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Drugs

Fosrolapitant/Palonosetron: First Approval

  • 24-09-2025
  • Vomiting
  • AdisInsight Report
Published in:
Author
Simon Fung
Published in
Drugs | Issue 11/2025

Abstract

Fosrolapitant/palonosetron (Ritanine®; 瑞坦宁®) is a fixed-dose combination of fosrolapitant, a novel neurokinin-1 (NK-1) receptor antagonist prodrug, and palonosetron, a second generation 5-hydroxytryptamine-3 (5-HT3) receptor antagonist. It is being developed by Fujian Shengdi Pharmaceutical as a preventative treatment of chemotherapy-induced nausea and vomiting. On the 29th of May 2025, fosrolapitant/palonosetron received its first approval in China for the prevention of acute and delayed nausea and vomiting caused by highly emetogenic chemotherapy in adults. This article summarizes the milestones in the development of fosrolapitant/palonosetron leading to this first approval in chemotherapy-induced nausea and vomiting.
Title
Fosrolapitant/Palonosetron: First Approval
Author
Simon Fung
Publication date
24-09-2025
Publisher
Springer International Publishing
Published in
Drugs / Issue 11/2025
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-025-02225-6
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Keynote webinar | Spotlight on dry eye disease

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  • Webinar | 28-05-2026 | 13:00 (CEST)

DED is highly prevalent yet challenging to diagnose and treat. Join leading experts to explore the latest developments and gain practical guidance on effective management in busy clinical settings. Brought to you by Springer Medicine and Eye.

Watch it live: 28 May 2026, 13:00–14:00 (CEST)

Prof. Harminder Dua
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