatus leaves hydroalcoholic extract on various ulcer models in rats. Acta Farm Bonaerense 21:165–168

Giannakou SA, Dallas PP, Rekkas DM, Choulis NH (1998) Development and in vitro evaluation of nimodipine transdermal formulations using factorial design. Pharm Dev Technol 3:517–525. https://doi.org/10.3109/10837459809028634CrossRefPubMed

Griffiths CE, Barker JN (2007) Pathogenesis and clinical features of psoriasis. The Lancet 370:263–271. https://doi.org/10.1016/S0140-6736(07)61128-3CrossRef

Gudjonsson JE, Johnston A, Sigmundsdottir H, Valdimarsson H (2004) Immunopathogenic mechanisms in psoriasis. Clin Exp Immunol 135:1–8. https://doi.org/10.1111/j.1365-2249.2004.02310.xCrossRefPubMedPubMedCentral

Hanna E, Abadi R, Abbas O (2016) Imiquimod in dermatology: an overview. Int J Dermatol 55:831–844. https://doi.org/10.1111/ijd.13235CrossRefPubMed

Hoang KHT, Lim J, Nguyen MTT, Lee N-Y, Lee C-K, Nguyen VD, Kim H-L, Park J-T, Kim J (2021) Comparative phytochemical analysis of Syzygium formosum (Wall.) masam leaf and its biological activities. Appl Sci 11, 10552. https://doi.org/10.3390/app112210552

Hyun S-W, Kim J, Jo K, Kim JS, Kim C-S (2018) Aster koraiensis extract improves impaired skin wound healing during hyperglycemia. Integr Med Res 7:351–357. https://doi.org/10.1016/j.imr.2018.09.001CrossRefPubMedPubMedCentral

Jaiswal R, Halabi EA, Karar MGE, Kuhnert N (2014) Identification and characterisation of the phenolics of Ilex glabra L. Gray (Aquifoliaceae) leaves by liquid chromatography tandem mass spectrometry. Phytochemistry 106:141–155. https://doi.org/10.1016/j.phytochem.2014.07.018CrossRefPubMed

Kakodkar SA, Kshirsagar SN, Kelkar AS, Nair AM, Dhawal PP, Satardekar KV, Barve SS (2019) Evaluation of phytochemical constituents, antioxidant property, DNA damage inhibition activity and cytotoxicity of aster (Callistephus chinensis) flower waste. World J Pharm Res 8(5), 977–991. https://doi.org/10.20959/wjpr20195-14575

Kalam A, Al-Sehemia AG, Alrummanc SA, Assiria MA, Alfaifyc AM, Moustafac MF, Almalkie H (2020) In vitro antimicrobial activity of silver nanoparticle synthesized using Aster squamatus flower extract against selected pathogenic microbial. J Indian Chem Soc 97:1462–1466

Kamal RM, Sabry MM, El-Halawany AM, Rabie MA, El sayed, NS, Hifnawy MS, Younis IY (2024) GC-MS analysis and the effect of topical application of essential oils of Pinus canariensis C.Sm., Cupressus lusitanica Mill. and Cupressus arizonica Greene aerial parts in imiquimod-induced psoriasis in mice. J Ethnopharmacol 318, 116947. https://doi.org/10.1016/j.jep.2023.116947

Karaköse H, Jaiswal R, Kuhnert N (2011) Characterization and quantification of hydroxycinnamate derivatives in Stevia rebaudiana leaves by LC-MSⁿ. J Agric Food Chem 59:10143–10150. https://doi.org/10.1021/jf202185mCrossRefPubMed

Khedr LH, Rahmo RM, Eldemerdash OM, Helmy EM, Ramzy FA, Lotfy GH, Zakaria HA, Gad MM, Youhanna MM, Samaan MH, Thabet NW, Ghazal RH, Rabie MA (2024) Implication of M2 macrophage on NLRP3 inflammasome signaling in mediating the neuroprotective effect of Canagliflozin against methotrexate-induced cognitive impairment. Int Immunopharmacol 130:111709. https://doi.org/10.1016/j.intimp.2024.111709CrossRefPubMed

Koo J (1999) Systemic sequential therapy of psoriasis: a new paradigm for improved therapeutic results. J Am Acad Dermatol 41:S25–S28. https://doi.org/10.1016/S0190-9622(99)70363-4CrossRefPubMed

Li L, He L, Su X, Amu H, Li J, Zhang Z (2022) Chemotaxonomy of Aster species from the Qinghai-Tibetan Plateau based on metabolomics. Phytochem Anal 33:23–39. https://doi.org/10.1002/pca.3058CrossRefPubMed

