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Open Access 16-05-2024 | Vulgar Psoriasis | Original Paper

Deep cardiac phenotyping by cardiovascular magnetic resonance reveals subclinical focal and diffuse myocardial injury in patients with psoriasis (PSOR-COR study)

Authors: Jan Gröschel, Leonhard Grassow, Edyta Blaszczyk, Kerstin Lommel, Georgios Kokolakis, Robert Sabat, Jeanette Schulz-Menger

Published in: Clinical Research in Cardiology

Abstract

Background

Psoriasis vulgaris (PV) is a chronic inflammatory disorder frequently associated with cardiovascular disease (CVD). This study aims to provide a prospective tissue characterization in patients with PV without major CVD using cardiovascular magnetic resonance (CMR).

Methods

Patients with PV underwent laboratory assessment, a 12-lead and 24-h ECG, and a CMR exam at a 1.5-T scanner. Scan protocol included assessment of left (LV) and right (RV) ventricular function and strain analysis, native and post-contrast T1 mapping, T2 mapping and late gadolinium enhancement (LGE).

Results

In total, 60 PV patients (median(IQR) age in years: 50.0 (36.0–60.8); 34 men (56.7%)) were recruited and compared to 40 healthy volunteers (age in years: 49.5 (37.3–57.8); 21 men (53.0%)). No differences were found regarding LV and RV function (p = 0.78 and p = 0.75). Global radial and circumferential strains were lower in patients (p < 0.001 and p < 0.001, respectively). PV had higher global T1 times (1001 (982–1026) ms vs. 991 (968–1005) ms; p = 0.01) and lower global T2 times (48 (47–49) ms vs. 50 (48–51) ms; p < 0.001); however, all values were within local reference ranges. Focal non-ischemic fibrosis was observed in 17 (28.3%) PV patients.

Conclusion

Deep cardiac phenotyping by CMR revealed subclinical myocardial injury in patients with PV without major CVD, despite preserved LV and RV function. Diffuse and focal fibrosis might be the first detectable signs of adverse tissue remodeling leading to reduced circumferential and radial myocardial deformation. In the background of local and systemic immunomodulatory therapy, no signs of myocardial inflammation were detected. The exact impact of immunomodulatory therapies on the myocardium needs to be addressed in future studies.

Study registration

ISRCTN71534700

Graphical Abstract

Available only for authorised users

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Title: Deep cardiac phenotyping by cardiovascular magnetic resonance reveals subclinical focal and diffuse myocardial injury in patients with psoriasis (PSOR-COR study)
Authors: Jan Gröschel
Leonhard Grassow
Edyta Blaszczyk
Kerstin Lommel
Georgios Kokolakis
Robert Sabat
Jeanette Schulz-Menger
Publication date: 16-05-2024
Publisher: Springer Berlin Heidelberg
Keyword: Vulgar Psoriasis
Published in: Clinical Research in Cardiology
Print ISSN: 1861-0684
Electronic ISSN: 1861-0692
DOI: https://doi.org/10.1007/s00392-024-02456-9

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Springer Medicine

Deep cardiac phenotyping by cardiovascular magnetic resonance reveals subclinical focal and diffuse myocardial injury in patients with psoriasis (PSOR-COR study)

Abstract

Background

Methods

Results

Conclusion

Study registration

Graphical Abstract

2024 ESC Congress

Noise pollution dangerous for heart health

Post-TAVI follow up: deploying virtual assistants

Antihypertensives: more effective at morning or night?

Low Lp(a) levels unlikely to increase the risk of diabetes

» View more highlights on the 2024 ESC Congress hub page

A quick guide to ECGs

Keynote webinar | Spotlight on medication adherence

EASD 2024

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Study registration

Graphical Abstract

Please log in to get access to this content

2024 ESC Congress

Noise pollution dangerous for heart health

Post-TAVI follow up: deploying virtual assistants

Antihypertensives: more effective at morning or night?

Low Lp(a) levels unlikely to increase the risk of diabetes

» View more highlights on the 2024 ESC Congress hub page

A quick guide to ECGs

Keynote webinar | Spotlight on medication adherence