Lim J-Y, Lee J-H, Lee D-H, Lee J-H, Kim D-K (2019) Umbelliferone reduces the expression of inflammatory chemokines in HaCaT cells and DNCB/DFE-induced atopic dermatitis symptoms in mice. Int Immunopharmacol 75:105830. https://doi.org/10.1016/j.intimp.2019.105830CrossRefPubMed

Liu L, Cui Z-X, Zhang Y-B, Xu W, Yang X-W, Zhong L-J, Zhang P, Gong Y (2021) Identification and quantification analysis of the chemical constituents from Mahonia fortune using Q-Exactive HF mass spectrrometer and UPLC–ESI-MS/MS. J Pharm Biomed Anal 196:113903. https://doi.org/10.1016/j.jpba.2021.113903CrossRefPubMed

Liu Y, Krueger J, Bowcock A (2007) Psoriasis: genetic associations and immune system changes. Genes Immun 8:1–12. https://doi.org/10.1038/sj.gene.6364351CrossRefPubMed

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25:402–408. https://doi.org/10.1006/meth.2001.1262CrossRefPubMed

López-Lázaro M (2009) Distribution and biological activities of the flavonoid luteolin. Mini-Rev Med Chem 9:31–59. https://doi.org/10.2174/138955709787001712CrossRefPubMed

Lowes MA, Suarez-Farinas M, Krueger JG (2014) Immunology of psoriasis. Annu Rev Immunol 32:227–255. https://doi.org/10.1146/annurev-immunol-032713-120225CrossRefPubMedPubMedCentral

Made Ratih GA, Imawati MF, Nugroho RR, Purwanti DI, Wongso S, Prajogo B, Indrayanto G (2019) Phytochemicals of Gandarusa (Justicia gendarussa) and its preparations. Nat Prod Commun 14(6). https://doi.org/10.1177/1934578X19851406

Michalek I, Loring B, John S (2017) A systematic review of worldwide epidemiology of psoriasis. J Eur Acad Dermatol Venereol 31:205–212. https://doi.org/10.1111/jdv.13854CrossRefPubMed

Mohamed YT, Salama A, Rabie MA, Abd El MA, fattah (2023) Neuroprotective effect of secukinumab against rotenone induced Parkinson’s disease in rat model: involvement of IL-17, HMGB-1/TLR4 axis and BDNF/TrKB cascade. Int Immunopharmacol 114:109571. https://doi.org/10.1016/j.intimp.2022.109571CrossRefPubMed

Nadeem M, Mumtaz MW, Danish M, Rashid U, Mukhtar H, Irfan A, Anwar F, Saari N (2020) UHPLC-QTOF-MS/MS metabolites profiling and antioxidant/antidiabetic attributes of Cuscuta reflexa grown on Casearia tomentosa: exploring phytochemicals role via molecular docking. Int J Food Prop 23:918–940. https://doi.org/10.1080/10942912.2020.1764578CrossRef

Ng TB, Liu F, Lu Y, Cheng CHK, Wang Z (2003) Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp Biochem Physiol Part c: Toxicol Pharmacol 136:109–115. https://doi.org/10.1016/S1532-0456(03)00170-4CrossRef

Ngabire D, Seong Y, Patil MP, Niyonizigiye I, Seo YB, Kim G-D (2018) Anti-inflammatory effects of aster incisus through the inhibition of NF-κB, MAPK, and akt pathways in LPS-stimulated RAW 264.7 macrophages. Mediat Inflamm 2018, 10. https://doi.org/10.1155/2018/4675204

Ostrowski W, Wojakowska A, Grajzer M, Stobiecki M (2014) Mass spectrometric behavior of phenolic acids standards and their analysis in the plant samples with LC/ESI/MS system. J Chromatogr B 967:21–27. https://doi.org/10.1016/j.jchromb.2014.07.005CrossRef

Park SH, Kim DS, Kim S, Lorz LR, Choi E, Lim HY, Hossain MA, Jang S, Choi YI, Park KJ, Yoon K, Kim J-H, Cho JY (2019) Loliolide presents antiapoptosis and antiscratching effects in human keratinocytes. Int J Mol Sci 20:651. https://doi.org/10.3390/ijms20030651CrossRefPubMedPubMedCentral

Peixoto Araujo NM, Arruda HS, DosSantos FN, De Morais DR, Pereira GA, Pastore GM (2020) LC-MS/MS screening and identification of bioactive compounds in leaves, pulp and seed from Eugenia calycina Cambess. Food Res Int 137:109556. https://doi.org/10.1016/j.foodres.2020.109556CrossRefPubMed

Pinto MF, Moura CC, Nunes C, Segundo MA, Costa Lima SA, Reis S (2014) A new topical formulation for psoriasis: development of methotrexate-loaded nanostructured lipid carriers. Int J Pharm 477:519–526. https://doi.org/10.1016/j.ijpharm.2014.10.067CrossRefPubMed

Rachakonda TD, Schupp CW, Armstrong AW (2014) Psoriasis prevalence among adults in the United States. J Am Acad Dermatol 70:512–516. https://doi.org/10.1016/j.jaad.2013.11.013CrossRefPubMed

Shin J-S, Hong Y, Lee H-H, Ryu B, Cho Y-W, Kim N-J, Jang DS, Lee K-T (2015) Fulgidic acid isolated from the rhizomes of Cyperus rotundus suppresses LPS-induced iNOS, COX-2, TNF-α, and IL-6 expression by AP-1 inactivation in RAW264. 7 macrophages. Biol Pharm Bull 38:1081–1086. https://doi.org/10.1248/bpb.b15-00186CrossRefPubMed

Silva T, Oliveira C, Borges F (2014) Caffeic acid derivatives, analogs and applications: a patent review (2009–2013). Expert Opin Ther Pat 24:1257–1270. https://doi.org/10.1517/13543776.2014.959492CrossRefPubMed

Sperotto JS, Bialeski N, Savegnago L, Heinzmann BM, Karnikowski MG, Baldisserotto B (2002) Effect on gastrointestinal propulsion and preliminar phytochemical analysis of Aster squamatus (Asteraceae). Acta Farm Bonaer 21:279–282

Steingass CB, Glock MP, Schweiggert RM, Carle R (2015) Studies into the phenolic patterns of different tissues of pineapple (Ananas comosus [L.] Merr.) infructescence by HPLC-DAD-ESI-MSⁿ and GC-MS analysis. Anal Bioanal Chem 407:6463–6479. https://doi.org/10.1007/s00216-015-8811-2CrossRefPubMed

Su XD, Jang H-J, Li HX, Kim YH, Yang SY (2019) Identification of potential inflammatory inhibitors from Aster tataricus. Bioorg Chem 92:103208. https://doi.org/10.1016/j.bioorg.2019.103208CrossRefPubMed

Su Y, Zhang F, Wu L, Kuang H, Wang Q, Cheng G (2022) Total withanolides ameliorates imiquimod-induced psoriasis-like skin inflammation. J Ethnopharmacol 285:114895. https://doi.org/10.1016/j.jep.2021.114895CrossRefPubMed

Sun Y, Li L, Liao M, Su M, Wan C, Zhang L, Zhang H (2018) A systematic data acquisition and mining strategy for chemical profiling of Aster tataricus rhizoma (Ziwan) by UHPLC-Q-TOF-MS and the corresponding anti-depressive activity screening. J Pharm Biomed Anal 154:216–226. https://doi.org/10.1016/j.jpba.2018.03.022CrossRefPubMed

Tóth G, Alberti Á, Sólyomváry A, Barabás C, Boldizsár I, Noszál B (2015) Phenolic profiling of various olive bark-types and leaves: HPLC–ESI/MS study. Ind Crops Prod 67:432–438. https://doi.org/10.1016/j.indcrop.2015.01.077CrossRef

Van der Fits L, Mourits S, Voerman JSA, Kant M, Boon L, Laman JD, Cornelissen F, Mus A-M, Florencia E, Prens EP, Lubberts E (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 Axis1. J Immunol 182:5836–5845. https://doi.org/10.4049/jimmunol.0802999CrossRefPubMed

Wang W, Liu L, Yang Z, Lu C, Tu P, Zhao R, Zeng K (2024) Anti-psoriasis molecular targets and active components discovery of optimized yinxieling formula via affinity-purified strategy. Chin J Nat Med 22:127–136. https://doi.org/10.1016/S1875-5364(24)60563-7CrossRefPubMed

Wu L, Yang L (2018) The function and mechanism of HMGB1 in lung cancer and its potential therapeutic implications. Oncol Lett 15:6799–6805. https://doi.org/10.3892/ol.2018.8215CrossRefPubMedPubMedCentral

Xi M, Ove dragsted L, Tullin M, Ernst M, Zaharudin N, La Barbera G (2021) Discovery of urinary biomarkers of seaweed intake using untargeted LC–MS metabolomics in a three-way cross-over human study. Metabolites 11:11. https://doi.org/10.3390/metabo11010011CrossRef

Xie J, Huang S, Huang H, Deng X, Yue P, Lin J, Yang M, Han L, Zhang D-K (2021) Advances in the application of natural products and the novel drug delivery systems for psoriasis. Front Pharmacol 12. https://doi.org/10.3389/fphar.2021.644952

Xie WD, Weng CW, Niu YF, Lai PX, Row KH (2010) Eudesmane sesquiterpenes and other constituents from Aster himalaicus. Chem Biodivers 7:221–224. https://doi.org/10.1002/cbdv.200900007CrossRefPubMed

Yang H, Shi H, Zhang Q, Liu Y, Wan C, Zhang L (2015a) Simultaneous determination of five components in Aster tataricus by ultra performance liquid chromatography-tandem mass spectrometry. J Chromatogr Sci 54:500–506. https://doi.org/10.1016/j.steroids.2020.108648CrossRefPubMedPubMedCentral

Yang IJ, Lee DU, Shin HM (2015b) Anti-inflammatory and antioxidant effects of coumarins isolated from Foeniculum vulgare in lipopolysaccharide-stimulated macrophages and 12-O-tetradecanoylphorbol-13-acetate-stimulated mice. Immunopharmacol Immunotoxicol 37:308–317. https://doi.org/10.3109/08923973.2015.1038751CrossRefPubMed

Zengin G, Uysal A, Diuzheva A, Gunes E, Jekő J, Cziáky Z, Picot-Allain CMN, Mahomoodally MF (2018) Characterization of phytochemical components of Ferula halophila extracts using HPLC-MS/MS and their pharmacological potentials: a multi-functional insight. J Pharm Biomed Anal 160:374–382. https://doi.org/10.1016/j.jpba.2018.08.020CrossRefPubMed

Zhang F-X, Li Z-T, Li C, Li M, Yao Z-H, Yao X-S, Dai Y (2020) Characterization of lignans in forsythiae fructus and their metabolites in rats by ultra-performance liquid chromatography coupled time-of-flight mass spectrometry. J Pharm Pharmacol 72:1879–1892. https://doi.org/10.1111/jphp.13346CrossRefPubMed

Zhang J, Chen J, Liang Z, Zhao C (2014) New lignans and their biological activities. Chem Biodivers 11:1–54. https://doi.org/10.1002/cbdv.201100433CrossRefPubMed

Zhang J, Li L, Wang J, Jin W, Wang Y, Zhang Z (2023) A strategy for antioxidant quality evaluation of Aster yunnanensis based on fingerprint-activity relationship modeling and chemometric analysis. Arabian J Chem 16:104755. https://doi.org/10.1016/j.arabjc.2023.104755CrossRef

Zhang X-S, Cao J-Q, Liu Z-T, Yuan L, Chen G, Liu J-X, Qu F-Z, Zhao Y-Q (2015) Callistephus A, a novel sesquiterpene from the Callistephus chinensis flower. Phytochem Lett 11:5–8. https://doi.org/10.1016/j.phytol.2014.10.030CrossRef

Zhang X-S, Cao J-Q, Shi G-H, Liu Z-T, Liu J-X, Zhao Y-Q (2016) Two new isoaurones derivatives from Callistephus chinensis flower. Nat Prod Res 30:358–361. https://doi.org/10.1080/14786419.2015.1053090CrossRefPubMed

Zhao D-X, Hu B-Q, Zhang M, Zhang C-F, Xu X-H (2015) Simultaneous separation and determination of phenolic acids, pentapeptides, and triterpenoid saponins in the root of Aster tataricus by high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry. J Sep Science 38:571–575. https://doi.org/10.1002/jssc.201401008CrossRef

Zheleva-Dimitrova D, Sinan KI, Etienne OK, Zengin G, Gevrenova R, Mahomoodally MF, Lobine D, Mollica A (2020) Chemical composition and biological properties of Synedrella nodiflora (L.) Gaertn: a comparative investigation of different extraction methods. Process Biochem 96:202–212. https://doi.org/10.1016/j.procbio.2020.06.002CrossRef

Zhou T, Zhang S, Zhou Y, Lai S, Chen Y, Geng Y, Wang J (2021) Curcumin alleviates imiquimod-induced psoriasis in progranulin-knockout mice. Eur J Pharmacol 909:174431. https://doi.org/10.1016/j.ejphar.2021.174431CrossRefPubMed

Zhou W, Hu M, Zang X, Liu Q, Du J, Hu J, Zhang L, Du Z, Xiang Z (2020) Luteolin attenuates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via suppression of inflammation response. Biomed Pharmacother 131:110696. https://doi.org/10.1016/j.biopha.2020.110696CrossRefPubMed

Title: Efficacy of Aster chinensis aerial parts metabolites in BALB/c mice model of Imiquimod-induced psoriasis skin inflammation
Authors: Mai S. Hendawy
Mona M. Hashem
Ahmed A. Zaki
Mostafa A. Rabie
Nesrine S. El Sayed
Riham Salah El Dine
Ali M. El-Halawany
Publication date: 12-03-2025
Publisher: Springer International Publishing
Keywords: Vulgar Psoriasis
Multiple Sclerosis
Mometasone
Published in: Inflammopharmacology
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-025-01652-x

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Efficacy of Aster chinensis aerial parts metabolites in BALB/c mice model of Imiquimod-induced psoriasis skin inflammation

Abstract

Podcast | Sexual health in older age

Springer Medicine

Abstract

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